-
1
-
-
36448994709
-
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
-
18026097 10.1038/nn2014 1:CAS:528:DC%2BD2sXhtlKltLbP
-
B Ajami JL Bennett C Krieger W Tetzlaff FM Rossi 2007 Local self-renewal can sustain CNS microglia maintenance and function throughout adult life Nat Neurosci 10 1538 1543 18026097 10.1038/nn2014 1:CAS:528:DC%2BD2sXhtlKltLbP
-
(2007)
Nat Neurosci
, vol.10
, pp. 1538-1543
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
Tetzlaff, W.4
Rossi, F.M.5
-
2
-
-
0035833937
-
Immune reactivity in a mouse model of familial ALS correlates with disease progression
-
11591849 1:STN:280:DC%2BD3MrksVyhug%3D%3D
-
ME Alexianu M Kozovska SH Appel 2001 Immune reactivity in a mouse model of familial ALS correlates with disease progression Neurology 57 1282 1289 11591849 1:STN:280:DC%2BD3MrksVyhug%3D%3D
-
(2001)
Neurology
, vol.57
, pp. 1282-1289
-
-
Alexianu, M.E.1
Kozovska, M.2
Appel, S.H.3
-
3
-
-
0033018506
-
Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis
-
10349851 10.1046/j.1471-4159.1999.0722415.x 1:CAS:528:DyaK1MXjsV2hsLs%3D
-
G Almer S Vukosavic N Romero S Przedborski 1999 Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis J Neurochem 72 2415 2425 10349851 10.1046/j.1471-4159.1999. 0722415.x 1:CAS:528:DyaK1MXjsV2hsLs%3D
-
(1999)
J Neurochem
, vol.72
, pp. 2415-2425
-
-
Almer, G.1
Vukosavic, S.2
Romero, N.3
Przedborski, S.4
-
4
-
-
0035132167
-
Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis
-
11220737 10.1002/1531-8249(20010201)49:2 <176::AID-ANA37>3.0.CO;2-X 1:CAS:528:DC%2BD3MXhsVymur4%3D
-
G Almer C Guegan P Teismann A Naini G Rosoklija AP Hays C Chen S Przedborski 2001 Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis Ann Neurol 49 176 185 11220737 10.1002/1531-8249(20010201)49:2 <176::AID-ANA37>3.0.CO;2-X 1:CAS:528:DC%2BD3MXhsVymur4%3D
-
(2001)
Ann Neurol
, vol.49
, pp. 176-185
-
-
Almer, G.1
Guegan, C.2
Teismann, P.3
Naini, A.4
Rosoklija, G.5
Hays, A.P.6
Chen, C.7
Przedborski, S.8
-
5
-
-
0025865829
-
The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration
-
1713656 10.1016/0306-4522(91)90159-L 1:STN:280:DyaK3MzhvFakuw%3D%3D
-
PB Andersson VH Perry S Gordon 1991 The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration Neuroscience 42 201 214 1713656 10.1016/0306-4522(91) 90159-L 1:STN:280:DyaK3MzhvFakuw%3D%3D
-
(1991)
Neuroscience
, vol.42
, pp. 201-214
-
-
Andersson, P.B.1
Perry, V.H.2
Gordon, S.3
-
6
-
-
0031444384
-
Lack of evidence for HTLV tax-rex DNA in motor neurone disease
-
9455984 10.1016/S0022-510X(97)00199-8 1:STN:280:DyaK1c7hsFGiuw%3D%3D
-
WD Andrews A Al-Chalabi JA Garson 1997 Lack of evidence for HTLV tax-rex DNA in motor neurone disease J Neurol Sci 153 86 90 9455984 10.1016/S0022- 510X(97)00199-8 1:STN:280:DyaK1c7hsFGiuw%3D%3D
-
(1997)
J Neurol Sci
, vol.153
, pp. 86-90
-
-
Andrews, W.D.1
Al-Chalabi, A.2
Garson, J.A.3
-
7
-
-
0033923528
-
Detection of reverse transcriptase activity in the serum of patients with motor neurone disease
-
10897073 10.1002/1096-9071(200008)61:4 <527::AID-JMV17>3.0.CO;2-A 1:CAS:528:DC%2BD3cXlsVOis7k%3D
-
WD Andrews PW Tuke A Al-Chalabi P Gaudin S Ijaz MJ Parton JA Garson 2000 Detection of reverse transcriptase activity in the serum of patients with motor neurone disease J Med Virol 61 527 532 10897073 10.1002/1096-9071(200008)61: 4<527::AID-JMV17>3.0.CO;2-A 1:CAS:528:DC%2BD3cXlsVOis7k%3D
-
(2000)
J Med Virol
, vol.61
, pp. 527-532
-
-
Andrews, W.D.1
Tuke, P.W.2
Al-Chalabi, A.3
Gaudin, P.4
Ijaz, S.5
Parton, M.J.6
Garson, J.A.7
-
8
-
-
0344490328
-
Therapeutic vaccine for acute and chronic motor neuron diseases: Implications for amyotrophic lateral sclerosis
-
12668759 10.1073/pnas.0530191100 1:CAS:528:DC%2BD3sXjt12nsb0%3D
-
DN Angelov S Waibel O Guntinas-Lichius M Lenzen WF Neiss TL Tomov E Yoles J Kipnis H Schori A Reuter A Ludolph M Schwartz 2003 Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis Proc Natl Acad Sci USA 100 4790 4795 12668759 10.1073/pnas.0530191100 1:CAS:528:DC%2BD3sXjt12nsb0%3D
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4790-4795
-
-
Angelov, D.N.1
Waibel, S.2
Guntinas-Lichius, O.3
Lenzen, M.4
Neiss, W.F.5
Tomov, T.L.6
Yoles, E.7
Kipnis, J.8
Schori, H.9
Reuter, A.10
Ludolph, A.11
Schwartz, M.12
-
9
-
-
0027316880
-
Evidence for autoimmunity in amyotrophic lateral sclerosis
-
8229065 10.1016/0022-510X(93)90106-9 1:STN:280:DyaK2c%2FksFOmsA%3D%3D
-
SH Appel RG Smith JI Engelhardt E Stefani 1993 Evidence for autoimmunity in amyotrophic lateral sclerosis J Neurol Sci 118 169 174 8229065 10.1016/0022-510X(93)90106-9 1:STN:280:DyaK2c%2FksFOmsA%3D%3D
-
(1993)
J Neurol Sci
, vol.118
, pp. 169-174
-
-
Appel, S.H.1
Smith, R.G.2
Engelhardt, J.I.3
Stefani, E.4
-
10
-
-
55449090370
-
Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
-
18936424 10.1212/01.wnl.0000327668.43541.22 1:STN:280: DC%2BD1cnnsVOlug%3D%3D
-
SH Appel JI Engelhardt JS Henkel L Siklos DR Beers AA Yen EP Simpson Y Luo G Carrum HE Heslop MK Brenner U Popat 2008 Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis Neurology 71 1326 1334 18936424 10.1212/01.wnl.0000327668.43541.22 1:STN:280:DC%2BD1cnnsVOlug%3D%3D
-
(2008)
Neurology
, vol.71
, pp. 1326-1334
-
-
Appel, S.H.1
Engelhardt, J.I.2
Henkel, J.S.3
Siklos, L.4
Beers, D.R.5
Yen, A.A.6
Simpson, E.P.7
Luo, Y.8
Carrum, G.9
Heslop, H.E.10
Brenner, M.K.11
Popat, U.12
-
11
-
-
50549098607
-
Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice
-
Banerjee R, Mosley RL, Reynolds AD, Dhar A, Jackson-Lewis V, Gordon PH, Przedborski S, Gendelman HE (2008) Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice. PLoS One
-
(2008)
PLoS One
-
-
Banerjee, R.1
Mosley, R.L.2
Reynolds, A.D.3
Dhar, A.4
Jackson-Lewis, V.5
Gordon, P.H.6
Przedborski, S.7
Gendelman, H.E.8
-
12
-
-
9644255989
-
A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
-
15572176 10.1016/j.brainresrev.2004.05.003 1:CAS:528:DC%2BD2cXhtVantLvE
-
LH Barbeito M Pehar P Cassina MR Vargas H Peluffo L Viera AG Estevez JS Beckman 2004 A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis Brain Res Brain Res Rev 47 263 274 15572176 10.1016/j.brainresrev. 2004.05.003 1:CAS:528:DC%2BD2cXhtVantLvE
-
(2004)
Brain Res Brain Res Rev
, vol.47
, pp. 263-274
-
-
Barbeito, L.H.1
Pehar, M.2
Cassina, P.3
Vargas, M.R.4
Peluffo, H.5
Viera, L.6
Estevez, A.G.7
Beckman, J.S.8
-
13
-
-
33751003518
-
Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
-
16713195 1:CAS:528:DC%2BD28Xht1CgsLnJ
-
SC Barber RJ Mead PJ Shaw 2006 Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target Biochim Biophys Acta 1762 1051 1067 16713195 1:CAS:528:DC%2BD28Xht1CgsLnJ
-
(2006)
Biochim Biophys Acta
, vol.1762
, pp. 1051-1067
-
-
Barber, S.C.1
Mead, R.J.2
Shaw, P.J.3
-
14
-
-
25844496913
-
Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis
-
15962273 10.1002/mus.20376 1:CAS:528:DC%2BD2MXhtFGltrfL
-
P Baron S Bussini V Cardin M Corbo G Conti D Galimberti E Scarpini N Bresolin SB Wharton PJ Shaw V Silani 2005 Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis Muscle Nerve 32 541 544 15962273 10.1002/mus.20376 1:CAS:528:DC%2BD2MXhtFGltrfL
-
(2005)
Muscle Nerve
, vol.32
, pp. 541-544
-
-
Baron, P.1
Bussini, S.2
Cardin, V.3
Corbo, M.4
Conti, G.5
Galimberti, D.6
Scarpini, E.7
Bresolin, N.8
Wharton, S.B.9
Shaw, P.J.10
Silani, V.11
-
15
-
-
33846794822
-
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
-
17237347 10.1152/physrev.00044.2005 1:CAS:528:DC%2BD2sXitVagsr4%3D
-
K Bedard KH Krause 2007 The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology Physiol Rev 87 245 313 17237347 10.1152/physrev.00044.2005 1:CAS:528:DC%2BD2sXitVagsr4%3D
-
(2007)
Physiol Rev
, vol.87
, pp. 245-313
-
-
Bedard, K.1
Krause, K.H.2
-
16
-
-
33750478657
-
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
-
17043238 10.1073/pnas.0607423103 1:CAS:528:DC%2BD28XhtFyku7nE
-
DR Beers JS Henkel Q Xiao W Zhao J Wang AA Yen L Siklos SR McKercher SH Appel 2006 Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis Proc Natl Acad Sci USA 103 16021 16026 17043238 10.1073/pnas.0607423103 1:CAS:528:DC%2BD28XhtFyku7nE
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16021-16026
-
-
Beers, D.R.1
Henkel, J.S.2
Xiao, Q.3
Zhao, W.4
Wang, J.5
Yen, A.A.6
Siklos, L.7
McKercher, S.R.8
Appel, S.H.9
-
17
-
-
55749110043
-
CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
-
18809917 10.1073/pnas.0807419105
-
DR Beers JS Henkel W Zhao J Wang SH Appel 2008 CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS Proc Natl Acad Sci USA 105 15558 15563 18809917 10.1073/pnas.0807419105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 15558-15563
-
-
Beers, D.R.1
Henkel, J.S.2
Zhao, W.3
Wang, J.4
Appel, S.H.5
-
18
-
-
0027460054
-
Delayed hematopoietic development in osteopetrotic (op/op) mice
-
8418205 10.1084/jem.177.1.237 1:STN:280:DyaK3s7hsFKltQ%3D%3D
-
SK Begg JM Radley JW Pollard OT Chisholm ER Stanley I Bertoncello 1993 Delayed hematopoietic development in osteopetrotic (op/op) mice J Exp Med 177 237 242 8418205 10.1084/jem.177.1.237 1:STN:280:DyaK3s7hsFKltQ%3D%3D
-
(1993)
J Exp Med
, vol.177
, pp. 237-242
-
-
Begg, S.K.1
Radley, J.M.2
Pollard, J.W.3
Chisholm, O.T.4
Stanley, E.R.5
Bertoncello, I.6
-
19
-
-
3042592589
-
Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
-
15197276 10.1073/pnas.0400569101 1:CAS:528:DC%2BD2cXltlKjsLk%3D
-
EJ Benner RL Mosley CJ Destache TB Lewis V Jackson-Lewis S Gorantla C Nemachek SR Green S Przedborski HE Gendelman 2004 Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease Proc Natl Acad Sci USA 101 9435 9440 15197276 10.1073/pnas.0400569101 1:CAS:528: DC%2BD2cXltlKjsLk%3D
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 9435-9440
-
-
Benner, E.J.1
Mosley, R.L.2
Destache, C.J.3
Lewis, T.B.4
Jackson-Lewis, V.5
Gorantla, S.6
Nemachek, C.7
Green, S.R.8
Przedborski, S.9
Gendelman, H.E.10
-
20
-
-
33846887598
-
Microglial control of neuronal death and synaptic properties
-
17106878 10.1002/glia.20459
-
A Bessis C Bechade D Bernard A Roumier 2007 Microglial control of neuronal death and synaptic properties Glia 55 233 238 17106878 10.1002/glia.20459
-
(2007)
Glia
, vol.55
, pp. 233-238
-
-
Bessis, A.1
Bechade, C.2
Bernard, D.3
Roumier, A.4
-
21
-
-
33750959751
-
Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls
-
17116217 10.1111/j.1468-1331.2006.01503.x 1:STN:280: DC%2BD28nnvFKqtw%3D%3D
-
E Bilic I Rudan V Kusec N Zurak D Delimar M Zagar 2006 Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls Eur J Neurol 13 1340 1345 17116217 10.1111/j.1468-1331.2006.01503.x 1:STN:280:DC%2BD28nnvFKqtw%3D%3D
-
(2006)
Eur J Neurol
, vol.13
, pp. 1340-1345
-
-
Bilic, E.1
Rudan, I.2
Kusec, V.3
Zurak, N.4
Delimar, D.5
Zagar, M.6
-
22
-
-
33749056809
-
ALS: A disease of motor neurons and their nonneuronal neighbors
-
17015226 10.1016/j.neuron.2006.09.018 1:CAS:528:DC%2BD28XhtFensbfP
-
S Boillee C Vande Velde DW Cleveland 2006 ALS: a disease of motor neurons and their nonneuronal neighbors Neuron 52 39 59 17015226 10.1016/j.neuron.2006. 09.018 1:CAS:528:DC%2BD28XhtFensbfP
-
(2006)
Neuron
, vol.52
, pp. 39-59
-
-
Boillee, S.1
Vande Velde, C.2
Cleveland, D.W.3
-
23
-
-
33744798774
-
Onset and progression in inherited ALS determined by motor neurons and microglia
-
16741123 10.1126/science.1123511 1:CAS:528:DC%2BD28XltVOht7o%3D
-
S Boillee K Yamanaka CS Lobsiger NG Copeland NA Jenkins G Kassiotis G Kollias DW Cleveland 2006 Onset and progression in inherited ALS determined by motor neurons and microglia Science 312 1389 1392 16741123 10.1126/science. 1123511 1:CAS:528:DC%2BD28XltVOht7o%3D
-
(2006)
Science
, vol.312
, pp. 1389-1392
-
-
Boillee, S.1
Yamanaka, K.2
Lobsiger, C.S.3
Copeland, N.G.4
Jenkins, N.A.5
Kassiotis, G.6
Kollias, G.7
Cleveland, D.W.8
-
24
-
-
0031722582
-
A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group
-
9710040 1:CAS:528:DyaK1cXls1agsr8%3D
-
GD Borasio W Robberecht PN Leigh J Emile RJ Guiloff F Jerusalem V Silani PE Vos JH Wokke T Dobbins 1998 A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group Neurology 51 583 586 9710040 1:CAS:528:DyaK1cXls1agsr8%3D
-
(1998)
Neurology
, vol.51
, pp. 583-586
-
-
Borasio, G.D.1
Robberecht, W.2
Leigh, P.N.3
Emile, J.4
Guiloff, R.J.5
Jerusalem, F.6
Silani, V.7
Vos, P.E.8
Wokke, J.H.9
Dobbins, T.10
-
25
-
-
0023197677
-
Serum insulin-like growth factor-I levels in amyotrophic lateral sclerosis
-
3302111 10.1136/jnnp.50.6.792 1:STN:280:DyaL2s3ot1Citg%3D%3D
-
GD Braunstein AL Reviczky 1987 Serum insulin-like growth factor-I levels in amyotrophic lateral sclerosis J Neurol Neurosurg Psychiatry 50 792 794 3302111 10.1136/jnnp.50.6.792 1:STN:280:DyaL2s3ot1Citg%3D%3D
-
(1987)
J Neurol Neurosurg Psychiatry
, vol.50
, pp. 792-794
-
-
Braunstein, G.D.1
Reviczky, A.L.2
-
26
-
-
0036326074
-
Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease
-
12153485 10.1046/j.1471-4159.2002.00990.x 1:CAS:528:DC%2BD38Xmt1ejsLY%3D
-
T Breidert J Callebert MT Heneka G Landreth JM Launay EC Hirsch 2002 Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease J Neurochem 82 615 624 12153485 10.1046/j.1471-4159.2002.00990.x 1:CAS:528:DC%2BD38Xmt1ejsLY%3D
-
(2002)
J Neurochem
, vol.82
, pp. 615-624
-
-
Breidert, T.1
Callebert, J.2
Heneka, M.T.3
Landreth, G.4
Launay, J.M.5
Hirsch, E.C.6
-
27
-
-
0031051485
-
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
-
9052802 10.1016/S0896-6273(00)80272-X 1:CAS:528:DyaK2sXhslersLk%3D
-
LI Bruijn MW Becher MK Lee KL Anderson NA Jenkins NG Copeland SS Sisodia JD Rothstein DR Borchelt DL Price DW Cleveland 1997 ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions Neuron 18 327 338 9052802 10.1016/S0896-6273(00) 80272-X 1:CAS:528:DyaK2sXhslersLk%3D
-
(1997)
Neuron
, vol.18
, pp. 327-338
-
-
Bruijn, L.I.1
Becher, M.W.2
Lee, M.K.3
Anderson, K.L.4
Jenkins, N.A.5
Copeland, N.G.6
Sisodia, S.S.7
Rothstein, J.D.8
Borchelt, D.R.9
Price, D.L.10
Cleveland, D.W.11
-
28
-
-
33746827434
-
Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1
-
16864778 10.1073/pnas.0604681103 1:CAS:528:DC%2BD28XotFagurk%3D
-
O Butovsky M Koronyo-Hamaoui G Kunis E Ophir G Landa H Cohen M Schwartz 2006 Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1 Proc Natl Acad Sci USA 103 11784 11789 16864778 10.1073/pnas.0604681103 1:CAS:528: DC%2BD28XotFagurk%3D
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 11784-11789
-
-
Butovsky, O.1
Koronyo-Hamaoui, M.2
Kunis, G.3
Ophir, E.4
Landa, G.5
Cohen, H.6
Schwartz, M.7
-
29
-
-
33745573660
-
Control of microglial neurotoxicity by the fractalkine receptor
-
16732273 10.1038/nn1715 1:CAS:528:DC%2BD28XmtFCmsbw%3D
-
AE Cardona EP Pioro ME Sasse V Kostenko SM Cardona IM Dijkstra D Huang G Kidd S Dombrowski R Dutta JC Lee DN Cook S Jung SA Lira DR Littman RM Ransohoff 2006 Control of microglial neurotoxicity by the fractalkine receptor Nat Neurosci 9 917 924 16732273 10.1038/nn1715 1:CAS:528:DC%2BD28XmtFCmsbw%3D
-
(2006)
Nat Neurosci
, vol.9
, pp. 917-924
-
-
Cardona, A.E.1
Pioro, E.P.2
Sasse, M.E.3
Kostenko, V.4
