Down-regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells

Cell Growth and Differentiation

Volumn 8, Issue 4, 1997, Pages 443-449

  Robertson, Kent A ^a   Hill, David P ^a   Xu, Yi ^a   Liu, Lifei ^a   Van Epps, Steffany ^a   Hockenbery, David M ^b   Park, Jeff R ^b   Wilson, Teresa M ^a   Kelley, Mark R ^a,c  

^a RILEY HOSPITAL FOR CHILDREN   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; DIMETHYL SULFOXIDE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA NUCLEOTIDYLEXOTRANSFERASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN BCL 2; RETINOIC ACID;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EXCISION REPAIR; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE;

APOPTOSIS; CELL DIFFERENTIATION; DEOXYRIBONUCLEASE IV (PHAGE T4-INDUCED); DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DOWN-REGULATION; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID; LYASES; PROTO-ONCOGENE PROTEINS C-BCL-2; TRETINOIN;

ALOCASIA MACRORRHIZOS; ZIZIPHUS MAURITIANA;

EID: 0030954254     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Lindahl, T., and Nyberg, B. Rate of depurination of native deoxyribonucleic acid. Biochemistry, 11: 3610-3618, 1972.
2. Demple, B., and Harrison, L. Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem., 63: 915-948, 1994.
3. Loeb, L. A., and Preston, B. D. Mutagenesis by apurinic/apyrimidinic sites. Annu. Rev. Genet., 20: 201-230, 1986.
4. Friedberg, E. C., Backendorf, C., Burke, J., Collins, A., Grossman, L., Hoeijmakers, J. H., Lehmann, A. R., Seeberg, E., van der Schans, G. P., and van Zeeland, A. A. Molecular aspects of DNA repair. Mutat. Res., 184: 67-86, 1987.
5. Doetsch, P., and Cunningham, R. The enzymology of apurinic/apyrimidinic endonucleases. Mutat. Res. Mutant Res., 236: 173-201, 1990.
6. Lindahl, T. Repair of intrinsic DNA lesions. Mutat. Res., 238: 305-311, 1990.
7. Sancar, A., and Sancar, G. B. DNA repair enzymes. Annu. Rev. Biochem., 57: 29-67, 1988.
8. Wallace, S. S. AP endonucleases and DNA glycosylases that recognize oxidative DNA damage. Environ. Mol. Mutagen., 12: 431-477, 1988.
9. Demple, B., Herman, T., and Chen, D. S. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc. Natl. Acad. Sci. USA, 88: 11450-11454, 1991.
10. Robson, C. N., and Hickson, I. D. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants. Nucleic Acids Res., 19: 5519-5523, 1991.
11. Seki, S., Hatsushika, M., Watanabe, S., Akiyama, K., Nagao, K., and Tsutsui, K. cDNA cloning, sequencing, expression and possible domain structure of human Apex nuclease homologous to Escherichia coli exonuclease III. Biochim. Biophys. Acta, 1131: 287-299, 1992.
12. Xanthoudakis, S., and Curran, T. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J., 11: 653-665, 1992.
13. Xanthoudakis, S., Miao, G., Wang, F., Pan, Y. C., and Curran, T. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J., 11: 3323-3335, 1992.
14. Hockenbery, D. M. bcl-2, a novel regulator of cell death. BioEssays, 17: 631-638, 1995.
15. Yang, E. a. K. Molecular thanatopsis. A discourse on the BCL2 family and cell death. Blood, 88: 386-401, 1996.
16. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T., Yu, V. L., and Miller, D. K. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (Lond.), 376: 37-43, 1995.
17. Nicholson, D. W. ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis. Nature Biotechnology, 14: 297-301, 1996.
18. Ray, L. S., Chatterjee, S., Berger, N., Grishko, V. I., LeDoux, S. P., and Wilson, G. L. Catalytic activity of polyADP-ribose polymerase is necessary for repair of N-methylpurines in nontranscribed but not in transcribed nuclear sequences. Mutat. Res., 363: 105-114, 1996.
