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Volumn 117, Issue 8, 2010, Pages 981-1000

Motor neuron-immune interactions: The vicious circle of ALS

Author keywords

Cytokines; Immune system; Macrophages; Microglia; Neurodegeneration; Neuroinflammation; T lymphocytes

Indexed keywords

ANTIINFLAMMATORY AGENT; CELECOXIB; COLONY STIMULATING FACTOR 1; COPPER ZINC SUPEROXIDE DISMUTASE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; LENALIDOMIDE; MINOCYCLINE; PIOGLITAZONE; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 77956978329     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-010-0429-0     Document Type: Review
Times cited : (41)

References (217)
  • 1
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • 18026097 10.1038/nn2014 1:CAS:528:DC%2BD2sXhtlKltLbP
    • B Ajami JL Bennett C Krieger W Tetzlaff FM Rossi 2007 Local self-renewal can sustain CNS microglia maintenance and function throughout adult life Nat Neurosci 10 1538 1543 18026097 10.1038/nn2014 1:CAS:528:DC%2BD2sXhtlKltLbP
    • (2007) Nat Neurosci , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 2
    • 0035833937 scopus 로고    scopus 로고
    • Immune reactivity in a mouse model of familial ALS correlates with disease progression
    • 11591849 1:STN:280:DC%2BD3MrksVyhug%3D%3D
    • ME Alexianu M Kozovska SH Appel 2001 Immune reactivity in a mouse model of familial ALS correlates with disease progression Neurology 57 1282 1289 11591849 1:STN:280:DC%2BD3MrksVyhug%3D%3D
    • (2001) Neurology , vol.57 , pp. 1282-1289
    • Alexianu, M.E.1    Kozovska, M.2    Appel, S.H.3
  • 3
    • 0033018506 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • 10349851 10.1046/j.1471-4159.1999.0722415.x 1:CAS:528:DyaK1MXjsV2hsLs%3D
    • G Almer S Vukosavic N Romero S Przedborski 1999 Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis J Neurochem 72 2415 2425 10349851 10.1046/j.1471-4159.1999. 0722415.x 1:CAS:528:DyaK1MXjsV2hsLs%3D
    • (1999) J Neurochem , vol.72 , pp. 2415-2425
    • Almer, G.1    Vukosavic, S.2    Romero, N.3    Przedborski, S.4
  • 4
    • 0035132167 scopus 로고    scopus 로고
    • Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis
    • 11220737 10.1002/1531-8249(20010201)49:2 <176::AID-ANA37>3.0.CO;2-X 1:CAS:528:DC%2BD3MXhsVymur4%3D
    • G Almer C Guegan P Teismann A Naini G Rosoklija AP Hays C Chen S Przedborski 2001 Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis Ann Neurol 49 176 185 11220737 10.1002/1531-8249(20010201)49:2 <176::AID-ANA37>3.0.CO;2-X 1:CAS:528:DC%2BD3MXhsVymur4%3D
    • (2001) Ann Neurol , vol.49 , pp. 176-185
    • Almer, G.1    Guegan, C.2    Teismann, P.3    Naini, A.4    Rosoklija, G.5    Hays, A.P.6    Chen, C.7    Przedborski, S.8
  • 5
    • 0025865829 scopus 로고
    • The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration
    • 1713656 10.1016/0306-4522(91)90159-L 1:STN:280:DyaK3MzhvFakuw%3D%3D
    • PB Andersson VH Perry S Gordon 1991 The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration Neuroscience 42 201 214 1713656 10.1016/0306-4522(91) 90159-L 1:STN:280:DyaK3MzhvFakuw%3D%3D
    • (1991) Neuroscience , vol.42 , pp. 201-214
    • Andersson, P.B.1    Perry, V.H.2    Gordon, S.3
  • 6
    • 0031444384 scopus 로고    scopus 로고
    • Lack of evidence for HTLV tax-rex DNA in motor neurone disease
    • 9455984 10.1016/S0022-510X(97)00199-8 1:STN:280:DyaK1c7hsFGiuw%3D%3D
    • WD Andrews A Al-Chalabi JA Garson 1997 Lack of evidence for HTLV tax-rex DNA in motor neurone disease J Neurol Sci 153 86 90 9455984 10.1016/S0022- 510X(97)00199-8 1:STN:280:DyaK1c7hsFGiuw%3D%3D
    • (1997) J Neurol Sci , vol.153 , pp. 86-90
    • Andrews, W.D.1    Al-Chalabi, A.2    Garson, J.A.3
  • 7
    • 0033923528 scopus 로고    scopus 로고
    • Detection of reverse transcriptase activity in the serum of patients with motor neurone disease
    • 10897073 10.1002/1096-9071(200008)61:4 <527::AID-JMV17>3.0.CO;2-A 1:CAS:528:DC%2BD3cXlsVOis7k%3D
    • WD Andrews PW Tuke A Al-Chalabi P Gaudin S Ijaz MJ Parton JA Garson 2000 Detection of reverse transcriptase activity in the serum of patients with motor neurone disease J Med Virol 61 527 532 10897073 10.1002/1096-9071(200008)61: 4<527::AID-JMV17>3.0.CO;2-A 1:CAS:528:DC%2BD3cXlsVOis7k%3D
    • (2000) J Med Virol , vol.61 , pp. 527-532
    • Andrews, W.D.1    Tuke, P.W.2    Al-Chalabi, A.3    Gaudin, P.4    Ijaz, S.5    Parton, M.J.6    Garson, J.A.7
  • 9
    • 0027316880 scopus 로고
    • Evidence for autoimmunity in amyotrophic lateral sclerosis
    • 8229065 10.1016/0022-510X(93)90106-9 1:STN:280:DyaK2c%2FksFOmsA%3D%3D
    • SH Appel RG Smith JI Engelhardt E Stefani 1993 Evidence for autoimmunity in amyotrophic lateral sclerosis J Neurol Sci 118 169 174 8229065 10.1016/0022-510X(93)90106-9 1:STN:280:DyaK2c%2FksFOmsA%3D%3D
    • (1993) J Neurol Sci , vol.118 , pp. 169-174
    • Appel, S.H.1    Smith, R.G.2    Engelhardt, J.I.3    Stefani, E.4
  • 12
    • 9644255989 scopus 로고    scopus 로고
    • A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
    • 15572176 10.1016/j.brainresrev.2004.05.003 1:CAS:528:DC%2BD2cXhtVantLvE
    • LH Barbeito M Pehar P Cassina MR Vargas H Peluffo L Viera AG Estevez JS Beckman 2004 A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis Brain Res Brain Res Rev 47 263 274 15572176 10.1016/j.brainresrev. 2004.05.003 1:CAS:528:DC%2BD2cXhtVantLvE
    • (2004) Brain Res Brain Res Rev , vol.47 , pp. 263-274
    • Barbeito, L.H.1    Pehar, M.2    Cassina, P.3    Vargas, M.R.4    Peluffo, H.5    Viera, L.6    Estevez, A.G.7    Beckman, J.S.8
  • 13
    • 33751003518 scopus 로고    scopus 로고
    • Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
    • 16713195 1:CAS:528:DC%2BD28Xht1CgsLnJ
    • SC Barber RJ Mead PJ Shaw 2006 Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target Biochim Biophys Acta 1762 1051 1067 16713195 1:CAS:528:DC%2BD28Xht1CgsLnJ
    • (2006) Biochim Biophys Acta , vol.1762 , pp. 1051-1067
    • Barber, S.C.1    Mead, R.J.2    Shaw, P.J.3
  • 15
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • 17237347 10.1152/physrev.00044.2005 1:CAS:528:DC%2BD2sXitVagsr4%3D
    • K Bedard KH Krause 2007 The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology Physiol Rev 87 245 313 17237347 10.1152/physrev.00044.2005 1:CAS:528:DC%2BD2sXitVagsr4%3D
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 16
    • 33750478657 scopus 로고    scopus 로고
    • Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    • 17043238 10.1073/pnas.0607423103 1:CAS:528:DC%2BD28XhtFyku7nE
    • DR Beers JS Henkel Q Xiao W Zhao J Wang AA Yen L Siklos SR McKercher SH Appel 2006 Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis Proc Natl Acad Sci USA 103 16021 16026 17043238 10.1073/pnas.0607423103 1:CAS:528:DC%2BD28XhtFyku7nE
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16021-16026
    • Beers, D.R.1    Henkel, J.S.2    Xiao, Q.3    Zhao, W.4    Wang, J.5    Yen, A.A.6    Siklos, L.7    McKercher, S.R.8    Appel, S.H.9
  • 17
    • 55749110043 scopus 로고    scopus 로고
    • CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
    • 18809917 10.1073/pnas.0807419105
    • DR Beers JS Henkel W Zhao J Wang SH Appel 2008 CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS Proc Natl Acad Sci USA 105 15558 15563 18809917 10.1073/pnas.0807419105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15558-15563
    • Beers, D.R.1    Henkel, J.S.2    Zhao, W.3    Wang, J.4    Appel, S.H.5
  • 18
    • 0027460054 scopus 로고
    • Delayed hematopoietic development in osteopetrotic (op/op) mice
    • 8418205 10.1084/jem.177.1.237 1:STN:280:DyaK3s7hsFKltQ%3D%3D
    • SK Begg JM Radley JW Pollard OT Chisholm ER Stanley I Bertoncello 1993 Delayed hematopoietic development in osteopetrotic (op/op) mice J Exp Med 177 237 242 8418205 10.1084/jem.177.1.237 1:STN:280:DyaK3s7hsFKltQ%3D%3D
    • (1993) J Exp Med , vol.177 , pp. 237-242
    • Begg, S.K.1    Radley, J.M.2    Pollard, J.W.3    Chisholm, O.T.4    Stanley, E.R.5    Bertoncello, I.6
  • 20
    • 33846887598 scopus 로고    scopus 로고
    • Microglial control of neuronal death and synaptic properties
    • 17106878 10.1002/glia.20459
    • A Bessis C Bechade D Bernard A Roumier 2007 Microglial control of neuronal death and synaptic properties Glia 55 233 238 17106878 10.1002/glia.20459
    • (2007) Glia , vol.55 , pp. 233-238
    • Bessis, A.1    Bechade, C.2    Bernard, D.3    Roumier, A.4
  • 21
    • 33750959751 scopus 로고    scopus 로고
    • Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls
    • 17116217 10.1111/j.1468-1331.2006.01503.x 1:STN:280: DC%2BD28nnvFKqtw%3D%3D
    • E Bilic I Rudan V Kusec N Zurak D Delimar M Zagar 2006 Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls Eur J Neurol 13 1340 1345 17116217 10.1111/j.1468-1331.2006.01503.x 1:STN:280:DC%2BD28nnvFKqtw%3D%3D
    • (2006) Eur J Neurol , vol.13 , pp. 1340-1345
    • Bilic, E.1    Rudan, I.2    Kusec, V.3    Zurak, N.4    Delimar, D.5    Zagar, M.6
  • 22
    • 33749056809 scopus 로고    scopus 로고
    • ALS: A disease of motor neurons and their nonneuronal neighbors
    • 17015226 10.1016/j.neuron.2006.09.018 1:CAS:528:DC%2BD28XhtFensbfP
    • S Boillee C Vande Velde DW Cleveland 2006 ALS: a disease of motor neurons and their nonneuronal neighbors Neuron 52 39 59 17015226 10.1016/j.neuron.2006. 09.018 1:CAS:528:DC%2BD28XhtFensbfP
    • (2006) Neuron , vol.52 , pp. 39-59
    • Boillee, S.1    Vande Velde, C.2    Cleveland, D.W.3
  • 23
    • 33744798774 scopus 로고    scopus 로고
    • Onset and progression in inherited ALS determined by motor neurons and microglia
    • 16741123 10.1126/science.1123511 1:CAS:528:DC%2BD28XltVOht7o%3D
    • S Boillee K Yamanaka CS Lobsiger NG Copeland NA Jenkins G Kassiotis G Kollias DW Cleveland 2006 Onset and progression in inherited ALS determined by motor neurons and microglia Science 312 1389 1392 16741123 10.1126/science. 1123511 1:CAS:528:DC%2BD28XltVOht7o%3D
    • (2006) Science , vol.312 , pp. 1389-1392
    • Boillee, S.1    Yamanaka, K.2    Lobsiger, C.S.3    Copeland, N.G.4    Jenkins, N.A.5    Kassiotis, G.6    Kollias, G.7    Cleveland, D.W.8
  • 24
    • 0031722582 scopus 로고    scopus 로고
    • A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group
    • 9710040 1:CAS:528:DyaK1cXls1agsr8%3D
    • GD Borasio W Robberecht PN Leigh J Emile RJ Guiloff F Jerusalem V Silani PE Vos JH Wokke T Dobbins 1998 A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group Neurology 51 583 586 9710040 1:CAS:528:DyaK1cXls1agsr8%3D
    • (1998) Neurology , vol.51 , pp. 583-586
    • Borasio, G.D.1    Robberecht, W.2    Leigh, P.N.3    Emile, J.4    Guiloff, R.J.5    Jerusalem, F.6    Silani, V.7    Vos, P.E.8    Wokke, J.H.9    Dobbins, T.10
  • 25
    • 0023197677 scopus 로고
    • Serum insulin-like growth factor-I levels in amyotrophic lateral sclerosis
    • 3302111 10.1136/jnnp.50.6.792 1:STN:280:DyaL2s3ot1Citg%3D%3D
    • GD Braunstein AL Reviczky 1987 Serum insulin-like growth factor-I levels in amyotrophic lateral sclerosis J Neurol Neurosurg Psychiatry 50 792 794 3302111 10.1136/jnnp.50.6.792 1:STN:280:DyaL2s3ot1Citg%3D%3D
    • (1987) J Neurol Neurosurg Psychiatry , vol.50 , pp. 792-794
    • Braunstein, G.D.1    Reviczky, A.L.2
  • 26
    • 0036326074 scopus 로고    scopus 로고
    • Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease
    • 12153485 10.1046/j.1471-4159.2002.00990.x 1:CAS:528:DC%2BD38Xmt1ejsLY%3D
    • T Breidert J Callebert MT Heneka G Landreth JM Launay EC Hirsch 2002 Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease J Neurochem 82 615 624 12153485 10.1046/j.1471-4159.2002.00990.x 1:CAS:528:DC%2BD38Xmt1ejsLY%3D
    • (2002) J Neurochem , vol.82 , pp. 615-624
    • Breidert, T.1    Callebert, J.2    Heneka, M.T.3    Landreth, G.4    Launay, J.M.5    Hirsch, E.C.6
  • 28
    • 33746827434 scopus 로고    scopus 로고
    • Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1
    • 16864778 10.1073/pnas.0604681103 1:CAS:528:DC%2BD28XotFagurk%3D
    • O Butovsky M Koronyo-Hamaoui G Kunis E Ophir G Landa H Cohen M Schwartz 2006 Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1 Proc Natl Acad Sci USA 103 11784 11789 16864778 10.1073/pnas.0604681103 1:CAS:528: DC%2BD28XotFagurk%3D
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11784-11789
    • Butovsky, O.1    Koronyo-Hamaoui, M.2    Kunis, G.3    Ophir, E.4    Landa, G.5    Cohen, H.6    Schwartz, M.7
  • 30
    • 38149037132 scopus 로고    scopus 로고
    • Minocycline for patients with ALS
    • 18207105 10.1016/S1474-4422(08)70005-X (author reply 120-111)
    • MT Carri 2008 Minocycline for patients with ALS Lancet Neurol 7 118 119 18207105 10.1016/S1474-4422(08)70005-X (author reply 120-111)
    • (2008) Lancet Neurol , vol.7 , pp. 118-119
    • Carri, M.T.1
  • 32
    • 77950458426 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice
    • 19888600
    • K Chen FJ Northington LJ Martin 2009 Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice Brain Struct Funct 214 2-3 219 234 19888600
    • (2009) Brain Struct Funct , vol.214 , Issue.23 , pp. 219-234
    • Chen, K.1    Northington, F.J.2    Martin, L.J.3
  • 33
    • 58149354213 scopus 로고    scopus 로고
    • Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase
    • 19005069 10.1523/JNEUROSCI.3568-08.2008 1:CAS:528:DC%2BD1cXhsVarurbL
    • C Cheret A Gervais A Lelli C Colin L Amar P Ravassard J Mallet A Cumano KH Krause M Mallat 2008 Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase J Neurosci 28 12039 12051 19005069 10.1523/JNEUROSCI.3568-08.2008 1:CAS:528:DC%2BD1cXhsVarurbL
    • (2008) J Neurosci , vol.28 , pp. 12039-12051
    • Cheret, C.1    Gervais, A.2    Lelli, A.3    Colin, C.4    Amar, L.5    Ravassard, P.6    Mallet, J.7    Cumano, A.8    Krause, K.H.9    Mallat, M.10
  • 38
    • 0032528350 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: Correlation with induction of heme oxygenase 1
    • 9670978 1:CAS:528:DyaK1cXksFKisrk%3D
    • PR Colville-Nash SS Qureshi D Willis DA Willoughby 1998 Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1 J Immunol 161 978 984 9670978 1:CAS:528:DyaK1cXksFKisrk%3D
    • (1998) J Immunol , vol.161 , pp. 978-984
    • Colville-Nash, P.R.1    Qureshi, S.S.2    Willis, D.3    Willoughby, D.A.4
  • 39
    • 1842714301 scopus 로고    scopus 로고
    • Neuroinflammation, COX-2, and ALS - A dual role?
    • 15081582 10.1016/j.expneurol.2003.12.009 1:CAS:528:DC%2BD2cXjtVChtrw%3D
    • C Consilvio AM Vincent EL Feldman 2004 Neuroinflammation, COX-2, and ALS-a dual role? Exp Neurol 187 1 10 15081582 10.1016/j.expneurol.2003.12.009 1:CAS:528:DC%2BD2cXjtVChtrw%3D
    • (2004) Exp Neurol , vol.187 , pp. 1-10
    • Consilvio, C.1    Vincent, A.M.2    Feldman, E.L.3
  • 40
    • 77649097159 scopus 로고    scopus 로고
    • Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients
    • 19845745 10.1111/j.1468-1331.2009.02815.x
    • M Corbo C Lunetta P Magni E Dozio M Ruscica L Adobbati V Silani 2009 Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients Eur J Neurol 17 398 404 19845745 10.1111/j.1468-1331.2009.02815.x
    • (2009) Eur J Neurol , vol.17 , pp. 398-404
    • Corbo, M.1    Lunetta, C.2    Magni, P.3    Dozio, E.4    Ruscica, M.5    Adobbati, L.6    Silani, V.7
  • 41
    • 8144229995 scopus 로고    scopus 로고
    • Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues
    • 15469951 10.1093/brain/awh273
    • S Corti F Locatelli C Donadoni M Guglieri D Papadimitriou S Strazzer R Del Bo GP Comi 2004 Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues Brain 127 2518 2532 15469951 10.1093/brain/awh273
    • (2004) Brain , vol.127 , pp. 2518-2532
    • Corti, S.1    Locatelli, F.2    Donadoni, C.3    Guglieri, M.4    Papadimitriou, D.5    Strazzer, S.6    Del Bo, R.7    Comi, G.P.8
  • 42
    • 0031690332 scopus 로고    scopus 로고
    • The origin and differentiation of microglial cells during development
    • 9760700 10.1016/S0301-0082(98)00035-5 1:STN:280:DyaK1cvjtlCjuw%3D%3D
    • MA Cuadros J Navascues 1998 The origin and differentiation of microglial cells during development Prog Neurobiol 56 173 189 9760700 10.1016/S0301- 0082(98)00035-5 1:STN:280:DyaK1cvjtlCjuw%3D%3D
    • (1998) Prog Neurobiol , vol.56 , pp. 173-189
    • Cuadros, M.A.1    Navascues, J.2
  • 44
    • 70449732762 scopus 로고    scopus 로고
    • The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis
    • 19734218 10.4049/jimmunol.0901212 1:CAS:528:DC%2BD1MXhtFGjsLzP
    • N D'Ambrosi P Finocchi S Apolloni M Cozzolino A Ferri V Padovano G Pietrini MT Carri C Volonte 2009 The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J Immunol 183 4648 4656 19734218 10.4049/jimmunol.0901212 1:CAS:528:DC%2BD1MXhtFGjsLzP
    • (2009) J Immunol , vol.183 , pp. 4648-4656
    • D'Ambrosi, N.1    Finocchi, P.2    Apolloni, S.3    Cozzolino, M.4    Ferri, A.5    Padovano, V.6    Pietrini, G.7    Carri, M.T.8    Volonte, C.9
  • 45
    • 0036092801 scopus 로고    scopus 로고
    • Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
    • 11756160 10.1182/blood.V99.1.111 1:CAS:528:DC%2BD38XivF2isA%3D%3D
    • XM Dai GR Ryan AJ Hapel MG Dominguez RG Russell S Kapp V Sylvestre ER Stanley 2002 Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects Blood 99 111 120 11756160 10.1182/blood.V99.1.111 1:CAS:528:DC%2BD38XivF2isA%3D%3D
    • (2002) Blood , vol.99 , pp. 111-120
    • Dai, X.M.1    Ryan, G.R.2    Hapel, A.J.3    Dominguez, M.G.4    Russell, R.G.5    Kapp, S.6    Sylvestre, V.7    Stanley, E.R.8
  • 47
    • 0347087323 scopus 로고    scopus 로고
    • Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with i kappa B alpha induction and block of NF kappa B and iNOS activation
    • 14690537 10.1046/j.1471-4159.2003.02210.x 1:CAS:528: DC%2BD2cXntlWjug%3D%3D
    • T Dehmer MT Heneka M Sastre J Dichgans JB Schulz 2004 Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation J Neurochem 88 494 501 14690537 10.1046/j.1471-4159.2003.02210.x 1:CAS:528:DC%2BD2cXntlWjug%3D%3D
    • (2004) J Neurochem , vol.88 , pp. 494-501
    • Dehmer, T.1    Heneka, M.T.2    Sastre, M.3    Dichgans, J.4    Schulz, J.B.5
  • 49
    • 34247473080 scopus 로고    scopus 로고
    • Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
    • 17435754 10.1038/nn1885 1:CAS:528:DC%2BD2sXksFShsLg%3D
    • FP Di Giorgio MA Carrasco MC Siao T Maniatis K Eggan 2007 Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model Nat Neurosci 10 608 614 17435754 10.1038/nn1885 1:CAS:528: DC%2BD2sXksFShsLg%3D
    • (2007) Nat Neurosci , vol.10 , pp. 608-614
    • Di Giorgio, F.P.1    Carrasco, M.A.2    Siao, M.C.3    Maniatis, T.4    Eggan, K.5
  • 50
    • 13844253540 scopus 로고    scopus 로고
    • Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model
    • 15657392 10.1083/jcb.200407021 1:CAS:528:DC%2BD2MXls1OgsA%3D%3D
    • G Dobrowolny C Giacinti L Pelosi C Nicoletti N Winn L Barberi M Molinaro N Rosenthal A Musaro 2005 Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model J Cell Biol 168 193 199 15657392 10.1083/jcb.200407021 1:CAS:528:DC%2BD2MXls1OgsA%3D%3D
    • (2005) J Cell Biol , vol.168 , pp. 193-199
    • Dobrowolny, G.1    Giacinti, C.2    Pelosi, L.3    Nicoletti, C.4    Winn, N.5    Barberi, L.6    Molinaro, M.7    Rosenthal, N.8    Musaro, A.9
  • 52
    • 0036895241 scopus 로고    scopus 로고
    • Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS
    • 12447931 10.1002/ana.10374 1:CAS:528:DC%2BD38Xps1Oqs7c%3D
    • DB Drachman K Frank M Dykes-Hoberg P Teismann G Almer S Przedborski JD Rothstein 2002 Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS Ann Neurol 52 771 778 12447931 10.1002/ana.10374 1:CAS:528:DC%2BD38Xps1Oqs7c%3D
    • (2002) Ann Neurol , vol.52 , pp. 771-778
    • Drachman, D.B.1    Frank, K.2    Dykes-Hoberg, M.3    Teismann, P.4    Almer, G.5    Przedborski, S.6    Rothstein, J.D.7
  • 53
    • 74949142875 scopus 로고    scopus 로고
    • Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death
    • 20071543 10.1523/JNEUROSCI.5411-09.2010 1:CAS:528:DC%2BC3cXhtFahtbk%3D
    • L Duplan N Bernard W Casseron K Dudley E Thouvenot J Honnorat V Rogemond B De Bovis P Aebischer P Marin C Raoul CE Henderson B Pettmann 2010 Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death J Neurosci 30 785 796 20071543 10.1523/JNEUROSCI.5411-09.2010 1:CAS:528: DC%2BC3cXhtFahtbk%3D
    • (2010) J Neurosci , vol.30 , pp. 785-796
    • Duplan, L.1    Bernard, N.2    Casseron, W.3    Dudley, K.4    Thouvenot, E.5    Honnorat, J.6    Rogemond, V.7    De Bovis, B.8    Aebischer, P.9    Marin, P.10    Raoul, C.11    Henderson, C.E.12    Pettmann, B.13
  • 54
    • 0035500386 scopus 로고    scopus 로고
    • Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis
    • 11687290 10.1016/S0169-328X(01)00242-X 1:CAS:528:DC%2BD3MXnvFClt7g%3D
    • JL Elliott 2001 Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis Brain Res Mol Brain Res 95 172 178 11687290 10.1016/S0169-328X(01)00242-X 1:CAS:528:DC%2BD3MXnvFClt7g%3D
    • (2001) Brain Res Mol Brain Res , vol.95 , pp. 172-178
    • Elliott, J.L.1
  • 55
    • 0034717016 scopus 로고    scopus 로고
    • Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis)
    • 10896029 10.1016/S0024-3205(00)00602-0 1:CAS:528:DC%2BD3cXjvFOnt7c%3D
    • N Ende F Weinstein R Chen M Ende 2000 Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis) Life Sci 67 53 59 10896029 10.1016/S0024-3205(00)00602-0 1:CAS:528:DC%2BD3cXjvFOnt7c%3D
    • (2000) Life Sci , vol.67 , pp. 53-59
    • Ende, N.1    Weinstein, F.2    Chen, R.3    Ende, M.4
  • 56
    • 0027473452 scopus 로고
    • Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis
    • 8093428 1:STN:280:DyaK3s7hvFaquw%3D%3D
    • JI Engelhardt J Tajti SH Appel 1993 Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis Arch Neurol 50 30 36 8093428 1:STN:280:DyaK3s7hvFaquw%3D%3D
    • (1993) Arch Neurol , vol.50 , pp. 30-36
    • Engelhardt, J.I.1    Tajti, J.2    Appel, S.H.3
  • 57
    • 34250177650 scopus 로고    scopus 로고
    • Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation
    • 17394546 10.1111/j.1471-4159.2007.04531.x 1:CAS:528:DC%2BD2sXnvVWjtbk%3D
    • SA Ezzi M Urushitani JP Julien 2007 Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation J Neurochem 102 170 178 17394546 10.1111/j.1471-4159.2007.04531.x 1:CAS:528:DC%2BD2sXnvVWjtbk%3D
    • (2007) J Neurochem , vol.102 , pp. 170-178
    • Ezzi, S.A.1    Urushitani, M.2    Julien, J.P.3
  • 58
    • 0032954386 scopus 로고    scopus 로고
    • Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis
    • 10338314 10.1016/S0306-4522(98)00492-8 1:CAS:528:DyaK1MXisFKiurs%3D
    • F Facchinetti M Sasaki FB Cutting P Zhai JE MacDonald D Reif MF Beal PL Huang TM Dawson ME Gurney VL Dawson 1999 Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis Neuroscience 90 1483 1492 10338314 10.1016/S0306-4522(98)00492-8 1:CAS:528:DyaK1MXisFKiurs%3D
    • (1999) Neuroscience , vol.90 , pp. 1483-1492
    • Facchinetti, F.1    Sasaki, M.2    Cutting, F.B.3    Zhai, P.4    MacDonald, J.E.5    Reif, D.6    Beal, M.F.7    Huang, P.L.8    Dawson, T.M.9    Gurney, M.E.10    Dawson, V.L.11
  • 59
    • 33847783428 scopus 로고    scopus 로고
    • Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene
    • 17328801 10.1186/1742-2094-4-9 1:CAS:528:DC%2BD2sXjsl2rsrg%3D
    • SE Fendrick QS Xue WJ Streit 2007 Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene J Neuroinflammation 4 9 17328801 10.1186/1742-2094-4-9 1:CAS:528:DC%2BD2sXjsl2rsrg%3D
    • (2007) J Neuroinflammation , vol.4 , pp. 9
    • Fendrick, S.E.1    Xue, Q.S.2    Streit, W.J.3
  • 60
    • 0035476293 scopus 로고    scopus 로고
    • Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy
    • 11599003 10.1002/jnr.1198 1:CAS:528:DC%2BD3MXnsVyqsrc%3D
    • A Flugel M Bradl GW Kreutzberg MB Graeber 2001 Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy J Neurosci Res 66 74 82 11599003 10.1002/jnr.1198 1:CAS:528:DC%2BD3MXnsVyqsrc%3D
    • (2001) J Neurosci Res , vol.66 , pp. 74-82
    • Flugel, A.1    Bradl, M.2    Kreutzberg, G.W.3    Graeber, M.B.4
  • 61
    • 24644435506 scopus 로고    scopus 로고
    • Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease
    • 16100572 10.1172/JCI23241 1:CAS:528:DC%2BD2MXhtVSjsrfK
    • D Frenkel R Maron DS Burt HL Weiner 2005 Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease J Clin Invest 115 2423 2433 16100572 10.1172/JCI23241 1:CAS:528:DC%2BD2MXhtVSjsrfK
    • (2005) J Clin Invest , vol.115 , pp. 2423-2433
    • Frenkel, D.1    Maron, R.2    Burt, D.S.3    Weiner, H.L.4
  • 62
    • 10744223784 scopus 로고    scopus 로고
    • Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: Distribution, migration, and differentiation
    • 12857367 10.1089/152581603322022990 1:CAS:528:DC%2BD3sXkvVSmu7o%3D