Cardona, S.M.5
Dijkstra, I.M.6
Huang, D.7
Kidd, G.8
Dombrowski, S.9
Dutta, R.10
Lee, J.C.11
Cook, D.N.12
Jung, S.13
Lira, S.A.14
Littman, D.R.15
Ransohoff, R.M.16
-
30
-
-
38149037132
-
Minocycline for patients with ALS
-
18207105 10.1016/S1474-4422(08)70005-X (author reply 120-111)
-
MT Carri 2008 Minocycline for patients with ALS Lancet Neurol 7 118 119 18207105 10.1016/S1474-4422(08)70005-X (author reply 120-111)
-
(2008)
Lancet Neurol
, vol.7
, pp. 118-119
-
-
Carri, M.T.1
-
31
-
-
39849105705
-
TNF and sTNFR1/2 plasma levels in ALS patients
-
18083240 10.1016/j.jneuroim.2007.10.028 1:CAS:528:DC%2BD1cXjtVWnsL0%3D
-
C Cereda C Baiocchi P Bongioanni E Cova S Guareschi MR Metelli B Rossi I Sbalsi MC Cuccia M Ceroni 2008 TNF and sTNFR1/2 plasma levels in ALS patients J Neuroimmunol 194 123 131 18083240 10.1016/j.jneuroim.2007.10.028 1:CAS:528:DC%2BD1cXjtVWnsL0%3D
-
(2008)
J Neuroimmunol
, vol.194
, pp. 123-131
-
-
Cereda, C.1
Baiocchi, C.2
Bongioanni, P.3
Cova, E.4
Guareschi, S.5
Metelli, M.R.6
Rossi, B.7
Sbalsi, I.8
Cuccia, M.C.9
Ceroni, M.10
-
32
-
-
77950458426
-
Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice
-
19888600
-
K Chen FJ Northington LJ Martin 2009 Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice Brain Struct Funct 214 2-3 219 234 19888600
-
(2009)
Brain Struct Funct
, vol.214
, Issue.23
, pp. 219-234
-
-
Chen, K.1
Northington, F.J.2
Martin, L.J.3
-
33
-
-
58149354213
-
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase
-
19005069 10.1523/JNEUROSCI.3568-08.2008 1:CAS:528:DC%2BD1cXhsVarurbL
-
C Cheret A Gervais A Lelli C Colin L Amar P Ravassard J Mallet A Cumano KH Krause M Mallat 2008 Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase J Neurosci 28 12039 12051 19005069 10.1523/JNEUROSCI.3568-08.2008 1:CAS:528:DC%2BD1cXhsVarurbL
-
(2008)
J Neurosci
, vol.28
, pp. 12039-12051
-
-
Cheret, C.1
Gervais, A.2
Lelli, A.3
Colin, C.4
Amar, L.5
Ravassard, P.6
Mallet, J.7
Cumano, A.8
Krause, K.H.9
Mallat, M.10
-
34
-
-
56649100689
-
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
-
18997009 10.1073/pnas.0804610105
-
IM Chiu A Chen Y Zheng B Kosaras SA Tsiftsoglou TK Vartanian RH Brown Jr MC Carroll 2008 T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS Proc Natl Acad Sci USA 105 17913 17918 18997009 10.1073/pnas.0804610105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17913-17918
-
-
Chiu, I.M.1
Chen, A.2
Zheng, Y.3
Kosaras, B.4
Tsiftsoglou, S.A.5
Vartanian, T.K.6
Brown, Jr.R.H.7
Carroll, M.C.8
-
35
-
-
73949128974
-
Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
-
19933335 10.1073/pnas.0911405106
-
IM Chiu H Phatnani M Kuligowski JC Tapia MA Carrasco M Zhang T Maniatis MC Carroll 2009 Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice Proc Natl Acad Sci USA 106 20960 20965 19933335 10.1073/pnas.0911405106
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 20960-20965
-
-
Chiu, I.M.1
Phatnani, H.2
Kuligowski, M.3
Tapia, J.C.4
Carrasco, M.A.5
Zhang, M.6
Maniatis, T.7
Carroll, M.C.8
-
36
-
-
58049192812
-
Deleterious variants of FIG 4, a phosphoinositide phosphatase, in patients with ALS
-
19118816 10.1016/j.ajhg.2008.12.010 1:CAS:528:DC%2BD1MXpsFartw%3D%3D
-
CY Chow JE Landers SK Bergren PC Sapp AE Grant JM Jones L Everett GM Lenk DM McKenna-Yasek LS Weisman D Figlewicz RH Brown MH Meisler 2009 Deleterious variants of FIG 4, a phosphoinositide phosphatase, in patients with ALS Am J Hum Genet 84 85 88 19118816 10.1016/j.ajhg.2008.12.010 1:CAS:528: DC%2BD1MXpsFartw%3D%3D
-
(2009)
Am J Hum Genet
, vol.84
, pp. 85-88
-
-
Chow, C.Y.1
Landers, J.E.2
Bergren, S.K.3
Sapp, P.C.4
Grant, A.E.5
Jones, J.M.6
Everett, L.7
Lenk, G.M.8
McKenna-Yasek, D.M.9
Weisman, L.S.10
Figlewicz, D.11
Brown, R.H.12
Meisler, M.H.13
-
37
-
-
0141642203
-
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
-
14526083 10.1126/science.1086071 1:CAS:528:DC%2BD3sXnslSjsLo%3D
-
AM Clement MD Nguyen EA Roberts ML Garcia S Boillee M Rule AP McMahon W Doucette D Siwek RJ Ferrante RH Brown Jr JP Julien LS Goldstein DW Cleveland 2003 Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice Science 302 113 117 14526083 10.1126/science.1086071 1:CAS:528:DC%2BD3sXnslSjsLo%3D
-
(2003)
Science
, vol.302
, pp. 113-117
-
-
Clement, A.M.1
Nguyen, M.D.2
Roberts, E.A.3
Garcia, M.L.4
Boillee, S.5
Rule, M.6
McMahon, A.P.7
Doucette, W.8
Siwek, D.9
Ferrante, R.J.10
Brown, Jr.R.H.11
Julien, J.P.12
Goldstein, L.S.13
Cleveland, D.W.14
-
38
-
-
0032528350
-
Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: Correlation with induction of heme oxygenase 1
-
9670978 1:CAS:528:DyaK1cXksFKisrk%3D
-
PR Colville-Nash SS Qureshi D Willis DA Willoughby 1998 Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1 J Immunol 161 978 984 9670978 1:CAS:528:DyaK1cXksFKisrk%3D
-
(1998)
J Immunol
, vol.161
, pp. 978-984
-
-
Colville-Nash, P.R.1
Qureshi, S.S.2
Willis, D.3
Willoughby, D.A.4
-
39
-
-
1842714301
-
Neuroinflammation, COX-2, and ALS - A dual role?
-
15081582 10.1016/j.expneurol.2003.12.009 1:CAS:528:DC%2BD2cXjtVChtrw%3D
-
C Consilvio AM Vincent EL Feldman 2004 Neuroinflammation, COX-2, and ALS-a dual role? Exp Neurol 187 1 10 15081582 10.1016/j.expneurol.2003.12.009 1:CAS:528:DC%2BD2cXjtVChtrw%3D
-
(2004)
Exp Neurol
, vol.187
, pp. 1-10
-
-
Consilvio, C.1
Vincent, A.M.2
Feldman, E.L.3
-
40
-
-
77649097159
-
Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients
-
19845745 10.1111/j.1468-1331.2009.02815.x
-
M Corbo C Lunetta P Magni E Dozio M Ruscica L Adobbati V Silani 2009 Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients Eur J Neurol 17 398 404 19845745 10.1111/j.1468-1331.2009.02815.x
-
(2009)
Eur J Neurol
, vol.17
, pp. 398-404
-
-
Corbo, M.1
Lunetta, C.2
Magni, P.3
Dozio, E.4
Ruscica, M.5
Adobbati, L.6
Silani, V.7
-
41
-
-
8144229995
-
Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues
-
15469951 10.1093/brain/awh273
-
S Corti F Locatelli C Donadoni M Guglieri D Papadimitriou S Strazzer R Del Bo GP Comi 2004 Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues Brain 127 2518 2532 15469951 10.1093/brain/awh273
-
(2004)
Brain
, vol.127
, pp. 2518-2532
-
-
Corti, S.1
Locatelli, F.2
Donadoni, C.3
Guglieri, M.4
Papadimitriou, D.5
Strazzer, S.6
Del Bo, R.7
Comi, G.P.8
-
42
-
-
0031690332
-
The origin and differentiation of microglial cells during development
-
9760700 10.1016/S0301-0082(98)00035-5 1:STN:280:DyaK1cvjtlCjuw%3D%3D
-
MA Cuadros J Navascues 1998 The origin and differentiation of microglial cells during development Prog Neurobiol 56 173 189 9760700 10.1016/S0301- 0082(98)00035-5 1:STN:280:DyaK1cvjtlCjuw%3D%3D
-
(1998)
Prog Neurobiol
, vol.56
, pp. 173-189
-
-
Cuadros, M.A.1
Navascues, J.2
-
44
-
-
70449732762
-
The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis
-
19734218 10.4049/jimmunol.0901212 1:CAS:528:DC%2BD1MXhtFGjsLzP
-
N D'Ambrosi P Finocchi S Apolloni M Cozzolino A Ferri V Padovano G Pietrini MT Carri C Volonte 2009 The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J Immunol 183 4648 4656 19734218 10.4049/jimmunol.0901212 1:CAS:528:DC%2BD1MXhtFGjsLzP
-
(2009)
J Immunol
, vol.183
, pp. 4648-4656
-
-
D'Ambrosi, N.1
Finocchi, P.2
Apolloni, S.3
Cozzolino, M.4
Ferri, A.5
Padovano, V.6
Pietrini, G.7
Carri, M.T.8
Volonte, C.9
-
45
-
-
0036092801
-
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
-
11756160 10.1182/blood.V99.1.111 1:CAS:528:DC%2BD38XivF2isA%3D%3D
-
XM Dai GR Ryan AJ Hapel MG Dominguez RG Russell S Kapp V Sylvestre ER Stanley 2002 Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects Blood 99 111 120 11756160 10.1182/blood.V99.1.111 1:CAS:528:DC%2BD38XivF2isA%3D%3D
-
(2002)
Blood
, vol.99
, pp. 111-120
-
-
Dai, X.M.1
Ryan, G.R.2
Hapel, A.J.3
Dominguez, M.G.4
Russell, R.G.5
Kapp, S.6
Sylvestre, V.7
Stanley, E.R.8
-
46
-
-
22244464662
-
ATP mediates rapid microglial response to local brain injury in vivo
-
15895084 10.1038/nn1472 1:CAS:528:DC%2BD2MXksVeit7Y%3D
-
D Davalos J Grutzendler G Yang JV Kim Y Zuo S Jung DR Littman ML Dustin WB Gan 2005 ATP mediates rapid microglial response to local brain injury in vivo Nat Neurosci 8 752 758 15895084 10.1038/nn1472 1:CAS:528:DC%2BD2MXksVeit7Y%3D
-
(2005)
Nat Neurosci
, vol.8
, pp. 752-758
-
-
Davalos, D.1
Grutzendler, J.2
Yang, G.3
Kim, J.V.4
Zuo, Y.5
Jung, S.6
Littman, D.R.7
Dustin, M.L.8
Gan, W.B.9
-
47
-
-
0347087323
-
Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with i kappa B alpha induction and block of NF kappa B and iNOS activation
-
14690537 10.1046/j.1471-4159.2003.02210.x 1:CAS:528: DC%2BD2cXntlWjug%3D%3D
-
T Dehmer MT Heneka M Sastre J Dichgans JB Schulz 2004 Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation J Neurochem 88 494 501 14690537 10.1046/j.1471-4159.2003.02210.x 1:CAS:528:DC%2BD2cXntlWjug%3D%3D
-
(2004)
J Neurochem
, vol.88
, pp. 494-501
-
-
Dehmer, T.1
Heneka, M.T.2
Sastre, M.3
Dichgans, J.4
Schulz, J.B.5
-
48
-
-
33646466296
-
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
-
16636275 10.1073/pnas.0602046103 1:CAS:528:DC%2BD28XkslCktLg%3D
-
HX Deng Y Shi Y Furukawa H Zhai R Fu E Liu GH Gorrie MS Khan WY Hung EH Bigio T Lukas MC Dal Canto TV O'Halloran T Siddique 2006 Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria Proc Natl Acad Sci USA 103 7142 7147 16636275 10.1073/pnas.0602046103 1:CAS:528:DC%2BD28XkslCktLg%3D
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 7142-7147
-
-
Deng, H.X.1
Shi, Y.2
Furukawa, Y.3
Zhai, H.4
Fu, R.5
Liu, E.6
Gorrie, G.H.7
Khan, M.S.8
Hung, W.Y.9
Bigio, E.H.10
Lukas, T.11
Dal Canto, M.C.12
O'Halloran, T.V.13
Siddique, T.14
-
49
-
-
34247473080
-
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
-
17435754 10.1038/nn1885 1:CAS:528:DC%2BD2sXksFShsLg%3D
-
FP Di Giorgio MA Carrasco MC Siao T Maniatis K Eggan 2007 Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model Nat Neurosci 10 608 614 17435754 10.1038/nn1885 1:CAS:528: DC%2BD2sXksFShsLg%3D
-
(2007)
Nat Neurosci
, vol.10
, pp. 608-614
-
-
Di Giorgio, F.P.1
Carrasco, M.A.2
Siao, M.C.3
Maniatis, T.4
Eggan, K.5
-
50
-
-
13844253540
-
Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model
-
15657392 10.1083/jcb.200407021 1:CAS:528:DC%2BD2MXls1OgsA%3D%3D
-
G Dobrowolny C Giacinti L Pelosi C Nicoletti N Winn L Barberi M Molinaro N Rosenthal A Musaro 2005 Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model J Cell Biol 168 193 199 15657392 10.1083/jcb.200407021 1:CAS:528:DC%2BD2MXls1OgsA%3D%3D
-
(2005)
J Cell Biol
, vol.168
, pp. 193-199
-
-
Dobrowolny, G.1
Giacinti, C.2
Pelosi, L.3
Nicoletti, C.4
Winn, N.5
Barberi, L.6
Molinaro, M.7
Rosenthal, N.8
Musaro, A.9
-
51
-
-
44349162407
-
Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity
-
18388910 10.1038/mt.2008.60 1:CAS:528:DC%2BD1cXmt1Oku70%3D
-
JC Dodge AM Haidet W Yang MA Passini M Hester J Clarke EM Roskelley CM Treleaven L Rizo H Martin SH Kim R Kaspar TV Taksir DA Griffiths SH Cheng LS Shihabuddin BK Kaspar 2008 Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity Mol Ther 16 1056 1064 18388910 10.1038/mt.2008.60 1:CAS:528:DC%2BD1cXmt1Oku70%3D
-
(2008)
Mol Ther
, vol.16
, pp. 1056-1064
-
-
Dodge, J.C.1
Haidet, A.M.2
Yang, W.3
Passini, M.A.4
Hester, M.5
Clarke, J.6
Roskelley, E.M.7
Treleaven, C.M.8
Rizo, L.9
Martin, H.10
Kim, S.H.11
Kaspar, R.12
Taksir, T.V.13
Griffiths, D.A.14
Cheng, S.H.15
Shihabuddin, L.S.16
Kaspar, B.K.17
-
52
-
-
0036895241
-
Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS
-
12447931 10.1002/ana.10374 1:CAS:528:DC%2BD38Xps1Oqs7c%3D
-
DB Drachman K Frank M Dykes-Hoberg P Teismann G Almer S Przedborski JD Rothstein 2002 Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS Ann Neurol 52 771 778 12447931 10.1002/ana.10374 1:CAS:528:DC%2BD38Xps1Oqs7c%3D
-
(2002)
Ann Neurol
, vol.52
, pp. 771-778
-
-
Drachman, D.B.1
Frank, K.2
Dykes-Hoberg, M.3
Teismann, P.4
Almer, G.5
Przedborski, S.6
Rothstein, J.D.7
-
53
-
-
74949142875
-
Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death
-
20071543 10.1523/JNEUROSCI.5411-09.2010 1:CAS:528:DC%2BC3cXhtFahtbk%3D
-
L Duplan N Bernard W Casseron K Dudley E Thouvenot J Honnorat V Rogemond B De Bovis P Aebischer P Marin C Raoul CE Henderson B Pettmann 2010 Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death J Neurosci 30 785 796 20071543 10.1523/JNEUROSCI.5411-09.2010 1:CAS:528: DC%2BC3cXhtFahtbk%3D
-
(2010)
J Neurosci
, vol.30
, pp. 785-796
-
-
Duplan, L.1
Bernard, N.2
Casseron, W.3
Dudley, K.4
Thouvenot, E.5
Honnorat, J.6
Rogemond, V.7
De Bovis, B.8
Aebischer, P.9
Marin, P.10
Raoul, C.11
Henderson, C.E.12
Pettmann, B.13
-
54
-
-
0035500386
-
Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis
-
11687290 10.1016/S0169-328X(01)00242-X 1:CAS:528:DC%2BD3MXnvFClt7g%3D
-
JL Elliott 2001 Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis Brain Res Mol Brain Res 95 172 178 11687290 10.1016/S0169-328X(01)00242-X 1:CAS:528:DC%2BD3MXnvFClt7g%3D
-
(2001)
Brain Res Mol Brain Res
, vol.95
, pp. 172-178
-
-
Elliott, J.L.1
-
55
-
-
0034717016
-
Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis)
-
10896029 10.1016/S0024-3205(00)00602-0 1:CAS:528:DC%2BD3cXjvFOnt7c%3D
-
N Ende F Weinstein R Chen M Ende 2000 Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis) Life Sci 67 53 59 10896029 10.1016/S0024-3205(00)00602-0 1:CAS:528:DC%2BD3cXjvFOnt7c%3D
-
(2000)
Life Sci
, vol.67
, pp. 53-59
-
-
Ende, N.1
Weinstein, F.2
Chen, R.3
Ende, M.4
-
56
-
-
0027473452
-
Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis
-
8093428 1:STN:280:DyaK3s7hvFaquw%3D%3D
-
JI Engelhardt J Tajti SH Appel 1993 Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis Arch Neurol 50 30 36 8093428 1:STN:280:DyaK3s7hvFaquw%3D%3D
-
(1993)
Arch Neurol
, vol.50
, pp. 30-36
-
-
Engelhardt, J.I.1
Tajti, J.2
Appel, S.H.3
-
57
-
-
34250177650
-
Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation
-
17394546 10.1111/j.1471-4159.2007.04531.x 1:CAS:528:DC%2BD2sXnvVWjtbk%3D
-
SA Ezzi M Urushitani JP Julien 2007 Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation J Neurochem 102 170 178 17394546 10.1111/j.1471-4159.2007.04531.x 1:CAS:528:DC%2BD2sXnvVWjtbk%3D
-
(2007)
J Neurochem
, vol.102
, pp. 170-178
-
-
Ezzi, S.A.1
Urushitani, M.2
Julien, J.P.3
-
58
-
-
0032954386
-
Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis
-
10338314 10.1016/S0306-4522(98)00492-8 1:CAS:528:DyaK1MXisFKiurs%3D
-
F Facchinetti M Sasaki FB Cutting P Zhai JE MacDonald D Reif MF Beal PL Huang TM Dawson ME Gurney VL Dawson 1999 Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis Neuroscience 90 1483 1492 10338314 10.1016/S0306-4522(98)00492-8 1:CAS:528:DyaK1MXisFKiurs%3D
-
(1999)
Neuroscience
, vol.90
, pp. 1483-1492
-
-
Facchinetti, F.1
Sasaki, M.2
Cutting, F.B.3
Zhai, P.4
MacDonald, J.E.5
Reif, D.6
Beal, M.F.7
Huang, P.L.8
Dawson, T.M.9
Gurney, M.E.10
Dawson, V.L.11
-
59
-
-
33847783428
-
Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene
-
17328801 10.1186/1742-2094-4-9 1:CAS:528:DC%2BD2sXjsl2rsrg%3D
-
