Reaction-Path Energetics and Kinetics of the Hydride Transfer Reaction Catalyzed by Dihydrofolate Reductase

Biochemistry

Volumn 42, Issue 46, 2003, Pages 13558-13575

  Garcia Viloca, Mireia ^a   Truhlar, Donald G ^a   Gao, Jiali ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSMISSION COEFFICIENTS; VALENCE BOND POTENTIAL;

AMINES; BIOCHEMISTRY; BOUNDARY CONDITIONS; CHEMICAL BONDS; COMPUTER SIMULATION; ELECTROSTATICS; ENZYME KINETICS; FREE ENERGY; ISOTOPES; PH EFFECTS; RATE CONSTANTS; SUBSTRATES;

ENZYMES;

DIHYDROFOLATE REDUCTASE; ION; ISOTOPE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROFOLIC ACID;

ARTICLE; CALCULATION; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; ELECTRICITY; ENERGY TRANSFER; ENZYME SUBSTRATE; FORCE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR STABILITY; PH; PRIORITY JOURNAL; QUANTUM MECHANICS; SIMULATION; SURFACE PROPERTY; THERMODYNAMICS; VIBRATION;

AMINO ACIDS; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; DEUTERIUM; FOLIC ACID; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; NADP; QUANTUM THEORY; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

EID: 0344391945     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034824f     Document Type: Article

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