    • S Garbuzova-Davis AE Willing T Zigova S Saporta EB Justen JC Lane JE Hudson N Chen CD Davis PR Sanberg 2003 Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation J Hematother Stem Cell Res 12 255 270 12857367 10.1089/152581603322022990 1:CAS:528:DC%2BD3sXkvVSmu7o%3D
    • (2003) J Hematother Stem Cell Res , vol.12 , pp. 255-270
    • Garbuzova-Davis, S.1    Willing, A.E.2    Zigova, T.3    Saporta, S.4    Justen, E.B.5    Lane, J.C.6    Hudson, J.E.7    Chen, N.8    Davis, C.D.9    Sanberg, P.R.10
  • 63
    • 54049123282 scopus 로고    scopus 로고
    • Implications of blood-brain barrier disruption in ALS
    • 18608097 10.1080/17482960802160990
    • S Garbuzova-Davis S Saporta PR Sanberg 2008 Implications of blood-brain barrier disruption in ALS Amyotroph Lateral Scler 9 375 376 18608097 10.1080/17482960802160990
    • (2008) Amyotroph Lateral Scler , vol.9 , pp. 375-376
    • Garbuzova-Davis, S.1    Saporta, S.2    Sanberg, P.R.3
  • 65
    • 0034651102 scopus 로고    scopus 로고
    • Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration
    • 10632595 1:CAS:528:DC%2BD3cXhtF2hsbk%3D
    • YH Gong AS Parsadanian A Andreeva WD Snider JL Elliott 2000 Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration J Neurosci 20 660 665 10632595 1:CAS:528:DC%2BD3cXhtF2hsbk%3D
    • (2000) J Neurosci , vol.20 , pp. 660-665
    • Gong, Y.H.1    Parsadanian, A.S.2    Andreeva, A.3    Snider, W.D.4    Elliott, J.L.5
  • 67
    • 33750962014 scopus 로고    scopus 로고
    • Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations
    • 17079668 10.1523/JNEUROSCI.0602-06.2006 1:CAS:528:DC%2BD28Xht1aksbvE
    • G Gowing F Dequen G Soucy JP Julien 2006 Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations J Neurosci 26 11397 11402 17079668 10.1523/JNEUROSCI.0602-06.2006 1:CAS:528:DC%2BD28Xht1aksbvE
    • (2006) J Neurosci , vol.26 , pp. 11397-11402
    • Gowing, G.1    Dequen, F.2    Soucy, G.3    Julien, J.P.4
  • 68
    • 55049120934 scopus 로고    scopus 로고
    • Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase
    • 18842883 10.1523/JNEUROSCI.3494-08.2008 1:CAS:528:DC%2BD1cXht1GksLbM
    • G Gowing T Philips B Van Wijmeersch JN Audet M Dewil L Van Den Bosch AD Billiau W Robberecht JP Julien 2008 Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase J Neurosci 28 10234 10244 18842883 10.1523/JNEUROSCI.3494-08.2008 1:CAS:528:DC%2BD1cXht1GksLbM
    • (2008) J Neurosci , vol.28 , pp. 10234-10244
    • Gowing, G.1    Philips, T.2    Van Wijmeersch, B.3    Audet, J.N.4    Dewil, M.5    Van Den Bosch, L.6    Billiau, A.D.7    Robberecht, W.8    Julien, J.P.9
  • 69
    • 71549119504 scopus 로고    scopus 로고
    • Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase
    • 19733170 10.1016/j.expneurol.2009.08.021 1:CAS:528:DC%2BD1MXhsVGnt7zK
    • G Gowing M Lalancette-Hebert JN Audet F Dequen JP Julien 2009 Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase Exp Neurol 220 267 275 19733170 10.1016/j.expneurol.2009.08.021 1:CAS:528:DC%2BD1MXhsVGnt7zK
    • (2009) Exp Neurol , vol.220 , pp. 267-275
    • Gowing, G.1    Lalancette-Hebert, M.2    Audet, J.N.3    Dequen, F.4    Julien, J.P.5
  • 70
    • 77349114038 scopus 로고    scopus 로고
    • Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis
    • 20109233 10.1186/1742-2094-7-8 1:CAS:528:DC%2BC3cXhsFGku7k%3D
    • DJ Graber WF Hickey BT Harris 2010 Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis J Neuroinflammation 7 8 20109233 10.1186/1742-2094-7-8 1:CAS:528:DC%2BC3cXhsFGku7k%3D
    • (2010) J Neuroinflammation , vol.7 , pp. 8
    • Graber, D.J.1    Hickey, W.F.2    Harris, B.T.3
  • 71
    • 0027420887 scopus 로고
    • Macrophage systems in peripheral nerves: A review
    • 7693878 10.1097/00005072-199311000-00001 1:STN:280:DyaK2c%2FksFOlsw%3D%3D
    • JW Griffin R George T Ho 1993 Macrophage systems in peripheral nerves: a review J Neuropathol Exp Neurol 52 553 560 7693878 10.1097/00005072-199311000- 00001 1:STN:280:DyaK2c%2FksFOlsw%3D%3D
    • (1993) J Neuropathol Exp Neurol , vol.52 , pp. 553-560
    • Griffin, J.W.1    George, R.2    Ho, T.3
  • 73
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
    • 8209258 10.1126/science.8209258 1:CAS:528:DyaK2cXksFGisbk%3D
    • ME Gurney H Pu AY Chiu MC Dal Canto CY Polchow DD Alexander J Caliendo A Hentati YW Kwon HX Deng, et al. 1994 Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation Science 264 1772 1775 8209258 10.1126/science.8209258 1:CAS:528:DyaK2cXksFGisbk%3D
    • (1994) Science , vol.264 , pp. 1772-1775
    • Gurney, M.E.1    Pu, H.2    Chiu, A.Y.3    Dal Canto, M.C.4    Polchow, C.Y.5    Alexander, D.D.6    Caliendo, J.7    Hentati, A.8    Kwon, Y.W.9    Deng, H.X.10
  • 74
    • 33947216452 scopus 로고    scopus 로고
    • Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS
    • 17276077 10.1016/j.nbd.2006.12.013 1:CAS:528:DC%2BD2sXjsVGhsrY%3D
    • C Haenggeli JP Julien RL Mosley N Perez A Dhar HE Gendelman JD Rothstein 2007 Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS Neurobiol Dis 26 146 152 17276077 10.1016/j.nbd.2006.12.013 1:CAS:528:DC%2BD2sXjsVGhsrY%3D
    • (2007) Neurobiol Dis , vol.26 , pp. 146-152
    • Haenggeli, C.1    Julien, J.P.2    Mosley, R.L.3    Perez, N.4    Dhar, A.5    Gendelman, H.E.6    Rothstein, J.D.7
  • 75
    • 0032125587 scopus 로고    scopus 로고
    • Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
    • 9633809 10.1002/(SICI)1098-1136(199807)23:3 <249::AID-GLIA7>3.0. CO;2-# 1:STN:280:DyaK1c3psFGltA%3D%3D
    • ED Hall JA Oostveen ME Gurney 1998 Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS Glia 23 249 256 9633809 10.1002/(SICI)1098-1136(199807)23:3<249: :AID-GLIA7>3.0.CO;2-# 1:STN:280:DyaK1c3psFGltA%3D%3D
    • (1998) Glia , vol.23 , pp. 249-256
    • Hall, E.D.1    Oostveen, J.A.2    Gurney, M.E.3
  • 76
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
    • 17965659 10.1038/nn1997 1:CAS:528:DC%2BD2sXht1ajsbbE
    • UK Hanisch H Kettenmann 2007 Microglia: active sensor and versatile effector cells in the normal and pathologic brain Nat Neurosci 10 1387 1394 17965659 10.1038/nn1997 1:CAS:528:DC%2BD2sXht1ajsbbE
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 78
    • 10744229158 scopus 로고    scopus 로고
    • Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
    • 14755726 10.1002/ana.10805 1:CAS:528:DC%2BD2cXhs1SgtbY%3D
    • JS Henkel JI Engelhardt L Siklos EP Simpson SH Kim T Pan JC Goodman T Siddique DR Beers SH Appel 2004 Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue Ann Neurol 55 221 235 14755726 10.1002/ana.10805 1:CAS:528: DC%2BD2cXhs1SgtbY%3D
    • (2004) Ann Neurol , vol.55 , pp. 221-235
    • Henkel, J.S.1    Engelhardt, J.I.2    Siklos, L.3    Simpson, E.P.4    Kim, S.H.5    Pan, T.6    Goodman, J.C.7    Siddique, T.8    Beers, D.R.9    Appel, S.H.10
  • 79
    • 33644821966 scopus 로고    scopus 로고
    • The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS
    • 16337133 10.1016/j.mcn.2005.10.016 1:CAS:528:DC%2BD28Xit1CmtLw%3D
    • JS Henkel DR Beers L Siklos SH Appel 2006 The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS Mol Cell Neurosci 31 427 437 16337133 10.1016/j.mcn.2005.10.016 1:CAS:528:DC%2BD28Xit1CmtLw%3D
    • (2006) Mol Cell Neurosci , vol.31 , pp. 427-437
    • Henkel, J.S.1    Beers, D.R.2    Siklos, L.3    Appel, S.H.4
  • 80
    • 0041833409 scopus 로고    scopus 로고
    • Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis
    • 13678668 10.1016/S0969-9961(03)00087-1 1:CAS:528:DC%2BD3sXnt1amt7s%3D
    • K Hensley J Fedynyshyn S Ferrell RA Floyd B Gordon P Grammas L Hamdheydari M Mhatre S Mou QN Pye C Stewart M West S West KS Williamson 2003 Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis Neurobiol Dis 14 74 80 13678668 10.1016/S0969-9961(03)00087-1 1:CAS:528:DC%2BD3sXnt1amt7s%3D
    • (2003) Neurobiol Dis , vol.14 , pp. 74-80
    • Hensley, K.1    Fedynyshyn, J.2    Ferrell, S.3    Floyd, R.A.4    Gordon, B.5    Grammas, P.6    Hamdheydari, L.7    Mhatre, M.8    Mou, S.9    Pye, Q.N.10    Stewart, C.11    West, M.12    West, S.13    Williamson, K.S.14
  • 82
    • 35848932533 scopus 로고    scopus 로고
    • Circulating insulin-like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis
    • 17697791 10.1016/j.ghir.2007.06.002 1:CAS:528:DC%2BD2sXht1ylsrbI
    • S Hosback O Hardiman CM Nolan MA Doyle G Gorman C Lynch O O'Toole P Jakeman 2007 Circulating insulin-like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis Growth Horm IGF Res 17 472 479 17697791 10.1016/j.ghir.2007.06.002 1:CAS:528:DC%2BD2sXht1ylsrbI
    • (2007) Growth Horm IGF Res , vol.17 , pp. 472-479
    • Hosback, S.1    Hardiman, O.2    Nolan, C.M.3    Doyle, M.A.4    Gorman, G.5    Lynch, C.6    O'Toole, O.7    Jakeman, P.8
  • 84
    • 74049164709 scopus 로고    scopus 로고
    • Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
    • 19951898 10.1083/jcb.200908164 1:CAS:528:DC%2BD1MXhsF2qtb3F
    • H Ilieva M Polymenidou DW Cleveland 2009 Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond J Cell Biol 187 761 772 19951898 10.1083/jcb.200908164 1:CAS:528:DC%2BD1MXhsF2qtb3F
    • (2009) J Cell Biol , vol.187 , pp. 761-772
    • Ilieva, H.1    Polymenidou, M.2    Cleveland, D.W.3
  • 85
    • 28444486336 scopus 로고    scopus 로고
    • The function of microglia through purinergic receptors: Neuropathic pain and cytokine release
    • 16169595 10.1016/j.pharmthera.2005.07.001 1:CAS:528:DC%2BD2MXht12ktbbL
    • K Inoue 2006 The function of microglia through purinergic receptors: neuropathic pain and cytokine release Pharmacol Ther 109 210 226 16169595 10.1016/j.pharmthera.2005.07.001 1:CAS:528:DC%2BD2MXht12ktbbL
    • (2006) Pharmacol Ther , vol.109 , pp. 210-226
    • Inoue, K.1
  • 86
    • 39849103473 scopus 로고    scopus 로고
    • Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
    • 18305242 10.1523/JNEUROSCI.5258-07.2008 1:CAS:528:DC%2BD1cXjt1Cqtb8%3D
    • D Jaarsma E Teuling ED Haasdijk CI De Zeeuw CC Hoogenraad 2008 Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice J Neurosci 28 2075 2088 18305242 10.1523/JNEUROSCI.5258-07.2008 1:CAS:528:DC%2BD1cXjt1Cqtb8%3D
    • (2008) J Neurosci , vol.28 , pp. 2075-2088
    • Jaarsma, D.1    Teuling, E.2    Haasdijk, E.D.3    De Zeeuw, C.I.4    Hoogenraad, C.C.5
  • 87
    • 37849007550 scopus 로고    scopus 로고
    • Oxidized/misfolded superoxide dismutase-1: The cause of all amyotrophic lateral sclerosis?
    • 18074357 10.1002/ana.21319 1:CAS:528:DC%2BD1cXhsVCrtbk%3D
    • E Kabashi PN Valdmanis P Dion GA Rouleau 2007 Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis? Ann Neurol 62 553 559 18074357 10.1002/ana.21319 1:CAS:528:DC%2BD1cXhsVCrtbk%3D
    • (2007) Ann Neurol , vol.62 , pp. 553-559
    • Kabashi, E.1    Valdmanis, P.N.2    Dion, P.3    Rouleau, G.A.4
  • 89
    • 0035939448 scopus 로고    scopus 로고
    • Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: Impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice
    • 11438923 10.1002/cne.1060 1:STN:280:DC%2BD3MzosVOhsw%3D%3D
    • R Kalla Z Liu S Xu A Koppius Y Imai CU Kloss S Kohsaka A Gschwendtner JC Moller A Werner G Raivich 2001 Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice J Comp Neurol 436 182 201 11438923 10.1002/cne.1060 1:STN:280: DC%2BD3MzosVOhsw%3D%3D
    • (2001) J Comp Neurol , vol.436 , pp. 182-201
    • Kalla, R.1    Liu, Z.2    Xu, S.3    Koppius, A.4    Imai, Y.5    Kloss, C.U.6    Kohsaka, S.7    Gschwendtner, A.8    Moller, J.C.9    Werner, A.10    Raivich, G.11
  • 90
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • 12907804 10.1126/science.1086137 1:CAS:528:DC%2BD3sXmtVGqs7c%3D
    • BK Kaspar J Llado N Sherkat JD Rothstein FH Gage 2003 Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model Science 301 839 842 12907804 10.1126/science.1086137 1:CAS:528:DC%2BD3sXmtVGqs7c%3D
    • (2003) Science , vol.301 , pp. 839-842
    • Kaspar, B.K.1    Llado, J.2    Sherkat, N.3    Rothstein, J.D.4    Gage, F.H.5
  • 91
    • 0026605961 scopus 로고
    • Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue
    • 1347673 1:STN:280:DyaK387ovFSrsQ%3D%3D
    • T Kawamata H Akiyama T Yamada PL McGeer 1992 Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue Am J Pathol 140 691 707 1347673 1:STN:280:DyaK387ovFSrsQ%3D%3D
    • (1992) Am J Pathol , vol.140 , pp. 691-707
    • Kawamata, T.1    Akiyama, H.2    Yamada, T.3    McGeer, P.L.4
  • 92
    • 11844269951 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis
    • 15649489 10.1016/j.expneurol.2004.10.007 1:CAS:528:DC%2BD2MXksFKisw%3D%3D
    • M Kiaei K Kipiani J Chen NY Calingasan MF Beal 2005 Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis Exp Neurol 191 331 336 15649489 10.1016/j.expneurol.2004.10.007 1:CAS:528:DC%2BD2MXksFKisw%3D%3D
    • (2005) Exp Neurol , vol.191 , pp. 331-336
    • Kiaei, M.1    Kipiani, K.2    Chen, J.3    Calingasan, N.Y.4    Beal, M.F.5
  • 94
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • 8843599 10.1016/0166-2236(96)10049-7 1:STN:280:DyaK2s%2FgtVGitg%3D%3D
    • GW Kreutzberg 1996 Microglia: a sensor for pathological events in the CNS Trends Neurosci 19 312 318 8843599 10.1016/0166-2236(96)10049-7 1:STN:280:DyaK2s%2FgtVGitg%3D%3D
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 95
    • 0036406903 scopus 로고    scopus 로고
    • Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis
    • 12270689 10.1006/nbdi.2002.0487 1:CAS:528:DC%2BD38XmvFais74%3D
    • J Kriz MD Nguyen JP Julien 2002 Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis Neurobiol Dis 10 268 278 12270689 10.1006/nbdi.2002.0487 1:CAS:528:DC%2BD38XmvFais74%3D
    • (2002) Neurobiol Dis , vol.10 , pp. 268-278
    • Kriz, J.1    Nguyen, M.D.2    Julien, J.P.3
  • 96
    • 65449167187 scopus 로고    scopus 로고
    • Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis
    • 19236470 10.1111/j.1468-1331.2009.02560.x 1:STN:280: DC%2BD1MzlvFyqsw%3D%3D
    • J Kuhle RL Lindberg A Regeniter M Mehling AJ Steck L Kappos A Czaplinski 2009 Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis Eur J Neurol 16 771 774 19236470 10.1111/j.1468-1331.2009.02560.x 1:STN:280:DC%2BD1MzlvFyqsw%3D%3D
    • (2009) Eur J Neurol , vol.16 , pp. 771-774
    • Kuhle, J.1    Lindberg, R.L.2    Regeniter, A.3    Mehling, M.4    Steck, A.J.5    Kappos, L.6    Czaplinski, A.7
  • 98
    • 6844266272 scopus 로고    scopus 로고
    • Effect of recombinant human insulin-like growth factor-I on progression of ALS: A placebo-controlled study. The North America ALS/IGF-I Study Group
    • 9409357 1:CAS:528:DyaK1cXitVCnsg%3D%3D
    • EC Lai KJ Felice BW Festoff MJ Gawel DF Gelinas R Kratz MF Murphy HM Natter FH Norris SA Rudnicki 1997 Effect of recombinant human insulin-like growth factor-I on progression of ALS: a placebo-controlled study. The North America ALS/IGF-I Study Group Neurology 49 1621 1630 9409357 1:CAS:528:DyaK1cXitVCnsg%3D%3D
    • (1997) Neurology , vol.49 , pp. 1621-1630
    • Lai, E.C.1    Felice, K.J.2    Festoff, B.W.3    Gawel, M.J.4    Gelinas, D.F.5    Kratz, R.6    Murphy, M.F.7    Natter, H.M.8    Norris, F.H.9    Rudnicki, S.A.10
  • 99
    • 0024997449 scopus 로고
    • Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis
    • 2241118 10.1002/ana.410280311 1:STN:280:DyaK3M%2FltlSluw%3D%3D
    • LA Lampson PD Kushner RA Sobel 1990 Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis Ann Neurol 28 365 372 2241118 10.1002/ana.410280311 1:STN:280:DyaK3M%2FltlSluw%3D%3D
    • (1990) Ann Neurol , vol.28 , pp. 365-372
    • Lampson, L.A.1    Kushner, P.D.2    Sobel, R.A.3
  • 100
    • 33846794644 scopus 로고    scopus 로고
    • CD4+ T cells from copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine model of Parkinson's disease
    • 17196666 10.1016/j.jneuroim.2006.11.009 1:CAS:528:DC%2BD2sXhs1Citbk%3D
    • C Laurie A Reynolds O Coskun E Bowman HE Gendelman RL Mosley 2007 CD4+ T cells from copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine model of Parkinson's disease J Neuroimmunol 183 60 68 17196666 10.1016/j.jneuroim.2006.11.009 1:CAS:528:DC%2BD2sXhs1Citbk%3D
    • (2007) J Neuroimmunol , vol.183 , pp. 60-68
    • Laurie, C.1    Reynolds, A.2    Coskun, O.3    Bowman, E.4    Gendelman, H.E.5    Mosley, R.L.6
  • 101
    • 0026552605 scopus 로고
    • Turnover of resident microglia in the normal adult mouse brain
    • 1603325 10.1016/0306-4522(92)90500-2 1:STN:280:DyaK383ptlCquw%3D%3D
    • LJ Lawson VH Perry S Gordon 1992 Turnover of resident microglia in the normal adult mouse brain Neuroscience 48 405 415 1603325 10.1016/0306-4522(92) 90500-2 1:STN:280:DyaK383ptlCquw%3D%3D
    • (1992) Neuroscience , vol.48 , pp. 405-415
    • Lawson, L.J.1    Perry, V.H.2    Gordon, S.3
  • 102
    • 38149018442 scopus 로고    scopus 로고
    • Minocycline for patients with ALS
    • 18207106 10.1016/S1474-4422(08)70006-1 (author reply 120-111)
    • PN Leigh V Meininger G Bensimon M Cudkowicz W Robberecht 2008 Minocycline for patients with ALS Lancet Neurol 7 119 120 18207106 10.1016/S1474-4422(08) 70006-1 (author reply 120-111)
    • (2008) Lancet Neurol , vol.7 , pp. 119-120
    • Leigh, P.N.1    Meininger, V.2    Bensimon, G.3    Cudkowicz, M.4    Robberecht, W.5
  • 103
    • 0026436932 scopus 로고
    • Amoeboid and ramified microglia: Their interrelationship and response to brain injury
    • 1380949 10.1002/glia.440060106 1:STN:280:DyaK38zotVOgug%3D%3D
    • SK Leong EA Ling 1992 Amoeboid and ramified microglia: their interrelationship and response to brain injury Glia 6 39 47 1380949 10.1002/glia.440060106 1:STN:280:DyaK38zotVOgug%3D%3D
    • (1992) Glia , vol.6 , pp. 39-47
    • Leong, S.K.1    Ling, E.A.2
  • 104
    • 36448942946 scopus 로고    scopus 로고
    • Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS
    • 17963733 10.1016/j.brainres.2007.09.034 1:CAS:528:DC%2BD2sXhtlykurrM
    • AC Lepore C Haenggeli M Gasmi KM Bishop RT Bartus NJ Maragakis JD Rothstein 2007 Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS Brain Res 1185 256 265 17963733 10.1016/j.brainres.2007.09.034 1:CAS:528:DC%2BD2sXhtlykurrM
    • (2007) Brain Res , vol.1185 , pp. 256-265
    • Lepore, A.C.1    Haenggeli, C.2    Gasmi, M.3    Bishop, K.M.4    Bartus, R.T.5    Maragakis, N.J.6    Rothstein, J.D.7
  • 105
    • 54949126674 scopus 로고    scopus 로고
    • Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease
    • 18931666 10.1038/nn.2210 1:CAS:528:DC%2BD1cXht12ltrjN
    • AC Lepore B Rauck C Dejea AC Pardo MS Rao JD Rothstein NJ Maragakis 2008 Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease Nat Neurosci 11 1294 1301 18931666 10.1038/nn.2210 1:CAS:528:DC%2BD1cXht12ltrjN
    • (2008) Nat Neurosci , vol.11 , pp. 1294-1301
    • Lepore, A.C.1    Rauck, B.2    Dejea, C.3    Pardo, A.C.4    Rao, M.S.5    Rothstein, J.D.6    Maragakis, N.J.7
  • 106
    • 70349154606 scopus 로고    scopus 로고
    • Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1
    • 19243075 10.1002/glia.20859
    • CA Lewis JN Solomon FM Rossi C Krieger 2009 Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1 Glia 57 1410 1419 19243075 10.1002/glia.20859
    • (2009) Glia , vol.57 , pp. 1410-1419
    • Lewis, C.A.1    Solomon, J.N.2    Rossi, F.M.3    Krieger, C.4
  • 107
    • 54849418885 scopus 로고    scopus 로고
    • The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis
    • 18825663 10.1002/ana.21437 1:CAS:528:DC%2BD1cXht1yisr3O
    • X Liang Q Wang J Shi L Lokteva RM Breyer TJ Montine K Andreasson 2008 The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis Ann Neurol 64 304 314 18825663 10.1002/ana.21437 1:CAS:528:DC%2BD1cXht1yisr3O
    • (2008) Ann Neurol , vol.64 , pp. 304-314
    • Liang, X.1    Wang, Q.2    Shi, J.3    Lokteva, L.4    Breyer, R.M.5    Montine, T.J.6    Andreasson, K.7
  • 108
    • 0019129071 scopus 로고
    • Use of carbon labeling to demonstrate the role of blood monocytes as precursors of the 'ameboid cells' present in the corpus callosum of postnatal rats
    • 6969268 10.1002/cne.901930304 1:STN:280:DyaL3M%2FntVahtQ%3D%3D
    • EA Ling D Penney CP Leblond 1980 Use of carbon labeling to demonstrate the role of blood monocytes as precursors of the 'ameboid cells' present in the corpus callosum of postnatal rats J Comp Neurol 193 631 657 6969268 10.1002/cne.901930304 1:STN:280:DyaL3M%2FntVahtQ%3D%3D
    • (1980) J Comp Neurol , vol.193 , pp. 631-657
    • Ling, E.A.1    Penney, D.2    Leblond, C.P.3
  • 109
    • 0037096354 scopus 로고    scopus 로고
    • Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease
    • 12077179 1:CAS:528:DC%2BD38Xlt1Sgsrg%3D
    • MM Lino C Schneider P Caroni 2002 Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease J Neurosci 22 4825 4832 12077179 1:CAS:528:DC%2BD38Xlt1Sgsrg%3D
    • (2002) J Neurosci , vol.22 , pp. 4825-4832
    • Lino, M.M.1    Schneider, C.2    Caroni, P.3
  • 110
    • 63649152262 scopus 로고    scopus 로고
    • Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2
    • 19091752 10.1074/jbc.M804446200 1:CAS:528:DC%2BD1MXht1Ortbg%3D
