A new conceptual framework for enzyme catalysis: Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes

European Journal of Biochemistry

Volumn 269, Issue 13, 2002, Pages 3096-3102

  Sutcliffe, Michael J ^a   Scrutton, Nigel S ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Computational simulation; Flavoprotein; H tunneling; Kinetic isotope effect; Molecular mechanics; Protein dynamics; Quantum mechanics; Quinoprotein; Stopped flow kinetics; Transition state theory

Indexed keywords

AMINE DEHYDROGENASE; CARBON; ENZYME; FLAVOPROTEIN; HYDROGEN; OXIDOREDUCTASE; PROTEIN; QUINOPROTEIN; SARCOSINE; UNCLASSIFIED DRUG;

CATALYSIS; CHEMICAL REACTION KINETICS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HYDROGEN BOND; MOLECULAR MODEL; MUTAGENESIS; MUTATION; PRIORITY JOURNAL; PROTON TRANSPORT; SHORT SURVEY;

CATALYSIS; ENZYMES; HYDROGEN; MODELS, MOLECULAR; MUTATION; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; OXIDOREDUCTASES, N-DEMETHYLATING; SARCOSINE OXIDASE;

EID: 0036305396     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03020.x     Document Type: Short Survey

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