Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NFκB activation

Biochemical Pharmacology

Volumn 63, Issue 8, 2002, Pages 1423-1430

  Yeh, Pei Yen ^a,b   Chuang, Shuang En ^a,c   Yeh, Kun Huei ^a,b   Song, Ying Chyi ^a   Ea, Chee Kwee ^a   Cheng, Ann Lii ^a,b,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Cervical cancer; Drug resistance; ERK; NF B; PD98059

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CISPLATIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR;

ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL LINE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG RESISTANCE; DRUG SELECTIVITY; ENZYME ACTIVATION; GENE REPRESSION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; UTERINE CERVIX CARCINOMA;

ANTINEOPLASTIC AGENTS; CISPLATIN; DNA-BINDING PROTEINS; DOXORUBICIN; DRUG INTERACTIONS; FEMALE; FLAVONOIDS; HUMANS; I-KAPPA B PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 0037091048     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00908-5     Document Type: Article

References (40)

1. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
2. Transcriptional regulation by extracellular signals: Mechanisms and specificity
3. How MAP kinases are regulated
4. Parallel signal processing among mammalian MAPKs
5. The MAPK signaling cascade
6. The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway: A potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity
7. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
8. The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis
9. Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: Role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death
10. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway
11. 2-terminal kinase, activation correlates with surface IgM-mediated apoptosis in the WEHI 231 B cell line
12. The extracellular signal-regulated kinase pathway is required for activation-induced cell death of T cells
13. Role of mitogen-activated protein kinases in activation-induced apoptosis of T cells
14. Role of NF-κB in p53-mediated programmed cell death
15. The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival
16. Suppression of TNF-α-induced apoptosis by NF-κB
17. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
18. Impaired regulation of nuclear factor-κB results in apoptosis by gamma radiation
19. NF-κB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type
20. The pro- or anti-apoptotic function of NF-κB is determined by the nature of the apoptotic stimulus
21. Requirement for ERK activation in cisplatin-induced apoptosis
22. A constitutive active MEK → ERK pathway negatively regulates NF-κB-dependent gene expression by modulating TATA-binding protein phosphorylation
23. Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated kinase signal transduction pathway: Potential role in promoting cytotoxic drug action
24. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
25. Nuclear extracellular signal-regulated kinase 2 phosphorylates p53 at Thr55 in response to doxorubicin
26. Both amino- and carboxyl-terminal sequences within I kappa B alpha regulate its inducible degradation
27. NFκB controls expression of inhibitor IκBα: Evidence for an inducible autoregulatory pathway
28. Stable inhibition of nuclear factor κB in cancer cells does not increase sensitivity to cytotoxic drugs
29. Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin
30. Transcriptional cross talk between NFκB and p53
31. Cisplatin-induced response of c-jun N-terminal kinase 1 and extracellular signal-regulated protein kinases 1 and 2 in a series of cisplatin-resistant ovarian carcinoma cell lines
32. Cisplatin-induced activation of mitogen-activated protein kinase in ovarian carcinoma cells: Inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin
33. Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin
34. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
35. Signal-induced site-specific phosphorylation targets IκB to the ubiquitin-proteasome pathway
36. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation
37. Signal-induced degradation of IκBα requires site-specific ubiquitination
38. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis
39. The DNA-dependent protein kinase participates in the activation of NFκB following DNA damage