Expression of yeast but not human apurinic/apyrimidinic endonuclease renders Chinese hamster cells more resistant to DNA damaging agents

Mutation Research - DNA Repair

Volumn 383, Issue 2, 1997, Pages 155-165

  Tomicic, Maja ^a   Eschbach, Erik ^b   Kaina, Bernd ^a,b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Apurinic endonuclease; Cellular defense mechanisms; DNA repair

Indexed keywords

DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; ENDONUCLEASE; HYDROGEN PEROXIDE; MESYLIC ACID METHYL ESTER; MUTAGENIC AGENT;

ANIMAL CELL; ARTICLE; CHINESE HAMSTER; CHROMOSOME ABERRATION; CYTOTOXICITY; DEFENSE MECHANISM; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; YEAST;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARBON-OXYGEN LYASES; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; CHO CELLS; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; CRICETINAE; DNA DAMAGE; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENDODEOXYRIBONUCLEASES; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; METHYL METHANESULFONATE; NUCLEAR PROTEINS; PLASMIDS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSFECTION;

ALOCASIA MACRORRHIZOS; ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 0030933193     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(96)00055-9     Document Type: Article

References (39)

1. Lindahl, T. and B. Nyberg (1972) Rate of depurination of native deoxyribonucleic acid, Biochemistry, 11, 3610-3618.
2. Hutchinson, F. (1985) Chemical changes induced in DNA by ionizing radiation. Prog. Nucleic Acids Res. Mol. Biol., 32, 115-154.
3. Hemminki, K. (1983) Nucleic acid adducts of chemical carcinogens and mutagens, Arch. Toxicol., 52, 249-285.
4. Weiss, B. and L. Grossman (1987) Phosphodiesterases involved in DNA repair, Adv. Enzymol., 60, 1-34.
5. Halliwell, B. and O.I. Aruoma (1991) DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett., 281, 9-19.
6. Loeb, L.A. and B.D. Preston (1986) Mutagenesis by apurinic/apyrimidinic sites, Annu. Rev. Genet., 20, 201-230.
7. Bailly, V. and W.G. Verly (1987) Escherichia coli endonuclease III is not an endonuclease but a β-elimination catalyst, J. Biochem., 242, 565-572.
8. Doetsch, P. and R. Cunningham (1990) Enzymology of AP endonucleases, Mutation Res., 236, 173-201.
9. Warner, H.R., B. Demple, W.A. Deutsch, C.M. Kane and S. Linn (1980) Apurinic/apyrimidinic endonucleases in repair of pyrimidine dimers and other lesions in DNA, Proc. Natl. Acad. Sci. USA, 77, 4602-4606.
10. Wallace, S.S. (1988) AP endonucleases and DNA glycosylases that recognize oxidative DNA damage, Environ. Mol. Mutagen., 12, 431-477.
11. Barzilay, G. and I.D. Hickson (1995) Structure and function of apurinic/apyrimidinic endonucleases, BioEssays, 17, 713-719.
12. Lindahl, T. (1982) DNA repair enzymes, Annu. Rev. Biochem., 51, 61-87.
13. Johnson, A.W. and B. Demple (1988) Yeast DNA diesterase for 3′-fragments of deoxyribose: purification and physical properties of a repair enzyme for oxidative DNA damage, J. Biol. Chem., 263, 18009-18016.
14. Johnson, A.W. and B. Demple (1988) Yeast DNA 3′ repair dieasterase is the major cellular apurinic/apyrimidinic endonuclease: substrate specificity and kinetics, J. Biol. Chem., 263, 18017-18022.
15. Ramotar, D., S.C. Popoff, E.B. Gralla and B. Demple (1991) Cellular role of yeast Apn1 apurinic endonuclease/3′-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation, Mol. Cell. Biol., 11, 4537-4544.
16. Popoff, S.C., A.I. Spira, A.W. Johnson and B. Demple (1990) Yeast structural gene (APN1) for the major apurinic endonuclease: Homology to Escherichia coli endonuclease IV, Proc. Natl. Acad. Sci. USA, 87, 4193-4197.
17. Ramotar, D., S.C. Popoff and B. Demple (1991) Complementation of DNA repair-deficient Escherichia coli by the yeast Apn1 apurinic/apyrimidinic endonuclease, Mol. Microbiol., 5, 149-155.