SE Fendrick QS Xue WJ Streit 2007 Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene J Neuroinflammation 4 9 17328801 10.1186/1742-2094-4-9 1:CAS:528:DC%2BD2sXjsl2rsrg%3D
-
(2007)
J Neuroinflammation
, vol.4
, pp. 9
-
-
Fendrick, S.E.1
Xue, Q.S.2
Streit, W.J.3
-
60
-
-
0035476293
-
Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy
-
11599003 10.1002/jnr.1198 1:CAS:528:DC%2BD3MXnsVyqsrc%3D
-
A Flugel M Bradl GW Kreutzberg MB Graeber 2001 Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy J Neurosci Res 66 74 82 11599003 10.1002/jnr.1198 1:CAS:528:DC%2BD3MXnsVyqsrc%3D
-
(2001)
J Neurosci Res
, vol.66
, pp. 74-82
-
-
Flugel, A.1
Bradl, M.2
Kreutzberg, G.W.3
Graeber, M.B.4
-
61
-
-
24644435506
-
Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease
-
16100572 10.1172/JCI23241 1:CAS:528:DC%2BD2MXhtVSjsrfK
-
D Frenkel R Maron DS Burt HL Weiner 2005 Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease J Clin Invest 115 2423 2433 16100572 10.1172/JCI23241 1:CAS:528:DC%2BD2MXhtVSjsrfK
-
(2005)
J Clin Invest
, vol.115
, pp. 2423-2433
-
-
Frenkel, D.1
Maron, R.2
Burt, D.S.3
Weiner, H.L.4
-
62
-
-
10744223784
-
Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: Distribution, migration, and differentiation
-
12857367 10.1089/152581603322022990 1:CAS:528:DC%2BD3sXkvVSmu7o%3D
-
S Garbuzova-Davis AE Willing T Zigova S Saporta EB Justen JC Lane JE Hudson N Chen CD Davis PR Sanberg 2003 Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation J Hematother Stem Cell Res 12 255 270 12857367 10.1089/152581603322022990 1:CAS:528:DC%2BD3sXkvVSmu7o%3D
-
(2003)
J Hematother Stem Cell Res
, vol.12
, pp. 255-270
-
-
Garbuzova-Davis, S.1
Willing, A.E.2
Zigova, T.3
Saporta, S.4
Justen, E.B.5
Lane, J.C.6
Hudson, J.E.7
Chen, N.8
Davis, C.D.9
Sanberg, P.R.10
-
63
-
-
54049123282
-
Implications of blood-brain barrier disruption in ALS
-
18608097 10.1080/17482960802160990
-
S Garbuzova-Davis S Saporta PR Sanberg 2008 Implications of blood-brain barrier disruption in ALS Amyotroph Lateral Scler 9 375 376 18608097 10.1080/17482960802160990
-
(2008)
Amyotroph Lateral Scler
, vol.9
, pp. 375-376
-
-
Garbuzova-Davis, S.1
Saporta, S.2
Sanberg, P.R.3
-
64
-
-
41949119043
-
TDP-43 A315T mutation in familial motor neuron disease
-
18288693 10.1002/ana.21344 1:CAS:528:DC%2BD1cXmsFGqtLg%3D
-
MA Gitcho RH Baloh S Chakraverty K Mayo JB Norton D Levitch KJ Hatanpaa CL White 3rd EH Bigio R Caselli M Baker MT Al-Lozi JC Morris A Pestronk R Rademakers AM Goate NJ Cairns 2008 TDP-43 A315T mutation in familial motor neuron disease Ann Neurol 63 535 538 18288693 10.1002/ana.21344 1:CAS:528:DC%2BD1cXmsFGqtLg%3D
-
(2008)
Ann Neurol
, vol.63
, pp. 535-538
-
-
Gitcho, M.A.1
Baloh, R.H.2
Chakraverty, S.3
Mayo, K.4
Norton, J.B.5
Levitch, D.6
Hatanpaa, K.J.7
White III, C.L.8
Bigio, E.H.9
Caselli, R.10
Baker, M.11
Al-Lozi, M.T.12
Morris, J.C.13
Pestronk, A.14
Rademakers, R.15
Goate, A.M.16
Cairns, N.J.17
-
65
-
-
0034651102
-
Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration
-
10632595 1:CAS:528:DC%2BD3cXhtF2hsbk%3D
-
YH Gong AS Parsadanian A Andreeva WD Snider JL Elliott 2000 Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration J Neurosci 20 660 665 10632595 1:CAS:528:DC%2BD3cXhtF2hsbk%3D
-
(2000)
J Neurosci
, vol.20
, pp. 660-665
-
-
Gong, Y.H.1
Parsadanian, A.S.2
Andreeva, A.3
Snider, W.D.4
Elliott, J.L.5
-
66
-
-
36148960127
-
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: A phase III randomised trial
-
17980667 10.1016/S1474-4422(07)70270-3 1:CAS:528:DC%2BD1cXjsF2isQ%3D%3D
-
PH Gordon DH Moore RG Miller JM Florence JL Verheijde C Doorish JF Hilton GM Spitalny RB MacArthur H Mitsumoto HE Neville K Boylan T Mozaffar JM Belsh J Ravits RS Bedlack MC Graves LF McCluskey RJ Barohn R Tandan 2007 Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial Lancet Neurol 6 1045 1053 17980667 10.1016/S1474-4422(07)70270- 3 1:CAS:528:DC%2BD1cXjsF2isQ%3D%3D
-
(2007)
Lancet Neurol
, vol.6
, pp. 1045-1053
-
-
Gordon, P.H.1
Moore, D.H.2
Miller, R.G.3
Florence, J.M.4
Verheijde, J.L.5
Doorish, C.6
Hilton, J.F.7
Spitalny, G.M.8
MacArthur, R.B.9
Mitsumoto, H.10
Neville, H.E.11
Boylan, K.12
Mozaffar, T.13
Belsh, J.M.14
Ravits, J.15
Bedlack, R.S.16
Graves, M.C.17
McCluskey, L.F.18
Barohn, R.J.19
Tandan, R.20
more..
-
67
-
-
33750962014
-
Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations
-
17079668 10.1523/JNEUROSCI.0602-06.2006 1:CAS:528:DC%2BD28Xht1aksbvE
-
G Gowing F Dequen G Soucy JP Julien 2006 Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations J Neurosci 26 11397 11402 17079668 10.1523/JNEUROSCI.0602-06.2006 1:CAS:528:DC%2BD28Xht1aksbvE
-
(2006)
J Neurosci
, vol.26
, pp. 11397-11402
-
-
Gowing, G.1
Dequen, F.2
Soucy, G.3
Julien, J.P.4
-
68
-
-
55049120934
-
Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase
-
18842883 10.1523/JNEUROSCI.3494-08.2008 1:CAS:528:DC%2BD1cXht1GksLbM
-
G Gowing T Philips B Van Wijmeersch JN Audet M Dewil L Van Den Bosch AD Billiau W Robberecht JP Julien 2008 Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase J Neurosci 28 10234 10244 18842883 10.1523/JNEUROSCI.3494-08.2008 1:CAS:528:DC%2BD1cXht1GksLbM
-
(2008)
J Neurosci
, vol.28
, pp. 10234-10244
-
-
Gowing, G.1
Philips, T.2
Van Wijmeersch, B.3
Audet, J.N.4
Dewil, M.5
Van Den Bosch, L.6
Billiau, A.D.7
Robberecht, W.8
Julien, J.P.9
-
69
-
-
71549119504
-
Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase
-
19733170 10.1016/j.expneurol.2009.08.021 1:CAS:528:DC%2BD1MXhsVGnt7zK
-
G Gowing M Lalancette-Hebert JN Audet F Dequen JP Julien 2009 Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase Exp Neurol 220 267 275 19733170 10.1016/j.expneurol.2009.08.021 1:CAS:528:DC%2BD1MXhsVGnt7zK
-
(2009)
Exp Neurol
, vol.220
, pp. 267-275
-
-
Gowing, G.1
Lalancette-Hebert, M.2
Audet, J.N.3
Dequen, F.4
Julien, J.P.5
-
70
-
-
77349114038
-
Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis
-
20109233 10.1186/1742-2094-7-8 1:CAS:528:DC%2BC3cXhsFGku7k%3D
-
DJ Graber WF Hickey BT Harris 2010 Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis J Neuroinflammation 7 8 20109233 10.1186/1742-2094-7-8 1:CAS:528:DC%2BC3cXhsFGku7k%3D
-
(2010)
J Neuroinflammation
, vol.7
, pp. 8
-
-
Graber, D.J.1
Hickey, W.F.2
Harris, B.T.3
-
71
-
-
0027420887
-
Macrophage systems in peripheral nerves: A review
-
7693878 10.1097/00005072-199311000-00001 1:STN:280:DyaK2c%2FksFOlsw%3D%3D
-
JW Griffin R George T Ho 1993 Macrophage systems in peripheral nerves: a review J Neuropathol Exp Neurol 52 553 560 7693878 10.1097/00005072-199311000- 00001 1:STN:280:DyaK2c%2FksFOlsw%3D%3D
-
(1993)
J Neuropathol Exp Neurol
, vol.52
, pp. 553-560
-
-
Griffin, J.W.1
George, R.2
Ho, T.3
-
72
-
-
76049085112
-
Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis
-
20007371 10.1073/pnas.0902174106
-
F Gros-Louis PM Andersen N Dupre M Urushitani P Dion F Souchon M D'Amour W Camu V Meininger JP Bouchard GA Rouleau JP Julien 2009 Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis Proc Natl Acad Sci USA 106 21777 21782 20007371 10.1073/pnas. 0902174106
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 21777-21782
-
-
Gros-Louis, F.1
Andersen, P.M.2
Dupre, N.3
Urushitani, M.4
Dion, P.5
Souchon, F.6
D'Amour, M.7
Camu, W.8
Meininger, V.9
Bouchard, J.P.10
Rouleau, G.A.11
Julien, J.P.12
-
73
-
-
0028284779
-
Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
-
8209258 10.1126/science.8209258 1:CAS:528:DyaK2cXksFGisbk%3D
-
ME Gurney H Pu AY Chiu MC Dal Canto CY Polchow DD Alexander J Caliendo A Hentati YW Kwon HX Deng, et al. 1994 Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation Science 264 1772 1775 8209258 10.1126/science.8209258 1:CAS:528:DyaK2cXksFGisbk%3D
-
(1994)
Science
, vol.264
, pp. 1772-1775
-
-
Gurney, M.E.1
Pu, H.2
Chiu, A.Y.3
Dal Canto, M.C.4
Polchow, C.Y.5
Alexander, D.D.6
Caliendo, J.7
Hentati, A.8
Kwon, Y.W.9
Deng, H.X.10
-
74
-
-
33947216452
-
Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS
-
17276077 10.1016/j.nbd.2006.12.013 1:CAS:528:DC%2BD2sXjsVGhsrY%3D
-
C Haenggeli JP Julien RL Mosley N Perez A Dhar HE Gendelman JD Rothstein 2007 Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS Neurobiol Dis 26 146 152 17276077 10.1016/j.nbd.2006.12.013 1:CAS:528:DC%2BD2sXjsVGhsrY%3D
-
(2007)
Neurobiol Dis
, vol.26
, pp. 146-152
-
-
Haenggeli, C.1
Julien, J.P.2
Mosley, R.L.3
Perez, N.4
Dhar, A.5
Gendelman, H.E.6
Rothstein, J.D.7
-
75
-
-
0032125587
-
Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
-
9633809 10.1002/(SICI)1098-1136(199807)23:3 <249::AID-GLIA7>3.0. CO;2-# 1:STN:280:DyaK1c3psFGltA%3D%3D
-
ED Hall JA Oostveen ME Gurney 1998 Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS Glia 23 249 256 9633809 10.1002/(SICI)1098-1136(199807)23:3<249: :AID-GLIA7>3.0.CO;2-# 1:STN:280:DyaK1c3psFGltA%3D%3D
-
(1998)
Glia
, vol.23
, pp. 249-256
-
-
Hall, E.D.1
Oostveen, J.A.2
Gurney, M.E.3
-
76
-
-
35548986304
-
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
-
17965659 10.1038/nn1997 1:CAS:528:DC%2BD2sXht1ajsbbE
-
UK Hanisch H Kettenmann 2007 Microglia: active sensor and versatile effector cells in the normal and pathologic brain Nat Neurosci 10 1387 1394 17965659 10.1038/nn1997 1:CAS:528:DC%2BD2sXht1ajsbbE
-
(2007)
Nat Neurosci
, vol.10
, pp. 1387-1394
-
-
Hanisch, U.K.1
Kettenmann, H.2
-
77
-
-
38849182472
-
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model
-
18219391 1:CAS:528:DC%2BD1cXhsFOms7w%3D
-
MM Harraz JJ Marden W Zhou Y Zhang A Williams VS Sharov K Nelson M Luo H Paulson C Schoneich JF Engelhardt 2008 SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model J Clin Invest 118 659 670 18219391 1:CAS:528:DC%2BD1cXhsFOms7w%3D
-
(2008)
J Clin Invest
, vol.118
, pp. 659-670
-
-
Harraz, M.M.1
Marden, J.J.2
Zhou, W.3
Zhang, Y.4
Williams, A.5
Sharov, V.S.6
Nelson, K.7
Luo, M.8
Paulson, H.9
Schoneich, C.10
Engelhardt, J.F.11
-
78
-
-
10744229158
-
Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
-
14755726 10.1002/ana.10805 1:CAS:528:DC%2BD2cXhs1SgtbY%3D
-
JS Henkel JI Engelhardt L Siklos EP Simpson SH Kim T Pan JC Goodman T Siddique DR Beers SH Appel 2004 Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue Ann Neurol 55 221 235 14755726 10.1002/ana.10805 1:CAS:528: DC%2BD2cXhs1SgtbY%3D
-
(2004)
Ann Neurol
, vol.55
, pp. 221-235
-
-
Henkel, J.S.1
Engelhardt, J.I.2
Siklos, L.3
Simpson, E.P.4
Kim, S.H.5
Pan, T.6
Goodman, J.C.7
Siddique, T.8
Beers, D.R.9
Appel, S.H.10
-
79
-
-
33644821966
-
The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS
-
16337133 10.1016/j.mcn.2005.10.016 1:CAS:528:DC%2BD28Xit1CmtLw%3D
-
JS Henkel DR Beers L Siklos SH Appel 2006 The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS Mol Cell Neurosci 31 427 437 16337133 10.1016/j.mcn.2005.10.016 1:CAS:528:DC%2BD28Xit1CmtLw%3D
-
(2006)
Mol Cell Neurosci
, vol.31
, pp. 427-437
-
-
Henkel, J.S.1
Beers, D.R.2
Siklos, L.3
Appel, S.H.4
-
80
-
-
0041833409
-
Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis
-
13678668 10.1016/S0969-9961(03)00087-1 1:CAS:528:DC%2BD3sXnt1amt7s%3D
-
K Hensley J Fedynyshyn S Ferrell RA Floyd B Gordon P Grammas L Hamdheydari M Mhatre S Mou QN Pye C Stewart M West S West KS Williamson 2003 Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis Neurobiol Dis 14 74 80 13678668 10.1016/S0969-9961(03)00087-1 1:CAS:528:DC%2BD3sXnt1amt7s%3D
-
(2003)
Neurobiol Dis
, vol.14
, pp. 74-80
-
-
Hensley, K.1
Fedynyshyn, J.2
Ferrell, S.3
Floyd, R.A.4
Gordon, B.5
Grammas, P.6
Hamdheydari, L.7
Mhatre, M.8
Mou, S.9
Pye, Q.N.10
Stewart, C.11
West, M.12
West, S.13
Williamson, K.S.14
-
81
-
-
17744388105
-
Down-regulation of the macrophage lineage through interaction with OX2 (CD200)
-
11099416 10.1126/science.290.5497.1768 1:CAS:528:DC%2BD3cXovVOhuro%3D
-
RM Hoek SR Ruuls CA Murphy GJ Wright R Goddard SM Zurawski B Blom ME Homola WJ Streit MH Brown AN Barclay JD Sedgwick 2000 Down-regulation of the macrophage lineage through interaction with OX2 (CD200) Science 290 1768 1771 11099416 10.1126/science.290.5497.1768 1:CAS:528:DC%2BD3cXovVOhuro%3D
-
(2000)
Science
, vol.290
, pp. 1768-1771
-
-
Hoek, R.M.1
Ruuls, S.R.2
Murphy, C.A.3
Wright, G.J.4
Goddard, R.5
Zurawski, S.M.6
Blom, B.7
Homola, M.E.8
Streit, W.J.9
Brown, M.H.10
Barclay, A.N.11
Sedgwick, J.D.12
-
82
-
-
35848932533
-
Circulating insulin-like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis
-
17697791 10.1016/j.ghir.2007.06.002 1:CAS:528:DC%2BD2sXht1ylsrbI
-
S Hosback O Hardiman CM Nolan MA Doyle G Gorman C Lynch O O'Toole P Jakeman 2007 Circulating insulin-like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis Growth Horm IGF Res 17 472 479 17697791 10.1016/j.ghir.2007.06.002 1:CAS:528:DC%2BD2sXht1ylsrbI
-
(2007)
Growth Horm IGF Res
, vol.17
, pp. 472-479
-
-
Hosback, S.1
Hardiman, O.2
Nolan, C.M.3
Doyle, M.A.4
Gorman, G.5
Lynch, C.6
O'Toole, O.7
Jakeman, P.8
-
83
-
-
0037022339
-
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
-
11818550 10.1073/pnas.032539299 1:CAS:528:DC%2BD38Xht1Clt78%3D
-
DS Howland J Liu Y She B Goad NJ Maragakis B Kim J Erickson J Kulik L DeVito G Psaltis LJ DeGennaro DW Cleveland JD Rothstein 2002 Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) Proc Natl Acad Sci USA 99 1604 1609 11818550 10.1073/pnas.032539299 1:CAS:528:DC%2BD38Xht1Clt78%3D
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 1604-1609
-
-
Howland, D.S.1
Liu, J.2
She, Y.3
Goad, B.4
Maragakis, N.J.5
Kim, B.6
Erickson, J.7
Kulik, J.8
Devito, L.9
Psaltis, G.10
Degennaro, L.J.11
Cleveland, D.W.12
Rothstein, J.D.13
-
84
-
-
74049164709
-
Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
-
19951898 10.1083/jcb.200908164 1:CAS:528:DC%2BD1MXhsF2qtb3F
-
H Ilieva M Polymenidou DW Cleveland 2009 Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond J Cell Biol 187 761 772 19951898 10.1083/jcb.200908164 1:CAS:528:DC%2BD1MXhsF2qtb3F
-
(2009)
J Cell Biol
, vol.187
, pp. 761-772
-
-
Ilieva, H.1
Polymenidou, M.2
Cleveland, D.W.3
-
85
-
-
28444486336
-
The function of microglia through purinergic receptors: Neuropathic pain and cytokine release
-
16169595 10.1016/j.pharmthera.2005.07.001 1:CAS:528:DC%2BD2MXht12ktbbL
-
K Inoue 2006 The function of microglia through purinergic receptors: neuropathic pain and cytokine release Pharmacol Ther 109 210 226 16169595 10.1016/j.pharmthera.2005.07.001 1:CAS:528:DC%2BD2MXht12ktbbL
-
(2006)
Pharmacol Ther
, vol.109
, pp. 210-226
-
-
Inoue, K.1
-
86
-
-
39849103473
-
Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
-
18305242 10.1523/JNEUROSCI.5258-07.2008 1:CAS:528:DC%2BD1cXjt1Cqtb8%3D
-
D Jaarsma E Teuling ED Haasdijk CI De Zeeuw CC Hoogenraad 2008 Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice J Neurosci 28 2075 2088 18305242 10.1523/JNEUROSCI.5258-07.2008 1:CAS:528:DC%2BD1cXjt1Cqtb8%3D
-
(2008)
J Neurosci
, vol.28
, pp. 2075-2088
-
-
Jaarsma, D.1
Teuling, E.2
Haasdijk, E.D.3
De Zeeuw, C.I.4
Hoogenraad, C.C.5
-
87
-
-
37849007550
-
Oxidized/misfolded superoxide dismutase-1: The cause of all amyotrophic lateral sclerosis?
-
18074357 10.1002/ana.21319 1:CAS:528:DC%2BD1cXhsVCrtbk%3D
-
E Kabashi PN Valdmanis P Dion GA Rouleau 2007 Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis? Ann Neurol 62 553 559 18074357 10.1002/ana.21319 1:CAS:528:DC%2BD1cXhsVCrtbk%3D
-
(2007)
Ann Neurol
, vol.62
, pp. 553-559
-
-
Kabashi, E.1
Valdmanis, P.N.2
Dion, P.3
Rouleau, G.A.4
-
88
-
-
42649120983
-
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
-
18372902 10.1038/ng.132 1:CAS:528:DC%2BD1cXltFylu7k%3D
-
E Kabashi PN Valdmanis P Dion D Spiegelman BJ McConkey C Vande Velde JP Bouchard L Lacomblez K Pochigaeva F Salachas PF Pradat W Camu V Meininger N Dupre GA Rouleau 2008 TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis Nat Genet 40 572 574 18372902 10.1038/ng.132 1:CAS:528:DC%2BD1cXltFylu7k%3D
-
(2008)
Nat Genet
, vol.40
, pp. 572-574
-
-
Kabashi, E.1
Valdmanis, P.N.2
Dion, P.3
Spiegelman, D.4
McConkey, B.J.5
Vande Velde, C.6
Bouchard, J.P.7
Lacomblez, L.8
Pochigaeva, K.9
Salachas, F.10
Pradat, P.F.11
Camu, W.12
Meininger, V.13
Dupre, N.14
Rouleau, G.A.15
-
89
-
-
0035939448
-
Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: Impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice
-
11438923 10.1002/cne.1060 1:STN:280:DC%2BD3MzosVOhsw%3D%3D
-
R Kalla Z Liu S Xu A Koppius Y Imai CU Kloss S Kohsaka A Gschwendtner JC Moller A Werner G Raivich 2001 Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice J Comp Neurol 436 182 201 11438923 10.1002/cne.1060 1:STN:280: DC%2BD3MzosVOhsw%3D%3D
-
(2001)
J Comp Neurol
, vol.436
, pp. 182-201
-
-
Kalla, R.1
Liu, Z.2
Xu, S.3
Koppius, A.4
Imai, Y.5
Kloss, C.U.6
Kohsaka, S.7
Gschwendtner, A.8
Moller, J.C.9
Werner, A.10
Raivich, G.11
-
90
-
-
0042528664
-
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
-
12907804 10.1126/science.1086137 1:CAS:528:DC%2BD3sXmtVGqs7c%3D
-
BK Kaspar J Llado N Sherkat JD Rothstein FH Gage 2003 Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model Science 301 839 842 12907804 10.1126/science.1086137 1:CAS:528:DC%2BD3sXmtVGqs7c%3D
-
(2003)
Science
, vol.301
, pp. 839-842
-
-
Kaspar, B.K.1
Llado, J.2
Sherkat, N.3
Rothstein, J.D.4
Gage, F.H.5
-
91
-
-
0026605961
-
Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue
-
1347673 1:STN:280:DyaK387ovFSrsQ%3D%3D
-
T Kawamata H Akiyama T Yamada PL McGeer 1992 Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue Am J Pathol 140 691 707 1347673 1:STN:280:DyaK387ovFSrsQ%3D%3D
-
(1992)
Am J Pathol
, vol.140
, pp. 691-707
-
-
Kawamata, T.1
Akiyama, H.2
Yamada, T.3
McGeer, P.L.4
-
92
-
-
11844269951
-
Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis
-
15649489 10.1016/j.expneurol.2004.10.007 1:CAS:528:DC%2BD2MXksFKisw%3D%3D
-
M Kiaei K Kipiani J Chen NY Calingasan MF Beal 2005 Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis Exp Neurol 191 331 336 15649489 10.1016/j.expneurol.2004.10.007 1:CAS:528:DC%2BD2MXksFKisw%3D%3D
-
(2005)
Exp Neurol
, vol.191
, pp. 331-336
-
-
Kiaei, M.1
Kipiani, K.2
Chen, J.3
Calingasan, N.Y.4
Beal, M.F.5
-
93
-
-
33645642112
-
Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis
-
16510725 10.1523/JNEUROSCI.5253-05.2006 1:CAS:528:DC%2BD28XislKru7Y%3D
-
M Kiaei S Petri K Kipiani G Gardian DK Choi J Chen NY Calingasan P Schafer GW Muller C Stewart K Hensley MF Beal 2006 Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis J Neurosci 26 2467 2473 16510725 10.1523/JNEUROSCI.5253-05.2006 1:CAS:528:DC%2BD28XislKru7Y%3D
-
(2006)
J Neurosci
, vol.26
, pp. 2467-2473
-
-
Kiaei, M.1
Petri, S.2
Kipiani, K.3
Gardian, G.4
Choi, D.K.5
Chen, J.6
Calingasan, N.Y.7
Schafer, P.8
Muller, G.W.9
Stewart, C.10
Hensley, K.11
Beal, M.F.12
-
94
-
-
0030222037
-
Microglia: A sensor for pathological events in the CNS
-
8843599 10.1016/0166-2236(96)10049-7 1:STN:280:DyaK2s%2FgtVGitg%3D%3D
-
GW Kreutzberg 1996 Microglia: a sensor for pathological events in the CNS Trends Neurosci 19 312 318 8843599 10.1016/0166-2236(96)10049-7 1:STN:280:DyaK2s%2FgtVGitg%3D%3D
-
(1996)
Trends Neurosci
, vol.19
, pp. 312-318
-
-
Kreutzberg, G.W.1
-
95
-
-
0036406903
-
Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis
-
12270689 10.1006/nbdi.2002.0487 1:CAS:528:DC%2BD38XmvFais74%3D
-
J Kriz MD Nguyen JP Julien 2002 Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis Neurobiol Dis 10 268 278 12270689 10.1006/nbdi.2002.0487 1:CAS:528:DC%2BD38XmvFais74%3D
-
(2002)
Neurobiol Dis
, vol.10
, pp. 268-278
-
-
Kriz, J.1
Nguyen, M.D.2
Julien, J.P.3
-
96
-
-
65449167187
-
Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis
-
19236470 10.1111/j.1468-1331.2009.02560.x 1:STN:280: DC%2BD1MzlvFyqsw%3D%3D
-
J Kuhle RL Lindberg A Regeniter M Mehling AJ Steck L Kappos A Czaplinski 2009 Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis Eur J Neurol 16 771 774 19236470 10.1111/j.1468-1331.2009.02560.x 1:STN:280:DC%2BD1MzlvFyqsw%3D%3D
-
(2009)
Eur J Neurol
, vol.16
, pp. 771-774
-
-
Kuhle, J.1
Lindberg, R.L.2
Regeniter, A.3
Mehling, M.4
Steck, A.J.5
Kappos, L.6
Czaplinski, A.7
-
97
-
-
61349156118
-
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
-
19251627 10.1126/science.1166066 1:CAS:528:DC%2BD1MXit1eltbw%3D
-
TJ Kwiatkowski Jr DA Bosco AL Leclerc E Tamrazian CR Vanderburg C Russ A Davis J Gilchrist EJ Kasarskis T Munsat P Valdmanis GA Rouleau BA Hosler P Cortelli PJ de Jong Y Yoshinaga JL Haines MA Pericak-Vance J Yan N Ticozzi T Siddique D McKenna-Yasek PC Sapp HR Horvitz JE Landers RH Brown Jr 2009 Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis Science 323 1205 1208 19251627 10.1126/science.1166066 1:CAS:528:DC%2BD1MXit1eltbw%3D
-
(2009)
Science
, vol.323
, pp. 1205-1208
-
-
Kwiatkowski, Jr.T.J.1
Bosco, D.A.2
Leclerc, A.L.3
Tamrazian, E.4
Vanderburg, C.R.5
Russ, C.6
Davis, A.7
Gilchrist, J.8
Kasarskis, E.J.9
Munsat, T.10
Valdmanis, P.11
Rouleau, G.A.12
Hosler, B.A.13
Cortelli, P.14
De Jong, P.J.15
Yoshinaga, Y.16
Haines, J.L.17
Pericak-Vance, M.A.18
Yan, J.19
Ticozzi, N.20
Siddique, T.21
McKenna-Yasek, D.22
Sapp, P.C.23
Horvitz, H.R.24
Landers, J.E.25
Brown, Jr.R.H.26
more..
-
98
-
-
6844266272
-
Effect of recombinant human insulin-like growth factor-I on progression of ALS: A placebo-controlled study. The North America ALS/IGF-I Study Group
-
9409357 1:CAS:528:DyaK1cXitVCnsg%3D%3D
-
EC Lai KJ Felice BW Festoff MJ Gawel DF Gelinas R Kratz MF Murphy HM Natter FH Norris SA Rudnicki 1997 Effect of recombinant human insulin-like growth factor-I on progression of ALS: a placebo-controlled study. The North America ALS/IGF-I Study Group Neurology 49 1621 1630 9409357 1:CAS:528:DyaK1cXitVCnsg%3D%3D
-
(1997)
Neurology
, vol.49
, pp. 1621-1630
-
-
Lai, E.C.1
Felice, K.J.2
Festoff, B.W.3
Gawel, M.J.4
Gelinas, D.F.5
Kratz, R.6
Murphy, M.F.7
Natter, H.M.8
Norris, F.H.9
Rudnicki, S.A.10
-
99
-
-
0024997449
-
Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis
-
2241118 10.1002/ana.410280311 1:STN:280:DyaK3M%2FltlSluw%3D%3D
-
LA Lampson PD Kushner RA Sobel 1990 Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis Ann Neurol 28 365 372 2241118 10.1002/ana.410280311 1:STN:280:DyaK3M%2FltlSluw%3D%3D
-
(1990)
Ann Neurol
, vol.28
, pp. 365-372
-
-
Lampson, L.A.1
Kushner, P.D.2
Sobel, R.A.3
-
100
-
-
33846794644
-
CD4+ T cells from copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine model of Parkinson's disease
-
17196666 10.1016/j.jneuroim.2006.11.009 1:CAS:528:DC%2BD2sXhs1Citbk%3D
-
C Laurie A Reynolds O Coskun E Bowman HE Gendelman RL Mosley 2007 CD4+ T cells from copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine model of Parkinson's disease J Neuroimmunol 183 60 68 17196666 10.1016/j.jneuroim.2006.11.009 1:CAS:528:DC%2BD2sXhs1Citbk%3D
-
(2007)
J Neuroimmunol
, vol.183
, pp. 60-68
-
-
Laurie, C.1
Reynolds, A.2
Coskun, O.3
Bowman, E.4
Gendelman, H.E.5
Mosley, R.L.6
-
101
-
-
0026552605
-
Turnover of resident microglia in the normal adult mouse brain
-
1603325 10.1016/0306-4522(92)90500-2 1:STN:280:DyaK383ptlCquw%3D%3D
-
LJ Lawson VH Perry S Gordon 1992 Turnover of resident microglia in the normal adult mouse brain Neuroscience 48 405 415 1603325 10.1016/0306-4522(92) 90500-2 1:STN:280:DyaK383ptlCquw%3D%3D
-
(1992)
Neuroscience
, vol.48
, pp. 405-415
-
-
Lawson, L.J.1
Perry, V.H.2
Gordon, S.3
-
102
-
-
38149018442
-
Minocycline for patients with ALS
-
18207106 10.1016/S1474-4422(08)70006-1 (author reply 120-111)
-
PN Leigh V Meininger G Bensimon M Cudkowicz W Robberecht 2008 Minocycline for patients with ALS Lancet Neurol 7 119 120 18207106 10.1016/S1474-4422(08) 70006-1 (author reply 120-111)
-
(2008)
Lancet Neurol
, vol.7
, pp. 119-120
-
-
Leigh, P.N.1
Meininger, V.2
Bensimon, G.3
Cudkowicz, M.4
Robberecht, W.5
-
103
-
-
0026436932
-
Amoeboid and ramified microglia: Their interrelationship and response to brain injury
-
1380949 10.1002/glia.440060106 1:STN:280:DyaK38zotVOgug%3D%3D
-
SK Leong EA Ling 1992 Amoeboid and ramified microglia: their interrelationship and response to brain injury Glia 6 39 47 1380949 10.1002/glia.440060106 1:STN:280:DyaK38zotVOgug%3D%3D
-
(1992)
Glia
, vol.6
, pp. 39-47
-
-
Leong, S.K.1
Ling, E.A.2
-
104
-
-
36448942946
-
Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS
-
17963733 10.1016/j.brainres.2007.09.034 1:CAS:528:DC%2BD2sXhtlykurrM
-
AC Lepore C Haenggeli M Gasmi KM Bishop RT Bartus NJ Maragakis JD Rothstein 2007 Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS Brain Res 1185 256 265 17963733 10.1016/j.brainres.2007.09.034 1:CAS:528:DC%2BD2sXhtlykurrM
-
(2007)
Brain Res
, vol.1185
, pp. 256-265
-
-
Lepore, A.C.1
Haenggeli, C.2
Gasmi, M.3
Bishop, K.M.4
Bartus, R.T.5
Maragakis, N.J.6
Rothstein, J.D.7
-
105
-
-
54949126674
-
Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease
-
18931666 10.1038/nn.2210 1:CAS:528:DC%2BD1cXht12ltrjN
-
AC Lepore B Rauck C Dejea AC Pardo MS Rao JD Rothstein NJ Maragakis 2008 Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease Nat Neurosci 11 1294 1301 18931666 10.1038/nn.2210 1:CAS:528:DC%2BD1cXht12ltrjN
-
(2008)
Nat Neurosci
, vol.11
, pp. 1294-1301
-
-
Lepore, A.C.1
Rauck, B.2
Dejea, C.3
Pardo, A.C.4
Rao, M.S.5
Rothstein, J.D.6
Maragakis, N.J.7
-
106
-
-
70349154606
-
Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1
-
19243075 10.1002/glia.20859
-
CA Lewis JN Solomon FM Rossi C Krieger 2009 Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1 Glia 57 1410 1419 19243075 10.1002/glia.20859
-
(2009)
Glia
, vol.57
, pp. 1410-1419
-
-
Lewis, C.A.1
Solomon, J.N.2
Rossi, F.M.3
Krieger, C.4
-
107
-
-
54849418885
-
The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis
-
18825663 10.1002/ana.21437 1:CAS:528:DC%2BD1cXht1yisr3O
-
X Liang Q Wang J Shi L Lokteva RM Breyer TJ Montine K Andreasson 2008 The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis Ann Neurol 64 304 314 18825663 10.1002/ana.21437 1:CAS:528:DC%2BD1cXht1yisr3O
-
(2008)
Ann Neurol
, vol.64
, pp. 304-314
-
-
Liang, X.1
Wang, Q.2
Shi, J.3
Lokteva, L.4
Breyer, R.M.5
Montine, T.J.6
Andreasson, K.7
-
108
-
-
0019129071
-
Use of carbon labeling to demonstrate the role of blood monocytes as precursors of the 'ameboid cells' present in the corpus callosum of postnatal rats
-
6969268 10.1002/cne.901930304 1:STN:280:DyaL3M%2FntVahtQ%3D%3D
-
EA Ling D Penney CP Leblond 1980 Use of carbon labeling to demonstrate the role of blood monocytes as precursors of the 'ameboid cells' present in the corpus callosum of postnatal rats J Comp Neurol 193 631 657 6969268 10.1002/cne.901930304 1:STN:280:DyaL3M%2FntVahtQ%3D%3D
-
(1980)
J Comp Neurol
, vol.193
, pp. 631-657
-
-
Ling, E.A.1
Penney, D.2
Leblond, C.P.3
-
109
-
-
0037096354
-
Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease
-
12077179 1:CAS:528:DC%2BD38Xlt1Sgsrg%3D
-
MM Lino C Schneider P Caroni 2002 Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease J Neurosci 22 4825 4832 12077179 1:CAS:528:DC%2BD38Xlt1Sgsrg%3D
-
(2002)
J Neurosci
, vol.22
, pp. 4825-4832
-
-
Lino, M.M.1
Schneider, C.2
Caroni, P.3
-
110
-
-
63649152262
-
Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2
-
19091752 10.1074/jbc.M804446200 1:CAS:528:DC%2BD1MXht1Ortbg%3D
-
Y Liu W Hao A Dawson S Liu K Fassbender 2009 Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2 J Biol Chem 284 3691 3699 19091752 10.1074/jbc.M804446200 1:CAS:528:DC%2BD1MXht1Ortbg%3D
-
(2009)
J Biol Chem
, vol.284
, pp. 3691-3699
-
-
Liu, Y.1
Hao, W.2
Dawson, A.3
Liu, S.4
Fassbender, K.5
-
111
-
-
34250656185
-
Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons
-
17463094 10.1073/pnas.0702230104 1:CAS:528:DC%2BD2sXlslWqsb8%3D
-
CS Lobsiger S Boillee DW Cleveland 2007 Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons Proc Natl Acad Sci USA 104 7319 7326 17463094 10.1073/pnas.0702230104 1:CAS:528:DC%2BD2sXlslWqsb8%3D
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 7319-7326
-
-
Lobsiger, C.S.1
Boillee, S.2
Cleveland, D.W.3
-
113
-
-
77649285022
-
Guidelines for preclinical animal research in ALS/MND: A consensus meeting
-
20184514 10.3109/17482960903545334
-
AC Ludolph C Bendotti E Blaugrund A Chio L Greensmith JP Loeffler R Mead HG Niessen S Petri PF Pradat W Robberecht M Ruegg B Schwalenstocker D Stiller L van den Berg F Vieira S von Horsten 2010 Guidelines for preclinical animal research in ALS/MND: a consensus meeting Amyotroph Lateral Scler 11 38 45 20184514 10.3109/17482960903545334
-
(2010)
Amyotroph Lateral Scler
, vol.11
, pp. 38-45
-
-
Ludolph, A.C.1
Bendotti, C.2
Blaugrund, E.3
Chio, A.4
Greensmith, L.5
Loeffler, J.P.6
Mead, R.7
Niessen, H.G.8
Petri, S.9
Pradat, P.F.10
Robberecht, W.11
Ruegg, M.12
Schwalenstocker, B.13
Stiller, D.14
Van Den Berg, L.15
Vieira, F.16
Von Horsten, S.17
-
114
-
-
0141816705
-
Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis
-
14511332 10.1046/j.1460-9568.2003.02879.x
-
C Maihofner S Probst-Cousin M Bergmann W Neuhuber B Neundorfer D Heuss 2003 Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis Eur J Neurosci 18 1527 1534 14511332 10.1046/j.1460-9568.2003.02879.x
-
(2003)
Eur J Neurosci
, vol.18
, pp. 1527-1534
-
-
Maihofner, C.1
Probst-Cousin, S.2
Bergmann, M.3
Neuhuber, W.4
Neundorfer, B.5
Heuss, D.6
-
116
-
-
1942447829
-
Microglia promote the death of developing Purkinje cells
-
14980203 10.1016/S0896-6273(04)00069-8 1:CAS:528:DC%2BD2cXhvFOrsLs%3D
-
JL Marin-Teva I Dusart C Colin A Gervais N van Rooijen M Mallat 2004 Microglia promote the death of developing Purkinje cells Neuron 41 535 547 14980203 10.1016/S0896-6273(04)00069-8 1:CAS:528:DC%2BD2cXhvFOrsLs%3D
-
(2004)
Neuron
, vol.41
, pp. 535-547
-
-
Marin-Teva, J.L.1
Dusart, I.2
Colin, C.3
Gervais, A.4
Van Rooijen, N.5
Mallat, M.6
-
117
-
-
33845361630
-
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: Mechanisms of mitochondriopathy and cell death
-
17099894 10.1002/cne.21160 1:CAS:528:DC%2BD2sXktlCrtg%3D%3D
-
LJ Martin Z Liu K Chen AC Price Y Pan JA Swaby WC Golden 2007 Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death J Comp Neurol 500 20 46 17099894 10.1002/cne.21160 1:CAS:528: DC%2BD2sXktlCrtg%3D%3D
-
(2007)
J Comp Neurol
, vol.500
, pp. 20-46
-
-
Martin, L.J.1
Liu, Z.2
Chen, K.3
Price, A.C.4
Pan, Y.5
Swaby, J.A.6
Golden, W.C.7
-
118
-
-
0025786684
-
Glial changes following an excitotoxic lesion in the CNS-I. Microglia/macrophages
-
1775231 10.1016/0306-4522(91)90268-S 1:STN:280:DyaK387jtFantg%3D%3D
-
S Marty I Dusart M Peschanski 1991 Glial changes following an excitotoxic lesion in the CNS-I. Microglia/macrophages Neuroscience 45 529 539 1775231 10.1016/0306-4522(91)90268-S 1:STN:280:DyaK387jtFantg%3D%3D
-
(1991)
Neuroscience
, vol.45
, pp. 529-539
-
-
Marty, S.1
Dusart, I.2
Peschanski, M.3
-
119
-
-
0029610011
-
The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
-
8866675 10.1016/0165-0173(95)00011-9 1:STN:280:DyaK2s%2FitVaqsg%3D%3D
-
PL McGeer EG McGeer 1995 The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases Brain Res Brain Res Rev 21 195 218 8866675 10.1016/0165-0173(95)00011-9 1:STN:280:DyaK2s%2FitVaqsg%3D%3D
-
(1995)
Brain Res Brain Res Rev
, vol.21
, pp. 195-218
-
-
McGeer, P.L.1
McGeer, E.G.2
-
120
-
-
0036787810
-
Inflammatory processes in amyotrophic lateral sclerosis
-
12362410 10.1002/mus.10191 1:CAS:528:DC%2BD38Xot1Ggs7Y%3D
-
PL McGeer EG McGeer 2002 Inflammatory processes in amyotrophic lateral sclerosis Muscle Nerve 26 459 470 12362410 10.1002/mus.10191 1:CAS:528:DC%2BD38Xot1Ggs7Y%3D
-
(2002)
Muscle Nerve
, vol.26
, pp. 459-470
-
-
McGeer, P.L.1
McGeer, E.G.2
-
121
-
-
0027354835
-
Microglia in degenerative neurological disease
-
8423066 10.1002/glia.440070114 1:STN:280:DyaK3s7jvVOnug%3D%3D
-
PL McGeer T Kawamata DG Walker H Akiyama I Tooyama EG McGeer 1993 Microglia in degenerative neurological disease Glia 7 84 92 8423066 10.1002/glia.440070114 1:STN:280:DyaK3s7jvVOnug%3D%3D
-
(1993)
Glia
, vol.7
, pp. 84-92
-
-
McGeer, P.L.1
Kawamata, T.2
Walker, D.G.3
Akiyama, H.4
Tooyama, I.5
McGeer, E.G.6
-
122
-
-
0242549003
-
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
-
8896458 1:CAS:528:DyaK28XmvVOkt78%3D
-
SR McKercher BE Torbett KL Anderson GW Henkel DJ Vestal H Baribault M Klemsz AJ Feeney GE Wu CJ Paige RA Maki 1996 Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities EMBO J 15 5647 5658 8896458 1:CAS:528:DyaK28XmvVOkt78%3D
-
(1996)
EMBO J
, vol.15
, pp. 5647-5658
-
-
McKercher, S.R.1
Torbett, B.E.2
Anderson, K.L.3
Henkel, G.W.4
Vestal, D.J.5
Baribault, H.6
Klemsz, M.7
Feeney, A.J.8
Wu, G.E.9
Paige, C.J.10
Maki, R.A.11
-
123
-
-
70449697216
-
Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double-blind, randomized, multicentre, placebo-controlled trial
-
19922128 10.3109/17482960902803432 1:CAS:528:DC%2BD1MXhsFCiurjF
-
V Meininger VE Drory PN Leigh A Ludolph W Robberecht V Silani 2009 Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: a double-blind, randomized, multicentre, placebo-controlled trial Amyotroph Lateral Scler 10 378 383 19922128 10.3109/17482960902803432 1:CAS:528: DC%2BD1MXhsFCiurjF
-
(2009)
Amyotroph Lateral Scler
, vol.10
, pp. 378-383
-
-
Meininger, V.1
Drory, V.E.2
Leigh, P.N.3
Ludolph, A.4
Robberecht, W.5
Silani, V.6
-
124
-
-
34548294685
-
The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS
-
17597610 10.1016/j.expneurol.2007.05.016 1:CAS:528:DC%2BD2sXpvF2lt7c%3D
-
ML Messi HM Clark DM Prevette RW Oppenheim O Delbono 2007 The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS Exp Neurol 207 52 63 17597610 10.1016/j.expneurol.2007.05.016 1:CAS:528: DC%2BD2sXpvF2lt7c%3D
-
(2007)
Exp Neurol
, vol.207
, pp. 52-63
-
-
Messi, M.L.1
Clark, H.M.2
Prevette, D.M.3
Oppenheim, R.W.4
Delbono, O.5
-
125
-
-
36448955070
-
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
-
18026096 10.1038/nn2015 1:CAS:528:DC%2BD2sXhtlKltLbI
-
A Mildner H Schmidt M Nitsche D Merkler UK Hanisch M Mack M Heikenwalder W Bruck J Priller M Prinz 2007 Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions Nat Neurosci 10 1544 1553 18026096 10.1038/nn2015 1:CAS:528:DC%2BD2sXhtlKltLbI
-
(2007)
Nat Neurosci
, vol.10
, pp. 1544-1553
-
-
Mildner, A.1
Schmidt, H.2
Nitsche, M.3
Merkler, D.4
Hanisch, U.K.5
MacK, M.6
Heikenwalder, M.7
Bruck, W.8
Priller, J.9
Prinz, M.10
-
126
-
-
33845876647
-
Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis
-
17164329 10.1073/pnas.0609411103 1:CAS:528:DC%2BD2sXhsVaitw%3D%3D
-
TM Miller SH Kim K Yamanaka M Hester P Umapathi H Arnson L Rizo JR Mendell FH Gage DW Cleveland BK Kaspar 2006 Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis Proc Natl Acad Sci USA 103 19546 19551 17164329 10.1073/pnas.0609411103 1:CAS:528:DC%2BD2sXhsVaitw%3D%3D
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 19546-19551
-
-
Miller, T.M.1
Kim, S.H.2
Yamanaka, K.3
Hester, M.4
Umapathi, P.5
Arnson, H.6
Rizo, L.7
Mendell, J.R.8
Gage, F.H.9
Cleveland, D.W.10
Kaspar, B.K.11
-
127
-
-
34247475338
-
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
-
17435755 10.1038/nn1876 1:CAS:528:DC%2BD2sXksFShs7c%3D
-
M Nagai DB Re T Nagata A Chalazonitis TM Jessell H Wichterle S Przedborski 2007 Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons Nat Neurosci 10 615 622 17435755 10.1038/nn1876 1:CAS:528:DC%2BD2sXksFShs7c%3D
-
(2007)
Nat Neurosci
, vol.10
, pp. 615-622
-
-
Nagai, M.1
Re, D.B.2
Nagata, T.3
Chalazonitis, A.4
Jessell, T.M.5
Wichterle, H.6
Przedborski, S.7
-
128
-
-
22844452812
-
Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of amyotrophic lateral sclerosis
-
15990113 10.1016/j.jns.2005.04.011 1:CAS:528:DC%2BD2MXmsVOqsr4%3D
-
I Nagano H Ilieva M Shiote T Murakami M Yokoyama M Shoji K Abe 2005 Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of amyotrophic lateral sclerosis J Neurol Sci 235 61 68 15990113 10.1016/j.jns.2005.04.011 1:CAS:528:DC%2BD2MXmsVOqsr4%3D
-
(2005)
J Neurol Sci
, vol.235
, pp. 61-68
-
-
Nagano, I.1
Ilieva, H.2
Shiote, M.3
Murakami, T.4
Yokoyama, M.5
Shoji, M.6
Abe, K.7
-
129
-
-
27244455282
-
Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis
-
16197815 10.1179/016164105X39860 1:CAS:528:DC%2BD2MXht1Wkt7fN
-
I Nagano M Shiote T Murakami H Kamada Y Hamakawa E Matsubara M Yokoyama K Moritaz M Shoji K Abe 2005 Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis Neurol Res 27 768 772 16197815 10.1179/016164105X39860 1:CAS:528:DC%2BD2MXht1Wkt7fN
-
(2005)
Neurol Res
, vol.27
, pp. 768-772
-
-
Nagano, I.1
Shiote, M.2
Murakami, T.3
Kamada, H.4
Hamakawa, Y.5
Matsubara, E.6
Yokoyama, M.7
Moritaz, K.8
Shoji, M.9
Abe, K.10
-
130
-
-
37149006825
-
Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patients
-
17672928 10.1179/016164107X229795 1:CAS:528:DC%2BD1cXhtFKksbg%3D
-
T Nagata I Nagano M Shiote H Narai T Murakami T Hayashi M Shoji K Abe 2007 Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patients Neurol Res 29 772 776 17672928 10.1179/016164107X229795 1:CAS:528:DC%2BD1cXhtFKksbg%3D
-
(2007)
Neurol Res
, vol.29
, pp. 772-776
-
-
Nagata, T.1
Nagano, I.2
Shiote, M.3
Narai, H.4
Murakami, T.5
Hayashi, T.6
Shoji, M.7
Abe, K.8
-
131
-
-
68349146013
-
Development of ALS-like disease in SOD-1 mice deficient of B lymphocytes
-
19280101 10.1007/s00415-009-5097-3 1:CAS:528:DC%2BD1MXpsVegtrY%3D
-
S Naor Z Keren T Bronshtein E Goren M Machluf D Melamed 2009 Development of ALS-like disease in SOD-1 mice deficient of B lymphocytes J Neurol 256 1228 1235 19280101 10.1007/s00415-009-5097-3 1:CAS:528:DC%2BD1MXpsVegtrY%3D
-
(2009)
J Neurol
, vol.256
, pp. 1228-1235
-
-
Naor, S.1
Keren, Z.2
Bronshtein, T.3
Goren, E.4
MacHluf, M.5
Melamed, D.6
-
132
-
-
77649323766
-
Recombinant human granulocyte-colony stimulating factor administration for treating amyotrophic lateral sclerosis: A pilot study
-
10.3109/17482960902933809 1:CAS:528:DC%2BC3cXisV2mtr4%3D
-
B Nefussy I Artamonov V Deutsch E Naparstek A Nagler VE Drory 2009 Recombinant human granulocyte-colony stimulating factor administration for treating amyotrophic lateral sclerosis: a pilot study Amyotroph Lateral Scler 11 187 193 10.3109/17482960902933809 1:CAS:528:DC%2BC3cXisV2mtr4%3D
-
(2009)
Amyotroph Lateral Scler
, vol.11
, pp. 187-193
-
-
Nefussy, B.1
Artamonov, I.2
Deutsch, V.3
Naparstek, E.4
Nagler, A.5
Drory, V.E.6
-
133
-
-
70349751944
-
Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis
-
19733563 10.1016/j.expneurol.2009.08.028 1:CAS:528:DC%2BD1MXht1GmtL3F
-
A Neymotin S Petri NY Calingasan E Wille P Schafer C Stewart K Hensley MF Beal M Kiaei 2009 Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis Exp Neurol 220 191 197 19733563 10.1016/j.expneurol.2009.08.028 1:CAS:528:DC%2BD1MXht1GmtL3F
-
(2009)
Exp Neurol
, vol.220
, pp. 191-197
-
-
Neymotin, A.1
Petri, S.2
Calingasan, N.Y.3
Wille, E.4
Schafer, P.5
Stewart, C.6
Hensley, K.7
Beal, M.F.8
Kiaei, M.9
-
134
-
-
0034765498
-
Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: No requirement for proapoptotic interleukin-1beta in neurodegeneration
-
11706969 10.1002/ana.1256 1:CAS:528:DC%2BD3MXovVGhtbY%3D
-
MD Nguyen JP Julien S Rivest 2001 Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration Ann Neurol 50 630 639 11706969 10.1002/ana.1256 1:CAS:528:DC%2BD3MXovVGhtbY%3D
-
(2001)
Ann Neurol
, vol.50
, pp. 630-639
-
-
Nguyen, M.D.1
Julien, J.P.2
Rivest, S.3
-
135
-
-
1242336763
-
Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis
-
14960605 10.1523/JNEUROSCI.4786-03.2004 1:CAS:528:DC%2BD2cXhs1Sqtro%3D
-
MD Nguyen T D'Aigle G Gowing JP Julien S Rivest 2004 Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis J Neurosci 24 1340 1349 14960605 10.1523/JNEUROSCI.4786-03.2004 1:CAS:528:DC%2BD2cXhs1Sqtro%3D
-
(2004)
J Neurosci
, vol.24
, pp. 1340-1349
-
-
Nguyen, M.D.1
D'Aigle, T.2
Gowing, G.3
Julien, J.P.4
Rivest, S.5
-
136
-
-
19744380563
-
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
-
15831717 10.1126/science.1110647 1:CAS:528:DC%2BD2MXks1Ciuro%3D
-
A Nimmerjahn F Kirchhoff F Helmchen 2005 Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 308 1314 1318 15831717 10.1126/science.1110647 1:CAS:528:DC%2BD2MXks1Ciuro%3D
-
(2005)
Science
, vol.308
, pp. 1314-1318
-
-
Nimmerjahn, A.1
Kirchhoff, F.2
Helmchen, F.3
-
137
-
-
70349265930
-
Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis
-
19686706 10.1016/j.brainres.2009.08.012 1:CAS:528:DC%2BD1MXhtFyqsbzL
-
S Ohnishi H Ito Y Suzuki Y Adachi R Wate J Zhang S Nakano H Kusaka S Ikehara 2009 Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis Brain Res 1296 216 224 19686706 10.1016/j.brainres.2009.08.012 1:CAS:528:DC%2BD1MXhtFyqsbzL
-
(2009)
Brain Res
, vol.1296
, pp. 216-224
-
-
Ohnishi, S.1
Ito, H.2
Suzuki, Y.3
Adachi, Y.4
Wate, R.5
Zhang, J.6
Nakano, S.7
Kusaka, H.8
Ikehara, S.9
-
138
-
-
0035194691
-
Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord
-
11761470 10.1002/ana.1252 1:CAS:528:DC%2BD38Xhs1Kntg%3D%3D
-
MK Olsen SL Roberds BR Ellerbrock TJ Fleck DK McKinley ME Gurney 2001 Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord Ann Neurol 50 730 740 11761470 10.1002/ana.1252 1:CAS:528:DC%2BD38Xhs1Kntg%3D%3D
-
(2001)
Ann Neurol
, vol.50
, pp. 730-740
-
-
Olsen, M.K.1
Roberds, S.L.2
Ellerbrock, B.R.3
Fleck, T.J.4
McKinley, D.K.5
Gurney, M.E.6
-
139
-
-
33747101645
-
Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice
-
16753145 10.1016/j.expneurol.2006.03.028 1:CAS:528:DC%2BD28XotlKkt7g%3D
-
AC Pardo V Wong LM Benson M Dykes K Tanaka JD Rothstein NJ Maragakis 2006 Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice Exp Neurol 201 120 130 16753145 10.1016/j.expneurol.2006.03.028 1:CAS:528:DC%2BD28XotlKkt7g%3D
-
(2006)
Exp Neurol
, vol.201
, pp. 120-130
-
-
Pardo, A.C.1
Wong, V.2
Benson, L.M.3
Dykes, M.4
Tanaka, K.5
Rothstein, J.D.6
Maragakis, N.J.7
-
140
-
-
77956955302
-
The GH-IGF system in amyotrophic lateral sclerosis: Correlations between pituitary GH secretion capacity, insulin-like growth factors and clinical features
-
Pellecchia MT, Pivonello R, Monsurro MR, Trojsi F, Longo K, Piccirillo G, Pivonello C, Rocco M, Di Somma C, Colao A, Tedeschi G, Barone P (2009) The GH-IGF system in amyotrophic lateral sclerosis: correlations between pituitary GH secretion capacity, insulin-like growth factors and clinical features. Eur J Neurol
-
(2009)
Eur J Neurol
-
-
Pellecchia, M.T.1
Pivonello, R.2
Monsurro, M.R.3
Trojsi, F.4
Longo, K.5
Piccirillo, G.6
Pivonello, C.7
Rocco, M.8
Di Somma, C.9
Colao, A.10
Tedeschi, G.11
Barone, P.12
-
141
-
-
0022387412
-
Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
-
3895031 10.1016/0306-4522(85)90215-5 1:STN:280:DyaL2M3mvVCqsg%3D%3D
-
VH Perry DA Hume S Gordon 1985 Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain Neuroscience 15 313 326 3895031 10.1016/0306-4522(85)90215-5 1:STN:280:DyaL2M3mvVCqsg%3D%3D
-
(1985)
Neuroscience
, vol.15
, pp. 313-326
-
-
Perry, V.H.1
Hume, D.A.2
Gordon, S.3
-
142
-
-
58149119552
-
Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis
-
18835867 10.1093/brain/awn243
-
C Pitzer C Kruger C Plaas F Kirsch T Dittgen R Muller R Laage S Kastner S Suess R Spoelgen A Henriques H Ehrenreich WR Schabitz A Bach A Schneider 2008 Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis Brain 131 3335 3347 18835867 10.1093/brain/awn243
-
(2008)
Brain
, vol.131
, pp. 3335-3347
-
-
Pitzer, C.1
Kruger, C.2
Plaas, C.3
Kirsch, F.4
Dittgen, T.5
Muller, R.6
Laage, R.7
Kastner, S.8
Suess, S.9
Spoelgen, R.10
Henriques, A.11
Ehrenreich, H.12
Schabitz, W.R.13
Bach, A.14
Schneider, A.15
-
143
-
-
0034733968
-
Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis
-
10863032 10.1016/S0304-3940(00)01177-0 1:CAS:528:DC%2BD3cXktV2qu7o%3D
-
M Poloni D Facchetti R Mai A Micheli L Agnoletti G Francolini G Mora C Camana L Mazzini T Bachetti 2000 Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis Neurosci Lett 287 211 214 10863032 10.1016/S0304-3940(00)01177-0 1:CAS:528:DC%2BD3cXktV2qu7o%3D
-
(2000)
Neurosci Lett
, vol.287
, pp. 211-214
-
-
Poloni, M.1
Facchetti, D.2
Mai, R.3
Micheli, A.4
Agnoletti, L.5
Francolini, G.6
Mora, G.7
Camana, C.8
Mazzini, L.9
Bachetti, T.10
-
144
-
-
0037389393
-
A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis
-
12586733 1:CAS:528:DC%2BD3sXislGmu7s%3D
-
PN Pompl L Ho M Bianchi T McManus W Qin GM Pasinetti 2003 A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis FASEB J 17 725 727 12586733 1:CAS:528:DC%2BD3sXislGmu7s%3D
-
(2003)
FASEB J
, vol.17
, pp. 725-727
-
-
Pompl, P.N.1
Ho, L.2
Bianchi, M.3
McManus, T.4
Qin, W.5
Pasinetti, G.M.6
-
145
-
-
0035873076
-
Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment
-
11331366 1:CAS:528:DC%2BD3MXjs1antrs%3D
-
A Pramatarova J Laganiere J Roussel K Brisebois GA Rouleau 2001 Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment J Neurosci 21 3369 3374 11331366 1:CAS:528:DC%2BD3MXjs1antrs%3D
-
(2001)
J Neurosci
, vol.21
, pp. 3369-3374
-
-
Pramatarova, A.1
Laganiere, J.2
Roussel, J.3
Brisebois, K.4
Rouleau, G.A.5
-
146
-
-
0035658031
-
Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment
-
11726978 10.1038/nm1201-1356 1:CAS:528:DC%2BD3MXovFKmt7c%3D
-
J Priller A Flugel T Wehner M Boentert CA Haas M Prinz F Fernandez-Klett K Prass I Bechmann BA de Boer M Frotscher GW Kreutzberg DA Persons U Dirnagl 2001 Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment Nat Med 7 1356 1361 11726978 10.1038/nm1201-1356 1:CAS:528:DC%2BD3MXovFKmt7c%3D
-
(2001)
Nat Med
, vol.7
, pp. 1356-1361
-
-
Priller, J.1
Flugel, A.2
Wehner, T.3
Boentert, M.4
Haas, C.A.5
Prinz, M.6
Fernandez-Klett, F.7
Prass, K.8
Bechmann, I.9
De Boer, B.A.10
Frotscher, M.11
Kreutzberg, G.W.12
Persons, D.A.13
Dirnagl, U.14
-
147
-
-
0028050415
-
Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse
-
7850025 10.1111/j.1460-9568.1994.tb00552.x 1:STN:280:DyaK2M7lt1yltw%3D%3D
-
G Raivich MT Moreno-Flores JC Moller GW Kreutzberg 1994 Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse Eur J Neurosci 6 1615 1618 7850025 10.1111/j.1460-9568.1994.tb00552.x 1:STN:280:DyaK2M7lt1yltw%3D%3D
-
(1994)
Eur J Neurosci
, vol.6
, pp. 1615-1618
-
-
Raivich, G.1
Moreno-Flores, M.T.2
Moller, J.C.3
Kreutzberg, G.W.4
-
148
-
-
0347155578
-
Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis
-
12356748 10.1074/jbc.M207356200 1:CAS:528:DC%2BD38XptFSqsrY%3D
-
R Rakhit P Cunningham A Furtos-Matei S Dahan XF Qi JP Crow NR Cashman LH Kondejewski A Chakrabartty 2002 Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis J Biol Chem 277 47551 47556 12356748 10.1074/jbc.M207356200 1:CAS:528: DC%2BD38XptFSqsrY%3D
-
(2002)
J Biol Chem
, vol.277
, pp. 47551-47556
-
-
Rakhit, R.1
Cunningham, P.2
Furtos-Matei, A.3
Dahan, S.4
Qi, X.F.5
Crow, J.P.6
Cashman, N.R.7
Kondejewski, L.H.8
Chakrabartty, A.9
-
149
-
-
0037068836
-
Motoneuron death triggered by a specific pathway downstream of Fas: Potentiation by ALS-linked SOD1 mutations
-
12354397 10.1016/S0896-6273(02)00905-4 1:CAS:528:DC%2BD38XnsV2hsbc%3D
-
C Raoul AG Estevez H Nishimune DW Cleveland O deLapeyriere CE Henderson G Haase B Pettmann 2002 Motoneuron death triggered by a specific pathway downstream of Fas: potentiation by ALS-linked SOD1 mutations Neuron 35 1067 1083 12354397 10.1016/S0896-6273(02)00905-4 1:CAS:528:DC%2BD38XnsV2hsbc%3D
-
(2002)
Neuron
, vol.35
, pp. 1067-1083
-
-
Raoul, C.1
Estevez, A.G.2
Nishimune, H.3
Cleveland, D.W.4
Delapeyriere, O.5
Henderson, C.E.6
Haase, G.7
Pettmann, B.8
-
150
-
-
33645822300
-
Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL
-
16581901 10.1073/pnas.0508774103 1:CAS:528:DC%2BD28XktFaitbY%3D
-
C Raoul E Buhler C Sadeghi A Jacquier P Aebischer B Pettmann CE Henderson G Haase 2006 Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL Proc Natl Acad Sci USA 103 6007 6012 16581901 10.1073/pnas.0508774103 1:CAS:528: DC%2BD28XktFaitbY%3D
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6007-6012
-
-
Raoul, C.1
Buhler, E.2
Sadeghi, C.3
Jacquier, A.4
Aebischer, P.5
Pettmann, B.6
Henderson, C.E.7
Haase, G.8
-
151
-
-
15844393658
-
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
-
8673102 10.1038/ng0596-43 1:CAS:528:DyaK28XksVWgtbs%3D
-
AG Reaume JL Elliott EK Hoffman NW Kowall RJ Ferrante DF Siwek HM Wilcox DG Flood MF Beal RH Brown Jr RW Scott WD Snider 1996 Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury Nat Genet 13 43 47 8673102 10.1038/ng0596-43 1:CAS:528:DyaK28XksVWgtbs%3D
-
(1996)
Nat Genet
, vol.13
, pp. 43-47
-
-
Reaume, A.G.1
Elliott, J.L.2
Hoffman, E.K.3
Kowall, N.W.4
Ferrante, R.J.5
Siwek, D.F.6
Wilcox, H.M.7
Flood, D.G.8
Beal, M.F.9
Brown, Jr.R.H.10
Scott, R.W.11
Snider, W.D.12
-
152
-
-
35148846456
-
RANTES levels are elevated in serum and cerebrospinal fluid in patients with amyotrophic lateral sclerosis
-
17852013 10.1080/17482960701419232 1:CAS:528:DC%2BD2sXhtFWqs73I
-
M Rentzos C Nikolaou A Rombos F Boufidou M Zoga A Dimitrakopoulos A Tsoutsou D Vassilopoulos 2007 RANTES levels are elevated in serum and cerebrospinal fluid in patients with amyotrophic lateral sclerosis Amyotroph Lateral Scler 8 283 287 17852013 10.1080/17482960701419232 1:CAS:528: DC%2BD2sXhtFWqs73I
-
(2007)
Amyotroph Lateral Scler
, vol.8
, pp. 283-287
-
-
Rentzos, M.1
Nikolaou, C.2
Rombos, A.3
Boufidou, F.4
Zoga, M.5
Dimitrakopoulos, A.6
Tsoutsou, A.7
Vassilopoulos, D.8
-
153
-
-
0031886864
-
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
-
9422508 10.1038/34178 1:CAS:528:DyaK1cXktVShtQ%3D%3D
-
M Ricote AC Li TM Willson CJ Kelly CK Glass 1998 The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation Nature 391 79 82 9422508 10.1038/34178 1:CAS:528:DyaK1cXktVShtQ%3D%3D
-
(1998)
Nature
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
Kelly, C.J.4
Glass, C.K.5
-
154
-
-
0028888945
-
Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
-
7846037 10.1073/pnas.92.3.689 1:CAS:528:DyaK2MXjsVKitL8%3D
-
ME Ripps GW Huntley PR Hof JH Morrison JW Gordon 1995 Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis Proc Natl Acad Sci USA 92 689 693 7846037 10.1073/pnas.92.3.689 1:CAS:528:DyaK2MXjsVKitL8%3D
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 689-693
-
-
Ripps, M.E.1
Huntley, G.W.2
Hof, P.R.3
Morrison, J.H.4
Gordon, J.W.5
-
155
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
8446170 10.1038/362059a0 1:CAS:528:DyaK3sXhvV2hs74%3D
-
DR Rosen T Siddique D Patterson DA Figlewicz P Sapp A Hentati D Donaldson J Goto JP O'Regan HX Deng, et al. 1993 Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 59 62 8446170 10.1038/362059a0 1:CAS:528:DyaK3sXhvV2hs74%3D
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
Donaldson, D.7
Goto, J.8
O'Regan, J.P.9
Deng, H.X.10
-
156
-
-
0029975105
-
Absence of serological evidence for foamy virus infection in patients with amyotrophic lateral sclerosis
-
8801281 10.1002/(SICI)1096-9071(199603)48:3 <222::AID-JMV2>3.0. CO;2-A 1:STN:280:DyaK283ksFSgtA%3D%3D
-
M Rosener H Hahn M Kranz J Heeney A Rethwilm 1996 Absence of serological evidence for foamy virus infection in patients with amyotrophic lateral sclerosis J Med Virol 48 222 226 8801281 10.1002/(SICI)1096-9071(199603)48: 3<222::AID-JMV2>3.0.CO;2-A 1:STN:280:DyaK283ksFSgtA%3D%3D
-
(1996)
J Med Virol
, vol.48
, pp. 222-226
-
-
Rosener, M.1
Hahn, H.2
Kranz, M.3
Heeney, J.4
Rethwilm, A.5
-
157
-
-
0029030610
-
Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
-
7611729 10.1002/ana.410380114 1:CAS:528:DyaK2MXnt12lsbw%3D
-
JD Rothstein M Van Kammen AI Levey LJ Martin RW Kuncl 1995 Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis Ann Neurol 38 73 84 7611729 10.1002/ana.410380114 1:CAS:528:DyaK2MXnt12lsbw%3D
-
(1995)
Ann Neurol
, vol.38
, pp. 73-84
-
-
Rothstein, J.D.1
Van Kammen, M.2
Levey, A.I.3
Martin, L.J.4
Kuncl, R.W.5
-
158
-
-
52949094629
-
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis
-
18802454 10.1371/journal.pgen.1000193 1:CAS:528:DC%2BD1cXht1ygtrzE
-
NJ Rutherford YJ Zhang M Baker JM Gass NA Finch YF Xu H Stewart BJ Kelley K Kuntz RJ Crook J Sreedharan C Vance E Sorenson C Lippa EH Bigio DH Geschwind DS Knopman H Mitsumoto RC Petersen NR Cashman M Hutton CE Shaw KB Boylan B Boeve NR Graff-Radford ZK Wszolek RJ Caselli DW Dickson IR Mackenzie L Petrucelli R Rademakers 2008 Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis PLoS Genet 4 9 e1000193 18802454 10.1371/journal.pgen.1000193 1:CAS:528:DC%2BD1cXht1ygtrzE
-
(2008)
PLoS Genet
, vol.4
, Issue.9
, pp. 1000193
-
-
Rutherford, N.J.1
Zhang, Y.J.2
Baker, M.3
Gass, J.M.4
Finch, N.A.5
Xu, Y.F.6
Stewart, H.7
Kelley, B.J.8
Kuntz, K.9
Crook, R.J.10
Sreedharan, J.11
Vance, C.12
Sorenson, E.13
Lippa, C.14
Bigio, E.H.15
Geschwind, D.H.16
Knopman, D.S.17
Mitsumoto, H.18
Petersen, R.C.19
Cashman, N.R.20
Hutton, M.21
Shaw, C.E.22
Boylan, K.B.23
Boeve, B.24
Graff-Radford, N.R.25
Wszolek, Z.K.26
Caselli, R.J.27
Dickson, D.W.28
MacKenzie, I.R.29
Petrucelli, L.30
Rademakers, R.31
more..
-
159
-
-
74049122793
-
Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1
-
19752764 10.1097/WNR.0b013e328331e8fa 1:CAS:528:DC%2BD1MXht1ymsL7O
-
SA Sargsyan DJ Blackburn SC Barber PN Monk PJ Shaw 2009 Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1 Neuroreport 20 1450 1455 19752764 10.1097/WNR.0b013e328331e8fa 1:CAS:528:DC%2BD1MXht1ymsL7O
-
(2009)
Neuroreport
, vol.20
, pp. 1450-1455
-
-
Sargsyan, S.A.1
Blackburn, D.J.2
Barber, S.C.3
Monk, P.N.4
Shaw, P.J.5
-
160
-
-
58149232639
-
Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis
-
18957896 10.1097/NEN.0b013e31818b4906 1:CAS:528:DC%2BD1cXhsVeqtLbL
-
A Sarlette K Krampfl C Grothe N Neuhoff R Dengler S Petri 2008 Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis J Neuropathol Exp Neurol 67 1055 1062 18957896 10.1097/NEN.0b013e31818b4906 1:CAS:528: DC%2BD1cXhsVeqtLbL
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 1055-1062
-
-
Sarlette, A.1
Krampfl, K.2
Grothe, C.3
Neuhoff, N.4
Dengler, R.5
Petri, S.6
-
161
-
-
37549052559
-
A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF)
-
17457367 10.1038/sj.jcbfm.9600496 1:CAS:528:DC%2BD1cXht1Sjtg%3D%3D
-
WR Schabitz C Kruger C Pitzer D Weber R Laage N Gassler J Aronowski W Mier F Kirsch T Dittgen A Bach C Sommer A Schneider 2008 A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF) J Cereb Blood Flow Metab 28 29 43 17457367 10.1038/sj.jcbfm. 9600496 1:CAS:528:DC%2BD1cXht1Sjtg%3D%3D
-
(2008)
J Cereb Blood Flow Metab
, vol.28
, pp. 29-43
-
-
Schabitz, W.R.1
Kruger, C.2
Pitzer, C.3
Weber, D.4
Laage, R.5
Gassler, N.6
Aronowski, J.7
Mier, W.8
Kirsch, F.9
Dittgen, T.10
Bach, A.11
Sommer, C.12
Schneider, A.13
-
162
-
-
49649095887
-
Neuroscience: Standard model
-
18685674 10.1038/454682a 1:CAS:528:DC%2BD1cXps1SntbY%3D
-
J Schnabel 2008 Neuroscience: standard model Nature 454 682 685 18685674 10.1038/454682a 1:CAS:528:DC%2BD1cXps1SntbY%3D
-
(2008)
Nature
, vol.454
, pp. 682-685
-
-
Schnabel, J.1
-
163
-
-
23644445498
-
The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
-
16007267 10.1172/JCI23559 1:CAS:528:DC%2BD2MXntFCmtL0%3D
-
A Schneider C Kruger T Steigleder D Weber C Pitzer R Laage J Aronowski MH Maurer N Gassler W Mier M Hasselblatt R Kollmar S Schwab C Sommer A Bach HG Kuhn WR Schabitz 2005 The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis J Clin Invest 115 2083 2098 16007267 10.1172/JCI23559 1:CAS:528:DC%2BD2MXntFCmtL0%3D
-
(2005)
J Clin Invest
, vol.115
, pp. 2083-2098
-
-
Schneider, A.1
Kruger, C.2
Steigleder, T.3
Weber, D.4
Pitzer, C.5
Laage, R.6
Aronowski, J.7
Maurer, M.H.8
Gassler, N.9
Mier, W.10
Hasselblatt, M.11
Kollmar, R.12
Schwab, S.13
Sommer, C.14
Bach, A.15
Kuhn, H.G.16
Schabitz, W.R.17
-
164
-
-
23944490153
-
The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice
-
16120782 10.1523/JNEUROSCI.2038-05.2005 1:CAS:528:DC%2BD2MXpvVKgu7k%3D
-
B Schutz J Reimann L Dumitrescu-Ozimek K Kappes-Horn GE Landreth B Schurmann A Zimmer MT Heneka 2005 The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice J Neurosci 25 7805 7812 16120782 10.1523/JNEUROSCI.2038-05.2005 1:CAS:528:DC%2BD2MXpvVKgu7k%3D
-
(2005)
J Neurosci
, vol.25
, pp. 7805-7812
-
-
Schutz, B.1
Reimann, J.2
Dumitrescu-Ozimek, L.3
Kappes-Horn, K.4
Landreth, G.E.5
Schurmann, B.6
Zimmer, A.7
Heneka, M.T.8
-
165
-
-
39349107014
-
Design, power, and interpretation of studies in the standard murine model of ALS
-
18273714 10.1080/17482960701856300 1:CAS:528:DC%2BD1cXhvVWnur0%3D
-
S Scott JE Kranz J Cole JM Lincecum K Thompson N Kelly A Bostrom J Theodoss BM Al-Nakhala FG Vieira J Ramasubbu JA Heywood 2008 Design, power, and interpretation of studies in the standard murine model of ALS Amyotroph Lateral Scler 9 4 15 18273714 10.1080/17482960701856300 1:CAS:528:DC%2BD1cXhvVWnur0%3D
-
(2008)
Amyotroph Lateral Scler
, vol.9
, pp. 4-15
-
-
Scott, S.1
Kranz, J.E.2
Cole, J.3
Lincecum, J.M.4
Thompson, K.5
Kelly, N.6
Bostrom, A.7
Theodoss, J.8
Al-Nakhala, B.M.9
Vieira, F.G.10
Ramasubbu, J.11
Heywood, J.A.12
-
166
-
-
77949937746
-
Thymic involution in amyotrophic lateral sclerosis
-
Seksenyan A, Ron-Harel N, Azoulay D, Cahalon L, Cardon M, Rogeri P, Ko MK, Weil M, Bulvik S, Rechavi G, Amariglio N, Konen E, Koronyo-Hamaoui M, Somech R, Schwartz M (2009) Thymic involution in amyotrophic lateral sclerosis. J Cell Mol Med
-
(2009)
J Cell Mol Med
-
-
Seksenyan, A.1
Ron-Harel, N.2
Azoulay, D.3
Cahalon, L.4
Cardon, M.5
Rogeri, P.6
Ko, M.K.7
Weil, M.8
Bulvik, S.9
Rechavi, G.10
Amariglio, N.11
Konen, E.12
Koronyo-Hamaoui, M.13
Somech, R.14
Schwartz, M.15
-
167
-
-
0035955478
-
Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients
-
11602233 10.1016/S0006-8993(01)02926-2 1:CAS:528:DC%2BD3MXnsF2gsbY%3D
-
N Shibata R Nagai K Uchida S Horiuchi S Yamada A Hirano M Kawaguchi T Yamamoto S Sasaki M Kobayashi 2001 Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients Brain Res 917 97 104 11602233 10.1016/S0006-8993(01)02926-2 1:CAS:528:DC%2BD3MXnsF2gsbY%3D
-
(2001)
Brain Res
, vol.917
, pp. 97-104
-
-
Shibata, N.1
Nagai, R.2
Uchida, K.3
Horiuchi, S.4
Yamada, S.5
Hirano, A.6
Kawaguchi, M.7
Yamamoto, T.8
Sasaki, S.9
Kobayashi, M.10
-
168
-
-
6944234040
-
Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia
-
15084516 1:CAS:528:DC%2BD2cXkslWit7g%3D
-
AR Simard S Rivest 2004 Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia FASEB J 18 998 1000 15084516 1:CAS:528:DC%2BD2cXkslWit7g%3D
-
(2004)
FASEB J
, vol.18
, pp. 998-1000
-
-
Simard, A.R.1
Rivest, S.2
-
169
-
-
2442701519
-
Increased lipid peroxidation in sera of ALS patients: A potential biomarker of disease burden
-
15159474 1:CAS:528:DC%2BD2cXjs1yltLs%3D
-
EP Simpson YK Henry JS Henkel RG Smith SH Appel 2004 Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden Neurology 62 1758 1765 15159474 1:CAS:528:DC%2BD2cXjs1yltLs%3D
-
(2004)
Neurology
, vol.62
, pp. 1758-1765
-
-
Simpson, E.P.1
Henry, Y.K.2
Henkel, J.S.3
Smith, R.G.4
Appel, S.H.5
-
170
-
-
0031722955
-
Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis
-
9778272 10.1002/ana.410440419 1:STN:280:DyaK1cvkvFOhsw%3D%3D
-
RG Smith YK Henry MP Mattson SH Appel 1998 Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis Ann Neurol 44 696 699 9778272 10.1002/ana.410440419 1:STN:280: DyaK1cvkvFOhsw%3D%3D
-
(1998)
Ann Neurol
, vol.44
, pp. 696-699
-
-
Smith, R.G.1
Henry, Y.K.2
Mattson, M.P.3
Appel, S.H.4
-
171
-
-
33646250429
-
Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis
-
16518833 10.1002/glia.20331
-
JN Solomon CA Lewis B Ajami SY Corbel FM Rossi C Krieger 2006 Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis Glia 53 744 753 16518833 10.1002/glia.20331
-
(2006)
Glia
, vol.53
, pp. 744-753
-
-
Solomon, J.N.1
Lewis, C.A.2
Ajami, B.3
Corbel, S.Y.4
Rossi, F.M.5
Krieger, C.6
-
172
-
-
0034905496
-
Survival in a transgenic model of FALS is independent of iNOS expression
-
11506415 10.1002/ana.1104 1:STN:280:DC%2BD3MvmtFOitg%3D%3D
-
M Son HM Fathallah-Shaykh JL Elliott 2001 Survival in a transgenic model of FALS is independent of iNOS expression Ann Neurol 50 273 11506415 10.1002/ana.1104 1:STN:280:DC%2BD3MvmtFOitg%3D%3D
-
(2001)
Ann Neurol
, vol.50
, pp. 273
-
-
Son, M.1
Fathallah-Shaykh, H.M.2
Elliott, J.L.3
-
173
-
-
58149242839
-
Subcutaneous IGF-1 is not beneficial in 2-year ALS trial
-
19029516 10.1212/01.wnl.0000335970.78664.36 1:CAS:528:DC%2BD1cXhtlylurjK
-
EJ Sorenson AJ Windbank JN Mandrekar WR Bamlet SH Appel C Armon PE Barkhaus P Bosch K Boylan WS David E Feldman J Glass L Gutmann J Katz W King CA Luciano LF McCluskey S Nash DS Newman RM Pascuzzi E Pioro LJ Sams S Scelsa EP Simpson SH Subramony E Tiryaki CA Thornton 2008 Subcutaneous IGF-1 is not beneficial in 2-year ALS trial Neurology 71 1770 1775 19029516 10.1212/01.wnl.0000335970.78664.36 1:CAS:528:DC%2BD1cXhtlylurjK
-
(2008)
Neurology
, vol.71
, pp. 1770-1775
-
-
Sorenson, E.J.1
Windbank, A.J.2
Mandrekar, J.N.3
Bamlet, W.R.4
Appel, S.H.5
Armon, C.6
Barkhaus, P.E.7
Bosch, P.8
Boylan, K.9
David, W.S.10
Feldman, E.11
Glass, J.12
Gutmann, L.13
Katz, J.14
King, W.15
Luciano, C.A.16
McCluskey, L.F.17
Nash, S.18
Newman, D.S.19
Pascuzzi, R.M.20
Pioro, E.21
Sams, L.J.22
Scelsa, S.23
Simpson, E.P.24
Subramony, S.H.25
Tiryaki, E.26
Thornton, C.A.27
more..
-
174
-
-
41149180753
-
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
-
18309045 10.1126/science.1154584 1:CAS:528:DC%2BD1cXjsVamtbo%3D
-
J Sreedharan IP Blair VB Tripathi X Hu C Vance B Rogelj S Ackerley JC Durnall KL Williams E Buratti F Baralle J de Belleroche JD Mitchell PN Leigh A Al-Chalabi CC Miller G Nicholson CE Shaw 2008 TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis Science 319 1668 1672 18309045 10.1126/science.1154584 1:CAS:528:DC%2BD1cXjsVamtbo%3D
-
(2008)
Science
, vol.319
, pp. 1668-1672
-
-
Sreedharan, J.1
Blair, I.P.2
Tripathi, V.B.3
Hu, X.4
Vance, C.5
Rogelj, B.6
Ackerley, S.7
Durnall, J.C.8
Williams, K.L.9
Buratti, E.10
Baralle, F.11
De Belleroche, J.12
Mitchell, J.D.13
Leigh, P.N.14
Al-Chalabi, A.15
Miller, C.C.16
Nicholson, G.17
Shaw, C.E.18
-
175
-
-
70449718115
-
Efficacy of thalidomide for the treatment of amyotrophic lateral sclerosis: A phase II open label clinical trial
-
19922130 10.3109/17482960802709416 1:CAS:528:DC%2BD1MXhsFCiurnM
-
EW Stommel JA Cohen CE Fadul CH Cogbill DJ Graber L Kingman T Mackenzie JY Channon Smith BT Harris 2009 Efficacy of thalidomide for the treatment of amyotrophic lateral sclerosis: a phase II open label clinical trial Amyotroph Lateral Scler 10 393 404 19922130 10.3109/17482960802709416 1:CAS:528: DC%2BD1MXhsFCiurnM
-
(2009)
Amyotroph Lateral Scler
, vol.10
, pp. 393-404
-
-
Stommel, E.W.1
Cohen, J.A.2
Fadul, C.E.3
Cogbill, C.H.4
Graber, D.J.5
Kingman, L.6
MacKenzie, T.7
Channon Smith, J.Y.8
Harris, B.T.9
-
176
-
-
0036847816
-
Microglia as neuroprotective, immunocompetent cells of the CNS
-
12379901 10.1002/glia.10154
-
WJ Streit 2002 Microglia as neuroprotective, immunocompetent cells of the CNS Glia 40 133 139 12379901 10.1002/glia.10154
-
(2002)
Glia
, vol.40
, pp. 133-139
-
-
Streit, W.J.1
-
177
-
-
0028811503
-
Search for persistent infection with poliovirus or other enteroviruses in amyotrophic lateral sclerosis-motor neurone disease
-
8580727 10.1016/0960-8966(95)00002-5 1:STN:280:DyaK287ls1Cnuw%3D%3D
-
NR Swanson SA Fox FL Mastaglia 1995 Search for persistent infection with poliovirus or other enteroviruses in amyotrophic lateral sclerosis-motor neurone disease Neuromuscul Disord 5 457 465 8580727 10.1016/0960-8966(95)00002-5 1:STN:280:DyaK287ls1Cnuw%3D%3D
-
(1995)
Neuromuscul Disord
, vol.5
, pp. 457-465
-
-
Swanson, N.R.1
Fox, S.A.2
Mastaglia, F.L.3
-
178
-
-
0031895401
-
The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis and in multiple sclerosis
-
9521273 1:STN:280:DyaK1c7otVGluw%3D%3D
-
I Torres-Aleman V Barrios J Berciano 1998 The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis and in multiple sclerosis Neurology 50 772 776 9521273 1:STN:280:DyaK1c7otVGluw%3D%3D
-
(1998)
Neurology
, vol.50
, pp. 772-776
-
-
Torres-Aleman, I.1
Barrios, V.2
Berciano, J.3
-
179
-
-
0024955336
-
Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis
-
2533530 1:STN:280:DyaK3c7ltVyltQ%3D%3D
-
D Troost JJ van den Oord JM de Jong DF Swaab 1989 Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis Clin Neuropathol 8 289 294 2533530 1:STN:280:DyaK3c7ltVyltQ%3D%3D
-
(1989)
Clin Neuropathol
, vol.8
, pp. 289-294
-
-
Troost, D.1
Van Den Oord, J.J.2
De Jong, J.M.3
Swaab, D.F.4
-
180
-
-
0025185079
-
Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis
-
2263315 10.1111/j.1365-2990.1990.tb01276.x 1:STN:280: DyaK3M%2FovVSjsg%3D%3D
-
D Troost JJ Van den Oord JM Vianney de Jong 1990 Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis Neuropathol Appl Neurobiol 16 401 410 2263315 10.1111/j.1365-2990.1990.tb01276. x 1:STN:280:DyaK3M%2FovVSjsg%3D%3D
-
(1990)
Neuropathol Appl Neurobiol
, vol.16
, pp. 401-410
-
-
Troost, D.1
Van Den Oord, J.J.2
Vianney De Jong, J.M.3
-
181
-
-
1842471942
-
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: An [11C](R)-PK11195 positron emission tomography study
-
15056468 10.1016/j.nbd.2003.12.012 1:CAS:528:DC%2BD2cXivVKmsro%3D
-
MR Turner A Cagnin FE Turkheimer CC Miller CE Shaw DJ Brooks PN Leigh RB Banati 2004 Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study Neurobiol Dis 15 601 609 15056468 10.1016/j.nbd.2003.12.012 1:CAS:528: DC%2BD2cXivVKmsro%3D
-
(2004)
Neurobiol Dis
, vol.15
, pp. 601-609
-
-
Turner, M.R.1
Cagnin, A.2
Turkheimer, F.E.3
Miller, C.C.4
Shaw, C.E.5
Brooks, D.J.6
Leigh, P.N.7
Banati, R.B.8
-
182
-
-
77950528523
-
Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice
-
Turner BJ, Ackerley S, Davies KE, Talbot K (2009) Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice. Hum Mol Genet
-
(2009)
Hum Mol Genet
-
-
Turner, B.J.1
Ackerley, S.2
Davies, K.E.3
Talbot, K.4
-
183
-
-
29444443348
-
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
-
16369483 10.1038/nn1603 1:CAS:528:DC%2BD2MXhtlCms7rF
-
M Urushitani A Sik T Sakurai N Nukina R Takahashi JP Julien 2006 Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis Nat Neurosci 9 108 118 16369483 10.1038/nn1603 1:CAS:528:DC%2BD2MXhtlCms7rF
-
(2006)
Nat Neurosci
, vol.9
, pp. 108-118
-
-
Urushitani, M.1
Sik, A.2
Sakurai, T.3
Nukina, N.4
Takahashi, R.5
Julien, J.P.6
-
184
-
-
33847787621
-
Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis
-
17277077 10.1073/pnas.0606201104 1:CAS:528:DC%2BD2sXisVSgt7w%3D
-
M Urushitani SA Ezzi JP Julien 2007 Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis Proc Natl Acad Sci USA 104 2495 2500 17277077 10.1073/pnas.0606201104 1:CAS:528:DC%2BD2sXisVSgt7w%3D
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2495-2500
-
-
Urushitani, M.1
Ezzi, S.A.2
Julien, J.P.3
-
185
-
-
42749097816
-
Crosstalk between astrocytes and motor neurons: What is the message?
-
10.1016/j.expneurol.2008.01.008 1:CAS:528:DC%2BD1cXlsF2qt7w%3D
-
L Van Den Bosch W Robberecht 2008 Crosstalk between astrocytes and motor neurons: what is the message? Exp Neurol 211 1 6 10.1016/j.expneurol.2008.01.008 1:CAS:528:DC%2BD1cXlsF2qt7w%3D
-
(2008)
Exp Neurol
, vol.211
, pp. 1-6
-
-
Van Den Bosch, L.1
Robberecht, W.2
-
186
-
-
0037067009
-
Minocycline delays disease onset and mortality in a transgenic model of ALS
-
10.1097/00001756-200206120-00018
-
L Van Den Bosch P Tilkin G Lemmens W Robberecht 2002 Minocycline delays disease onset and mortality in a transgenic model of ALS Neuroreport 13 1067 1070 10.1097/00001756-200206120-00018
-
(2002)
Neuroreport
, vol.13
, pp. 1067-1070
-
-
Van Den Bosch, L.1
Tilkin, P.2
Lemmens, G.3
Robberecht, W.4
-
188
-
-
61349162349
-
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
-
19251628 10.1126/science.1165942 1:CAS:528:DC%2BD1MXit1eltbs%3D
-
C Vance B Rogelj T Hortobagyi KJ De Vos AL Nishimura J Sreedharan X Hu B Smith D Ruddy P Wright J Ganesalingam KL Williams V Tripathi S Al-Saraj A Al-Chalabi PN Leigh IP Blair G Nicholson J de Belleroche JM Gallo CC Miller CE Shaw 2009 Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6 Science 323 1208 1211 19251628 10.1126/science.1165942 1:CAS:528:DC%2BD1MXit1eltbs%3D
-
(2009)
Science
, vol.323
, pp. 1208-1211
-
-
Vance, C.1
Rogelj, B.2
Hortobagyi, T.3
De Vos, K.J.4
Nishimura, A.L.5
Sreedharan, J.6
Hu, X.7
Smith, B.8
Ruddy, D.9
Wright, P.10
Ganesalingam, J.11
Williams, K.L.12
Tripathi, V.13
Al-Saraj, S.14
Al-Chalabi, A.15
Leigh, P.N.16
Blair, I.P.17
Nicholson, G.18
De Belleroche, J.19
Gallo, J.M.20
Miller, C.C.21
Shaw, C.E.22
more..
-
189
-
-
33645881327
-
Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis
-
16524372 10.1111/j.1471-4159.2006.03742.x 1:CAS:528:DC%2BD28XkslCjsrk%3D
-
MR Vargas M Pehar P Cassina JS Beckman L Barbeito 2006 Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis J Neurochem 97 687 696 16524372 10.1111/j.1471-4159.2006.03742.x 1:CAS:528:DC%2BD28XkslCjsrk%3D
-
(2006)
J Neurochem
, vol.97
, pp. 687-696
-
-
Vargas, M.R.1
Pehar, M.2
Cassina, P.3
Beckman, J.S.4
Barbeito, L.5
-
190
-
-
58149379610
-
Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
-
19074031 10.1523/JNEUROSCI.4099-08.2008 1:CAS:528:DC%2BD1cXhsFCqsb7N
-
MR Vargas DA Johnson DW Sirkis A Messing JA Johnson 2008 Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis J Neurosci 28 13574 13581 19074031 10.1523/JNEUROSCI.4099-08.2008 1:CAS:528:DC%2BD1cXhsFCqsb7N
-
(2008)
J Neurosci
, vol.28
, pp. 13574-13581
-
-
Vargas, M.R.1
Johnson, D.A.2
Sirkis, D.W.3
Messing, A.4
Johnson, J.A.5
-
191
-
-
0035132168
-
Absence of echovirus sequences in brain and spinal cord of amyotrophic lateral sclerosis patients
-
11221802 10.1002/1531-8249(20010201)49:2 <249::AID-ANA46>3.0.CO;2-3 1:CAS:528:DC%2BD3MXhsVymurs%3D
-
MP Walker R Schlaberg AP Hays R Bowser WI Lipkin 2001 Absence of echovirus sequences in brain and spinal cord of amyotrophic lateral sclerosis patients Ann Neurol 49 249 253 11221802 10.1002/1531-8249(20010201)49:2<249:: AID-ANA46>3.0.CO;2-3 1:CAS:528:DC%2BD3MXhsVymurs%3D
-
(2001)
Ann Neurol
, vol.49
, pp. 249-253
-
-
Walker, M.P.1
Schlaberg, R.2
Hays, A.P.3
Bowser, R.4
Lipkin, W.I.5
-
192
-
-
0036076642
-
Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site
-
12127151 10.1006/nbdi.2002.0498 1:CAS:528:DC%2BD38XltFyrtb8%3D
-
J Wang G Xu V Gonzales M Coonfield D Fromholt NG Copeland NA Jenkins DR Borchelt 2002 Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site Neurobiol Dis 10 128 138 12127151 10.1006/nbdi.2002.0498 1:CAS:528: DC%2BD38XltFyrtb8%3D
-
(2002)
Neurobiol Dis
, vol.10
, pp. 128-138
-
-
Wang, J.1
Xu, G.2
Gonzales, V.3
Coonfield, M.4
Fromholt, D.5
Copeland, N.G.6
Jenkins, N.A.7
Borchelt, D.R.8
-
193
-
-
64549124726
-
Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse
-
19233858 10.1093/hmg/ddp085 1:CAS:528:DC%2BD1MXksVeitbg%3D
-
L Wang HX Deng G Grisotti H Zhai T Siddique RP Roos 2009 Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse Hum Mol Genet 18 1642 1651 19233858 10.1093/hmg/ddp085 1:CAS:528:DC%2BD1MXksVeitbg%3D
-
(2009)
Hum Mol Genet
, vol.18
, pp. 1642-1651
-
-
Wang, L.1
Deng, H.X.2
Grisotti, G.3
Zhai, H.4
Siddique, T.5
Roos, R.P.6
-
194
-
-
67649486844
-
The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis
-
19442735 10.1016/j.nbd.2009.05.002 1:CAS:528:DC%2BD1MXotFCgt7o%3D
-
L Wang K Sharma G Grisotti RP Roos 2009 The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis Neurobiol Dis 35 234 240 19442735 10.1016/j.nbd.2009.05.002 1:CAS:528:DC%2BD1MXotFCgt7o%3D
-
(2009)
Neurobiol Dis
, vol.35
, pp. 234-240
-
-
Wang, L.1
Sharma, K.2
Grisotti, G.3
Roos, R.P.4
-
195
-
-
0344734124
-
Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice
-
9729335 10.1016/S0006-8993(98)00618-0 1:CAS:528:DyaK1cXltlensLw%3D
-
J Wegiel HM Wisniewski J Dziewiatkowski M Tarnawski R Kozielski E Trenkner W Wiktor-Jedrzejczak 1998 Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice Brain Res 804 135 139 9729335 10.1016/S0006-8993(98)00618-0 1:CAS:528:DyaK1cXltlensLw%3D
-
(1998)
Brain Res
, vol.804
, pp. 135-139
-
-
Wegiel, J.1
Wisniewski, H.M.2
Dziewiatkowski, J.3
Tarnawski, M.4
Kozielski, R.5
Trenkner, E.6
Wiktor-Jedrzejczak, W.7
-
196
-
-
73249152831
-
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
-
19833869 10.1073/pnas.0908767106
-
I Wegorzewska S Bell NJ Cairns TM Miller RH Baloh 2009 TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration Proc Natl Acad Sci USA 106 18809 18814 19833869 10.1073/pnas.0908767106
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 18809-18814
-
-
Wegorzewska, I.1
Bell, S.2
Cairns, N.J.3
Miller, T.M.4
Baloh, R.H.5
-
197
-
-
9144230806
-
Increased cytotoxic potential of microglia from ALS-transgenic mice
-
15378658 10.1002/glia.20062
-
P Weydt EC Yuen BR Ransom T Moller 2004 Increased cytotoxic potential of microglia from ALS-transgenic mice Glia 48 179 182 15378658 10.1002/glia.20062
-
(2004)
Glia
, vol.48
, pp. 179-182
-
-
Weydt, P.1
Yuen, E.C.2
Ransom, B.R.3
Moller, T.4
-
198
-
-
0020462249
-
Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation
-
7130905 10.1084/jem.156.5.1516 1:STN:280:DyaL3s%2Fjt1eqtw%3D%3D
-
WW Wiktor-Jedrzejczak A Ahmed C Szczylik RR Skelly 1982 Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation J Exp Med 156 1516 1527 7130905 10.1084/jem.156.5.1516 1:STN:280:DyaL3s%2Fjt1eqtw%3D%3D
-
(1982)
J Exp Med
, vol.156
, pp. 1516-1527
-
-
Wiktor-Jedrzejczak, W.W.1
Ahmed, A.2
Szczylik, C.3
Skelly, R.R.4
-
199
-
-
0142226956
-
Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: Further evidence for microglial activation in neurodegeneration
-
14597108 10.1016/j.jneuroim.2003.08.042 1:CAS:528:DC%2BD3sXosFSlsLY%3D
-
H Wilms J Sievers R Dengler J Bufler G Deuschl R Lucius 2003 Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration J Neuroimmunol 144 139 142 14597108 10.1016/j.jneuroim.2003.08.042 1:CAS:528:DC%2BD3sXosFSlsLY%3D
-
(2003)
J Neuroimmunol
, vol.144
, pp. 139-142
-
-
Wilms, H.1
Sievers, J.2
Dengler, R.3
Bufler, J.4
Deuschl, G.5
Lucius, R.6
-
200
-
-
77649269011
-
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
-
20133711 10.1073/pnas.0912417107
-
H Wils G Kleinberger J Janssens S Pereson G Joris I Cuijt V Smits C Ceuterick-de Groote C Van Broeckhoven S Kumar-Singh 2010 TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration Proc Natl Acad Sci USA 107 3858 3863 20133711 10.1073/pnas.0912417107
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 3858-3863
-
-
Wils, H.1
Kleinberger, G.2
Janssens, J.3
Pereson, S.4
Joris, G.5
Cuijt, I.6
Smits, V.7
Ceuterick-De Groote, C.8
Van Broeckhoven, C.9
Kumar-Singh, S.10
-
201
-
-
0029053881
-
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
-
7605627 10.1016/0896-6273(95)90259-7 1:CAS:528:DyaK2MXms1Wrtr8%3D
-
PC Wong CA Pardo DR Borchelt MK Lee NG Copeland NA Jenkins SS Sisodia DW Cleveland DL Price 1995 An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria Neuron 14 1105 1116 7605627 10.1016/0896-6273(95)90259-7 1:CAS:528:DyaK2MXms1Wrtr8%3D
-
(1995)
Neuron
, vol.14
, pp. 1105-1116
-
-
Wong, P.C.1
Pardo, C.A.2
Borchelt, D.R.3
Lee, M.K.4
Copeland, N.G.5
Jenkins, N.A.6
Sisodia, S.S.7
Cleveland, D.W.8
Price, D.L.9
-
202
-
-
33747047814
-
The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice
-
16877542 10.1073/pnas.0603670103 1:CAS:528:DC%2BD28Xotlyhsbc%3D
-
DC Wu DB Re M Nagai H Ischiropoulos S Przedborski 2006 The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice Proc Natl Acad Sci USA 103 12132 12137 16877542 10.1073/pnas.0603670103 1:CAS:528:DC%2BD28Xotlyhsbc%3D
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 12132-12137
-
-
Wu, D.C.1
Re, D.B.2
Nagai, M.3
Ischiropoulos, H.4
Przedborski, S.5
-
203
-
-
0036685522
-
Inflammation in neurodegenerative disease - A double-edged sword
-
12165466 10.1016/S0896-6273(02)00794-8 1:CAS:528:DC%2BD38Xmt12isrs%3D
-
T Wyss-Coray L Mucke 2002 Inflammation in neurodegenerative disease-a double-edged sword Neuron 35 419 432 12165466 10.1016/S0896-6273(02)00794-8 1:CAS:528:DC%2BD38Xmt12isrs%3D
-
(2002)
Neuron
, vol.35
, pp. 419-432
-
-
Wyss-Coray, T.1
Mucke, L.2
-
204
-
-
34548233140
-
Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia
-
17555556 10.1111/j.1471-4159.2007.04677.x 1:CAS:528:DC%2BD2sXhtVyksb7I
-
Q Xiao W Zhao DR Beers AA Yen W Xie JS Henkel SH Appel 2007 Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia J Neurochem 102 2008 2019 17555556 10.1111/j.1471-4159.2007.04677.x 1:CAS:528:DC%2BD2sXhtVyksb7I
-
(2007)
J Neurochem
, vol.102
, pp. 2008-2019
-
-
Xiao, Q.1
Zhao, W.2
Beers, D.R.3
Yen, A.A.4
Xie, W.5
Henkel, J.S.6
Appel, S.H.7
-
205
-
-
44649152645
-
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice
-
18492803 10.1073/pnas.0802556105
-
K Yamanaka S Boillee EA Roberts ML Garcia M McAlonis-Downes OR Mikse DW Cleveland LS Goldstein 2008 Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice Proc Natl Acad Sci USA 105 7594 7599 18492803 10.1073/pnas.0802556105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 7594-7599
-
-
Yamanaka, K.1
Boillee, S.2
Roberts, E.A.3
Garcia, M.L.4
McAlonis-Downes, M.5
Mikse, O.R.6
Cleveland, D.W.7
Goldstein, L.S.8
-
206
-
-
39749188753
-
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
-
18246065 10.1038/nn2047 1:CAS:528:DC%2BD1cXisFOrurw%3D
-
K Yamanaka SJ Chun S Boillee N Fujimori-Tonou H Yamashita DH Gutmann R Takahashi H Misawa DW Cleveland 2008 Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis Nat Neurosci 11 251 253 18246065 10.1038/nn2047 1:CAS:528:DC%2BD1cXisFOrurw%3D
-
(2008)
Nat Neurosci
, vol.11
, pp. 251-253
-
-
Yamanaka, K.1
Chun, S.J.2
Boillee, S.3
Fujimori-Tonou, N.4
Yamashita, H.5
Gutmann, D.H.6
Takahashi, R.7
Misawa, H.8
Cleveland, D.W.9
-
207
-
-
0035949799
-
Marked increase in cyclooxygenase-2 in ALS spinal cord: Implications for therapy
-
11571316 1:CAS:528:DC%2BD3MXnsVCnsb8%3D
-
K Yasojima WW Tourtellotte EG McGeer PL McGeer 2001 Marked increase in cyclooxygenase-2 in ALS spinal cord: implications for therapy Neurology 57 952 956 11571316 1:CAS:528:DC%2BD3MXnsVCnsb8%3D
-
(2001)
Neurology
, vol.57
, pp. 952-956
-
-
Yasojima, K.1
Tourtellotte, W.W.2
McGeer, E.G.3
McGeer, P.L.4
-
208
-
-
33645224970
-
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
-
16512913 10.1186/1471-2377-6-12 1:CAS:528:DC%2BD28XmtVWkurw%3D
-
Y Yiangou P Facer P Durrenberger IP Chessell A Naylor C Bountra RR Banati P Anand 2006 COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord BMC Neurol 6 12 16512913 10.1186/1471-2377-6-12 1:CAS:528:DC%2BD28XmtVWkurw%3D
-
(2006)
BMC Neurol
, vol.6
, pp. 12
-
-
Yiangou, Y.1
Facer, P.2
Durrenberger, P.3
Chessell, I.P.4
Naylor, A.5
Bountra, C.6
Banati, R.R.7
Anand, P.8
-
209
-
-
0036269810
-
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis
-
11796754 10.1046/j.0022-3042.2001.00683.x 1:CAS:528: DC%2BD38Xjt1aisg%3D%3D
-
T Yoshihara S Ishigaki M Yamamoto Y Liang J Niwa H Takeuchi M Doyu G Sobue 2002 Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis J Neurochem 80 158 167 11796754 10.1046/j.0022-3042.2001. 00683.x 1:CAS:528:DC%2BD38Xjt1aisg%3D%3D
-
(2002)
J Neurochem
, vol.80
, pp. 158-167
-
-
Yoshihara, T.1
Ishigaki, S.2
Yamamoto, M.3
Liang, Y.4
Niwa, J.5
Takeuchi, H.6
Doyu, M.7
Sobue, G.8
-
210
-
-
0033539522
-
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
-
10557349 10.1073/pnas.96.23.13496 1:CAS:528:DyaK1MXns1GmurY%3D
-
J Yrjanheikki T Tikka R Keinanen G Goldsteins PH Chan J Koistinaho 1999 A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window Proc Natl Acad Sci USA 96 13496 13500 10557349 10.1073/pnas.96.23.13496 1:CAS:528:DyaK1MXns1GmurY%3D
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13496-13500
-
-
Yrjanheikki, J.1
Tikka, T.2
Keinanen, R.3
Goldsteins, G.4
Chan, P.H.5
Koistinaho, J.6
-
211
-
-
33750442559
-
Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia
-
17018025 10.1111/j.1471-4159.2006.04172.x 1:CAS:528:DC%2BD28Xht1yks7jM
-
W Zhao W Xie Q Xiao DR Beers SH Appel 2006 Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia J Neurochem 99 1176 1187 17018025 10.1111/j.1471-4159.2006. 04172.x 1:CAS:528:DC%2BD28Xht1yks7jM
-
(2006)
J Neurochem
, vol.99
, pp. 1176-1187
-
-
Zhao, W.1
Xie, W.2
Xiao, Q.3
Beers, D.R.4
Appel, S.H.5
-
212
-
-
33644934738
-
Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity
-
16442504 10.1016/j.brainres.2005.12.061 1:CAS:528:DC%2BD28Xis1Squrg%3D
-
X Zhao Z Ou JC Grotta N Waxham J Aronowski 2006 Peroxisome-proliferator- activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity Brain Res 1073-1074 460 469 16442504 10.1016/j.brainres.2005.12. 061 1:CAS:528:DC%2BD28Xis1Squrg%3D
-
(2006)
Brain Res
, vol.1073-1074
, pp. 460-469
-
-
Zhao, X.1
Ou, Z.2
Grotta, J.C.3
Waxham, N.4
Aronowski, J.5
-
214
-
-
41149097086
-
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
-
18344992 10.1038/nn2073 1:CAS:528:DC%2BD1cXjslSrt7s%3D
-
Z Zhong R Deane Z Ali M Parisi Y Shapovalov MK O'Banion K Stojanovic A Sagare S Boillee DW Cleveland BV Zlokovic 2008 ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration Nat Neurosci 11 420 422 18344992 10.1038/nn2073 1:CAS:528:DC%2BD1cXjslSrt7s%3D
-
(2008)
Nat Neurosci
, vol.11
, pp. 420-422
-
-
Zhong, Z.1
Deane, R.2
Ali, Z.3
Parisi, M.4
Shapovalov, Y.5
O'Banion, M.K.6
Stojanovic, K.7
Sagare, A.8
Boillee, S.9
Cleveland, D.W.10
Zlokovic, B.V.11
-
215
-
-
70449433875
-
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
-
19841542 1:CAS:528:DC%2BD1MXhtlOitrbJ
-
Z Zhong H Ilieva L Hallagan R Bell I Singh N Paquette M Thiyagarajan R Deane JA Fernandez S Lane AB Zlokovic T Liu JH Griffin N Chow FJ Castellino K Stojanovic DW Cleveland BV Zlokovic 2009 Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells J Clin Invest 119 3437 3449 19841542 1:CAS:528: DC%2BD1MXhtlOitrbJ
-
(2009)
J Clin Invest
, vol.119
, pp. 3437-3449
-
-
Zhong, Z.1
Ilieva, H.2
Hallagan, L.3
Bell, R.4
Singh, I.5
Paquette, N.6
Thiyagarajan, M.7
Deane, R.8
Fernandez, J.A.9
Lane, S.10
Zlokovic, A.B.11
Liu, T.12
Griffin, J.H.13
Chow, N.14
Castellino, F.J.15
Stojanovic, K.16
Cleveland, D.W.17
Zlokovic, B.V.18
-
216
-
-
77950421249
-
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene
-
20361056 10.1371/journal.pgen.1000887 1:CAS:528:DC%2BC3cXksFeiur8%3D
-
H Zhou C Huang H Chen D Wang CP Landel PY Xia R Bowser YJ Liu XG Xia 2010 Transgenic rat model of neurodegeneration caused by mutation in the TDP gene PLoS Genet 6 3 e1000887 20361056 10.1371/journal.pgen.1000887 1:CAS:528:DC%2BC3cXksFeiur8%3D
-
(2010)
PLoS Genet
, vol.6
, Issue.3
, pp. 1000887
-
-
Zhou, H.1
Huang, C.2
Chen, H.3
Wang, D.4
Landel, C.P.5
Xia, P.Y.6
Bowser, R.7
Liu, Y.J.8
Xia, X.G.9
-
217
-
-
0037007645
-
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
-
11986668 10.1038/417074a 1:CAS:528:DC%2BD38XjsFOgtbg%3D
-
S Zhu IG Stavrovskaya M Drozda BY Kim V Ona M Li S Sarang AS Liu DM Hartley DC Wu S Gullans RJ Ferrante S Przedborski BS Kristal RM Friedlander 2002 Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice Nature 417 74 78 11986668 10.1038/417074a 1:CAS:528:DC%2BD38XjsFOgtbg%3D
-
(2002)
Nature
, vol.417
, pp. 74-78
-
-
Zhu, S.1
Stavrovskaya, I.G.2
Drozda, M.3
Kim, B.Y.4
Ona, V.5
Li, M.6
Sarang, S.7
Liu, A.S.8
Hartley, D.M.9
Wu, D.C.10
Gullans, S.11
Ferrante, R.J.12
Przedborski, S.13
Kristal, B.S.14
Friedlander, R.M.15
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