Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas

Clinical Cancer Research

Volumn 7, Issue 11, 2001, Pages 3510-3518

  Bobola, Michael S ^a,c   Blank, A ^b   Berger, Mitchel S ^a   Stevens, Bobby A ^a,c   Silber, John R ^a  

^a Northwest Neurological Surgery   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; PROTEIN APE1; PROTEIN APEX; PROTEIN HAP 1; REDOX EFFECTOR FACTOR 1; UNCLASSIFIED DRUG;

ANEUPLOIDY; ARTICLE; CANCER GRADING; CARCINOGENESIS; CELL CYCLE S PHASE; CONTROLLED STUDY; DIPLOIDY; DISEASE ACTIVITY; DNA REPAIR; ENZYME ACTIVITY; ENZYME ASSAY; GLIOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IONIZING RADIATION; PRIORITY JOURNAL; WESTERN BLOTTING;

ADOLESCENT; ADULT; AGED; ANEUPLOIDY; BRAIN; BRAIN NEOPLASMS; CARBON-OXYGEN LYASES; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; GLIOMA; HUMANS; MIDDLE AGED; REGRESSION ANALYSIS; S PHASE; SEVERITY OF ILLNESS INDEX;

EID: 0035176178     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Going APE over ref-1
2. Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: The 3′ ends justify the means
3. Two distinct human diesterases that act on 3′-fragments of deoxyribose in radical damaged DNA
4. Repair of oxidative damage to DNA: Enzymology and biology
5. Base excision repair in yeast and mammals
6. Requirement for human AP endonuclease 1 for repair of 3′-blocking damages at DNA single-strand breaks induced by reactive oxygen species
7. Removal by human apurinic/apyrmidinic endonuclease I (APEI) and Escherichia coli exonuclease III of 3′-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin and γ-radiation
8. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
9. C-jun and Erg-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure
10. Induction of the mammalian stress response gene GADD153 by oxidative stress: Role of AP-1 element
11. Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo
12. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
13. A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity
14. Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III
15. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress
16. Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional enzyme. APEX nuclease
17. Biological response of human apurinic endonuclease to radiation-induced DNA damage
18. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals
19. Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation
20. Transient adaptation to oxidative stress in mammalian cells
21. Radiotherapy of primary malignant brain tumors
22. Chemotherapy of brain tumors
23. Relationship between expression of a major apurinic/apyrimidinic endonuclease (APEX nuclease) and susceptibility to genotoxic agents in human glioma cell lines
24. Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers
25. Altered expression of Ape1/Ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation
26. 6-methylguanine-DNA methyltransferase activity in adult gliomas: Relation to patient and tumor characteristics
27. Analysis of repair of abasic sites in early onset breast cancer patients
28. Epidemiology
29. AP endonuclease activity in humans: Development of a simple assay and analysis of ten normal individuals
30. 6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors
31. Evidence of reduced DNA repair in amyotrophic lateral sclerosis brain tissue
32. Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: Potential coordination of the initial steps in base excision repair
33. Histological grading and bromodeoxyuridine labeling index of astrocytomas
34. Cell kinetics
35. The role of radiosurgery for glial neoplasms
36. Interstitial brachytherapy for malignant brain tumors
37. Biology and treatment of malignant glioma
38. Chemotherapy for adults with malignant glioma
39. Brain tumors
40. Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains
41. Differential expression of the apurinic/apyrimidinic endonuclease (APE1/ref-1) multifunctional DNA base excision repair gene during fetal development and in the adult rat brain and testis
42. Nuclear localization of human Ap endonuclease 1 (HAP1/Ref-1) associates with prognosis in early operable non-small cell lung cancer (NSCLC)
43. Heat shock protein 70 binds to human apurinic/apyrimidinic endonuclease and stimulates endonuclease activity at abasic sites
44. Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer