RANTES levels are elevated in serum and cerebrospinal fluid in patients with amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis

Volumn 8, Issue 5, 2007, Pages 283-287

  Rentzos, Michael ^a   Nikolaou, Chryssoula ^b   Rombos, Antonis ^a   Boufidou, Fotini ^b   Zoga, Margarita ^b   Dimitrakopoulos, Antonis ^a   Tsoutsou, Anthousa ^b   Vassilopoulos, Demetrios ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Activated microglia; Amyotrophic lateral sclerosis; Cerebrospinal fluid; ELISA; RANTES; Serum

Indexed keywords

CHEMOKINE; RANTES; T LYMPHOCYTE ANTIGEN;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOPATHOGENESIS; IMMUNOREGULATION; IMMUNOSTIMULATION; MALE; MONOCYTE; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; REGRESSION ANALYSIS; T LYMPHOCYTE;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; CHEMOKINE CCL5; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC;

EID: 35148846456     PISSN: 17482968     EISSN: 1471180X     Source Type: Journal    
DOI: 10.1080/17482960701419232     Document Type: Article

References (30)

1. Eisen, A. (1995) Amyotrophic lateral sclerosis is a multifactorial disease. Muscle and Nerve, 18, pp. 741-752.
2. McGeer, E. G. and McGeer, P. L. (1994) Neurodegeneration and the immune system. Neurodegenerative diseases, pp. 277-299. Saunders, Philadelphia
3. Smith, R. G., Enghelhardt, J. T., Tajti, J. and Appel, S. H. (1993) Experimental immune-mediated motor neuron disease: Models for human ALS. Brain Res Bull, 30, pp. 373-380.
4. Appel, S. H., Stockton-Appel, V., Stewart, S. S. and Kerman, R. H. (1986) Amyotrophic lateral sclerosis. Associated clinical disorders and immunological evaluations. Arch Neurol, 43, pp. 224-238.
5. Younger, D. S., Rowland, L. P., Latov, N., Sherman, W., Pesce, M. and Lange, D. J. (1990) Motor neuron disease and amyotrophic lateral sclerosis: Relation of high CSF protein content to paraproteinaemia and clinical syndromes. Neurology, 40, pp. 595-599.
6. Pestronk, A., Adams, R. N., Clauson, L., Cornblath, D., Kuncl, R. W. and Griffin, D. (1988) Serum antibodies to GM1 ganglioside in amyotrophic lateral sclerosis. Neurology, 38, pp. 1457-1461.
7. Latov, N., Hays, A. P., Donofrio, P. D., Liao, J., Ito, H. and McGinnis, S. (1988) Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron diseases. Neurology, 38, pp. 763-768.
8. Fratantoni, S. A., Weisz, G., Pardal, A. M., Reisin, R. C. and Uchitel, O. D. (2000) Amyotrophic lateralsclerosis IgG treated neuromuscular junctions develop sensitivity to L-type calcium channel blocker. Muscle Nerve, 23, pp. 543-550.
9. Benadar, M. (1999) Antibodies from ALS patients inhibit dopamine release mediated by L-type calcium channels. Neurology, 52, pp. 1520-1521.
10. Apostolski, S., Nikolic, J., Bugarski-Prokopljevic, C., Miletic, V., Pavlovic, S. and Filipovic, S. (1991) Serum and CSF immunological findings in ALS. Acta Neurol Scand, 83, pp. 96-98.
11. Troost, D., Oord, J. J. van den and de Jong, J. M. Vianney (1990) Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol, 16, pp. 401-410.
12. Enghelhartdt, J. I. and Appel, S. H. (1990) IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis. Arch Neurol, 47, pp. 1210-1216.
13. Ono, S., Hu, J., Shimizu, N., Imai, T. and Nakagawa, H. (2001) Increased interleukin-6 of skin and serum in amyotrophic lateral sclerosis. J Neurol Sci, 187, pp. 27-34.
14. Panzara, M. A., Gussoni, E., Begovich, A. B., Murray, R. S., Zang, Y. Q. and Appel, S. H. (1999) T-cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic multiple sclerosis. Neurobiol Dis, 6, pp. 392-405.
15. Sekizawa, T., Openshaw, H., Obbo, K., Sugamura, K., Itoyama, Y. and Niland, J. C. (1998) Cerebrospinal fluid interleukin-6 in amyotrophic lateral sclerosis: Immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases. J Neurol Sci, 154, pp. 194-199.
16. Moser, B. and Loetscher, P. (2001) Lymphocyte traffic control by chemokines. Nat Immunol, 2, pp. 123-128.
17. Luster, A. (1998) Chemokines: Chemotactic cytokines that mediate inflammation. N Engl J Med, 338, pp. 436-445.
18. Iarlori, C., Gambi, D., Gambi, F., Lucci, I., Feliciani, C. and Salvatore, M. (2005) Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer's disease. Exp Gerontol, 40, pp. 605-611.
19. Bartosik-Psujek, H. and Stelmasiak, Z. (2005) The levels of chemokines CXCL8, CCL2 and CCL5 in multiple sclerosis patients are linked to the activity of the disease. Eur J Neurol, 12, pp. 49-54.
20. Andavolou, R. G., Comings, D. E., MacMurray, J., Vuthoori, R. K., Tourtellotte, W. W. and Nagra, R. M. (2004) RANTES: A genetic risk marker for multiple sclerosis. Mult Scler, 10, pp. 536-539.
21. Johnstone, M., Gearing, A. J. and Miller, K. M. (1999) A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced. J Neuroimmunol, 93, pp. 182-193.
22. Bona, E., Andersson, A. L., Blomgren, K., Gilland, E., Puka-Sundvall, M. and Gustafson, K. (1999) Chemokine and inflammatory cell response to hypoxia-ischaemia in immature rats. Pediatr Res, 45, pp. 500-509.
23. Brooks, B., Miller, R., Swash, M. and Munsat, T. (2000) El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis, 1, pp. 293-299.
24. Hensley, K., Fedynyshyn, J., Ferrell, S., Floyd, R. A., Gordon, B. and Grammas, P. (2003) Message and protein-level elevation of tumour necrosis factor a (TNFa) and TNFa-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis. Neurobiol Dis, 14, pp. 74-80.
25. Kawamata, T., Akiyama, H., Yamada, T. and McGeer, P. L. (1992) Immunological reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol, 140, pp. 691-707.
26. Baron, P., Bussini, S., Cardin, V., Corbo, M., Conti, G. and Galimberti, D. (2005) Production of monocyte chemo-attractant protein-1 in amyotrophic lateral sclerosis. Muscle and Nerve, 32, pp. 541-544.
27. Simpson, E., Henry, Y., Henkel, J., Smith, R. and Appel, S. (2004) Increased lipid peroxidation in sera of ALS patients. A potential biomarker of disease burden. Neurol, 64, pp. 1758-1765.
28. Henkel, J. S., Enghelhardt, J. I., Siklos, L., Simpson, E. P., Kim, S. H. and Pan, T. (2004) Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Ann Neurol, 55, pp. 221-235.
29. Wilms, H., Sievers, J., Dengler, R., Buffler, J., Deuschl, G. and Lucius, R. (2003) Intrathecal synthesis of monocyte chemo-attractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: Further evidence for microglial activation in neurodegeneration. J of Neuroimmunol, 144, pp. 139-142.
30. Opdenakker, G., Nelissen, I. and van Damme, J. (2003) Functional roles and therapeutic targeting of gelatinase B and chemokines in multiple sclerosis. Lancet Neurol, 2, pp. 747-756.