-
1
-
-
0035066332
-
Alzheimer's disease: genes, proteins, and therapy
-
Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001, 81:741-66.
-
(2001)
Physiol Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
2
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
-
Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nature Rev Mol Cell Biol. 2007, 8:101-12.
-
(2007)
Nature Rev Mol Cell Biol.
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
3
-
-
0037135111
-
Medicine-The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ. Medicine-The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002, 297:353-6.
-
(2002)
Science.
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
4
-
-
33646906138
-
Über eigenartige Krankheitsfälle des späteren Alters
-
Alzheimer A. Über eigenartige Krankheitsfälle des späteren Alters. Z ges Neurol Psychiatr. 1911, 4:356-85.
-
(1911)
Z ges Neurol Psychiatr.
, vol.4
, pp. 356-385
-
-
Alzheimer, A.1
-
5
-
-
0026508937
-
Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study
-
Bachman DL, Wolf PA, Linn R. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology. 1992, 42:115-9.
-
(1992)
Neurology.
, vol.42
, pp. 115-119
-
-
Bachman, D.L.1
Wolf, P.A.2
Linn, R.3
-
7
-
-
0024317904
-
Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported
-
Evans DA, Funkenstein HH, Albert MS. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA. 1989, 262:2551-6.
-
(1989)
JAMA.
, vol.262
, pp. 2551-2556
-
-
Evans, D.A.1
Funkenstein, H.H.2
Albert, M.S.3
-
8
-
-
38349146483
-
Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities
-
Cedazo-Minguez A. Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities. J Cell Mol Med. 2007, 11:1227-38.
-
(2007)
J Cell Mol Med.
, vol.11
, pp. 1227-1238
-
-
Cedazo-Minguez, A.1
-
9
-
-
0027194791
-
Gene dose of apolipoprotein-E type-4 allele and the risk of Alzheimers-disease in late-onset families
-
Corder EH, Saunders AM, Strittmatter WJ. Gene dose of apolipoprotein-E type-4 allele and the risk of Alzheimers-disease in late-onset families. Science. 1993, 261:921-3.
-
(1993)
Science.
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
-
10
-
-
1442264828
-
Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
-
Haass C. Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. EMBO J. 2004, 23:483-8.
-
(2004)
EMBO J.
, vol.23
, pp. 483-488
-
-
Haass, C.1
-
11
-
-
0034568802
-
Intramembrane proteolysis by presenilins
-
Steiner H, Haass C. Intramembrane proteolysis by presenilins. Nat Rev Mol Cell Biol. 2000, 1:217-24.
-
(2000)
Nat Rev Mol Cell Biol.
, vol.1
, pp. 217-224
-
-
Steiner, H.1
Haass, C.2
-
12
-
-
65249147834
-
Relevance of transgenic mouse models to human alzheimer disease
-
Morrissette DA, Parachikova A, Green KN. Relevance of transgenic mouse models to human alzheimer disease. J Biol Chem. 2009, 284:6033-7.
-
(2009)
J Biol Chem.
, vol.284
, pp. 6033-6037
-
-
Morrissette, D.A.1
Parachikova, A.2
Green, K.N.3
-
13
-
-
34248190279
-
A beta oligomers - a decade of discovery
-
Walsh DM, Selkoe DJ. A beta oligomers - a decade of discovery. J Neurochem. 2007, 101:1172-84.
-
(2007)
J Neurochem.
, vol.101
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
14
-
-
33747652958
-
Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides A beta 40 and A beta 42 - stable trimer or tetramer formation by A beta 42
-
Chen YR, Glabe CG. Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides A beta 40 and A beta 42 - stable trimer or tetramer formation by A beta 42. J Biol Chem. 2006, 281:24414-22.
-
(2006)
J Biol Chem.
, vol.281
, pp. 24414-24422
-
-
Chen, Y.R.1
Glabe, C.G.2
-
15
-
-
0015799240
-
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
-
Bliss TV, Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol. 1973, 232:331-56.
-
(1973)
J Physiol.
, vol.232
, pp. 331-356
-
-
Bliss, T.V.1
Lomo, T.2
-
16
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 2002, 416:535-9.
-
(2002)
Nature.
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
-
17
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
-
Shankar GM, Bloodgood BL, Townsend M. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007, 27:2866-75.
-
(2007)
J Neurosci.
, vol.27
, pp. 2866-2875
-
-
Shankar, G.M.1
Bloodgood, B.L.2
Townsend, M.3
-
18
-
-
33846633336
-
Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
-
Lacor PN, Buniel MC, Furlow PW. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci. 2007, 27:796-807.
-
(2007)
J Neurosci.
, vol.27
, pp. 796-807
-
-
Lacor, P.N.1
Buniel, M.C.2
Furlow, P.W.3
-
19
-
-
20844458090
-
Synaptic targeting by Alzheimer's-related amyloid beta oligomers
-
Lacor PN, Buniel MC, Chang L. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci. 2004, 24:10191-200.
-
(2004)
J Neurosci.
, vol.24
, pp. 10191-10200
-
-
Lacor, P.N.1
Buniel, M.C.2
Chang, L.3
-
20
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar GM, Li S, Mehta TH. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008, 14:837-42.
-
(2008)
Nat Med.
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
-
21
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesne S, Koh MT, Kotilinek L. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006, 440:352-7.
-
(2006)
Nature.
