Human AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with lymph node status and angiogenesis

British Journal of Cancer

Volumn 77, Issue 7, 1998, Pages 1169-1173

  Kakolyris, S ^a,b   Kaklamanis, L ^a   Engels, K ^a   Fox, S B ^a   Taylor, M ^c   Hickson, I D ^a   Gatter, K C ^a   Harris, A L ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY HOSPITAL OF IRAKLION   (Greece)

^c CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

Breast cancer; DNA repair; HAP1; Immunohistochemistry

Indexed keywords

CYTOPLASM PROTEIN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; NUCLEAR PROTEIN;

ADULT; ANGIOGENESIS; ARTICLE; BREAST CANCER; BREAST CARCINOMA; BREAST EPITHELIUM; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA REPAIR; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LACTATION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; TUMOR NECROSIS;

EID: 0031929069     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.194     Document Type: Article

References (34)

1. Abate C, Luk D and Curran T (1990) A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly. Cell Growth Diff 1: 455-462
2. Cordell JL, Falini B, Erber W, Ghosh A, Abdulaziz Z, MacDonald S, Pulford KAS, Stein H and Mason DY (1984) Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP). J Histochem Cytochem 32: 219-229
3. Curran T and Franza BJ (1988) Fos and Jun: the AP-1 connection. Cell 55: 395-397
4. Demple B, Herman T and Chen DS (1991) Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc Natl Acad Sci USA 88: 11450-11454
5. Driggers WJ, Grishko VI, LeDoux SP and Wilson GL (1996) Defective repair of oxidative damage in the mitochondrial DNA of a xeroderma pigmentosum Group A cell line. Cancer Res 56: 1262-1266
6. Duguid JR, Eble JN, Wilson TM and Kelley MR (1995) Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme. Cancer Res 55:6097-6102
7. Elston CW (1987) Grading of invasive breast carcinomas. In Diagnostic Histopathology of the Breast, Page DL and Anderson TJ. (eds), pp. 300-311. Churchill Livingstone: Edinburgh
8. Fishel RA, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, Kane M and Kolodner R (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75: 1027-1038
9. Fox SB, Leek RD, Weekes MP, Whitehouse RM, Gatter KC and Harris AL (1995) Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol 177: 275-283
10. Frame MC, Wilkie NM, Darling AJ, Chudleigh A, Pintzas A, Lang JC and Gillespie DAF (1991) Regulation of AP-1/DNA complex formation in vivo. Oncogene 6: 205-209
11. Guedson J-L, Ternynck T and Avrameas S ( 1979) The use of avidin-biotin interaction in immunoenzymatic techniques. J Histochem Cytochem 27: 1131-1139
12. Horak ER, Leek R, Klenk N, Lejeune S, Smith K, Stuart N, Greenall M, Stepniewska K and Harris AL (1992) Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer. Lancet 340: 1120-1124
13. Hutchinson F (1985) Chemical changes induced in DNA by ionizing radiation. Prog Nucleic Acid Res Mol Biol 32: 115-154
14. Ishibashi T, Nakabeppu Y, Kawate H, Sakumi K, Kayakawa H and Sekiguchi M (1995) Intracellular location and function of DNA repair methyltransferase in human cells. Mutat Res 315: 199-212
15. Kakolyris S, Kaklamanis L, Engels K, Turley H, Hickson ID, Gatter KC and Harris AL (1997) Human apurinic endonuclease 1 expression in a colorectal adenoma-carcinoma sequence. Cancer Res 57: 1794-1797
16. Kaplan EL and Meier P (1958) Non-parametric estimation from incomplete observations. J Am Stat Assoc 53:457-481
17. Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomaki P, Sistonen P, Aaltonen LA, Nytromlahti M et al (1993) Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75: 1215-1235
18. 6-alkylguanine-DNA-alkyltransferase in situ, in ovarian and Hodgkin's tumors. Eur J Cancer 29A: 1306-1312
19. Loeb LA and Preston BD (1986) Mutagenesis by apurinic/apyrimidinic sites. Annu Rev Gene: 20: 201-230
20. Malins DC, Holmes EH, Polissar NL and Gunselman SJ (1993) The etiology of breast cancer. Characteristic alteration in hydroxyl radical-induced DNA base lesions during oncogenesis with potential for evaluating incidence risk. Cancer 71:3036-3043
21. Needham GK, Nicholson S, Angus B, Famdon JR and Harris AL (1988) Relationship of membrane-bound tissue type and urokinase type plasminogen activators in human breast cancers to estrogen and epidermal growth factor receptors. Cancer Res 48: 6603-6607
22. Robson CN and Hickson ID (1991) Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease) mutants. Nucleic Acids Res 19:5519-5523
23. Robson CN, Milne AM, Pappin DJ and Hickson ID (1991) Isolation of cDNA clones encoding an enzyme from bovine cells that repairs oxidative DNA damage in vitro: homology with bacterial repair enzymes. Nucleic Acids Res 19: 1087-1092
24. Seki S, Akiyama K, Watanabe S, Hatsushika M, Ikeda S and Tsutsui K (1991) cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III. J Biol Chem 266: 20797-20802
25. Teoule R (1987) Radiation-induced DNA damage and its repair. Im J Radiat Biol Relat Stud Phys Chem Med 51: 573-589
26. Thorgeirsson SS (1993) Endogenous DNA damage and breast cancer (editorial). Cancer 71: 2897-2899
27. Tomkinson AE, Bonk RT and Linn S (1988) Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells. J Biol Chem 263: 12532-12537
28. Walker LJ, Robson CN, Black E, Gillespie D and Hickson ID (1993) Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of jun DNA binding. Mol Cell Biol 13:5370-5376
29. Walker LJ, Craig RB, Harris AL and Hickson ID (1994) A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress. Nucleic Acids Res 22: 4884-4889
30. Wilson DM, Deutsch WA and Kelley MR (1994) Drosophila ribosomal protein S3 contains an activity that cleaves DNA at apurinic/apyrimidinic sites. J Biol Chem 269: 25359-25364
31. Xanthoudakis S and Curran T (1992) Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. Embo J 11: 653-665
32. Xanthoudakis S, Miao G, Wang F, Pan YC and Curran T (1992) Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. Embo J 11: 3323-3335
33. Xanthoudakis S, Miao GG and Curran T (1994) The redox and DNA-repair activities of Ref-1 are encoded by nonoverlaping domains. Proc Natl Acad Sci USA 91: 23-27
34. Yao KS, Xanthoudakis S, Curran T and O'Dwyer PJ (1994) Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol Cell Biol 14: 5997-6003