Integrin α1β1 and transforming growth factor-β1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy

American Journal of Pathology

Volumn 157, Issue 5, 2000, Pages 1649-1659

  Cosgrove, Dominic ^a   Rodgers, Kathryn ^a   Meehan, Daniel ^a   Miller, Caroline ^a   Bovard, Karen ^a   Gilroy, Amy ^a   Gardner, Humphrey ^b   Kotelianski, Victor ^b   Gotwals, Phillip ^b   Amatucci, Aldo ^b   Kalluri, Raghu ^c  

^a BOYS TOWN NATIONAL RESEARCH HOSPITAL   (United States)

^b BIOGEN   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; TRANSFORMING GROWTH FACTOR BETA1; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; TGFB1 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; VERY LATE ACTIVATION ANTIGEN 1;

ALPORT SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLOMERULONEPHRITIS; IMMUNOFLUORESCENCE TEST; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PATHOGENESIS; PODOCYTE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BASEMENT MEMBRANE; DISEASE COURSE; ELECTRON MICROSCOPY; GENETICS; GLOMERULUS; MOUSE MUTANT; NEPHRITIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BASEMENT MEMBRANE; DISEASE PROGRESSION; IMMUNOGLOBULIN FC FRAGMENTS; INTEGRIN ALPHA1BETA1; INTEGRINS; KIDNEY GLOMERULUS; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; NEPHRITIS, HEREDITARY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT FUSION PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0033623532     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64802-X     Document Type: Article

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