, vol.440
, pp. 352-357
-
-
Lesne, S.1
Koh, M.T.2
Kotilinek, L.3
-
22
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
Selkoe DJ. Clearing the brain's amyloid cobwebs. Neuron. 2001, 32:177-80.
-
(2001)
Neuron.
, vol.32
, pp. 177-180
-
-
Selkoe, D.J.1
-
23
-
-
4444276735
-
Clearance of Alzheimer's Abeta peptide: the many roads to perdition
-
Tanzi RE, Moir RD, Wagner SL. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron. 2004, 43:605-8.
-
(2004)
Neuron.
, vol.43
, pp. 605-608
-
-
Tanzi, R.E.1
Moir, R.D.2
Wagner, S.L.3
-
24
-
-
0033621739
-
Identification of the major A beta(1-42)-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition
-
Iwata N, Tsubuki S, Takaki Y. Identification of the major A beta(1-42)-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med. 2000, 6:143-50.
-
(2000)
Nat Med.
, vol.6
, pp. 143-150
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
-
25
-
-
0346101885
-
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
-
Leissring MA, Farris W, Chang AY. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003, 40:1087-93.
-
(2003)
Neuron.
, vol.40
, pp. 1087-1093
-
-
Leissring, M.A.1
Farris, W.2
Chang, A.Y.3
-
26
-
-
33744465230
-
PKC epsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice
-
Choi DS, Wang D, Yu GQ. PKC epsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc Natl Acad Sci USA. 2006, 103:8215-20.
-
(2006)
Proc Natl Acad Sci USA.
, vol.103
, pp. 8215-8220
-
-
Choi, D.S.1
Wang, D.2
Yu, G.Q.3
-
27
-
-
18544410708
-
The plasmin system is induced by and degrades amyloid-beta aggregates
-
Tucker HM, Kihiko M, Caldwell JN. The plasmin system is induced by and degrades amyloid-beta aggregates. J Neurosci. 2000, 20:3937-46.
-
(2000)
J Neurosci.
, vol.20
, pp. 3937-3946
-
-
Tucker, H.M.1
Kihiko, M.2
Caldwell, J.N.3
-
28
-
-
33748524564
-
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease
-
Mueller-Steiner S, Zhou Y, Arai H. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron. 2006, 51:703-14.
-
(2006)
Neuron.
, vol.51
, pp. 703-714
-
-
Mueller-Steiner, S.1
Zhou, Y.2
Arai, H.3
-
29
-
-
60849097262
-
Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic A beta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice
-
Meilandt WJ, Cisse M, Ho K. Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic A beta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J Neurosci. 2009, 29:1977-86.
-
(2009)
J Neurosci.
, vol.29
, pp. 1977-1986
-
-
Meilandt, W.J.1
Cisse, M.2
Ho, K.3
-
30
-
-
31444448250
-
Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory
-
Mouri A, Zou LB, Iwata N. Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behav Brain Res. 2006, 168:83-91.
-
(2006)
Behav Brain Res.
, vol.168
, pp. 83-91
-
-
Mouri, A.1
Zou, L.B.2
Iwata, N.3
-
31
-
-
33745808762
-
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function
-
Huang SM, Mouri A, Kokubo H. Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J Biol Chem. 2006, 281:17941-51.
-
(2006)
J Biol Chem.
, vol.281
, pp. 17941-17951
-
-
Huang, S.M.1
Mouri, A.2
Kokubo, H.3
-
32
-
-
0037010286
-
Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging
-
Iwata N, Takaki Y, Fukami S. Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. J Neurosci Res. 2002, 70:493-500.
-
(2002)
J Neurosci Res.
, vol.70
, pp. 493-500
-
-
Iwata, N.1
Takaki, Y.2
Fukami, S.3
-
33
-
-
13644266898
-
Age- and region-dependent alterations in A beta-degrading enzymes: implications for A beta-induced disorders
-
Caccamo A, Oddo S, Sugarman MC. Age- and region-dependent alterations in A beta-degrading enzymes: implications for A beta-induced disorders. Neurobiol Aging. 2005, 26:645-54.
-
(2005)
Neurobiol Aging.
, vol.26
, pp. 645-654
-
-
Caccamo, A.1
Oddo, S.2
Sugarman, M.C.3
-
34
-
-
37549012213
-
Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels
-
Hellström-Lindahl E, Ravid R, Nordberg A. Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels. Neurobiol Aging. 2008, 29:210-21.
-
(2008)
Neurobiol Aging.
, vol.29
, pp. 210-221
-
-
Hellström-Lindahl, E.1
Ravid, R.2
Nordberg, A.3
-
35
-
-
0036830947
-
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
-
LaFerla FM. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nature Rev Neurosci. 2002, 3:862-72.
-
(2002)
Nature Rev Neurosci.
, vol.3
, pp. 862-872
-
-
LaFerla, F.M.1
-
36
-
-
0024954067
-
Calcium, membranes, aging, and Alzheimer's disease. Introduction and overview
-
Khachaturian ZS. Calcium, membranes, aging, and Alzheimer's disease. Introduction and overview. Ann N Y Acad Sci. 1989, 568:1-4.
-
(1989)
Ann N Y Acad Sci.
, vol.568
, pp. 1-4
-
-
Khachaturian, Z.S.1
-
37
-
-
0028651951
-
Calcium hypothesis of Alzheimer's disease and brain aging
-
Khachaturian ZS. Calcium hypothesis of Alzheimer's disease and brain aging. Ann N Y Acad Sci. 1994, 747:1-11.
-
(1994)
Ann N Y Acad Sci.