18. Robson, C.N. and I.D. Hickson (1991) Isolation of cDNA clones encoding a human AP endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth mutants, Nucleic Acids Res., 19, 5519-5523.
19. Demple, B., T. Herman and D.S. Chen (1991) Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc. Natl. Acad. Sci. USA, 88, 11450-11454.
20. Xantoudakis, S., G. Miao, F. Wang, Y.-C.E. Pan and T. Curran (1992) Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme, EMBO J. 11, 3323-3335.
21. Ono, Y., S. Seki, K. Akiyama, S. Watanabe, T. Furuta and T. Ohmoto (1993) Expression of a putative catalytic domain of the human APEX nuclease (a major apurinic/apyrimidinic endonuclease) in Escherichia coli, Int. J. Biochem., 25, 359-366.
22. Roberts, B. (1989) Nuclear location signal-mediated protein transport, Biochim. Biophys. Acta, 1008, 263-280.
23. Kane, C.M. and S. Linn (1981) Purification and characterization of an apurinic/apyrimidinic endonuclease from HeLa cells, J. Biol. Chem., 256, 3405-3414.
24. Shaper, N.L., R.H. Grafston and, L. Grossman (1982) Human placental apurinic/apyrimidinic endonuclease, J. Biol. Chem., 257, 13455-13458.
25. Okayama, H. and P. Berg (1983) A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells, Mol. Cell. Biol., 3, 280-289.
26. 6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster ovary cells: the role of MGMT in protection against the genotoxic effects of alkylating agents, Carcinogenesis, 12, 1857-1867.
27. 6-methylguanine-DNA methyltransferase mRNA in rat hepatoma cells, Biochim. Biophys. Acta, 1171, 35-40.
28. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248-254.
29. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680-685.
30. Kaina, B., G. Fritz, E. Eschbach, J. Dosch and I. Preuss (1995) Transfer of genes affecting resistance of mammalian cells to alkylating drugs-implications for cancer chemotherapy, in W.J. Zeller., G. Eisenbrand and K. Hellman (Eds.), Reduction of Anticancer Drug Toxicity. Pharmacologic, Biologic, Immunologic and Gene Therapeutic Approaches, Contrib. Oncol., Basel, Karger, 48, pp. 125-141.
31. Ibeanu, G., B. Hartenstein, W.C. Dunn, L.Y. Chang, E. Hofmann, T. Coquerelle, S. Mitra and B. Kaina (1992) Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells, Carcinogenesis, 13, 1989-1995.
32. Coquerelle, T., J. Dosch and B. Kaina (1995) Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents - a case of imbalanced DNA repair, Mutation Res., 336, 9-17.
33. Klungland, A., L. Fairbairn, A.J. Watson, G.P. Margison and E. Seeberg (1992) Expression of the E. coli 3-methyladenine-DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents, EMBO J., 11, 4439-4444.
34. Imperatori, L., G. Damia, P. Taverna, E. Garattini, L. Citti, L. Boldrini and M. D'Incalci (1994) 3T3 NIH murine fibroblasts and B78 murine melanoma cells expressing the Escherichiia coli N3-methyladenine-DNA glycosylase I do not become resistant to alkylating agents, Carcinogenesis, 15, 533-537.
35. Habraken, Y. and F. Laval (1993) Increased resistance of the Chinese hamster mutant irs1 cells to monofunctional agents by transfection of the E. coli or mammalian N3-methyladenine-DNA glycosylase genes, Mutation Res., 293, 187-195.
36. Ono, Y., T. Furuta, T. Ohmoto, K. Akiyama and S. Seki (1994) Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease, Mutation Res., 315, 55-63.
37. Levin, J.D., A.W. Johnson and B. Demple (1988) Homogeneous Escherichia coli endonuclease IV: Characterization of an enzyme that recognizes oxidative damage in DNA, J. Biol. Chem., 263, 8066-8071.
38. Marnett, L.J. and P.C. Burcham (1993) Endogeneous DNA adducts: Potential and Paradox, Chem. Res. Toxicol., 6, 771-785.
39. Walker, L.J., R.B. Craig, L. Harris and I.D. Hickson (1994) A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress, Nucleic Acids Res., 22, 4884-4889.