Blockade of α4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity

Diabetes

Volumn 57, Issue 7, 2008, Pages 1842-1851

  Féral, Chloé C ^a,b   Neels, Jaap G ^a   Kummer, Christiane ^a   Slepak, Marina ^a   Olefsky, Jerrold M ^a   Ginsberg, Mark H ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; MONOCYTE CHEMOTACTIC PROTEIN 1; FATTY ACID; INSULIN; LEPTIN; LIPID;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CALORIC INTAKE; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FEEDING; INSULIN RESISTANCE; LIPID DIET; LIPID METABOLISM; MACROPHAGE; MALE; MONOCYTE; MOUSE; MUTATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTECTION; SIGNAL TRANSDUCTION; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; BLOOD; C57BL MOUSE; CELL MOTION; DRUG EFFECT; FAT INTAKE; GENETICS; GLUCOSE TOLERANCE TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPOSE TISSUE; AMINO ACID SUBSTITUTION; ANIMALS; CELL MOVEMENT; DIETARY FATS; FATTY ACIDS, NONESTERIFIED; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE; INTEGRIN ALPHA4; LEPTIN; LIPIDS; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 48249117202     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-1751     Document Type: Article

References (45)

1. Golay A, Felber JP: Evolution from obesity to diabetes. Diabete Metab 20:3-14, 1994
2. Rader DJ: Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus. Am J Med 120:S12-S18, 2007
3. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw- Boris A, Poli G, Olefsky J, Karin M: IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191-198, 2005
4. Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, Kasuga M: MCP-1 contributes to macro- phage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116:1494-1505, 2006
5. Rychly J, Nebe B: Therapeutic strategies in autoimmune diseases by interfering with leukocyte endothelium interaction. Curr Pharm Des 12:3799-3806, 2006
6. Kaneider NC, Leger AJ, Kuliopulos A: Therapeutic targeting of molecules involved in leukocyte-endothelial cell interactions. FEBS J273:4416-4424, 2006
7. Ghosh S, Goldin E, Gordon FH, Malchow HA, Rask-Madsen J, Rutgeerts P, Vyhnalek P, Zadorova Z, Palmer T, Donoghue S: Natalizumab for active Crohn's disease. N Engl J Med 348:24-32, 2003
8. Miller DH, Khan OA, Sheremata WA, Blumhardt LD, Rice GP, Libonati MA, Willmer-Hulme AJ, Dalton CM, Miszkiel KA, O'Connor PW: A controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 348:15-23, 2003
9. Arroyo AG, Yang JT, Rayburn H, Hynes RO: Differential requirements for alpha4 integrins during fetal and adult hematopoiesis. Cell 85:997-1008, 1996
10. Sengbusch JK, He W, Pinco KA, Yang JT: Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment. J Cell Biol 157:873-882, 2002
11. Yang JT, Rayburn H, Hynes RO: Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development 121:549-560, 1995
12. Sheridan C: Tysabri raises alarm bells on drug class. Nat Biotechnol 23:397-398, 2005
13. Sheridan C: Third Tysabri adverse case hits drug class. Nat Rev Drug Discov 4:357-358, 2005
14. Kummer C, Ginsberg MH: New approaches to blockade of alpha4-integrins, proven therapeutic targets in chronic inflammation. Biochem Pharmacol 72:1460-1468, 2006
15. Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfafff M, Ginsberg MH: Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Nature 402:676-681, 1999
16. Alon R, Feigelson SW, Manevich E, Rose DM, Schmitz J, Overby DR, Winter E, Grabovsky V, Shinder V, Matthews BD, Sokolovsky-Eisenberg M, Ingber DE, Benoit M, Ginsberg MH: Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol 171:1073-1084, 2005
17. Rose DM, Liu S, Woodside DG, Han J, Schlaepfer DD, Ginsberg MH: Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol 170:5912-5918, 2003
18. Feral CC, Rose DM, Han J, Fox N, Silverman GJ, Kaushansky K, Ginsberg MH: Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin Invest 116:715-723, 2006
19. Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky JM: Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med 13:455-462, 2007
20. Xu W, Hou W, Yao G, Ji Y, Yeh M, Sun B: Inhibition of Th1- and enhancement of Th2-initiating cytokines and chemokines in trichosanthin-treated macrophages. Biochem Biophys Res Commun 284:168-172, 2001
21. Purves RD: Optimum numerical integration methods for estimation of area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC). J Pharmacokinet Biopharm 20:211-226, 1992
22. Bruning JC, Winnay J, Cheatham B, Kahn CR: Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol Cell Biol 17:1513-1521, 1997
23. Lobb RR, Hemler ME: The pathophysiologic role of alpha 4 integrins in vivo. J Clin Invest 94:1722-1728, 1994
24. von Andrian UH, Engelhardt B: Alpha4 integrins as therapeutic targets in autoimmune disease. N Engl J Med 348:68-72, 2003
25. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808, 2003
26. Hemler ME: VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol 8:365-400, 1990
27. Bouloumie A, Curat CA, Sengenes C, Lolmede K, Miranville A, Busse R: Role of macrophage tissue infiltration in metabolic diseases. Curr Opin Clin Nutr Metab Care 8:347-354, 2005
28. Tsou CL, Peters W, Si Y, Slaymaker S, Aslanian AM, Weisberg SP, Mack M, Charo IF: Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest 117:902-909, 2007
29. Drevets DA, Dillon MJ, Schawang JS, Van Rooijen N, Ehrchen J, Sun- derkotter C, Leenen PJ: The Ly-6C high monocyte subpopulation transports Listeria monocytogenes into the brain during systemic infection of mice. J Immunol 172:4418-4424, 2004
30. Henderson RB, Hobbs JA, Mathies M, Hogg N: Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 102:328-335, 2003
31. Sunderkotter C, Nikolic T, Dillon MJ, Van Rooijen N, Stehling M, Drevets DA, Leenen PJ: Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol 172:4410-4417, 2004
32. Tacke F, Ginhoux F, Jakubzick C, van Rooijen N, Merad M, Randolph GJ: Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery. J Exp Med 203:583-597, 2006
33. Cancello R, Tordjman J, Poitou C, Guilhem G, Bouillot JL, Hugol D, Coussieu C, Basdevant A, Bar Hen A, Bedossa P, Guerre-Millo M, Clement K: Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 55:1554-1561, 2006
34. Alexandraki K, Piperi C, Kalofoutis C, Singh J, Alaveras A, Kalofoutis A: Inflammatory process in type 2 diabetes: the role of cytokines. Ann NY Acad Sci 1084:89-117, 2006
35. Chen A, Mumick S, Zhang C, Lamb J, Dai H, Weingarth D, Mudgett J, Chen H,MacNeil DJ, Reitman ML, Qian S: Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. Obes Res 13:1311-1320, 2005
36. Matsushima K, Larsen CG, DuBois GC, Oppenheim JJ: Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J Exp Med 169:1485-1490, 1989
37. Yoshimura T, Yuhki N, Moore SK, Appella E, Lerman MI, Leonard EJ: Human monocyte chemoattractant protein-1 (MCP-1): full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. FEBS Lett 244: 487-493, 1989
38. Arroyo AG, Yang JT, Rayburn H, Hynes RO: Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity 11:555-566, 1999
39. Scott LM, Priestley GV, Papayannopoulou T: Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol Cell Biol 23:9349-9360, 2003
40. Sjoholm A, Nystrom T: Inflammation and the etiology of type 2 diabetes. Diabete Metab Res Rev 22:4-10, 2006
41. Patel SS, Thiagarajan R, Willerson JT, Yeh ET: Inhibition of alpha4 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in ApoE-deficient mice. Circulation 97:75-81, 1998
42. Lumeng CN, Bodzin JL, Saltiel AR: Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175-184, 2007
43. Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass CK, Neels JG, Olefsky JM: A subpopulation of macro- phages infiltrates hypertrophic adipose tissue and is activated by FFAS via TLR2, TLR4 and JNK-dependent pathways. J Biol Chem 282:35279-35292, 2007
44. Gordon S, Taylor PR: Monocyte and macrophage heterogeneity. Nat Rev Immunol 5:953-964, 2005 45. Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante AW Jr: CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116:115-124, 2006
45. Rana JS, Nieuwdorp M, Jukema JW, Kastelein JJ: Cardiovascular metabolic syndrome: an interplay of obesity, inflammation, diabetes and coronary heart disease. Diabetes Obes Metab 9:218-232, 2007