, vol.747
, pp. 1-11
-
-
Khachaturian, Z.S.1
-
38
-
-
47749095383
-
Linking calcium to A beta and Alzheimer's disease
-
Green KN, LaFerla FM. Linking calcium to A beta and Alzheimer's disease. Neuron. 2008, 59:190-4.
-
(2008)
Neuron.
, vol.59
, pp. 190-194
-
-
Green, K.N.1
LaFerla, F.M.2
-
39
-
-
0027508926
-
Alzheimer-disease amyloid beta-protein forms calcium channels in bilayer-membranes-blockade by tromethamine and aluminum
-
Arispe N, Rojas E, Pollard HB. Alzheimer-disease amyloid beta-protein forms calcium channels in bilayer-membranes-blockade by tromethamine and aluminum. Proc Natl Acad Sci USA. 1993, 90:567-71.
-
(1993)
Proc Natl Acad Sci USA.
, vol.90
, pp. 567-571
-
-
Arispe, N.1
Rojas, E.2
Pollard, H.B.3
-
40
-
-
33344463679
-
Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
-
Glabe CG. Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol Aging. 2006, 27:570-5.
-
(2006)
Neurobiol Aging.
, vol.27
, pp. 570-575
-
-
Glabe, C.G.1
-
41
-
-
0035997228
-
Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site
-
Lee G, Pollard HB, Arispe N. Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site. Peptides. 2002, 23:1249-63.
-
(2002)
Peptides.
, vol.23
, pp. 1249-1263
-
-
Lee, G.1
Pollard, H.B.2
Arispe, N.3
-
42
-
-
34547214510
-
A beta ion channels. Prospects for treating Alzheimer's disease with A beta channel blockers
-
Arispe N, Diaz JC, Simakova O. A beta ion channels. Prospects for treating Alzheimer's disease with A beta channel blockers. Biochim Biophys Acta. 2007, 1768:1952-65.
-
(2007)
Biochim Biophys Acta.
, vol.1768
, pp. 1952-1965
-
-
Arispe, N.1
Diaz, J.C.2
Simakova, O.3
-
43
-
-
20444496481
-
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
-
Demuro A, Mina E, Kayed R. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem. 2005, 280:17294-300.
-
(2005)
J Biol Chem.
, vol.280
, pp. 17294-17300
-
-
Demuro, A.1
Mina, E.2
Kayed, R.3
-
44
-
-
34249672242
-
Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
-
De Felice FG, Velasco PT, Lambert MP. Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem. 2007, 282:11590-601.
-
(2007)
J Biol Chem.
, vol.282
, pp. 11590-11601
-
-
De Felice, F.G.1
Velasco, P.T.2
Lambert, M.P.3
-
45
-
-
0031035954
-
Amyloid beta protein potentiates Ca2+ influx through L-type voltage-sensitive Ca2+ channels: a possible involvement of free radicals
-
Ueda K, Shinohara S, Yagami T. Amyloid beta protein potentiates Ca2+ influx through L-type voltage-sensitive Ca2+ channels: a possible involvement of free radicals. J Neurochem. 1997, 68:265-71.
-
(1997)
J Neurochem.
, vol.68
, pp. 265-271
-
-
Ueda, K.1
Shinohara, S.2
Yagami, T.3
-
46
-
-
38549141544
-
Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents
-
Nimmrich V, Grimm C, Draguhn A. Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents. J Neurosci. 2008, 28:788-97.
-
(2008)
J Neurosci.
, vol.28
, pp. 788-797
-
-
Nimmrich, V.1
Grimm, C.2
Draguhn, A.3
-
47
-
-
0035836747
-
Beta-Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons
-
Liu QS, Kawai H, Berg DK. beta-Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons. Proc Natl Acad Sci USA. 2001, 98:4734-9.
-
(2001)
Proc Natl Acad Sci USA.
, vol.98
, pp. 4734-4739
-
-
Liu, Q.S.1
Kawai, H.2
Berg, D.K.3
-
48
-
-
0028180518
-
A model for beta-amyloid aggregation and neurotoxicity based on free-radical generation by the peptide - relevance to alzheimer-disease
-
Hensley K, Carney JM, Mattson MP. A model for beta-amyloid aggregation and neurotoxicity based on free-radical generation by the peptide - relevance to alzheimer-disease. Proc Natl Acad Sci USA. 1994, 91:3270-4.
-
(1994)
Proc Natl Acad Sci USA.
, vol.91
, pp. 3270-3274
-
-
Hensley, K.1
Carney, J.M.2
Mattson, M.P.3
-
49
-
-
0028981159
-
Amyloid beta-peptide impairs ion-motive ATPase activities - evidence for a role in loss of neuronal Ca2+ homeostasis and cell-death
-
Mark RJ, Hensley K, Butterfield DA, Mattson MP. Amyloid beta-peptide impairs ion-motive ATPase activities - evidence for a role in loss of neuronal Ca2+ homeostasis and cell-death. J Neurosci. 1995, 15:6239-49.
-
(1995)
J Neurosci.
, vol.15
, pp. 6239-6249
-
-
Mark, R.J.1
Hensley, K.2
Butterfield, D.A.3
Mattson, M.P.4
-
50
-
-
0031020993
-
Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation
-
Mark RJ, Pang Z, Geddes JW. Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation. J Neurosci. 1997, 17:1046-54.
-
(1997)
J Neurosci.
