An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3′ mispaired DNA

Nature

Volumn 415, Issue 6872, 2002, Pages 655-659

  Chou, Kai Ming ^a   Cheng, Yung Chi ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYME KINETICS; GENETIC ENGINEERING;

THERAPUTIC INDEX;

ANIMAL CELL CULTURE;

BCCH 4556; DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA BASE; DNA DIRECTED DNA POLYMERASE BETA; NUCLEOSIDE ANALOG; STAVUDINE; TROXACITABINE; UNCLASSIFIED DRUG; ZIDOVUDINE;

DNA;

ARTICLE; BASE PAIRING; CONTROLLED STUDY; DNA DETERMINATION; ENZYME ACTIVITY; EXCISION REPAIR; HUMAN; HUMAN CELL; MISMATCH REPAIR; PRIORITY JOURNAL;

ANTI-HIV AGENTS; CARBON-OXYGEN LYASES; CELL LINE; DNA; DNA DAMAGE; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; EXODEOXYRIBONUCLEASES; HUMANS; REVERSE TRANSCRIPTASE INHIBITORS; STAVUDINE; SUBSTRATE SPECIFICITY; ZIDOVUDINE;

ANIMALIA; MURINAE;

EID: 0037034035     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/415655a     Document Type: Article

References (25)

1. Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA
2. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
3. Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair
4. Mutagenesis by apurinic/apyrimidinic sites
5. Excision of deoxyribose phosphate residues by DNA polymerase β during DNA repair
6. The mutational specificity of DNA polymerase-β during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations
7. Significance of of multiple mutation, in cancer
8. Cloningexpression of APE, the cDNA encoding the major human apurinic endonuclease: Definition of a family of DNA repair enzymes
9. Isolation of cDNA clones encoding an enzyme from bovine cells that repairs oxidative DNA damage in vitro: Homology with bacterial repair enzymes
10. A novel action of human apurinic/apyrimidinic endonuclease. Excision of L-configuration deoxyribonucleoside analogs, from the 3′ termini of DNA
11. Anticancer activity of β-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration
12. Passing the baton in base excision repair
13. Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway
14. Purification and characterization of DNA ligase III from bovine testes. Homology with DNA ligase II and vaccinia DNA ligase
15. DNA polymerases versus HIV reverse transcriptase in AIDS therapy
16. Overexpression of DNA polymerase β sensitizes mammalian cells to 2′,3′deoxycytidine and 3′-azido-3′-deoxythymidine
17. Removal of anti-human immunodeficiency virus 2′,3′dideoxynucleoside monophosphates front DNA by a novel human cytosolic 3′-5′ exonuclease
18. Drug combinations and effect parameters of zidovudine, stavudine and nevirapine in standardized drug-sensitive and resistant HIV type I strains
19. Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane mechanism
20. Initiation of base excision repair: Glycosylase mechanisms and structures
21. Two distinct human DNA diesterases that hydrolyze 3′blocking deoxyribose fragments from oxidized DNA
22. Delayed DNA joining at 3′ mismatches by human DNA ligases
23. A human DNA editing enzyme homologous to the Escherichia, coli DnaQ/MutD protein
24. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3′-5′ exonucleases
25. Excision of 3′ termini by the Trex1 and TREX2 3′-5′ exonucleases: Characterization of the recombinant proteins