Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid β and impairment of learning and memory

Behavioural Brain Research

Volumn 168, Issue 1, 2006, Pages 83-91

  Mouri, Akihiro ^a   Zou, Li Bo ^b   Iwata, Nobuhisa ^c   Saido, Takaomi C ^c   Wang, Dayong ^a   Wang, Min Wei ^b   Noda, Yukihiro ^a,d   Nabeshima, Toshitaka ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d MEIJO UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Amyloid ; Cognitive dysfunction; Neprilysin; Rat; Thiorphan

Indexed keywords

ACETYLCHOLINE; AMYLOID BETA PROTEIN; MEMBRANE METALLOENDOPEPTIDASE; NICOTINE; THIORPHAN;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN VENTRICLE; COGNITIVE DEFECT; CONDITIONING; CONTROLLED STUDY; HIPPOCAMPUS; LEARNING DISORDER; MALE; MEMORY DISORDER; NONHUMAN; PRIORITY JOURNAL; SPATIAL MEMORY; TASK PERFORMANCE;

ACETYLCHOLINE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN CHEMISTRY; CEREBRAL CORTEX; CUES; FEAR; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; LEARNING; MALE; MAZE LEARNING; MEMORY; MEMORY, SHORT-TERM; NEPRILYSIN; NICOTINE; NICOTINIC AGONISTS; PROTEASE INHIBITORS; RATS; RATS, WISTAR; RECOGNITION (PSYCHOLOGY); THIORPHAN;

EID: 31444448250     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2005.10.014     Document Type: Article

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