, vol.17
, pp. 1046-1054
-
-
Mark, R.J.1
Pang, Z.2
Geddes, J.W.3
-
51
-
-
50249135503
-
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
-
Bezprozvanny I, Mattson MP. Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci. 2008, 31:454-63.
-
(2008)
Trends Neurosci.
, vol.31
, pp. 454-463
-
-
Bezprozvanny, I.1
Mattson, M.P.2
-
52
-
-
0037007140
-
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP
-
Leissring MA, Murphy MP, Mead TR. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci USA. 2002, 99:4697-702.
-
(2002)
Proc Natl Acad Sci USA.
, vol.99
, pp. 4697-4702
-
-
Leissring, M.A.1
Murphy, M.P.2
Mead, T.R.3
-
53
-
-
0035816661
-
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X, Südhof TC. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science. 2001, 293:115-20.
-
(2001)
Science.
, vol.293
, pp. 115-120
-
-
Cao, X.1
Südhof, T.C.2
-
54
-
-
33745584643
-
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes
-
Hebert SS, Serneels L, Tolia A. Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep. 2006, 7:739-45.
-
(2006)
EMBO Rep.
, vol.7
, pp. 739-745
-
-
Hebert, S.S.1
Serneels, L.2
Tolia, A.3
-
55
-
-
48349085043
-
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease
-
Müller T, Meyer HE, Egensperger R. The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Prog Neurobiol. 2008, 85:393-406.
-
(2008)
Prog Neurobiol.
, vol.85
, pp. 393-406
-
-
Müller, T.1
Meyer, H.E.2
Egensperger, R.3
-
56
-
-
0027478347
-
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein
-
Mattson MP, Cheng B, Culwell AR. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron. 1993, 10:243-54.
-
(1993)
Neuron.
, vol.10
, pp. 243-254
-
-
Mattson, M.P.1
Cheng, B.2
Culwell, A.R.3
-
57
-
-
0030068094
-
Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein
-
Furukawa K, Barger SW, Blalock EM. Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. Nature. 1996, 379:74-8.
-
(1996)
Nature.
, vol.379
, pp. 74-78
-
-
Furukawa, K.1
Barger, S.W.2
Blalock, E.M.3
-
58
-
-
0028204224
-
Calcium ionophore increases amyloid-beta peptide production by cultured-cells
-
Querfurth HW, Selkoe DJ. Calcium ionophore increases amyloid-beta peptide production by cultured-cells. Biochemistry. 1994, 33:4550-61.
-
(1994)
Biochemistry.
, vol.33
, pp. 4550-4561
-
-
Querfurth, H.W.1
Selkoe, D.J.2
-
59
-
-
0030987603
-
Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells
-
Querfurth HW, Jiang JW, Geiger JD. Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells. J Neurochem. 1997, 69:1580-91.
-
(1997)
J Neurochem.
, vol.69
, pp. 1580-1591
-
-
Querfurth, H.W.1
Jiang, J.W.2
Geiger, J.D.3
-
60
-
-
0028207004
-
Calcium regulates processing of the alzheimer amyloid protein-precursor in a protein-kinase C-independent manner
-
Buxbaum JD, Ruefli AA, Parker CA. Calcium regulates processing of the alzheimer amyloid protein-precursor in a protein-kinase C-independent manner. Proc Natl Acad Sci USA. 1994, 91:4489-93.
-
(1994)
Proc Natl Acad Sci USA.
, vol.91
, pp. 4489-4493
-
-
Buxbaum, J.D.1
Ruefli, A.A.2
Parker, C.A.3
-
61
-
-
1442323991
-
Intraneuronal amyloid-beta 1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death
-
Pierrot N, Ghisdal P, Caumont AS. Intraneuronal amyloid-beta 1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death. J Neurochem. 2004, 88:1140-50.
-
(2004)
J Neurochem.
, vol.88
, pp. 1140-1150
-
-
Pierrot, N.1
Ghisdal, P.2
Caumont, A.S.3
-
62
-
-
45749130981
-
A polymorphism in CALHM1 influences Ca2+ homeostasis, A beta levels, and Alzheimer's disease risk
-
Dreses-Werringloer U, Lambert JC, Vingtdeux V. A polymorphism in CALHM1 influences Ca2+ homeostasis, A beta levels, and Alzheimer's disease risk. Cell. 2008, 133:1149-61.
-
(2008)
Cell.
, vol.133
, pp. 1149-1161
-
-
Dreses-Werringloer, U.1
Lambert, J.C.2
Vingtdeux, V.3
-
63
-
-
57149147125
-
No Association between CALHM1 and Alzheimer's disease risk
-
Bertram L, Schjeide BMM, Hooli B. No Association between CALHM1 and Alzheimer's disease risk. Cell. 2008, 135:993-4.
-
(2008)
Cell.
, vol.135
, pp. 993-994
-
-
Bertram, L.1
Schjeide, B.M.M.2
Hooli, B.3
-
64
-
-
63749123536
-
No association between CALHM1 and risk for Alzheimer dementia in a Belgian population
-
Sleegers K, Brouwers N, Bettens K. No association between CALHM1 and risk for Alzheimer dementia in a Belgian population. Hum Mutat 2009, 30:E570-74.
-
(2009)
Hum Mutat
, vol.30
-
-
Sleegers, K.1
Brouwers, N.2
Bettens, K.3
-
65
-
-
13944261267
-
Tau in neurodegenerative diseases: tau phosphorylation and assembly
-
Avila J, Perez M, Lim F. Tau in neurodegenerative diseases: tau phosphorylation and assembly. Neurotox Res. 2004, 6:477-82.