19. Park, J. R., Robertson, K., Hickstein, D. D., Tsai, S., Hockenbery, D. M., and Collins, S. J. Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes. Blood, 84: 440-445, 1994.
20. Collins, S. J. The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood, 70: 1233-1244, 1987.
21. Benito, A., Silva, M., Grillot, D., Nunez, G., and Fernandez-Luna, J. L. Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bel-XL. Blood, 87: 3837-3843, 1996.
22. McGahon, A., Bissonnette, R., Schmitt, M., Cotter, K. M., Green, D. R., and Cotter, T. G. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [Published erratum appears in Blood, 83: 3835]. Blood, 83: 1179-1187, 1994.
23. Linette, G. P., Hess, J. L., Sentman, C. L., and Korsmeyer, S. J. Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice. Blood, 86: 1255-1260, 1995.
24. Robertson, K. A., Emami, B., Mueller, L., and Collins, S. J. Multiple members of the retinoic acid receptor family are capable of mediating the granulocytic differentiation of HL-60 cells. Mol. Cell. Biol., 12: 3743-3749, 1992.
25. Robertson, K. A., Emami, B., and Collins, S. J. Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity. Blood, 80: 1885-1889, 1992.
26. Homburg, C. H. E., and Roos, D. Apoptosis of neutrophils. Curr. Opin. Hematol., 3: 94-99, 1996.
27. Duguid, J. R., Eble, J. N., Wilson, T. M., and Kelley, M. R. Differential cellular and subcellular expression of the human multifunctional apurinic/ apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme. Cancer Res., 55: 6097-6102, 1995.
28. Rivkees, S. A., and Kelley, M. R. Expression of a multifunctional DNA repair enzyme gene, apurinic/apyrimidinic endonuclease (APE; Ref-1) in the suprachiasmatic, supraoptic and paraventricular nuclei. Brain Res., 666: 137-142, 1994.
29. Wilson, T. M., Rivkees, S. A., Deutsch, W. A., and Kelley, M. R. Differential expression of the apurinic/apyrimidinic endonuclease (APE/ ref-1) multifunctional DNA base excision repair gene during fetal development and in adult rat brain and testis. Mutat. Res., 362: 237-248, 1996.
30. Yao, K. S., Xanthoudakis, S., Curran, T., and O'Dwyer, P. J. Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol. Cell. Biol., 14: 5997-6003, 1994.
31. Okazaki, T., Chung, U., Nishishita, T., Ebisu, S., Usuda, S., Mishiro, S., Xanthoudakis, S., Igarashi, T., and Ogata, E. A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium. J. Biol. Chem., 269: 27855-27862, 1994.
32. Harrison, L., Galanopoulos, T., Ascione, A. G., Antoniades, H. N., and Demple, B. Regulated expression of APE apurinic endonuclease mRNA during wound healing in porcine epidermis. Carcinogenesis (Lond.), 17: 377-381, 1996.
33. Walker, L. J., Robson, C. N., Black, E., Gillespie, D., and Hickson, I. D. Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Mol. Cell. Biol., 13: 5370-5376, 1993.
34. Sawai, H., Okazaki, T., Yamamoto, H., Okano, H., Takeda, Y., Tashima, M., Sawada, H., Okuma, M., Ishikura, H., and Umehara, H. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. J. Biol. Chem., 270: 27326-27331, 1995.
35. Chung, U., Igarashi, T., Nishishita, T., Iwanari, H., Iwamatsu, A., Suwa, A., Mimori, T., Hata, K., Ebisu, S., Ogata, E., and Fujita, T. The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium. J. Biol. Chem., 271: 8593-8598, 1996.
36. Barzilay, G., Walker, L. J., Robson, C. N., and Hickson, I. D. Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activity. Nucleic Acids Res., 23: 1544-1550, 1995.
37. Lozzio, C. B., and Lozzio, B. B. Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood, 45: 321-334, 1975.
38. Grabowski, D. T., Pieper, R. O., Futscher, B. W., Deutsch, W. A., Erickson, L. C., and Kelley, M. R. Expression of ribosomal phosphoprotein PO is induced by antitumor agents and increased in Mer-human tumor cell lines. Carcinogenesis (Lond.), 13: 259-263, 1992.