The presenilin 1 ΔE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations

Journal of Biological Chemistry

Volumn 277, Issue 39, 2002, Pages 36646-36655

  Cedazo Mínguez, Angel ^a   Popescu, Bogdan O ^a   Ankarcrona, Maria ^a   Nishimura, Takeshi ^a   Cowburn, Richard F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFECTANTS;

CALCIUM; CELLS; DISEASES; HYDROLYSIS; RUTHENIUM;

BIOCHEMISTRY;

CALPAIN; CARBACHOL; CYCLOPIAZONIC ACID; INOSITOL TRISPHOSPHATE; NERVE CELL ADHESION MOLECULE; PHOSPHOLIPASE C; PRESENILIN 1; RYANODINE RECEPTOR; AMYLOID BETA PROTEIN; CADHERIN; CALCIUM; CENTRAL MUSCLE RELAXANT; COLORING AGENT; DANTROLENE; ENZYME INHIBITOR; INDOLE DERIVATIVE; MACROCYCLIC COMPOUND; MEMBRANE PROTEIN; NEOMYCIN; OXAZOLE DERIVATIVE; PSEN1 PROTEIN, HUMAN; RUTHENIUM RED; RYANODINE; XESTOSPONGIN A;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CHROMOSOME 14; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NEUROBLASTOMA; PRIORITY JOURNAL; APOPTOSIS; CELL CULTURE; CELL LINE; CELL MEMBRANE; CONFOCAL MICROSCOPY; DRUG ANTAGONISM; EXON; GENETICS; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TIME;

AMYLOID BETA-PROTEIN; APOPTOSIS; CADHERINS; CALCIUM; CARBACHOL; CELL LINE; CELL MEMBRANE; COLORING AGENTS; DANTROLENE; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; EXONS; HUMANS; HYDROLYSIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INDOLES; MACROCYCLIC COMPOUNDS; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MUSCLE RELAXANTS, CENTRAL; MUTATION; NEOMYCIN; OXAZOLES; PHOSPHOLIPASE C; PRESENILIN-1; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RUTHENIUM RED; RYANODINE; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037183702     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M112117200     Document Type: Article

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