Base excision repair in a network of defence and tolerance

Carcinogenesis

Volumn 22, Issue 7, 2001, Pages 987-998

  Nilsen, Hilde ^a,b   Krokan, Hans E ^a,b  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; APC PROTEIN; BETA GLOBULIN; CYTOSINE; DNA; DNA GLYCOSYLTRANSFERASE; DNA POLYMERASE; GUANINE; HYPOXANTHINE; POLYUNSATURATED FATTY ACID; PURINE; PYRIMIDINE; REACTIVE OXYGEN METABOLITE; URACIL; WATER; XANTHINE;

ALKYLATION; ALLELE; ANIMAL CELL; ARTICLE; BASE MISPAIRING; CANCER CELL CULTURE; CARCINOGENESIS; CELL MEMBRANE; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DEAMINATION; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; EXCISION REPAIR; GENE MUTATION; GENETIC STABILITY; GENETIC TRANSCRIPTION; GENOME; HUMAN; HUMAN CELL; HYDROLYSIS; INHERITANCE; KNOCKOUT MOUSE; LIPID PEROXIDATION; MICROSATELLITE INSTABILITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATOR GENE;

EID: 0034930217     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.7.987     Document Type: Article

References (184)

1. + genes in Escherichia coli: Identification of gene products and effects on alkylation resistance
2. Release of normal bases from intact DNA by a native DNA repair enzyme
3. Generation of a strong mutator phenotype in yeast by imbalanced base excision repair
4. Overexpression of DNA polymerase β in cell results in a mutator phenotype and decreased sensitivity to anticancer drugs
5. Molecular interaction map of the mammalian cell cycle control and DNA repair systems
6. A phylogenomic study of DNA repair genes, proteins and processes
7. Damage repertoire of the Escherichia coli UvrABC nuclease complex includes abasic sites, base-damage analogues and lesions containing adjacent 5′ or 3′ nicks
8. Evidence for the involvement of nucleotide excision repair in the removal of abasic sites in yeast
9. Repair of chromosomal abasic sites in vivo involves at least three different repair pathways
10. Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage: Version 4
11. Instability and decay of the primary structure of DNA
12. Quality control by DNA repair
13. Rate of depurination of native DNA
14. Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions
15. Heat-induced deamination of cytosine residues in deoxyribonucleic acid
16. A sensitive genetic assay for the detection of cytosine deamination: Determination of rate constants and activation energy
17. The rate of hydrolytic deamination of 5-methyl cytosine in double-stranded DNA
18. Oxyradicals and DNA damage
19. Thymine glycols and urea residues in M13 DNA constitute replicative blocks in vitro
20. Possible role for thymine glycol in the selective inhibition of DNA synthesis on oxidized DNA templates
21. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
22. Internal hazards: Baseline DNA damage by endogenous products of normal metabolism
23. The base excision repair pathway
24. DNA glycosylases in the base excision repair of DNA
25. Envisioning the molecular choreography of DNA base excision repair
26. Initiation of base excision repair: Glycosylase mechanisms and structures
27. Base excision repair of DNA in mammalian cells
28. Passing the baton in base excision repair
29. DNA repair mechanisms for the recognition and removal of damaged DNA bases
30. Recent progress in the biology, chemistry and structural biology of DNA glycosylases
31. DNA N-glycosidases: Properties of uracil-DNA glycosidase from Escherichia coli
32. Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme
33. Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene
34. Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase
35. Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors
36. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
37. Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase
38. Isolation and structure of a cDNA expressing a mammalian 3-methyladenine-DNA glycosylase
39. Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere
40. Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae
41. Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
42. Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III
43. Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage
44. Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein
45. Structure of the DNA repair enzyme endonuclease IV and its DNA complex: Double-nucleotide flipping at abasic sites and three-metalion catalysis
46. Base excision repair of oxidative DNA damage activated by XPG protein
47. Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts
48. The type of DNA glycosylase determines the base excision repair pathway in mammalian cells
49. Second pathway for completion of human DNA base excision-repair: Reconstitution with purified proteins and requirement for DNase IV (FEN1)
50. Reconsitution of DNA base excision-repair with purified human proteins: Interaction between polymerase β and the XRCC1 protein
51. Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts
52. Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway
53. Different DNA polymerases are involved in the short-and long-patch base excision repair in mammalian cells
54. Mapping of the 5′-2-deoxyribose-5-phosphate lyase active site in DNA polymerase β by mass spectrometry
55. Requirement of mammalian DNA polymerase-β in base-excision repair
56. Characterization of the DNA polymerase requirement of human base excision repair
57. Role of DNA repair polymerase β in the excision step of long patch mammalian base excision repair
58. The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity
59. XRCC1 protein interacts with one of two distinct forms of DNA ligase III
60. Structure and function of mammalian DNA ligases
61. Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair
62. Mammalian base excision repair by DNA polymerases δ and ε
63. Proliferating cell nuclear antigen facilities excision in long-patch base excision repair
64. Reconsitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins
65. Long patch base excision repair with purified human proteins
66. Protein-PCNA interactions: A DNA-scanning mechanisms?
67. A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A
68. Post-replication base excision repair in replication foci
69. Replication protein A stimulates long patch DNA base excision repair
70. Replication protein A stimulates proliferating cell nuclear antigen-dependent repair of abasic sites in DNA by human cell extracts
71. An interaction between DNA ligase I and proliferating cell nuclear antigen: Implications for Okazaki fragment synthesis and joining
72. Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil-DNA glycosylase
73. Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase
74. Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA
75. Characterization of DNA polymerase β mRNA: Cell-cycle and growth response in cultured human cells
76. Further purification and characterization of a multienzyme complex for DNA synthesis in human cells
77. DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen. Identification of a common targeting mechanism for the assembly of replication factories
78. 1 to control the phosphorylation status of DNA ligase I
79. A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair
80. Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase
81. Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate
82. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication
83. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice
84. Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing
85. Identification and characterization of Ref-1, a nuclear protein that facilitate AP-1 DNA binding activity
86. Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs
87. Deletion of a DNA polymerase β gene segment in T-cells using cell type-specific gene targeting
88. Mice reconstituted with DNA polymerase β-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally
89. Evidence for a role for DNA polymerase β in mammalian meiosis
90. Requirement for the Xrcc1 DNA base excision repair gene during early mouse development
91. DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability
92. Specific interaction of DNA polymerase β and DNA ligase I in a multiprotein base excision repair complex from bovine testis
93. Control of Drosophila deoxyuridine triphosphatase. Existence of a developmentally expressed protein inhibitor
94. The presence of uracil-DNA glycosylase in insects is dependent on developmental complexity
95. Why do pupating insects lack an activity for the repair of uracil-containing DNA? One explanation involves apoptosis
96. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3
97. Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA
98. Molecular biology of ageing
99. Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria
100. Caloric restriction and aging
101. Immunolocalization of 8-oxoguanine in nutrient-deprived mammalian tissue culture cells
102. - strain of Escherichia coli
103. Mutagenic deamination of cytosine residues in DNA
104. Specific mutator effects of ung (uracil-DNA glycosylase) mutations in Escherichia coli
105. - strain of Escherichia coli
106. Genetic analysis of transcription-associated mutation in Saccharomyces cerevisiae
107. Novel substrates of Escherichia coli nth protein and its kinetics for excision of modified bases from DNA damaged by free radicals
108. Saccharomyces cerevisiae Ntg1p and Ntg2p: Broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria
109. Oxidative base damage to DNA: Specificity of base excision repair enzymes
110. Spontaneous and osmium tetroxide-induced mutagenesis in an Escherichia coli strain deficient in both endonuclease III and endonuclease VIII
111. The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast
112. Substrate spectrum of human excinuclease: Repair of abasic sites, methylated bases, mismatches and bulky adducts
113. In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in xeroderma pigmentosum patients
114. Defective transcription-coupled repair of oxidative base damage in Cockaynes syndrome from XP group G
115. Transcription-coupled repair of 8-oxoGuanine: Requirements for XPG, TFIIH and CSB and implications for Cockayne syndrome
116. Single nucleotide patch base excision repair is the major pathway for removal of thymine glycol from DNA in human cell extracts
117. Transcription coupled repair of 8-oxoguanine in murine cells: The ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences
118. A new mechanism for repairing oxidative damage to DNA: (A)BC excinuclease removes AP sites and thymine glycols from DNA
119. Overlapping specificities of base excision repair, nucleotide excision repair, recombination and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae
120. Synergism between yeast nucleotide and base excision repair pathways in the protection against methylation damage
121. Contribution of base excision repair, nucleotide excision repair and DNA recombination to alkylation resistance of the fission yeast Saccharomyces pombe
122. Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase
123. Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase
124. Uracil incorporation: A source of pulse-labelled DNA fragments in the replication of the Escerichia coli chromosome
125. Synthesis and metabolism of uracil-containing deoxyribonucleic acid in Escherichia coli
126. Multiple mutant of Escherichia coli synthesising virtually thymineless DNA during limited growth
127. Folate deficiency causes uracil misincorporation into human DNA and chromosomal breakage: Implications for cancer and neuronal damage
128. Uracil misincorporation, DNA strand-breaks and gene amplification are associated with tumourigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells
129. Methotrexate-induced misincorporation of uracil into DNA
130. Induction of fragile sites by fluorodeoxyuridine and caffeine accompanies with misincorporation of endogenous uridine nucleotide into DNA of feline fibroblasts
131. Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase
132. Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells
133. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults
134. Cancer prevention and diet: Help from single nucleotide polymorphisms
135. The contribution of exogenous and endogenous mutagens to in vivo mutations
136. DNA methylation: Past, present and future directions
137. Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog
138. Fidelity and mutational specificity of uracil-initiated base excision DNA repair synthesis in human glioblastoma cell extracts
139. The fidelity of DNA polymerase β during distributive and processive DNA synthesis
140. Endogenous lesions, S-phase-independent spontaneous mutations and evolutionary strategies for base excision repair
141. Deoxyuridine misincorporation causes site-specific mutational lesion in the lacI gene of Escherichia coli
142. A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein
143. Werner syndrome protein. II. Characterization of the integral 3′→5′ DNA exonuclease
144. p53 protein exhibits 3′ to 5′ exonuclease activity
145. Different regulation of the p53 core domain activities 3′-to-5′ exonuclease and sequence-specific DNA binding
146. The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of double-strand breaks
147. Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery
148. Transcription-coupled repair. Which lesions? Which diseases?
149. Illusory defects and mismatches: Why must DNA repair always be (slightly) error prone?
150. Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
151. Solution structure of the single-strand break repair protein XRCC1 N-terminal domain
152. Eukaryotic DNA polymerases, a growing family
153. The many faces of DNA polymerases: Strategies for mutagenesis and for mutational avoidance
154. Low fidelity DNA synthesis by human polymerase η
155. Poliota, a remarkably error-prone human DNA polymerase
156. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
157. Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein DinB
158. Rates of spontaneous mutation
159. How precisely can data from transgenic mouse mutation-detection systems be extrapolated to humans? : Lessons from the human factor IX gene
160. The high spontaneous mutation rate: Is it a health risk?
161. Evolution and the inevitability of human cancer
162. Estimation of mutation frequencies in normal mammalian cells and the development of cancer
163. Evidence for the adaptive evolution of mutation rates
164. Phenotypic change caused by transcriptional bypass of uracil in nondividing cells
165. Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
166. Error-prone bypass of certain lesions by the human DNA polymerase φ
167. Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily
168. Sequence variation in the human uracil-DNA glycosylase (UNG) gene
169. Genetic susceptibility to non-polyposis colorectal cancer
170. Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects
171. Conditional mutator phenotypes in hMSH2-deficient tumour cell lines
172. Cancer cells exhibit a mutator phenotype
173. Lessons from hereditary colorectal cancer
174. Mismatch repair deficiency in phenotypically normal human cells
175. The mutation rate and cancer
176. Mutation, cell kinetics and subpopulations at risk for colon cancer in the United States
177. Selection for β-2-microglobulin mutation in mismatch repair-defective colorectal carcinomas
178. DNA excision repair pathways
179. Apoptosis of late-stage erythroblasts in megaloblastic anemia: Association with DNA damage and macrocyte production
180. Folate status and neural tube defects
181. Robustness against mutations in genetic networks of yeast