SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury

Journal of Clinical Investigation

Volumn 107, Issue 9, 2001, Pages 1049-1054

  Bradshaw, Amy D ^a   Sage, E Helene ^a  

^a HOPE HEART INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MATRIX METALLOPROTEINASE; OSTEONECTIN;

ANGIOGENESIS; CELL DIFFERENTIATION; CELL STRUCTURE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TISSUE DISTRIBUTION; TISSUE INJURY; TISSUE REACTION; WOUND HEALING;

EID: 0035022957     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12939     Document Type: Review

References (30)

1. SPARC, a matricellular protein: At the crossroads of cell-matrix communication
2. SPARC, a matricellular glycoprotein with important biological functions
3. Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interface
4. Expression and distribution of SPARC in early Xenopus laevis embryos
5. Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis
6. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
7. Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendons
8. Altered wound healing in mice lacking a functional osteopontin gene (spp1)
9. Importance of the basement membrane protein SPARC for viability and fertility in Caenorhabditis elegans
10. Transient expression of SPARC in the dorsal axis of early Xenopus embryos: Correlation with calcium-dependent adhesion and electrical coupling
11. Transglutaminase-catalyzed matrix cross-linking in differentiating cartilage: Identification of osteonectin as a major glutaminyl substrate
12. Transglutaminases: Multifunctional cross-linking enzymes that stabilize tissues
13. Latent transforming growth factor-β binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-β
14. SPARC mediates focal adhesion disassembly in endothelial cells through a follistatin-like region and the calcium-binding EF-hand
15. The de-adhesive activity of matricellular proteins: Is intermediate cell adhesion an adaptive state?
16. A calcium-binding motif in SPARC/osteonectin inhibits chordomesoderm cell migration during Xenopus laevis gastrulation: Evidence of counter-adhesive activity in vivo
17. Increased sensitivity to the stimulant effects of morphine conferred by anti-adhesive glycoprotein SPARC in amygdala
18. Osteopenia and decreased bone formation in osteonectin-deficient mice
19. Characterization of cells with osteogenic potential from human marrow
20. Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation
21. Mice lacking smad-3 show accelerated wound healing and an impaired local inflammatory response
22. The proliferative response of epidermis of hairless mice to full thickness wounds
23. Leptin enhances wound re-epithlelialization and constitutes a direct function of leptin in skin repair
24. SPARC: A potential diagnostic marker of invasive meningiomas
25. Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells
26. Angiogenesis in cancer, vascular, rheumatoid and other disease
27. Pieces of eight: Bioactive fragments of extracellular proteins as regulators of angiogenesis
28. Developmental anomalies of Xenopus embryos following microinjection of SPARC antibodies
29. Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40