The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase

Proteins: Structure, Function and Genetics

Volumn 57, Issue 3, 2004, Pages 444-457

  Thorpe, Ian F ^a   Brooks III, Charles L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Catalytic rate; Conformational change; Energy barrier; Enzymes; Preorganization; Protein design

Indexed keywords

DIHYDROFOLATE REDUCTASE; ENZYME; GLYCINE; LIGAND; METHIONINE; SERINE; VALINE;

ARTICLE; CHEMICAL REACTION; CONFORMATION; CONTROLLED STUDY; GEOMETRY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE;

ALANINE; BINDING SITES; COMPUTER SIMULATION; ESCHERICHIA COLI; GLUTAMIC ACID; MODELS, MOLECULAR; MUTATION; OXYGEN; PROTEIN STRUCTURE, SECONDARY; TETRAHYDROFOLATE DEHYDROGENASE;

ESCHERICHIA COLI;

EID: 6344294816     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.20219     Document Type: Article

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