RAGE is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease

Cellular and Molecular Life Sciences

Volumn 59, Issue 7, 2002, Pages 1117-1128

  Bucciarelli, L G ^a   Wendt, T ^a   Rong, L ^a   Lalla, E ^a   Hofmann, M A ^a   Goova, M T ^a   Taguchi, A ^a   Yan, S F ^a   Yan, S D ^a   Stern, D M ^a   Schmidt, A M ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

Atherosclerosis; Cancer; Diabetes; Immunoglobulin; Inflammation; Receptor; Superfamily; Vasculopathy

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMYLOID BETA PROTEIN; CALGRANULIN; IMMUNOGLOBULIN; LIGAND; PROTEIN S 100;

ALZHEIMER DISEASE; AMYLOIDOSIS; CHRONIC DISEASE; DEGENERATIVE DISEASE; DIABETES MELLITUS; HOMEOSTASIS; INFLAMMATION; REVIEW; TUMOR;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMALS; ARTERIOSCLEROSIS; CELL MOVEMENT; CHRONIC DISEASE; DIABETIC ANGIOPATHIES; HOMEOSTASIS; HUMANS; IMMUNOGLOBULINS; INFLAMMATION; MICE; NEOPLASMS; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 18544375186     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8491-x     Document Type: Review

References (83)

