Dynamic Dysfunction in Dihydrofolate Reductase Results from Antifolate Drug Binding: Modulation of Dynamics within a Structural State

Structure

Volumn 17, Issue 3, 2009, Pages 386-394

  Mauldin, Randall V ^a   Carroll, Mary J ^b   Lee, Andrew L ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b The University of North Carolina at Chapel Hill   (United States)

Author keywords

PROTEINS

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; METHOTREXATE; METHYL GROUP; TRIMETHOPRIM;

ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ESCHERICHIA COLI; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN STRUCTURE;

BINDING SITES; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; LIGANDS; METHOTREXATE; MODELS, MOLECULAR; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM;

ESCHERICHIA COLI;

EID: 61449179228     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2009.01.005     Document Type: Article

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