Prognostic significance of Ape1/ref-1 subcellular localization in non-small cell lung carcinomas

Anticancer Research

Volumn 21, Issue 6 A, 2001, Pages 4041-4049

  Puglisi, Fabio ^a   Aprile, Giuseppe ^a   Minisini, Alessandro M ^a   Barbone, Fabio ^a   Cataldi, Palmina ^a   Tell, Gianluca ^a   Kelley, Mark R ^a   Damante, Giuseppe ^a   Beltrami, Carlo A ^a   Di Loreto, Carla ^a  

^a UNIVERSITY HOSPITAL OF UDINE   (Italy)

Author keywords

Ape1 ref 1; DNA repair; Immunohistochemistry; Multivariate analysis; Non small cell lung cancer; Prognosis

Indexed keywords

DEOXYRIBONUCLEOPROTEIN; PROTEIN APE1; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; DNA REPAIR; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN LOCALIZATION; RETROSPECTIVE STUDY; SCORING SYSTEM;

AGED; CARBON-OXYGEN LYASES; CARCINOMA, NON-SMALL-CELL LUNG; CELL NUCLEUS; CYTOPLASM; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENDODEOXYRIBONUCLEASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; SUBCELLULAR FRACTIONS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035570805     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Cancer statistics, 2001
2. K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung
3. Bcl-2 protein in non-small-cell lung carcinoma
4. Specific markers for pulmonary tumours
5. Cycloxigenase 2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer
6. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants
7. Drosophila Rpr1 protein: An apurinic endonuclease with homologous recombination activity
8. The Arabidopsis thaliana apurinic endonuclease Arp reduces human transcription factors Fos and Jun
9. Requirement for human AP endonuclease 1 for repair of 3′-blocking at DNA strand breaks induced by reactive oxygen species
10. The structure and functions of the HAP1/Ref-1 protein
11. The redox and DNA-repair activities of Ref-1 are encoded by non-overlapping domains
12. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
13. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity
14. Redox potential controls the structure and DNA binding activity of the paired domain
15. Identification of residues in the human DNA repair enzyme HAP-1 (ref-1) that are essential for redox regulation of Jun DNA binding
16. Identification of a redox/repair protein Ref-1 as a potent activator of p53
17. Nuclear localization of human AP endonuclease 1 (HAP1/Ref-1) associated with prognosis in early operable non-small cell lung cancer (NSCLC)
18. Human AP endonuclease 1 (HAP 1) expression in a colorectal adenoma-carcinoma sequence
19. Human AP endonuclease 1 (HAP 1) protein expression in breast cancer correlates with lymph nodes status and angiogenesis
20. Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer
21. Alterations in the expression of the DNA repair/redox enzyme APE/Ref-1 in epithelial ovarian cancers
22. Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation
23. Nuclear expression of human apurinic/apyrimidinic endonuclease (Hap/Ref-1) in head-and-neck cancer is associated with resistance to chemoradiotherapy and poor outcome
24. Combined analysis of MIB-1 and thyroid transcription factor-1 predicts survival in non-small cell lung carcinomas
25. Prognostic value of thyroid transcription factor-1 in primary, resected, non-small cell lung carcinoma
26. Revisions in the international system for staging for lung cancers
27. The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer
28. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of fetal brain
29. TTF-1 gene expression in human lung tumours
30. Non parametric estimation from incomplete observation
31. Regression models and life tables
32. Mitochondrial localization of APE/Ref-1 in thyroid cells
33. The nuclear pore complex as a transport machine
34. Regulation of protein transport to the nucleus: Central role of phosphorylation
35. The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation
36. Phosphorylation of the DNA repair protein APE/Ref-1 by CKII affects redox regulation of AP-1
37. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
38. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53