    • Y Liu W Hao A Dawson S Liu K Fassbender 2009 Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2 J Biol Chem 284 3691 3699 19091752 10.1074/jbc.M804446200 1:CAS:528:DC%2BD1MXht1Ortbg%3D
    • (2009) J Biol Chem , vol.284 , pp. 3691-3699
    • Liu, Y.1    Hao, W.2    Dawson, A.3    Liu, S.4    Fassbender, K.5
  • 111
    • 34250656185 scopus 로고    scopus 로고
    • Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons
    • 17463094 10.1073/pnas.0702230104 1:CAS:528:DC%2BD2sXlslWqsb8%3D
    • CS Lobsiger S Boillee DW Cleveland 2007 Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons Proc Natl Acad Sci USA 104 7319 7326 17463094 10.1073/pnas.0702230104 1:CAS:528:DC%2BD2sXlslWqsb8%3D
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7319-7326
    • Lobsiger, C.S.1    Boillee, S.2    Cleveland, D.W.3
  • 114
    • 0141816705 scopus 로고    scopus 로고
    • Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis
    • 14511332 10.1046/j.1460-9568.2003.02879.x
    • C Maihofner S Probst-Cousin M Bergmann W Neuhuber B Neundorfer D Heuss 2003 Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis Eur J Neurosci 18 1527 1534 14511332 10.1046/j.1460-9568.2003.02879.x
    • (2003) Eur J Neurosci , vol.18 , pp. 1527-1534
    • Maihofner, C.1    Probst-Cousin, S.2    Bergmann, M.3    Neuhuber, W.4    Neundorfer, B.5    Heuss, D.6
  • 115
    • 34948822926 scopus 로고    scopus 로고
    • Redox modifier genes in amyotrophic lateral sclerosis in mice
    • 17853944 10.1172/JCI31265 1:CAS:528:DC%2BD2sXhtFCnt7rJ
    • JJ Marden MM Harraz AJ Williams K Nelson M Luo H Paulson JF Engelhardt 2007 Redox modifier genes in amyotrophic lateral sclerosis in mice J Clin Invest 117 2913 2919 17853944 10.1172/JCI31265 1:CAS:528:DC%2BD2sXhtFCnt7rJ
    • (2007) J Clin Invest , vol.117 , pp. 2913-2919
    • Marden, J.J.1    Harraz, M.M.2    Williams, A.J.3    Nelson, K.4    Luo, M.5    Paulson, H.6    Engelhardt, J.F.7
  • 116
    • 1942447829 scopus 로고    scopus 로고
    • Microglia promote the death of developing Purkinje cells
    • 14980203 10.1016/S0896-6273(04)00069-8 1:CAS:528:DC%2BD2cXhvFOrsLs%3D
    • JL Marin-Teva I Dusart C Colin A Gervais N van Rooijen M Mallat 2004 Microglia promote the death of developing Purkinje cells Neuron 41 535 547 14980203 10.1016/S0896-6273(04)00069-8 1:CAS:528:DC%2BD2cXhvFOrsLs%3D
    • (2004) Neuron , vol.41 , pp. 535-547
    • Marin-Teva, J.L.1    Dusart, I.2    Colin, C.3    Gervais, A.4    Van Rooijen, N.5    Mallat, M.6
  • 117
    • 33845361630 scopus 로고    scopus 로고
    • Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: Mechanisms of mitochondriopathy and cell death
    • 17099894 10.1002/cne.21160 1:CAS:528:DC%2BD2sXktlCrtg%3D%3D
    • LJ Martin Z Liu K Chen AC Price Y Pan JA Swaby WC Golden 2007 Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death J Comp Neurol 500 20 46 17099894 10.1002/cne.21160 1:CAS:528: DC%2BD2sXktlCrtg%3D%3D
    • (2007) J Comp Neurol , vol.500 , pp. 20-46
    • Martin, L.J.1    Liu, Z.2    Chen, K.3    Price, A.C.4    Pan, Y.5    Swaby, J.A.6    Golden, W.C.7
  • 118
    • 0025786684 scopus 로고
    • Glial changes following an excitotoxic lesion in the CNS-I. Microglia/macrophages
    • 1775231 10.1016/0306-4522(91)90268-S 1:STN:280:DyaK387jtFantg%3D%3D
    • S Marty I Dusart M Peschanski 1991 Glial changes following an excitotoxic lesion in the CNS-I. Microglia/macrophages Neuroscience 45 529 539 1775231 10.1016/0306-4522(91)90268-S 1:STN:280:DyaK387jtFantg%3D%3D
    • (1991) Neuroscience , vol.45 , pp. 529-539
    • Marty, S.1    Dusart, I.2    Peschanski, M.3
  • 119
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • 8866675 10.1016/0165-0173(95)00011-9 1:STN:280:DyaK2s%2FitVaqsg%3D%3D
    • PL McGeer EG McGeer 1995 The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases Brain Res Brain Res Rev 21 195 218 8866675 10.1016/0165-0173(95)00011-9 1:STN:280:DyaK2s%2FitVaqsg%3D%3D
    • (1995) Brain Res Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 120
    • 0036787810 scopus 로고    scopus 로고
    • Inflammatory processes in amyotrophic lateral sclerosis
    • 12362410 10.1002/mus.10191 1:CAS:528:DC%2BD38Xot1Ggs7Y%3D
    • PL McGeer EG McGeer 2002 Inflammatory processes in amyotrophic lateral sclerosis Muscle Nerve 26 459 470 12362410 10.1002/mus.10191 1:CAS:528:DC%2BD38Xot1Ggs7Y%3D
    • (2002) Muscle Nerve , vol.26 , pp. 459-470
    • McGeer, P.L.1    McGeer, E.G.2
  • 121
    • 0027354835 scopus 로고
    • Microglia in degenerative neurological disease
    • 8423066 10.1002/glia.440070114 1:STN:280:DyaK3s7jvVOnug%3D%3D
    • PL McGeer T Kawamata DG Walker H Akiyama I Tooyama EG McGeer 1993 Microglia in degenerative neurological disease Glia 7 84 92 8423066 10.1002/glia.440070114 1:STN:280:DyaK3s7jvVOnug%3D%3D
    • (1993) Glia , vol.7 , pp. 84-92
    • McGeer, P.L.1    Kawamata, T.2    Walker, D.G.3    Akiyama, H.4    Tooyama, I.5    McGeer, E.G.6
  • 123
    • 70449697216 scopus 로고    scopus 로고
    • Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double-blind, randomized, multicentre, placebo-controlled trial
    • 19922128 10.3109/17482960902803432 1:CAS:528:DC%2BD1MXhsFCiurjF
    • V Meininger VE Drory PN Leigh A Ludolph W Robberecht V Silani 2009 Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: a double-blind, randomized, multicentre, placebo-controlled trial Amyotroph Lateral Scler 10 378 383 19922128 10.3109/17482960902803432 1:CAS:528: DC%2BD1MXhsFCiurjF
    • (2009) Amyotroph Lateral Scler , vol.10 , pp. 378-383
    • Meininger, V.1    Drory, V.E.2    Leigh, P.N.3    Ludolph, A.4    Robberecht, W.5    Silani, V.6
  • 124
    • 34548294685 scopus 로고    scopus 로고
    • The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS
    • 17597610 10.1016/j.expneurol.2007.05.016 1:CAS:528:DC%2BD2sXpvF2lt7c%3D
    • ML Messi HM Clark DM Prevette RW Oppenheim O Delbono 2007 The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS Exp Neurol 207 52 63 17597610 10.1016/j.expneurol.2007.05.016 1:CAS:528: DC%2BD2sXpvF2lt7c%3D
    • (2007) Exp Neurol , vol.207 , pp. 52-63
    • Messi, M.L.1    Clark, H.M.2    Prevette, D.M.3    Oppenheim, R.W.4    Delbono, O.5
  • 125
  • 126
    • 33845876647 scopus 로고    scopus 로고
    • Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis
    • 17164329 10.1073/pnas.0609411103 1:CAS:528:DC%2BD2sXhsVaitw%3D%3D
    • TM Miller SH Kim K Yamanaka M Hester P Umapathi H Arnson L Rizo JR Mendell FH Gage DW Cleveland BK Kaspar 2006 Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis Proc Natl Acad Sci USA 103 19546 19551 17164329 10.1073/pnas.0609411103 1:CAS:528:DC%2BD2sXhsVaitw%3D%3D
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19546-19551
    • Miller, T.M.1    Kim, S.H.2    Yamanaka, K.3    Hester, M.4    Umapathi, P.5    Arnson, H.6    Rizo, L.7    Mendell, J.R.8    Gage, F.H.9    Cleveland, D.W.10    Kaspar, B.K.11
  • 127
    • 34247475338 scopus 로고    scopus 로고
    • Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
    • 17435755 10.1038/nn1876 1:CAS:528:DC%2BD2sXksFShs7c%3D
    • M Nagai DB Re T Nagata A Chalazonitis TM Jessell H Wichterle S Przedborski 2007 Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons Nat Neurosci 10 615 622 17435755 10.1038/nn1876 1:CAS:528:DC%2BD2sXksFShs7c%3D
    • (2007) Nat Neurosci , vol.10 , pp. 615-622
    • Nagai, M.1    Re, D.B.2    Nagata, T.3    Chalazonitis, A.4    Jessell, T.M.5    Wichterle, H.6    Przedborski, S.7
  • 128
    • 22844452812 scopus 로고    scopus 로고
    • Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of amyotrophic lateral sclerosis
    • 15990113 10.1016/j.jns.2005.04.011 1:CAS:528:DC%2BD2MXmsVOqsr4%3D
    • I Nagano H Ilieva M Shiote T Murakami M Yokoyama M Shoji K Abe 2005 Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of amyotrophic lateral sclerosis J Neurol Sci 235 61 68 15990113 10.1016/j.jns.2005.04.011 1:CAS:528:DC%2BD2MXmsVOqsr4%3D
    • (2005) J Neurol Sci , vol.235 , pp. 61-68
    • Nagano, I.1    Ilieva, H.2    Shiote, M.3    Murakami, T.4    Yokoyama, M.5    Shoji, M.6    Abe, K.7
  • 129
    • 27244455282 scopus 로고    scopus 로고
    • Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis
    • 16197815 10.1179/016164105X39860 1:CAS:528:DC%2BD2MXht1Wkt7fN
    • I Nagano M Shiote T Murakami H Kamada Y Hamakawa E Matsubara M Yokoyama K Moritaz M Shoji K Abe 2005 Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis Neurol Res 27 768 772 16197815 10.1179/016164105X39860 1:CAS:528:DC%2BD2MXht1Wkt7fN
    • (2005) Neurol Res , vol.27 , pp. 768-772
    • Nagano, I.1    Shiote, M.2    Murakami, T.3    Kamada, H.4    Hamakawa, Y.5    Matsubara, E.6    Yokoyama, M.7    Moritaz, K.8    Shoji, M.9    Abe, K.10
  • 130
    • 37149006825 scopus 로고    scopus 로고
    • Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patients
    • 17672928 10.1179/016164107X229795 1:CAS:528:DC%2BD1cXhtFKksbg%3D
    • T Nagata I Nagano M Shiote H Narai T Murakami T Hayashi M Shoji K Abe 2007 Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patients Neurol Res 29 772 776 17672928 10.1179/016164107X229795 1:CAS:528:DC%2BD1cXhtFKksbg%3D
    • (2007) Neurol Res , vol.29 , pp. 772-776
    • Nagata, T.1    Nagano, I.2    Shiote, M.3    Narai, H.4    Murakami, T.5    Hayashi, T.6    Shoji, M.7    Abe, K.8
  • 131
    • 68349146013 scopus 로고    scopus 로고
    • Development of ALS-like disease in SOD-1 mice deficient of B lymphocytes
    • 19280101 10.1007/s00415-009-5097-3 1:CAS:528:DC%2BD1MXpsVegtrY%3D
    • S Naor Z Keren T Bronshtein E Goren M Machluf D Melamed 2009 Development of ALS-like disease in SOD-1 mice deficient of B lymphocytes J Neurol 256 1228 1235 19280101 10.1007/s00415-009-5097-3 1:CAS:528:DC%2BD1MXpsVegtrY%3D
    • (2009) J Neurol , vol.256 , pp. 1228-1235
    • Naor, S.1    Keren, Z.2    Bronshtein, T.3    Goren, E.4    MacHluf, M.5    Melamed, D.6
  • 132
    • 77649323766 scopus 로고    scopus 로고
    • Recombinant human granulocyte-colony stimulating factor administration for treating amyotrophic lateral sclerosis: A pilot study
    • 10.3109/17482960902933809 1:CAS:528:DC%2BC3cXisV2mtr4%3D
    • B Nefussy I Artamonov V Deutsch E Naparstek A Nagler VE Drory 2009 Recombinant human granulocyte-colony stimulating factor administration for treating amyotrophic lateral sclerosis: a pilot study Amyotroph Lateral Scler 11 187 193 10.3109/17482960902933809 1:CAS:528:DC%2BC3cXisV2mtr4%3D
    • (2009) Amyotroph Lateral Scler , vol.11 , pp. 187-193
    • Nefussy, B.1    Artamonov, I.2    Deutsch, V.3    Naparstek, E.4    Nagler, A.5    Drory, V.E.6
  • 133
    • 70349751944 scopus 로고    scopus 로고
    • Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis
    • 19733563 10.1016/j.expneurol.2009.08.028 1:CAS:528:DC%2BD1MXht1GmtL3F
    • A Neymotin S Petri NY Calingasan E Wille P Schafer C Stewart K Hensley MF Beal M Kiaei 2009 Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis Exp Neurol 220 191 197 19733563 10.1016/j.expneurol.2009.08.028 1:CAS:528:DC%2BD1MXht1GmtL3F
    • (2009) Exp Neurol , vol.220 , pp. 191-197
    • Neymotin, A.1    Petri, S.2    Calingasan, N.Y.3    Wille, E.4    Schafer, P.5    Stewart, C.6    Hensley, K.7    Beal, M.F.8    Kiaei, M.9
  • 134
    • 0034765498 scopus 로고    scopus 로고
    • Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: No requirement for proapoptotic interleukin-1beta in neurodegeneration
    • 11706969 10.1002/ana.1256 1:CAS:528:DC%2BD3MXovVGhtbY%3D
    • MD Nguyen JP Julien S Rivest 2001 Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration Ann Neurol 50 630 639 11706969 10.1002/ana.1256 1:CAS:528:DC%2BD3MXovVGhtbY%3D
    • (2001) Ann Neurol , vol.50 , pp. 630-639
    • Nguyen, M.D.1    Julien, J.P.2    Rivest, S.3
  • 135
    • 1242336763 scopus 로고    scopus 로고
    • Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis
    • 14960605 10.1523/JNEUROSCI.4786-03.2004 1:CAS:528:DC%2BD2cXhs1Sqtro%3D
    • MD Nguyen T D'Aigle G Gowing JP Julien S Rivest 2004 Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis J Neurosci 24 1340 1349 14960605 10.1523/JNEUROSCI.4786-03.2004 1:CAS:528:DC%2BD2cXhs1Sqtro%3D
    • (2004) J Neurosci , vol.24 , pp. 1340-1349
    • Nguyen, M.D.1    D'Aigle, T.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 136
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • 15831717 10.1126/science.1110647 1:CAS:528:DC%2BD2MXks1Ciuro%3D
    • A Nimmerjahn F Kirchhoff F Helmchen 2005 Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 308 1314 1318 15831717 10.1126/science.1110647 1:CAS:528:DC%2BD2MXks1Ciuro%3D
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 137
    • 70349265930 scopus 로고    scopus 로고
    • Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis
    • 19686706 10.1016/j.brainres.2009.08.012 1:CAS:528:DC%2BD1MXhtFyqsbzL
    • S Ohnishi H Ito Y Suzuki Y Adachi R Wate J Zhang S Nakano H Kusaka S Ikehara 2009 Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis Brain Res 1296 216 224 19686706 10.1016/j.brainres.2009.08.012 1:CAS:528:DC%2BD1MXhtFyqsbzL
    • (2009) Brain Res , vol.1296 , pp. 216-224
    • Ohnishi, S.1    Ito, H.2    Suzuki, Y.3    Adachi, Y.4    Wate, R.5    Zhang, J.6    Nakano, S.7    Kusaka, H.8    Ikehara, S.9
  • 138
    • 0035194691 scopus 로고    scopus 로고
    • Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord
    • 11761470 10.1002/ana.1252 1:CAS:528:DC%2BD38Xhs1Kntg%3D%3D
    • MK Olsen SL Roberds BR Ellerbrock TJ Fleck DK McKinley ME Gurney 2001 Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord Ann Neurol 50 730 740 11761470 10.1002/ana.1252 1:CAS:528:DC%2BD38Xhs1Kntg%3D%3D
    • (2001) Ann Neurol , vol.50 , pp. 730-740
    • Olsen, M.K.1    Roberds, S.L.2    Ellerbrock, B.R.3    Fleck, T.J.4    McKinley, D.K.5    Gurney, M.E.6
  • 139
    • 33747101645 scopus 로고    scopus 로고
    • Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice
    • 16753145 10.1016/j.expneurol.2006.03.028 1:CAS:528:DC%2BD28XotlKkt7g%3D
    • AC Pardo V Wong LM Benson M Dykes K Tanaka JD Rothstein NJ Maragakis 2006 Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice Exp Neurol 201 120 130 16753145 10.1016/j.expneurol.2006.03.028 1:CAS:528:DC%2BD28XotlKkt7g%3D
    • (2006) Exp Neurol , vol.201 , pp. 120-130
    • Pardo, A.C.1    Wong, V.2    Benson, L.M.3    Dykes, M.4    Tanaka, K.5    Rothstein, J.D.6    Maragakis, N.J.7
  • 141
    • 0022387412 scopus 로고
    • Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
    • 3895031 10.1016/0306-4522(85)90215-5 1:STN:280:DyaL2M3mvVCqsg%3D%3D
    • VH Perry DA Hume S Gordon 1985 Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain Neuroscience 15 313 326 3895031 10.1016/0306-4522(85)90215-5 1:STN:280:DyaL2M3mvVCqsg%3D%3D
    • (1985) Neuroscience , vol.15 , pp. 313-326
    • Perry, V.H.1    Hume, D.A.2    Gordon, S.3
  • 143
    • 0034733968 scopus 로고    scopus 로고
    • Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis
    • 10863032 10.1016/S0304-3940(00)01177-0 1:CAS:528:DC%2BD3cXktV2qu7o%3D
    • M Poloni D Facchetti R Mai A Micheli L Agnoletti G Francolini G Mora C Camana L Mazzini T Bachetti 2000 Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis Neurosci Lett 287 211 214 10863032 10.1016/S0304-3940(00)01177-0 1:CAS:528:DC%2BD3cXktV2qu7o%3D
    • (2000) Neurosci Lett , vol.287 , pp. 211-214
    • Poloni, M.1    Facchetti, D.2    Mai, R.3    Micheli, A.4    Agnoletti, L.5    Francolini, G.6    Mora, G.7    Camana, C.8    Mazzini, L.9    Bachetti, T.10
  • 144
    • 0037389393 scopus 로고    scopus 로고
    • A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis
    • 12586733 1:CAS:528:DC%2BD3sXislGmu7s%3D
    • PN Pompl L Ho M Bianchi T McManus W Qin GM Pasinetti 2003 A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis FASEB J 17 725 727 12586733 1:CAS:528:DC%2BD3sXislGmu7s%3D
    • (2003) FASEB J , vol.17 , pp. 725-727
    • Pompl, P.N.1    Ho, L.2    Bianchi, M.3    McManus, T.4    Qin, W.5    Pasinetti, G.M.6
  • 145
    • 0035873076 scopus 로고    scopus 로고
    • Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment
    • 11331366 1:CAS:528:DC%2BD3MXjs1antrs%3D
    • A Pramatarova J Laganiere J Roussel K Brisebois GA Rouleau 2001 Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment J Neurosci 21 3369 3374 11331366 1:CAS:528:DC%2BD3MXjs1antrs%3D
    • (2001) J Neurosci , vol.21 , pp. 3369-3374
    • Pramatarova, A.1    Laganiere, J.2    Roussel, J.3    Brisebois, K.4    Rouleau, G.A.5
  • 147
    • 0028050415 scopus 로고
    • Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse
    • 7850025 10.1111/j.1460-9568.1994.tb00552.x 1:STN:280:DyaK2M7lt1yltw%3D%3D
    • G Raivich MT Moreno-Flores JC Moller GW Kreutzberg 1994 Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse Eur J Neurosci 6 1615 1618 7850025 10.1111/j.1460-9568.1994.tb00552.x 1:STN:280:DyaK2M7lt1yltw%3D%3D
    • (1994) Eur J Neurosci , vol.6 , pp. 1615-1618
    • Raivich, G.1    Moreno-Flores, M.T.2    Moller, J.C.3    Kreutzberg, G.W.4
  • 148
    • 0347155578 scopus 로고    scopus 로고
    • Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis
    • 12356748 10.1074/jbc.M207356200 1:CAS:528:DC%2BD38XptFSqsrY%3D
    • R Rakhit P Cunningham A Furtos-Matei S Dahan XF Qi JP Crow NR Cashman LH Kondejewski A Chakrabartty 2002 Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis J Biol Chem 277 47551 47556 12356748 10.1074/jbc.M207356200 1:CAS:528: DC%2BD38XptFSqsrY%3D
    • (2002) J Biol Chem , vol.277 , pp. 47551-47556
    • Rakhit, R.1    Cunningham, P.2    Furtos-Matei, A.3    Dahan, S.4    Qi, X.F.5    Crow, J.P.6    Cashman, N.R.7    Kondejewski, L.H.8    Chakrabartty, A.9
  • 149
    • 0037068836 scopus 로고    scopus 로고
    • Motoneuron death triggered by a specific pathway downstream of Fas: Potentiation by ALS-linked SOD1 mutations
    • 12354397 10.1016/S0896-6273(02)00905-4 1:CAS:528:DC%2BD38XnsV2hsbc%3D
    • C Raoul AG Estevez H Nishimune DW Cleveland O deLapeyriere CE Henderson G Haase B Pettmann 2002 Motoneuron death triggered by a specific pathway downstream of Fas: potentiation by ALS-linked SOD1 mutations Neuron 35 1067 1083 12354397 10.1016/S0896-6273(02)00905-4 1:CAS:528:DC%2BD38XnsV2hsbc%3D
    • (2002) Neuron , vol.35 , pp. 1067-1083
    • Raoul, C.1    Estevez, A.G.2    Nishimune, H.3    Cleveland, D.W.4    Delapeyriere, O.5    Henderson, C.E.6    Haase, G.7    Pettmann, B.8
  • 150
    • 33645822300 scopus 로고    scopus 로고
    • Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL
    • 16581901 10.1073/pnas.0508774103 1:CAS:528:DC%2BD28XktFaitbY%3D
    • C Raoul E Buhler C Sadeghi A Jacquier P Aebischer B Pettmann CE Henderson G Haase 2006 Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL Proc Natl Acad Sci USA 103 6007 6012 16581901 10.1073/pnas.0508774103 1:CAS:528: DC%2BD28XktFaitbY%3D
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6007-6012
    • Raoul, C.1    Buhler, E.2    Sadeghi, C.3    Jacquier, A.4    Aebischer, P.5    Pettmann, B.6    Henderson, C.E.7    Haase, G.8
  • 152
    • 35148846456 scopus 로고    scopus 로고
    • RANTES levels are elevated in serum and cerebrospinal fluid in patients with amyotrophic lateral sclerosis
    • 17852013 10.1080/17482960701419232 1:CAS:528:DC%2BD2sXhtFWqs73I
    • M Rentzos C Nikolaou A Rombos F Boufidou M Zoga A Dimitrakopoulos A Tsoutsou D Vassilopoulos 2007 RANTES levels are elevated in serum and cerebrospinal fluid in patients with amyotrophic lateral sclerosis Amyotroph Lateral Scler 8 283 287 17852013 10.1080/17482960701419232 1:CAS:528: DC%2BD2sXhtFWqs73I
    • (2007) Amyotroph Lateral Scler , vol.8 , pp. 283-287
    • Rentzos, M.1    Nikolaou, C.2    Rombos, A.3    Boufidou, F.4    Zoga, M.5    Dimitrakopoulos, A.6    Tsoutsou, A.7    Vassilopoulos, D.8
  • 153
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • 9422508 10.1038/34178 1:CAS:528:DyaK1cXktVShtQ%3D%3D
    • M Ricote AC Li TM Willson CJ Kelly CK Glass 1998 The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation Nature 391 79 82 9422508 10.1038/34178 1:CAS:528:DyaK1cXktVShtQ%3D%3D
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 154
    • 0028888945 scopus 로고
    • Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
    • 7846037 10.1073/pnas.92.3.689 1:CAS:528:DyaK2MXjsVKitL8%3D
    • ME Ripps GW Huntley PR Hof JH Morrison JW Gordon 1995 Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis Proc Natl Acad Sci USA 92 689 693 7846037 10.1073/pnas.92.3.689 1:CAS:528:DyaK2MXjsVKitL8%3D
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 689-693
    • Ripps, M.E.1    Huntley, G.W.2    Hof, P.R.3    Morrison, J.H.4    Gordon, J.W.5
  • 155
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • 8446170 10.1038/362059a0 1:CAS:528:DyaK3sXhvV2hs74%3D
    • DR Rosen T Siddique D Patterson DA Figlewicz P Sapp A Hentati D Donaldson J Goto JP O'Regan HX Deng, et al. 1993 Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 59 62 8446170 10.1038/362059a0 1:CAS:528:DyaK3sXhvV2hs74%3D
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3    Figlewicz, D.A.4    Sapp, P.5    Hentati, A.6    Donaldson, D.7    Goto, J.8    O'Regan, J.P.9    Deng, H.X.10
  • 156
    • 0029975105 scopus 로고    scopus 로고
    • Absence of serological evidence for foamy virus infection in patients with amyotrophic lateral sclerosis
