Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction

Kidney International

Volumn 78, Issue 4, 2010, Pages 351-362

  Tapmeier, Thomas T ^a   Fearn, Amy ^b   Brown, Kathryn ^a   Chowdhury, Paramit ^a   Sacks, Steven H ^a   Sheerin, Neil S ^b   Wong, Wilson ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

fibrosis; ureteric obstruction

Indexed keywords

COLLAGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CELL POPULATION; CONTROLLED STUDY; FEMALE; IMMUNE SYSTEM; KIDNEY FIBROSIS; KIDNEY INJURY; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; URETER OBSTRUCTION; WILD TYPE;

EID: 77955174530     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.177     Document Type: Article

References (31)

1. Harris RC, Neilson EG. Toward a unified theory of renal progression. Annu Rev Med 2006; 57: 365-380.
2. Bohle A, Strutz F, Muller GA. On the pathogenesis of chronic renal failure in primary glomerulopathies: a view from the interstitium. Exp Nephrol 1994; 2: 205-210.
3. Robertson H, Ali S, McDonnell BJ et al. Chronic renal allograft dysfunction: the role of T cell-mediated tubular epithelial to mesenchymal cell transition. J Am Soc Nephrol 2004; 15: 390-397.
4. Anders HJ, Vielhauer V, Frink M et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest 2002; 109: 251-259.
5. Vielhauer V, Anders HJ, Mack M et al. Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2-and 5-positive leukocytes. J Am Soc Nephrol 2001; 12: 1173-1187.
6. Eis V, Luckow B, Vielhauer V et al. Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. J Am Soc Nephrol 2004; 15: 337-347.
7. Kitagawa K, Wada T, Furuichi K et al. Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am J Pathol 2004; 165: 237-246.
8. Zheng G, Wang Y, Mahajan D et al. The role of tubulointerstitial inflammation. Kidney Int Suppl 2005; 94: S96-S100.
9. Tipping PG, Holdsworth SR. T cells in crescentic glomerulonephritis. J Am Soc Nephrol 2006; 17: 1253-1263.
10. Mombaerts P, Iacomini J, Johnson RS et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992; 68: 869-877.
11. Moxham VF, Karegli J, Phillips RE et al. Homeostatic proliferation of lymphocytes results in augmented memory-like function and accelerated allograft rejection. J Immunol 2008; 180: 3910-3918.
12. Wong W, Morris PJ, Wood KJ. Syngeneic bone marrow expressing a single donor class I MHC molecule permits acceptance of a fully allogeneic cardiac allograft. Transplantation 1996; 62: 1462-1468.
13. Shappell SB, Gurpinar T, Lechago J et al. Chronic obstructive uropathy in severe combined immunodeficient (SCID) mice: lymphocyte infiltration is not required for progressive tubulointerstitial injury. J Am Soc Nephrol 1998; 9: 1008-1017.
14. Puri TS, Shakaib MI, Chang A et al. Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background. Am J Physiol Renal Physiol 2010; 298: F1024-F1032.
15. Niedermeier M, Reich B, Rodriguez Gomez M et al. CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes. Proc Natl Acad Sci USA 2009; 106: 17892-17897.
16. Nikolic-Paterson DJ, Lan HY, Hill PA et al. Macrophages in renal injury. Kidney Int Suppl 1994; 45: S79-S82.
17. Strutz F, Neilson EG. The role of lymphocytes in the progression of interstitial disease. Kidney Int Suppl 1994; 45: S106-S110.
18. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003; 3: 23-35.
19. Wynn TA. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol 2004; 4: 583-594.
20. Wang Y, Wang YP, Zheng G et al. Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney Int 2007; 72: 290-299.
21. Murali-Krishna K, Ahmed R. Cutting edge: naive T cells masquerading as memory cells. J Immunol 2000; 165: 1733-1737.
22. Wu MJ, Wen MC, Chiu YT et al. Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis. Kidney Int 2006; 69: 2029-2036.
23. Badid C, Vincent M, McGregor B et al. Mycophenolate mofetil reduces myofibroblast infiltration and collagen III deposition in rat remnant kidney. Kidney Int 2000; 58: 51-61.
24. Bayazit AK, Bayazit Y, Noyan A et al. Comparison of mycophenolate mofetil and azathioprine in obstructive nephropathy. Pediatr Nephrol 2003; 18: 100-104.
25. Goncalves RG, Biato MA, Colosimo RD et al. Effects of mycophenolate mofetil and lisinopril on collagen deposition in unilateral ureteral obstruction in rats. Am J Nephrol 2004; 24: 527-536.
26. Kumpers P, Gueler F, Rong S et al. Leptin is a coactivator of TGF-beta in unilateral ureteral obstructive kidney disease. Am J Physiol Renal Physiol 2007; 293: F1355-F1362.
27. Solez K, Colvin RB, Racusen LC et al. Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007; 7: 518-526.
28. Simmons CP, Clare S, Ghaem-Maghami M et al. Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium. Infect Immun 2003; 71: 5077-5086.
29. Tapmeier TT, Brown KL, Tang Z et al. Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation. Kidney Int 2008; 73: 885-889.
30. Rozen S, Skaletsky HJ. Primer3. In, The Whitehead Institute of Biomedical Research, 1998.
31. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: e45.