The hyperthermostable indoleglycerol phosphate synthase from Thermotoga maritima is destabilized by mutational disruption of two solvent-exposed salt bridges

Journal of Molecular Biology

Volumn 288, Issue 4, 1999, Pages 753-763

  Merz, Astrid ^a   Knöchel, Thorsten ^a   Jansonius, Johan N ^a   Kirschner, Kasper ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

( )8 barrel protein; Indoleglycerol phosphate synthase; Site directed mutagenesis; Thermostability; Tryptophan biosynthesis

Indexed keywords

RECOMBINANT PROTEIN; SYNTHETASE; TRYPTOPHAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL TEMPERATURE; ENZYME ACTIVITY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; THERMOPHILIC BACTERIUM; THERMOSTABILITY;

ARCHAEA; BACTERIA (MICROORGANISMS); SULFOLOBUS SOLFATARICUS; THERMOTOGA MARITIMA;

EID: 0344848664     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.2709     Document Type: Article

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