    • 8801281 10.1002/(SICI)1096-9071(199603)48:3 <222::AID-JMV2>3.0. CO;2-A 1:STN:280:DyaK283ksFSgtA%3D%3D
    • M Rosener H Hahn M Kranz J Heeney A Rethwilm 1996 Absence of serological evidence for foamy virus infection in patients with amyotrophic lateral sclerosis J Med Virol 48 222 226 8801281 10.1002/(SICI)1096-9071(199603)48: 3<222::AID-JMV2>3.0.CO;2-A 1:STN:280:DyaK283ksFSgtA%3D%3D
    • (1996) J Med Virol , vol.48 , pp. 222-226
    • Rosener, M.1    Hahn, H.2    Kranz, M.3    Heeney, J.4    Rethwilm, A.5
  • 157
    • 0029030610 scopus 로고
    • Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
    • 7611729 10.1002/ana.410380114 1:CAS:528:DyaK2MXnt12lsbw%3D
    • JD Rothstein M Van Kammen AI Levey LJ Martin RW Kuncl 1995 Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis Ann Neurol 38 73 84 7611729 10.1002/ana.410380114 1:CAS:528:DyaK2MXnt12lsbw%3D
    • (1995) Ann Neurol , vol.38 , pp. 73-84
    • Rothstein, J.D.1    Van Kammen, M.2    Levey, A.I.3    Martin, L.J.4    Kuncl, R.W.5
  • 159
    • 74049122793 scopus 로고    scopus 로고
    • Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1
    • 19752764 10.1097/WNR.0b013e328331e8fa 1:CAS:528:DC%2BD1MXht1ymsL7O
    • SA Sargsyan DJ Blackburn SC Barber PN Monk PJ Shaw 2009 Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1 Neuroreport 20 1450 1455 19752764 10.1097/WNR.0b013e328331e8fa 1:CAS:528:DC%2BD1MXht1ymsL7O
    • (2009) Neuroreport , vol.20 , pp. 1450-1455
    • Sargsyan, S.A.1    Blackburn, D.J.2    Barber, S.C.3    Monk, P.N.4    Shaw, P.J.5
  • 160
    • 58149232639 scopus 로고    scopus 로고
    • Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis
    • 18957896 10.1097/NEN.0b013e31818b4906 1:CAS:528:DC%2BD1cXhsVeqtLbL
    • A Sarlette K Krampfl C Grothe N Neuhoff R Dengler S Petri 2008 Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis J Neuropathol Exp Neurol 67 1055 1062 18957896 10.1097/NEN.0b013e31818b4906 1:CAS:528: DC%2BD1cXhsVeqtLbL
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 1055-1062
    • Sarlette, A.1    Krampfl, K.2    Grothe, C.3    Neuhoff, N.4    Dengler, R.5    Petri, S.6
  • 162
    • 49649095887 scopus 로고    scopus 로고
    • Neuroscience: Standard model
    • 18685674 10.1038/454682a 1:CAS:528:DC%2BD1cXps1SntbY%3D
    • J Schnabel 2008 Neuroscience: standard model Nature 454 682 685 18685674 10.1038/454682a 1:CAS:528:DC%2BD1cXps1SntbY%3D
    • (2008) Nature , vol.454 , pp. 682-685
    • Schnabel, J.1
  • 164
    • 23944490153 scopus 로고    scopus 로고
    • The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice
    • 16120782 10.1523/JNEUROSCI.2038-05.2005 1:CAS:528:DC%2BD2MXpvVKgu7k%3D
    • B Schutz J Reimann L Dumitrescu-Ozimek K Kappes-Horn GE Landreth B Schurmann A Zimmer MT Heneka 2005 The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice J Neurosci 25 7805 7812 16120782 10.1523/JNEUROSCI.2038-05.2005 1:CAS:528:DC%2BD2MXpvVKgu7k%3D
    • (2005) J Neurosci , vol.25 , pp. 7805-7812
    • Schutz, B.1    Reimann, J.2    Dumitrescu-Ozimek, L.3    Kappes-Horn, K.4    Landreth, G.E.5    Schurmann, B.6    Zimmer, A.7    Heneka, M.T.8
  • 167
    • 0035955478 scopus 로고    scopus 로고
    • Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients
    • 11602233 10.1016/S0006-8993(01)02926-2 1:CAS:528:DC%2BD3MXnsF2gsbY%3D
    • N Shibata R Nagai K Uchida S Horiuchi S Yamada A Hirano M Kawaguchi T Yamamoto S Sasaki M Kobayashi 2001 Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients Brain Res 917 97 104 11602233 10.1016/S0006-8993(01)02926-2 1:CAS:528:DC%2BD3MXnsF2gsbY%3D
    • (2001) Brain Res , vol.917 , pp. 97-104
    • Shibata, N.1    Nagai, R.2    Uchida, K.3    Horiuchi, S.4    Yamada, S.5    Hirano, A.6    Kawaguchi, M.7    Yamamoto, T.8    Sasaki, S.9    Kobayashi, M.10
  • 168
    • 6944234040 scopus 로고    scopus 로고
    • Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia
    • 15084516 1:CAS:528:DC%2BD2cXkslWit7g%3D
    • AR Simard S Rivest 2004 Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia FASEB J 18 998 1000 15084516 1:CAS:528:DC%2BD2cXkslWit7g%3D
    • (2004) FASEB J , vol.18 , pp. 998-1000
    • Simard, A.R.1    Rivest, S.2
  • 169
    • 2442701519 scopus 로고    scopus 로고
    • Increased lipid peroxidation in sera of ALS patients: A potential biomarker of disease burden
    • 15159474 1:CAS:528:DC%2BD2cXjs1yltLs%3D
    • EP Simpson YK Henry JS Henkel RG Smith SH Appel 2004 Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden Neurology 62 1758 1765 15159474 1:CAS:528:DC%2BD2cXjs1yltLs%3D
    • (2004) Neurology , vol.62 , pp. 1758-1765
    • Simpson, E.P.1    Henry, Y.K.2    Henkel, J.S.3    Smith, R.G.4    Appel, S.H.5
  • 170
    • 0031722955 scopus 로고    scopus 로고
    • Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis
    • 9778272 10.1002/ana.410440419 1:STN:280:DyaK1cvkvFOhsw%3D%3D
    • RG Smith YK Henry MP Mattson SH Appel 1998 Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis Ann Neurol 44 696 699 9778272 10.1002/ana.410440419 1:STN:280: DyaK1cvkvFOhsw%3D%3D
    • (1998) Ann Neurol , vol.44 , pp. 696-699
    • Smith, R.G.1    Henry, Y.K.2    Mattson, M.P.3    Appel, S.H.4
  • 171
    • 33646250429 scopus 로고    scopus 로고
    • Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis
    • 16518833 10.1002/glia.20331
    • JN Solomon CA Lewis B Ajami SY Corbel FM Rossi C Krieger 2006 Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis Glia 53 744 753 16518833 10.1002/glia.20331
    • (2006) Glia , vol.53 , pp. 744-753
    • Solomon, J.N.1    Lewis, C.A.2    Ajami, B.3    Corbel, S.Y.4    Rossi, F.M.5    Krieger, C.6
  • 172
    • 0034905496 scopus 로고    scopus 로고
    • Survival in a transgenic model of FALS is independent of iNOS expression
    • 11506415 10.1002/ana.1104 1:STN:280:DC%2BD3MvmtFOitg%3D%3D
    • M Son HM Fathallah-Shaykh JL Elliott 2001 Survival in a transgenic model of FALS is independent of iNOS expression Ann Neurol 50 273 11506415 10.1002/ana.1104 1:STN:280:DC%2BD3MvmtFOitg%3D%3D
    • (2001) Ann Neurol , vol.50 , pp. 273
    • Son, M.1    Fathallah-Shaykh, H.M.2    Elliott, J.L.3
  • 176
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective, immunocompetent cells of the CNS
    • 12379901 10.1002/glia.10154
    • WJ Streit 2002 Microglia as neuroprotective, immunocompetent cells of the CNS Glia 40 133 139 12379901 10.1002/glia.10154
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 177
    • 0028811503 scopus 로고
    • Search for persistent infection with poliovirus or other enteroviruses in amyotrophic lateral sclerosis-motor neurone disease
    • 8580727 10.1016/0960-8966(95)00002-5 1:STN:280:DyaK287ls1Cnuw%3D%3D
    • NR Swanson SA Fox FL Mastaglia 1995 Search for persistent infection with poliovirus or other enteroviruses in amyotrophic lateral sclerosis-motor neurone disease Neuromuscul Disord 5 457 465 8580727 10.1016/0960-8966(95)00002-5 1:STN:280:DyaK287ls1Cnuw%3D%3D
    • (1995) Neuromuscul Disord , vol.5 , pp. 457-465
    • Swanson, N.R.1    Fox, S.A.2    Mastaglia, F.L.3
  • 178
    • 0031895401 scopus 로고    scopus 로고
    • The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis and in multiple sclerosis
    • 9521273 1:STN:280:DyaK1c7otVGluw%3D%3D
    • I Torres-Aleman V Barrios J Berciano 1998 The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis and in multiple sclerosis Neurology 50 772 776 9521273 1:STN:280:DyaK1c7otVGluw%3D%3D
    • (1998) Neurology , vol.50 , pp. 772-776
    • Torres-Aleman, I.1    Barrios, V.2    Berciano, J.3
  • 179
    • 0024955336 scopus 로고
    • Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis
    • 2533530 1:STN:280:DyaK3c7ltVyltQ%3D%3D
    • D Troost JJ van den Oord JM de Jong DF Swaab 1989 Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis Clin Neuropathol 8 289 294 2533530 1:STN:280:DyaK3c7ltVyltQ%3D%3D
    • (1989) Clin Neuropathol , vol.8 , pp. 289-294
    • Troost, D.1    Van Den Oord, J.J.2    De Jong, J.M.3    Swaab, D.F.4
  • 180
    • 0025185079 scopus 로고
    • Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis
    • 2263315 10.1111/j.1365-2990.1990.tb01276.x 1:STN:280: DyaK3M%2FovVSjsg%3D%3D
    • D Troost JJ Van den Oord JM Vianney de Jong 1990 Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis Neuropathol Appl Neurobiol 16 401 410 2263315 10.1111/j.1365-2990.1990.tb01276. x 1:STN:280:DyaK3M%2FovVSjsg%3D%3D
    • (1990) Neuropathol Appl Neurobiol , vol.16 , pp. 401-410
    • Troost, D.1    Van Den Oord, J.J.2    Vianney De Jong, J.M.3
  • 181
    • 1842471942 scopus 로고    scopus 로고
    • Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: An [11C](R)-PK11195 positron emission tomography study
    • 15056468 10.1016/j.nbd.2003.12.012 1:CAS:528:DC%2BD2cXivVKmsro%3D
    • MR Turner A Cagnin FE Turkheimer CC Miller CE Shaw DJ Brooks PN Leigh RB Banati 2004 Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study Neurobiol Dis 15 601 609 15056468 10.1016/j.nbd.2003.12.012 1:CAS:528: DC%2BD2cXivVKmsro%3D
    • (2004) Neurobiol Dis , vol.15 , pp. 601-609
    • Turner, M.R.1    Cagnin, A.2    Turkheimer, F.E.3    Miller, C.C.4    Shaw, C.E.5    Brooks, D.J.6    Leigh, P.N.7    Banati, R.B.8
  • 182
    • 77950528523 scopus 로고    scopus 로고
    • Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice
    • Turner BJ, Ackerley S, Davies KE, Talbot K (2009) Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice. Hum Mol Genet
    • (2009) Hum Mol Genet
    • Turner, B.J.1    Ackerley, S.2    Davies, K.E.3    Talbot, K.4
  • 183
    • 29444443348 scopus 로고    scopus 로고
    • Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
    • 16369483 10.1038/nn1603 1:CAS:528:DC%2BD2MXhtlCms7rF
    • M Urushitani A Sik T Sakurai N Nukina R Takahashi JP Julien 2006 Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis Nat Neurosci 9 108 118 16369483 10.1038/nn1603 1:CAS:528:DC%2BD2MXhtlCms7rF
    • (2006) Nat Neurosci , vol.9 , pp. 108-118
    • Urushitani, M.1    Sik, A.2    Sakurai, T.3    Nukina, N.4    Takahashi, R.5    Julien, J.P.6
  • 184
    • 33847787621 scopus 로고    scopus 로고
    • Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis
    • 17277077 10.1073/pnas.0606201104 1:CAS:528:DC%2BD2sXisVSgt7w%3D
    • M Urushitani SA Ezzi JP Julien 2007 Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis Proc Natl Acad Sci USA 104 2495 2500 17277077 10.1073/pnas.0606201104 1:CAS:528:DC%2BD2sXisVSgt7w%3D
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2495-2500
    • Urushitani, M.1    Ezzi, S.A.2    Julien, J.P.3
  • 185
    • 42749097816 scopus 로고    scopus 로고
    • Crosstalk between astrocytes and motor neurons: What is the message?
    • 10.1016/j.expneurol.2008.01.008 1:CAS:528:DC%2BD1cXlsF2qt7w%3D
    • L Van Den Bosch W Robberecht 2008 Crosstalk between astrocytes and motor neurons: what is the message? Exp Neurol 211 1 6 10.1016/j.expneurol.2008.01.008 1:CAS:528:DC%2BD1cXlsF2qt7w%3D
    • (2008) Exp Neurol , vol.211 , pp. 1-6
    • Van Den Bosch, L.1    Robberecht, W.2
  • 186
    • 0037067009 scopus 로고    scopus 로고
    • Minocycline delays disease onset and mortality in a transgenic model of ALS
    • 10.1097/00001756-200206120-00018
    • L Van Den Bosch P Tilkin G Lemmens W Robberecht 2002 Minocycline delays disease onset and mortality in a transgenic model of ALS Neuroreport 13 1067 1070 10.1097/00001756-200206120-00018
    • (2002) Neuroreport , vol.13 , pp. 1067-1070
    • Van Den Bosch, L.1    Tilkin, P.2    Lemmens, G.3    Robberecht, W.4
  • 187
  • 189
    • 33645881327 scopus 로고    scopus 로고
    • Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis
    • 16524372 10.1111/j.1471-4159.2006.03742.x 1:CAS:528:DC%2BD28XkslCjsrk%3D
    • MR Vargas M Pehar P Cassina JS Beckman L Barbeito 2006 Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis J Neurochem 97 687 696 16524372 10.1111/j.1471-4159.2006.03742.x 1:CAS:528:DC%2BD28XkslCjsrk%3D
    • (2006) J Neurochem , vol.97 , pp. 687-696
    • Vargas, M.R.1    Pehar, M.2    Cassina, P.3    Beckman, J.S.4    Barbeito, L.5
  • 190
    • 58149379610 scopus 로고    scopus 로고
    • Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
    • 19074031 10.1523/JNEUROSCI.4099-08.2008 1:CAS:528:DC%2BD1cXhsFCqsb7N
    • MR Vargas DA Johnson DW Sirkis A Messing JA Johnson 2008 Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis J Neurosci 28 13574 13581 19074031 10.1523/JNEUROSCI.4099-08.2008 1:CAS:528:DC%2BD1cXhsFCqsb7N
    • (2008) J Neurosci , vol.28 , pp. 13574-13581
    • Vargas, M.R.1    Johnson, D.A.2    Sirkis, D.W.3    Messing, A.4    Johnson, J.A.5
  • 191
    • 0035132168 scopus 로고    scopus 로고
    • Absence of echovirus sequences in brain and spinal cord of amyotrophic lateral sclerosis patients
    • 11221802 10.1002/1531-8249(20010201)49:2 <249::AID-ANA46>3.0.CO;2-3 1:CAS:528:DC%2BD3MXhsVymurs%3D
    • MP Walker R Schlaberg AP Hays R Bowser WI Lipkin 2001 Absence of echovirus sequences in brain and spinal cord of amyotrophic lateral sclerosis patients Ann Neurol 49 249 253 11221802 10.1002/1531-8249(20010201)49:2<249:: AID-ANA46>3.0.CO;2-3 1:CAS:528:DC%2BD3MXhsVymurs%3D
    • (2001) Ann Neurol , vol.49 , pp. 249-253
    • Walker, M.P.1    Schlaberg, R.2    Hays, A.P.3    Bowser, R.4    Lipkin, W.I.5
  • 192
    • 0036076642 scopus 로고    scopus 로고
    • Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site
    • 12127151 10.1006/nbdi.2002.0498 1:CAS:528:DC%2BD38XltFyrtb8%3D
    • J Wang G Xu V Gonzales M Coonfield D Fromholt NG Copeland NA Jenkins DR Borchelt 2002 Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site Neurobiol Dis 10 128 138 12127151 10.1006/nbdi.2002.0498 1:CAS:528: DC%2BD38XltFyrtb8%3D
    • (2002) Neurobiol Dis , vol.10 , pp. 128-138
    • Wang, J.1    Xu, G.2    Gonzales, V.3    Coonfield, M.4    Fromholt, D.5    Copeland, N.G.6    Jenkins, N.A.7    Borchelt, D.R.8
  • 193
    • 64549124726 scopus 로고    scopus 로고
    • Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse
    • 19233858 10.1093/hmg/ddp085 1:CAS:528:DC%2BD1MXksVeitbg%3D
    • L Wang HX Deng G Grisotti H Zhai T Siddique RP Roos 2009 Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse Hum Mol Genet 18 1642 1651 19233858 10.1093/hmg/ddp085 1:CAS:528:DC%2BD1MXksVeitbg%3D
    • (2009) Hum Mol Genet , vol.18 , pp. 1642-1651
    • Wang, L.1    Deng, H.X.2    Grisotti, G.3    Zhai, H.4    Siddique, T.5    Roos, R.P.6
  • 194
    • 67649486844 scopus 로고    scopus 로고
    • The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis
    • 19442735 10.1016/j.nbd.2009.05.002 1:CAS:528:DC%2BD1MXotFCgt7o%3D
    • L Wang K Sharma G Grisotti RP Roos 2009 The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis Neurobiol Dis 35 234 240 19442735 10.1016/j.nbd.2009.05.002 1:CAS:528:DC%2BD1MXotFCgt7o%3D
    • (2009) Neurobiol Dis , vol.35 , pp. 234-240
    • Wang, L.1    Sharma, K.2    Grisotti, G.3    Roos, R.P.4
  • 195
    • 0344734124 scopus 로고    scopus 로고
    • Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice
    • 9729335 10.1016/S0006-8993(98)00618-0 1:CAS:528:DyaK1cXltlensLw%3D
    • J Wegiel HM Wisniewski J Dziewiatkowski M Tarnawski R Kozielski E Trenkner W Wiktor-Jedrzejczak 1998 Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice Brain Res 804 135 139 9729335 10.1016/S0006-8993(98)00618-0 1:CAS:528:DyaK1cXltlensLw%3D
    • (1998) Brain Res , vol.804 , pp. 135-139
    • Wegiel, J.1    Wisniewski, H.M.2    Dziewiatkowski, J.3    Tarnawski, M.4    Kozielski, R.5    Trenkner, E.6    Wiktor-Jedrzejczak, W.7
  • 196
    • 73249152831 scopus 로고    scopus 로고
    • TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
    • 19833869 10.1073/pnas.0908767106
    • I Wegorzewska S Bell NJ Cairns TM Miller RH Baloh 2009 TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration Proc Natl Acad Sci USA 106 18809 18814 19833869 10.1073/pnas.0908767106
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 18809-18814
    • Wegorzewska, I.1    Bell, S.2    Cairns, N.J.3    Miller, T.M.4    Baloh, R.H.5
  • 197
    • 9144230806 scopus 로고    scopus 로고
    • Increased cytotoxic potential of microglia from ALS-transgenic mice
    • 15378658 10.1002/glia.20062
    • P Weydt EC Yuen BR Ransom T Moller 2004 Increased cytotoxic potential of microglia from ALS-transgenic mice Glia 48 179 182 15378658 10.1002/glia.20062
    • (2004) Glia , vol.48 , pp. 179-182
    • Weydt, P.1    Yuen, E.C.2    Ransom, B.R.3    Moller, T.4
  • 198
    • 0020462249 scopus 로고
    • Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation
    • 7130905 10.1084/jem.156.5.1516 1:STN:280:DyaL3s%2Fjt1eqtw%3D%3D
    • WW Wiktor-Jedrzejczak A Ahmed C Szczylik RR Skelly 1982 Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation J Exp Med 156 1516 1527 7130905 10.1084/jem.156.5.1516 1:STN:280:DyaL3s%2Fjt1eqtw%3D%3D
    • (1982) J Exp Med , vol.156 , pp. 1516-1527
    • Wiktor-Jedrzejczak, W.W.1    Ahmed, A.2    Szczylik, C.3    Skelly, R.R.4
  • 199
    • 0142226956 scopus 로고    scopus 로고
    • Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: Further evidence for microglial activation in neurodegeneration
    • 14597108 10.1016/j.jneuroim.2003.08.042 1:CAS:528:DC%2BD3sXosFSlsLY%3D
    • H Wilms J Sievers R Dengler J Bufler G Deuschl R Lucius 2003 Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration J Neuroimmunol 144 139 142 14597108 10.1016/j.jneuroim.2003.08.042 1:CAS:528:DC%2BD3sXosFSlsLY%3D
    • (2003) J Neuroimmunol , vol.144 , pp. 139-142
    • Wilms, H.1    Sievers, J.2    Dengler, R.3    Bufler, J.4    Deuschl, G.5    Lucius, R.6
  • 201
    • 0029053881 scopus 로고
    • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
    • 7605627 10.1016/0896-6273(95)90259-7 1:CAS:528:DyaK2MXms1Wrtr8%3D
    • PC Wong CA Pardo DR Borchelt MK Lee NG Copeland NA Jenkins SS Sisodia DW Cleveland DL Price 1995 An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria Neuron 14 1105 1116 7605627 10.1016/0896-6273(95)90259-7 1:CAS:528:DyaK2MXms1Wrtr8%3D
    • (1995) Neuron , vol.14 , pp. 1105-1116
    • Wong, P.C.1    Pardo, C.A.2    Borchelt, D.R.3    Lee, M.K.4    Copeland, N.G.5    Jenkins, N.A.6    Sisodia, S.S.7    Cleveland, D.W.8    Price, D.L.9
  • 202
    • 33747047814 scopus 로고    scopus 로고
    • The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice
    • 16877542 10.1073/pnas.0603670103 1:CAS:528:DC%2BD28Xotlyhsbc%3D
    • DC Wu DB Re M Nagai H Ischiropoulos S Przedborski 2006 The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice Proc Natl Acad Sci USA 103 12132 12137 16877542 10.1073/pnas.0603670103 1:CAS:528:DC%2BD28Xotlyhsbc%3D
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12132-12137
    • Wu, D.C.1    Re, D.B.2    Nagai, M.3    Ischiropoulos, H.4    Przedborski, S.5
  • 203
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease - A double-edged sword
    • 12165466 10.1016/S0896-6273(02)00794-8 1:CAS:528:DC%2BD38Xmt12isrs%3D
    • T Wyss-Coray L Mucke 2002 Inflammation in neurodegenerative disease-a double-edged sword Neuron 35 419 432 12165466 10.1016/S0896-6273(02)00794-8 1:CAS:528:DC%2BD38Xmt12isrs%3D
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2
  • 204
    • 34548233140 scopus 로고    scopus 로고
    • Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia
    • 17555556 10.1111/j.1471-4159.2007.04677.x 1:CAS:528:DC%2BD2sXhtVyksb7I
    • Q Xiao W Zhao DR Beers AA Yen W Xie JS Henkel SH Appel 2007 Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia J Neurochem 102 2008 2019 17555556 10.1111/j.1471-4159.2007.04677.x 1:CAS:528:DC%2BD2sXhtVyksb7I
    • (2007) J Neurochem , vol.102 , pp. 2008-2019
    • Xiao, Q.1    Zhao, W.2    Beers, D.R.3    Yen, A.A.4    Xie, W.5    Henkel, J.S.6    Appel, S.H.7
  • 207
    • 0035949799 scopus 로고    scopus 로고
    • Marked increase in cyclooxygenase-2 in ALS spinal cord: Implications for therapy
    • 11571316 1:CAS:528:DC%2BD3MXnsVCnsb8%3D
    • K Yasojima WW Tourtellotte EG McGeer PL McGeer 2001 Marked increase in cyclooxygenase-2 in ALS spinal cord: implications for therapy Neurology 57 952 956 11571316 1:CAS:528:DC%2BD3MXnsVCnsb8%3D
    • (2001) Neurology , vol.57 , pp. 952-956
    • Yasojima, K.1    Tourtellotte, W.W.2    McGeer, E.G.3    McGeer, P.L.4
  • 208
    • 33645224970 scopus 로고    scopus 로고
    • COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
    • 16512913 10.1186/1471-2377-6-12 1:CAS:528:DC%2BD28XmtVWkurw%3D
    • Y Yiangou P Facer P Durrenberger IP Chessell A Naylor C Bountra RR Banati P Anand 2006 COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord BMC Neurol 6 12 16512913 10.1186/1471-2377-6-12 1:CAS:528:DC%2BD28XmtVWkurw%3D
    • (2006) BMC Neurol , vol.6 , pp. 12
    • Yiangou, Y.1    Facer, P.2    Durrenberger, P.3    Chessell, I.P.4    Naylor, A.5    Bountra, C.6    Banati, R.R.7    Anand, P.8
  • 209
    • 0036269810 scopus 로고    scopus 로고
    • Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis
    • 11796754 10.1046/j.0022-3042.2001.00683.x 1:CAS:528: DC%2BD38Xjt1aisg%3D%3D
    • T Yoshihara S Ishigaki M Yamamoto Y Liang J Niwa H Takeuchi M Doyu G Sobue 2002 Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis J Neurochem 80 158 167 11796754 10.1046/j.0022-3042.2001. 00683.x 1:CAS:528:DC%2BD38Xjt1aisg%3D%3D
    • (2002) J Neurochem , vol.80 , pp. 158-167
    • Yoshihara, T.1    Ishigaki, S.2    Yamamoto, M.3    Liang, Y.4    Niwa, J.5    Takeuchi, H.6    Doyu, M.7    Sobue, G.8
  • 210
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • 10557349 10.1073/pnas.96.23.13496 1:CAS:528:DyaK1MXns1GmurY%3D
    • J Yrjanheikki T Tikka R Keinanen G Goldsteins PH Chan J Koistinaho 1999 A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window Proc Natl Acad Sci USA 96 13496 13500 10557349 10.1073/pnas.96.23.13496 1:CAS:528:DyaK1MXns1GmurY%3D
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13496-13500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 211
    • 33750442559 scopus 로고    scopus 로고
    • Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia
    • 17018025 10.1111/j.1471-4159.2006.04172.x 1:CAS:528:DC%2BD28Xht1yks7jM
    • W Zhao W Xie Q Xiao DR Beers SH Appel 2006 Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia J Neurochem 99 1176 1187 17018025 10.1111/j.1471-4159.2006. 04172.x 1:CAS:528:DC%2BD28Xht1yks7jM
    • (2006) J Neurochem , vol.99 , pp. 1176-1187
    • Zhao, W.1    Xie, W.2    Xiao, Q.3    Beers, D.R.4    Appel, S.H.5
  • 212
    • 33644934738 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity
    • 16442504 10.1016/j.brainres.2005.12.061 1:CAS:528:DC%2BD28Xis1Squrg%3D
    • X Zhao Z Ou JC Grotta N Waxham J Aronowski 2006 Peroxisome-proliferator- activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity Brain Res 1073-1074 460 469 16442504 10.1016/j.brainres.2005.12. 061 1:CAS:528:DC%2BD28Xis1Squrg%3D
    • (2006) Brain Res , vol.1073-1074 , pp. 460-469
    • Zhao, X.1    Ou, Z.2    Grotta, J.C.3    Waxham, N.4    Aronowski, J.5
  • 213
    • 73149105494 scopus 로고    scopus 로고
    • Extracellular mutant SOD1 induces microglial-mediated motoneuron injury
    • 19672969 10.1002/glia.20919
    • W Zhao DR Beers JS Henkel W Zhang M Urushitani JP Julien SH Appel 2010 Extracellular mutant SOD1 induces microglial-mediated motoneuron injury Glia 58 231 243 19672969 10.1002/glia.20919
    • (2010) Glia , vol.58 , pp. 231-243
    • Zhao, W.1    Beers, D.R.2    Henkel, J.S.3    Zhang, W.4    Urushitani, M.5    Julien, J.P.6    Appel, S.H.7
  • 216
    • 77950421249 scopus 로고    scopus 로고
    • Transgenic rat model of neurodegeneration caused by mutation in the TDP gene
    • 20361056 10.1371/journal.pgen.1000887 1:CAS:528:DC%2BC3cXksFeiur8%3D
    • H Zhou C Huang H Chen D Wang CP Landel PY Xia R Bowser YJ Liu XG Xia 2010 Transgenic rat model of neurodegeneration caused by mutation in the TDP gene PLoS Genet 6 3 e1000887 20361056 10.1371/journal.pgen.1000887 1:CAS:528:DC%2BC3cXksFeiur8%3D
    • (2010) PLoS Genet , vol.6 , Issue.3 , pp. 1000887
    • Zhou, H.1    Huang, C.2    Chen, H.3    Wang, D.4    Landel, C.P.5    Xia, P.Y.6    Bowser, R.7    Liu, Y.J.8    Xia, X.G.9


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