Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer

Clinical Cancer Research

Volumn 7, Issue 4, 2001, Pages 824-830

  Kelley, Mark R ^a   Cheng, Liang ^a   Foster, Richard ^a   Tritt, Renee ^a   Jiang, Jiazhong ^a   Broshears, John ^a   Koch, Michael ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APURINIC APYRIMIDINIC ENDODEOXYRIBONUCLEASE 1; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; PROSTATE SPECIFIC ANTIGEN; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE MARKER; EARLY CANCER; EXCISION REPAIR; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN EXPRESSION;

CARBON-OXYGEN LYASES; DNA LIGASES; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HUMANS; MALE; ONCOGENE PROTEINS; OXIDATION-REDUCTION; PROGNOSIS; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0034905642     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Rate of depurination of native deoxyribonucleic acid
2. Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues
3. Repair of oxidative damage to DNA: Enzymology and biology
4. Mutagenesis by apurinic/apyrimidinic sites
5. Requirement for human AP endonuclease I for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species
6. Cellular role of yeast Apn1 apurinic endonuclease/3′-diesterase: Repair of oxidative and alkylation DNA damage and control of spontaneous mutation
7. The apurinic-apyrimidinic endonuclease IV family of DNA repair enzymes
8. 3′-Phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA doublestrand break ends
9. Complexities of DNA base excision repair in mammalian cells
10. The enzymology of apurinic/apyrimidinic endonucleases
11. The type of DNA glycosylase determines the base excision repair pathway in mammalian cells
12. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
13. Going APE over ref-1
14. Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs
15. A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium
16. The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium
17. Analysis of DNA binding proteins associated with hemin-induced transcriptional inhibition. The hemin response element binding protein is a heterogeneous complex that includes the Ku protein
18. The multifunctional DNA base excision repair and redox protein, AP endonuclease (APE/ref-1), and its role in germ cell tumors
19. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers
20. The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer
21. Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors
22. Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers
23. Human AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with lymph node status and angiogenesis
24. An 'environment to nucleus' signaling system operates in B lymphocytes: Redox status modulates BSAP/Pax-5 activation through ref-1 nuclear translocation
25. Down-regulation of AP endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells
26. Site-directed mutagenesis of the human DNA repair enzyme HAP1: Identification of residues important for AP endonuclease and RNase H activity
27. Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1
28. Structure and function of apurinic/apyrimidinic endonucleases
29. DNA repair in eukaryotes
30. Cloningexpression of APE, the cDNA encoding the major human apurinic endonuclease: Definition of a family of DNA repair enzymes
31. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. Coli xth (exonuclease III) mutants
32. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity
33. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains
34. Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia
35. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit
36. A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1α and the HIF-like factor
37. Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding
38. Escape from redox regulation enhances the transforming activity of Fos
39. Identification of redox/repair protein Ref-1 as a potent activator of p53
40. Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo
41. Genetic interaction between HAP1/REF-1 and p53
42. Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB
43. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals
44. APE/Ref-1 responses to ischemia in rat brain
45. Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
46. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
47. Increased expression of hypoxia inducible factor-1α in rat and human prostate cancer
48. Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease
49. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress
50. Evidence that the bifunctional redox factor/AP endonuclease Ref-1 is an anti-apoptotic protein associated with differentiation in the developing retina
51. Expression of nuclear redox factor ref-1 in the rat hippocampus following global ischemia induced by cardiac arrest
52. TSH controls Ref-1 nuclear translocation in thyroid cells
53. The DNA repair activity of human redox/repair protein APE/ref-1 is inactivated by phosphorylation
54. Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1
55. Overexpression of the hOGG1 gene and high 8-hydroxy-2′-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: Regulation mechanism of the 8-OHdG level in DNA