PKCε increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 21, 2006, Pages 8215-8220

  Choi, Doo Sup ^a,d   Wang, Dan ^a   Yu, Gui Qui ^b   Zhu, Guofen ^a   Kharazia, Viktor N ^a   Paredes, J Peter ^a   Chang, Wesley S ^a   Deitchman, Jason K ^a   Mucke, Lennart ^b,c   Messing, Robert O ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

Author keywords

Alzheimer's disease; Neurodegeneration; Phosphorylation; Proteolysis

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ENDOTHELIN CONVERTING ENZYME; INSULINASE; MEMBRANE METALLOENDOPEPTIDASE; PROTEIN KINASE C EPSILON; AMYLOID; ASPARTIC PROTEINASE; ENDOTHELIN-CONVERTING ENZYME 1; METALLOPROTEINASE;

ADOLESCENT; AGED; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; TRANSGENIC MOUSE; ANIMAL; BRAIN; CHEMISTRY; CYTOLOGY; DEGENERATIVE DISEASE; GLIOSIS; HIPPOCAMPUS; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

MUS MUSCULUS;

AMYLOID; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; ENDOTHELIUM, VASCULAR; GLIOSIS; HIPPOCAMPUS; HUMANS; METALLOENDOPEPTIDASES; MICE; MICE, TRANSGENIC; NEURODEGENERATIVE DISEASES; NEURONS; PHOSPHORYLATION; PROTEIN KINASE C-EPSILON;

EID: 33744465230     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509725103     Document Type: Article

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