The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites

EMBO Journal

Volumn 16, Issue 21, 1997, Pages 6548-6558

  Gorman, Michael A ^a   Morera, Solange ^a   Rothwell, Dominic G ^b   De La Fortelle, Eric ^c   Mol, Clifford D ^d   Tainer, John A ^d   Hickson, Ian D ^b   Freemont, Paul S ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Abasic sites; DNA repair; Endonuclease; HAP1; Ref 1

Indexed keywords

DEOXYRIBONUCLEASE I; DEOXYRIBOSE; ENDONUCLEASE; EXODEOXYRIBONUCLEASE III;

ARTICLE; CATTLE; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; ESCHERICHIA COLI; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; BINDING SITES; CARBON-OXYGEN LYASES; CATTLE; CRYSTALLOGRAPHY, X-RAY; DEOXYRIBONUCLEASE I; DNA; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENDONUCLEASES; ESCHERICHIA COLI; EXODEOXYRIBONUCLEASES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

BOS TAURUS; BOVINAE; ESCHERICHIA COLI;

EID: 0030728449     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.21.6548     Document Type: Article

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