-
(2004)
Neurotox Res.
, vol.6
, pp. 477-482
-
-
Avila, J.1
Perez, M.2
Lim, F.3
-
66
-
-
34548823253
-
The pathogenesis of Alzheimers disease - is it a lifelong " Calciumopathy" ?
-
Stutzmann GE. The pathogenesis of Alzheimers disease - is it a lifelong " Calciumopathy" ?. Neuroscientist. 2007, 13:546-59.
-
(2007)
Neuroscientist.
, vol.13
, pp. 546-559
-
-
Stutzmann, G.E.1
-
67
-
-
15244352734
-
Calcium dysregulation, IP3 signaling, and Alzheimer's disease
-
Stutzmann GE. Calcium dysregulation, IP3 signaling, and Alzheimer's disease. Neuroscientist. 2005, 11:110-5.
-
(2005)
Neuroscientist.
, vol.11
, pp. 110-115
-
-
Stutzmann, G.E.1
-
68
-
-
45249117227
-
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating
-
Cheung KH, Shineman D, Muller M. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 2008, 58:871-83.
-
(2008)
Neuron.
, vol.58
, pp. 871-883
-
-
Cheung, K.H.1
Shineman, D.2
Muller, M.3
-
69
-
-
33646945317
-
Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice
-
Stutzmann GE, Smith I, Caccamo A. Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci. 2006, 26:5180-9.
-
(2006)
J Neurosci.
, vol.26
, pp. 5180-5189
-
-
Stutzmann, G.E.1
Smith, I.2
Caccamo, A.3
-
70
-
-
35748954015
-
The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity
-
Rybalchenko V, Hwang SY, Rybalchenko N. The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity. Int J Biochem Cell Biol. 2008, 40:84-97.
-
(2008)
Int J Biochem Cell Biol.
, vol.40
, pp. 84-97
-
-
Rybalchenko, V.1
Hwang, S.Y.2
Rybalchenko, N.3
-
71
-
-
53549084850
-
The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein-protein interaction
-
Hayrapetyan V, Rybalchenko V, Rybalchenko N. The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein-protein interaction. Cell Calcium. 2008, 44:507-18.
-
(2008)
Cell Calcium.
, vol.44
, pp. 507-518
-
-
Hayrapetyan, V.1
Rybalchenko, V.2
Rybalchenko, N.3
-
72
-
-
46249123354
-
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production
-
Green KN, Demuro A, Akbari Y. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol. 2008, 181:1107-16.
-
(2008)
J Cell Biol.
, vol.181
, pp. 1107-1116
-
-
Green, K.N.1
Demuro, A.2
Akbari, Y.3
-
73
-
-
0028179578
-
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease
-
Ito E, Oka K, Etcheberrigaray R. Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc Natl Acad Sci USA. 1994, 91:534-8.
-
(1994)
Proc Natl Acad Sci USA.
, vol.91
, pp. 534-538
-
-
Ito, E.1
Oka, K.2
Etcheberrigaray, R.3
-
74
-
-
0032127927
-
Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families
-
Etcheberrigaray R, Hirashima N, Nee L. Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families. Neurobiol Dis. 1998, 5:37-45.
-
(1998)
Neurobiol Dis.
, vol.5
, pp. 37-45
-
-
Etcheberrigaray, R.1
Hirashima, N.2
Nee, L.3
-
75
-
-
0033016172
-
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
-
Guo Q, Fu W, Sopher BL. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med. 1999, 5:101-6.
-
(1999)
Nat Med.
, vol.5
, pp. 101-106
-
-
Guo, Q.1
Fu, W.2
Sopher, B.L.3
-
76
-
-
0032972683
-
Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes
-
Leissring MA, Paul BA, Parker I. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J Neurochem. 1999, 72:1061-8.
-
(1999)
J Neurochem.
, vol.72
, pp. 1061-1068
-
-
Leissring, M.A.1
Paul, B.A.2
Parker, I.3
-
77
-
-
0037183702
-
The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations
-
Cedazo-Minguez A, Popescu BO, Ankarcrona M. The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations. J Biol Chem. 2002, 277:36646-55.
-
(2002)
J Biol Chem.
, vol.277
, pp. 36646-36655
-
-
Cedazo-Minguez, A.1
Popescu, B.O.2
Ankarcrona, M.3
-
78
-
-
1342304119
-
Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction
-
Popescu BO, Cedazo-Minguez A, Benedikz E. Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction. J Biol Chem. 2004, 279:6455-64.
-
(2004)
J Biol Chem.
, vol.279
, pp. 6455-6464
-
-
Popescu, B.O.1
Cedazo-Minguez, A.2
Benedikz, E.3
-
79
-
-
67949086707
-
Presenilins are essential for regulating neurotransmitter release
-
Zhang C, Wu B, Beglopoulos V. Presenilins are essential for regulating neurotransmitter release. Nature. 2009, 460:632-6.
-
(2009)
Nature.
, vol.460
, pp. 632-636
-
-
Zhang, C.1
Wu, B.2
Beglopoulos, V.3
-
80
-
-
33748140720
-
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations
-
Tu H, Nelson O, Bezprozvanny A. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell. 2006, 126:981-93.
-
(2006)
Cell.
, vol.126
, pp. 981-993
-
-
Tu, H.1
Nelson, O.2
Bezprozvanny, A.3
-
81
-
-
34248185927
-
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1
-
Nelson O, Tu H, Lei T. Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J Clin Invest. 2007, 117:1230-9.
-
(2007)
J Clin Invest.
, vol.117
, pp. 1230-1239
-
-
Nelson, O.1
Tu, H.2
Lei, T.3
-
82
-
-
0030825675
-
Release and sequestration of calcium by ryanodine-sensitive stores in rat hippocampal neurones
-
Garaschuk O, Yaari Y, Konnerth A. Release and sequestration of calcium by ryanodine-sensitive stores in rat hippocampal neurones. J Physiol. 1997, 502:13-30.
-
(1997)
J Physiol.
, vol.502
, pp. 13-30
-
-
Garaschuk, O.1
Yaari, Y.2
Konnerth, A.3
-
83
-
-
15544368216
-
Store-operated calcium channels
-
Parekh AB, Putney JW. Store-operated calcium channels. Physiol Rev. 2005, 85:757-810.
-
(2005)
Physiol Rev.
, vol.85
, pp. 757-810
-
-
Parekh, A.B.1
Putney, J.W.2
-
84
-
-
0030810066
-
Store depletion and calcium influx
-
Parekh AB, Penner R. Store depletion and calcium influx. Physiol Rev. 1997, 77:901-30.
-
(1997)
Physiol Rev.
, vol.77
, pp. 901-930
-
-
Parekh, A.B.1
Penner, R.2
-
85
-
-
0346992041
-
Mitochondrial regulation of intracellular Ca2+ signaling: more than just simple Ca2+ buffers
-
Parekh AB. Mitochondrial regulation of intracellular Ca2+ signaling: more than just simple Ca2+ buffers. News Physiol Sci. 2003, 18:252-6.
-
(2003)
News Physiol Sci.
, vol.18
, pp. 252-256
-
-
Parekh, A.B.1
-
86
-
-
65449139544
-
Mitochondria, calcium and cell death: a deadly triad in neurodegeneration
-
Celsi F, Pizzo P, Brini M. Mitochondria, calcium and cell death: a deadly triad in neurodegeneration. Biochim Biophys Acta. 2009, 1787:335-44.
-
(2009)
Biochim Biophys Acta.
, vol.1787
, pp. 335-344
-
-
Celsi, F.1
Pizzo, P.2
Brini, M.3
-
87
-
-
53549088327
-
Portal to Alzheimer's disease
-
Starkov AA, Beal FM. Portal to Alzheimer's disease. Nat Med. 2008, 14:1020-1.
-
(2008)
Nat Med.
, vol.14
, pp. 1020-1021
-
-
Starkov, A.A.1
Beal, F.M.2
-
88
-
-
47749113650
-
Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks
-
Kuchibhotla KV, Goldman ST, Lattarulo CR. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron. 2008, 59:214-25.
-
(2008)
Neuron.
, vol.59
, pp. 214-225
-
-
Kuchibhotla, K.V.1
Goldman, S.T.2
Lattarulo, C.R.3
-
89
-
-
38949123792
-
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease
-
Meyer-Luehmann M, Spires-Jones TL, Prada C. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 2008, 451:720-4.
-
(2008)
Nature.
, vol.451
, pp. 720-724
-
-
Meyer-Luehmann, M.1
Spires-Jones, T.L.2
Prada, C.3
-
90
-
-
52249115856
-
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease
-
Busche MA, Eichhoff G, Adelsberger H. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science. 2008, 321:1686-9.
-
(2008)
Science.
, vol.321
, pp. 1686-1689
-
-
Busche, M.A.1
Eichhoff, G.2
Adelsberger, H.3
-
91
-
-
61349096009
-
Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice
-
Kuchibhotla KV, Lattarulo CR, Hyman BT. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science. 2009, 323:1211-5.
-
(2009)
Science.
, vol.323
, pp. 1211-1215
-
-
Kuchibhotla, K.V.1
Lattarulo, C.R.2
Hyman, B.T.3
-
92
-
-
34247580868
-
Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease
-
Takano T, Han X, Deane R. Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Ann N Y Acad Sci. 2007, 1097:40-50.
-
(2007)
Ann N Y Acad Sci.
, vol.1097
, pp. 40-50
-
-
Takano, T.1
Han, X.2
Deane, R.3
-
93
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe DJ. Alzheimer's disease is a synaptic failure. Science. 2002, 298:789-91.
-
(2002)
Science.
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
94
-
-
0020072221
-
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain
-
Whitehouse PJ, Price DL, Struble RG. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science. 1982, 215:1237-9.
-
(1982)
Science.
, vol.215
, pp. 1237-1239
-
-
Whitehouse, P.J.1
Price, D.L.2
Struble, R.G.3
-
95
-
-
0018726532
-
Dendritic growth in the aged human brain and failure of growth in senile dementia
-
Buell SJ, Coleman PD. Dendritic growth in the aged human brain and failure of growth in senile dementia. Science. 1979, 206:854-6.
-
(1979)
Science.
, vol.206
, pp. 854-856
-
-
Buell, S.J.1
Coleman, P.D.2
-
96
-
-
0024595972
-
Synaptic loss in Alzheimer's disease and other dementias
-
Hamos JE, DeGennaro LJ, Drachman DA. Synaptic loss in Alzheimer's disease and other dementias. Neurology. 1989, 39:355-61.
-
(1989)
Neurology.
, vol.39
, pp. 355-361
-
-
Hamos, J.E.1
DeGennaro, L.J.2
Drachman, D.A.3
-
97
-
-
0025269152
-
Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity
-
DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol. 1990, 27:457-64.
-
(1990)
Ann Neurol.
, vol.27
, pp. 457-464
-
-
DeKosky, S.T.1
Scheff, S.W.2
-
98
-
-
55149109190
-
Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease
-
Thal DR, Griffin WS, Braak H. Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease. J Cell Mol Med. 2008, 12:1848-62.
-
(2008)
J Cell Mol Med.
, vol.12
, pp. 1848-1862
-
-
Thal, D.R.1
Griffin, W.S.2
Braak, H.3
-
99
-
-
7044220336
-
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
-
Tsai J, Grutzendler J, Duff K. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci. 2004, 7:1181-3.
-
(2004)
Nat Neurosci.
, vol.7
, pp. 1181-1183
-
-
Tsai, J.1
Grutzendler, J.2
Duff, K.3
-
100
-
-
5444225566
-
Dendrite and dendritic spine alterations in Alzheimer models
-
Moolman DL, Vitolo OV, Vonsattel JP. Dendrite and dendritic spine alterations in Alzheimer models. J Neurocytol. 2004, 33:377-87.
-
(2004)
J Neurocytol.
, vol.33
, pp. 377-387
-
-
Moolman, D.L.1
Vitolo, O.V.2
Vonsattel, J.P.3
-
101
-
-
23444448170
-
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
-
Spires TL, Meyer-Luehmann M, Stern EA. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci. 2005, 25:7278-87.
-
(2005)
J Neurosci.
, vol.25
, pp. 7278-7287
-
-
Spires, T.L.1
Meyer-Luehmann, M.2
Stern, E.A.3
-
102
-
-
62649174753
-
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
-
Koffie RM, Meyer-Luehmann M, Hashimoto T. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci USA. 2009, 106:4012-7.
-
(2009)
Proc Natl Acad Sci USA.
, vol.106
, pp. 4012-4017
-
-
Koffie, R.M.1
Meyer-Luehmann, M.2
Hashimoto, T.3
-
103
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz F, Tomita T, Hsieh H. APP processing and synaptic function. Neuron. 2003, 37:925-37.
-
(2003)
Neuron.
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
-
104
-
-
33845411954
-
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
-
Hsieh H, Boehm J, Sato C. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 2006, 52:831-43.
-
(2006)
Neuron.
, vol.52
, pp. 831-843
-
-
Hsieh, H.1
Boehm, J.2
Sato, C.3
-
105
-
-
23044445669
-
Regulation of NMDA receptor trafficking by amyloid-beta
-
Snyder EM, Nong Y, Almeida CG. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci. 2005, 8:1051-8.
-
(2005)
Nat Neurosci.
, vol.8
, pp. 1051-1058
-
-
Snyder, E.M.1
Nong, Y.2
Almeida, C.G.3
-
106
-
-
33644749222
-
AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice
-
Chang EH, Savage MJ, Flood DG. AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice. Proc Natl Acad Sci USA. 2006, 103:3410-5.
-
(2006)
Proc Natl Acad Sci USA.
, vol.103
, pp. 3410-3415
-
-
Chang, E.H.1
Savage, M.J.2
Flood, D.G.3
-
107
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003, 39:409-21.
-
(2003)
Neuron.
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
-
108
-
-
34548264782
-
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
-
Palop JJ, Chin J, Roberson ED. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 2007, 55:697-711.
-
(2007)
Neuron.
, vol.55
, pp. 697-711
-
-
Palop, J.J.1
Chin, J.2
Roberson, E.D.3
-
109
-
-
65249091454
-
Epilepsy and cognitive impairments in Alzheimer disease
-
Palop JJ, Mucke L. Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol. 2009, 66:435-40.
-
(2009)
Arch Neurol.
, vol.66
, pp. 435-440
-
-
Palop, J.J.1
Mucke, L.2
-
110
-
-
63849180498
-
Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy
-
Minkeviciene R, Rheims S, Dobszay MB. Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci. 2009, 29:3453-62.
-
(2009)
J Neurosci.
, vol.29
, pp. 3453-3462
-
-
Minkeviciene, R.1
Rheims, S.2
Dobszay, M.B.3
-
111
-
-
0033215972
-
Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice
-
Phinney AL, Deller T, Stalder M. Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice. J Neurosci. 1999, 19:8552-9.
-
(1999)
J Neurosci.
, vol.19
, pp. 8552-8559
-
-
Phinney, A.L.1
Deller, T.2
Stalder, M.3
-
112
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
Sturchler-Pierrat C, Abramowski D, Duke M. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA. 1997, 94:13287-92.
-
(1997)
Proc Natl Acad Sci USA.
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
-
113
-
-
41549155927
-
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo
-
Cirrito JR, Kang JE, Lee J. Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron. 2008, 58:42-51.
-
(2008)
Neuron.
, vol.58
, pp. 42-51
-
-
Cirrito, J.R.1
Kang, J.E.2
Lee, J.3
-
114
-
-
0141761520
-
Seizures in elderly patients with dementia: epidemiology and management
-
Mendez M, Lim G. Seizures in elderly patients with dementia: epidemiology and management. Drug Aging. 2003, 20:791-803.
-
(2003)
Drug Aging.
, vol.20
, pp. 791-803
-
-
Mendez, M.1
Lim, G.2
-
115
-
-
28944432753
-
Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life
-
Snider BJ, Norton J, Coats MA. Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life. Arch Neurol. 2005, 62:1821-30.
-
(2005)
Arch Neurol.
, vol.62
, pp. 1821-1830
-
-
Snider, B.J.1
Norton, J.2
Coats, M.A.3
-
116
-
-
18044364799
-
Down syndrome, Alzheimer's disease and seizures
-
Menendez M. Down syndrome, Alzheimer's disease and seizures. Brain Dev. 2005, 27:246-52.
-
(2005)
Brain Dev.
, vol.27
, pp. 246-252
-
-
Menendez, M.1
-
117
-
-
42649121653
-
EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease
-
Ponomareva NV, Korovaitseva GI, Rogaev EI. EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease. Neurobiol Aging. 2008, 29:819-27.
-
(2008)
Neurobiol Aging.
, vol.29
, pp. 819-827
-
-
Ponomareva, N.V.1
Korovaitseva, G.I.2
Rogaev, E.I.3
-
118
-
-
67650875899
-
Amyloid deposition is associated with impaired default network function in older persons without dementia
-
Sperling RA, Laviolette PS, O'Keefe K. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 2009, 63:178-88.
-
(2009)
Neuron.
, vol.63
, pp. 178-188
-
-
Sperling, R.A.1
Laviolette, P.S.2
O'Keefe, K.3
-
119
-
-
0026743110
-
Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
-
Arriagada PV, Marzloff K, Hyman BT. Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease. Neurology. 1992, 42:1681-8.
-
(1992)
Neurology.
, vol.42
, pp. 1681-1688
-
-
Arriagada, P.V.1
Marzloff, K.2
Hyman, B.T.3
-
120
-
-
0027432101
-
Pathological markers associated with normal aging and dementia in the elderly
-
Crystal HA, Dickson DW, Sliwinski MJ. Pathological markers associated with normal aging and dementia in the elderly. Ann Neurol. 1993, 34:566-73.
-
(1993)
Ann Neurol.
, vol.34
, pp. 566-573
-
-
Crystal, H.A.1
Dickson, D.W.2
Sliwinski, M.J.3
-
121
-
-
0038117796
-
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
-
Naslund J, Haroutunian V, Mohs R. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA. 2000, 283:1571-7.
-
(2000)
JAMA.
, vol.283
, pp. 1571-1577
-
-
Naslund, J.1
Haroutunian, V.2
Mohs, R.3
-
122
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue LF, Kuo YM, Roher AE. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol. 1999, 155:853-62.
-
(1999)
Am J Pathol.
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
-
123
-
-
0035807829
-
Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques
-
Koistinaho M, Ort M, Cimadevilla JM. Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques. Proc Natl Acad Sci USA. 2001, 98:14675-80.
-
(2001)
Proc Natl Acad Sci USA.
, vol.98
, pp. 14675-14680
-
-
Koistinaho, M.1
Ort, M.2
Cimadevilla, J.M.3
-
124
-
-
0036489445
-
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease
-
Westerman MA, Cooper-Blacketer D, Mariash A. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci. 2002, 22:1858-67.
-
(2002)
J Neurosci.
, vol.22
, pp. 1858-1867
-
-
Westerman, M.A.1
Cooper-Blacketer, D.2
Mariash, A.3
-
125
-
-
0024436506
-
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
-
Itagaki S, McGeer PL, Akiyama H. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol. 1989, 24:173-82.
-
(1989)
J Neuroimmunol.
, vol.24
, pp. 173-182
-
-
Itagaki, S.1
McGeer, P.L.2
Akiyama, H.3
-
126
-
-
0025676284
-
The complex of microglial cells and amyloid star in three-dimensional reconstruction
-
Wegiel J, Wisniewski HM. The complex of microglial cells and amyloid star in three-dimensional reconstruction. Acta Neuropathol. 1990, 81:116-24.
-
(1990)
Acta Neuropathol.
, vol.81
, pp. 116-124
-
-
Wegiel, J.1
Wisniewski, H.M.2
-
127
-
-
3042845492
-
Microglia and Alzheimer's disease pathogenesis
-
Streit WJ. Microglia and Alzheimer's disease pathogenesis. J Neurosci Res. 2004, 77:1-8.
-
(2004)
J Neurosci Res.
, vol.77
, pp. 1-8
-
-
Streit, W.J.1
-
128
-
-
0034820507
-
Bacterial lipopolysaccharides and innate immunity
-
Alexander C, Rietschel ET. Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res. 2001, 7:167-202.
-
(2001)
J Endotoxin Res.
, vol.7
, pp. 167-202
-
-
Alexander, C.1
Rietschel, E.T.2
-
129
-
-
71549171171
-
The cortical innate immune response increases local neuronal excitability leading to seizures
-
Rodgers KM, Hutchinson MR, Northcutt A. The cortical innate immune response increases local neuronal excitability leading to seizures. Brain. 2009, 132:2478-86.
-
(2009)
Brain.
, vol.132
, pp. 2478-2486
-
-
Rodgers, K.M.1
Hutchinson, M.R.2
Northcutt, A.3
-
130
-
-
0031019589
-
Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene
-
Airaksinen MS, Eilers J, Garaschuk O. Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene. Proc Natl Acad Sci USA. 1997, 94:1488-93.
-
(1997)
Proc Natl Acad Sci USA.
, vol.94
, pp. 1488-1493
-
-
Airaksinen, M.S.1
Eilers, J.2
Garaschuk, O.3
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