Progressive renal fibrosis in routine polycystic kidney disease: An immunohistochemical observation

Kidney International

Volumn 58, Issue 2, 2000, Pages 587-597

  Okada, Hirokazu ^a,b,c   Ban, Shinichi ^a,b,c   Nagao, Shizuko ^a,b,c   Takahashi, Hisahide ^a,b,c   Suzuki, Hiromichi ^a,b,c   Neilson, Eric G ^a,b,c  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fibroblast; Heat shock protein 47; Myofibroblast; smooth muscle actin

Indexed keywords

ALPHA ACTIN; ANTISERUM; COLLAGEN; HEAT SHOCK PROTEIN 47; VIMENTIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; FIBROBLAST; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; KIDNEY POLYCYSTIC DISEASE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033865917     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.00205.x     Document Type: Article

References (57)

1. Autosomal dominant polycystic kidney disease
2. A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16
3. Polycystic kidney disease: The complete structure of the PKD1 gene and its protein
4. Autosomal recessive polycystic kidney disease
5. Diffuse renal cystic disease in children: Morphologic and genetic correlations
6. Hereditary polycystic kidney disease (adult form): A microdissection study of two cases at an early state of the disease
7. Molecular basis of autosomal dominant polycystic kidney disease
8. PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein
9. Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease
10. Evidence for a third genetic locus for autosomal dominant polycystic kidney disease
11. Fine mapping of the autosomal recessive polycystic kidney disease locus (PKHD1) and the genes MUT, RDS, CSNK2 beta, and GSTA1 at 6p21.1-p12
12. Understanding human cystic disease through experimental models
13. Rat models of polycystic kidney disease
14. Perinatal lethality with kidney and pancreas defects in mice with a targeted Pkd1 mutation
15. Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes
16. Somatic inactivation of Pkd results in polycystic kidney disease
17. The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: Recent advances
18. A hereditary model of slowly progressive polycystic kidney disease in the mouse
19. Possible mechanisms of renal fibrosis
20. The pathology of human renal cystic disease
21. Renal histology in polycystic kidney disease with incipient and advanced renal failure
22. Abnormalities in extracellular matrix regulation in autosomal dominant polycystic kidney disease
23. Altered extracellular matrix component gene expression in murine polycystic kidney
24. Coexpression of the collagen-binding stress protein HSP47 gene and the alpha 1 (I) and alpha 1 (III) collagens genes in carbon tetrachloride-induced rat liver fibrosis
25. Identification and characterization of a fibroblast marker. FSP1
26. Early role of Fspl in epithelial-mesenchymal transformation
27. Myofibroblast differentiation during fibrosis
28. Phenotypic modulation of renal ceils during experimental and clinical renal scarring
29. Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotypic modulations
30. Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas
31. Reactivity of monoclonal antibodies against intermediate filament proteins during embryonic development
32. Differential expression of cell-cell and cell-substratum adhesion proteins along the kidney nephron
33. Abnormal sodium pump distribution during renal tubulogenesis in congenital murine polycystic kidney disease
34. Polycystic kidney disease: Primary extracellular matrix abnormality or defective cellular differentiation?
35. Renal tubule Na, K-ATPase polarity in different animal models of polycystic kidney disease
36. Epidermal growth factor receptor expression is abnormal in murine polycystic kidney
37. Epithelial cell polarity and disease
38. Renal expression of a transforming growth factor-alpha transgene accelerates the progression of inherited, slowly progressive polycystic kidney disease in the mouse
39. Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mice
40. Disappearance of polycystic kidney disease in revertant c-myc transgenic mice
41. Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease
42. Apoptosis and loss of renal tissue in polycystic kidney diseases
43. Deregulation of cell survival in cystic and dysplastic renal development
44. Extracellular matrix formation by epithelial cells from human polycystic kidney cysts in culture
45. Tubular basement membrane changes during induction and regression of drug-induced polycystic kidney disease
46. Basement membrane chondroitin sulfate proteoglycan alterations in a rat model of polycystic kidney disease
47. Wound healing and collagen formation. VI. Origin
48. Development of non-granular leukocytes (lymphocytes and monocytes) into polyblasts (macrophages) and fibroblasts in vitro
49. Growth factor gene expression in kidney of murine polycystic kidney disease
50. The reninangiotensin-aldosterone system and autosomal dominant polycystic kidney disease
51. Renal injury from angiotensin II-mediated hypertension
52. Effect of sodium chloride, enalapril, and losartan on the development of polycystic kidney disease in Han:SPRD rats
53. Cilazapril delays progression of hypertension and uremia in rat polycystic kidney disease
54. Basement membrane gene expression in polycystic kidney disease
55. Differential expression of markers for endothelial cells, pericytes, and basal lamina in the microvasculature of tumors and granulation tissue
56. Autocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease