Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity

Molecular Therapy

Volumn 16, Issue 6, 2008, Pages 1056-1064

  Dodge, James C ^a   Haidet, Amanda M ^b,c   Yang, Wendy ^a   Passini, Marco A ^a   Hester, Mark ^a   Clarke, Jennifer ^a   Roskelley, Eric M ^a   Treleaven, Christopher M ^a   Rizo, Liza ^b   Martin, Heather ^b   Kim, Soo H ^b,c   Kaspar, Rita ^b,c   Taksir, Tatyana V ^a   Griffiths, Denise A ^a   Cheng, Seng H ^a   Shihabuddin, Lamya S ^a   Kaspar, Brian K ^b,c  

^a GENZYME CORPORATION   (United States)

^b THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; PARVOVIRUS VECTOR; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CENTRAL NERVOUS SYSTEM; CEREBELLUM NUCLEUS; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GLIA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; MUSCLE STRENGTH; NEUROPROTECTION; NONHUMAN; SURVIVAL TIME; VIRAL GENE DELIVERY SYSTEM;

MUS; RODENTIA;

EID: 44349162407     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.60     Document Type: Article

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