1. Isolation and characterization of binding proteins for advanced glycosylation endproducts from lung tissue which are present on the endothelial cell surface
2. Cloning and expression of RAGE: A cell surface receptor for advanced glycosylation end products of proteins
3. Age-dependent accumulation of N epsilon-(carboxymethyl)lysine and N epsilon-(carboxymethyl)hydroxylysine in human skin collagen
4. N epsilon-(carboxymethyl)lysine is a dominant advanced glycation endproduct (AGE) antigen in tissue proteins
5. N-(epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation endproducts of the Maillard reaction
6. Increased accumulation of the glycoxidation product N (epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging
7. ε (carboxymethyl)lysine modifications of proteins are ligands for RAGE that activate cell signalling pathways and modulate gene expression
8. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
9. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
10. RAGE mediates a novel proinflammatory axis: A central, cell surface receptor for S100/calgranulin polypeptides
11. The receptor for advanced glycation endproducts (RAGE) is a cellular binding site for amphoterin: Mediation of neurite outgrowth and co-expression of RAGE and amphoterin in the developing nervous system
12. Five-year incidence of atherosclerotic vascular disease in relation to general, risk factors, insulin level, and abnormalities in lipoprotein composition in NIDDM and non-diabetic subjects
13. A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women
14. Diabetes and cardiovascular disease: The Framingham Study
15. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
16. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues
17. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hyperglactosemia
18. Amelioration of vascular dysfunction in diabetic rats by an oral, PKC beta inhibitor
19. Hyperglycemia-induced activation of nuclear transcription factor-kappaB in vascular smooth muscle cells
20. High-glucose-induced nuclear factor kappaB activation in vascular smooth muscle cells
21. High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial, cells is PKC-NF-kappaB-dependent
22. Structure elucidation of senescence cross-link from human extracellular matrix: Implication of pentoses in the aging process
23. Accumulation of Maillard products in skin collagen in diabetes and aging
24. Immunohistochemical, detection of AGEs in diabetic tissues using monoclonal, antibody to pyrraline
25. Immunological, presence of AGEs in atherosclerotic lesions of euglycemic rabbits
26. Immunohistochemical, colocalization of glycoxidation products and lipid peroxidation products in diabetic renal, glomerular lesions
27. Advanced Maillard reaction end products are associated with Alzheimer disease pathology
28. Immunohistochemical, study of advanced glycation endproducts in aging and Alzheimer's disease brain
29. Formation of pentosidine during nonenzymatic browning of protein by glucose: Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo
30. Mechanisms of formation of the Maillard protein crosslink pentosidine: Ribose, glucose, fructose and ascorbate as pentosidine precursors
31. Pentosidine formation in skin correlates with severity of complications in individuals with longstanding IDDM
32. Identification of N epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated proteins
33. The myeloperoxidase system of human phagocytes generates N epsilon(carboxymethyl)lysine on proteins: A mechanism for producing advanced glycation endproducts at sites of inflammation
34. Macrophages adhere to glucose-modified basement membrane via their scavenger receptors
35. Galectin-3 as a high affinity binding protein for AGE: A new member of the AGE-receptor complex
36. Molecular identity and cellular distribution of advanced glycation endproduct receptors: Relationship of p60 to OST-48 and p90 and 80K-H membrane proteins
37. The dark side of glucose
38. Advanced glycation endproducts induce oxidant stress in the gingiva: A potential, mechanism underlying accelerated periodontal, disease associated with diabetes
39. Suppression of accelerated diabetic atherosclerosis by soluble receptor for AGE (sRAGE)
40. The expression of advanced glycation endproducts and their cellular receptor RAGE in diabetic nephropathy and non-diabetic renal disease
41. Blockade of receptor for AGE (RAGE) restores effective wound healing in diabetic mice
42. Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation endproducts
43. Increased transcapillary escape rate of albumin in type I (insulin-dependent) diabetic patients with microalbuminuria
44. Increased transcapillary escape rate of albumin in microalbuminuric type II diabetic subject
45. Coronary heart disease in young type 1 (insulin-dependent) diabetic patients with and without diabetic nephropathy: Incidence and risk factors
46. Prognostic significance of microalbuminuria in insulin-dependent diabetes mellitus: A twenty-three follow-up study
47. Receptor-mediated endothelial, cell dysfunction in diabetic vasculopathy: Soluble receptor for advanced glycation endproducts blocks hyperpermeability
48. RAGE mediates inflammation and enhanced expression of tissue factor in the vasculature of diabetic apolipoprotein E null mice
49. A murine model of accelerated atherosclerosis in diabetic LDL receptor deficient mice
50. Accelerated atherosclerosis and vascular inflammation develop in apo E null mice with type 2 diabetes
51. Blockade of receptor for AGE (RAGE) suppresses progression of established atherosclerotic lesions in apo E null mice with type 1 diabetes
52. Blockade of RAGE halts macrophage and smooth muscle cell migration and activation in established atherosclerosis in diabetic apo E null mice
53. Wound healing and the diabetic patient
54. Wound healing in diabetes mellitus
55. Studies of wound healing in experimental diabetes
56. The role of growth factors in wound healing
57. Clinical, efficacy of becaplermin (rh-PDGF-B) gel
58. Recombinant human platelet-derived growth factor-B (becaplermin) for healing chronic lower extremity diabetic ulcers: An open-label clinical, evaluation of efficacy
59. Prevalence of periodontal, disease in insulin-dependent diabetes mellitus
60. Type 2 diabetes mellitus and periodontal, disease
61. Periodontal disease: The sixth complication of diabetes mellitus
62. A murine model of accelerated periodontal, disease in diabetes
63. Blockade of RAGE suppresses periodontitis-associated alveolar bone loss in diabetic mice
64. Blockade of receptor for AGE (RAGE) suppresses albuminuria and glomerulosclerosis in murine diabetic kidney: Implications for podocyte activation in the pathogenesis of diabetic nephropathy
65. Amyloid-beta peptide-RAGE interaction elicits neuronal, expression of M-CSF: A proinflammatory pathway in Alzheimer's disease
66. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
67. S100: A multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles
68. Demonstration of novel anti-arthritic and anti-inflammatory effects of diphosphonates
69. Interleukin-10-deficient mice develop chronic enterocolitis
70. The myeloic related protein MRP8/14 (27E10 antigen) - Usefulness as a potential, marker for disease activity in ulcerative colitis and putative biological, function
71. Immunohistochemical, demonstration of calcium-binding proteins MRP8 and MRP14 and their heterodimer (27E10 antigen) in Crohns disease
72. The adhesive and neurite-promoting molecule p30: Analysis of the amino terminal, sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons
73. Isolation and some characteristics of an adhesive factor of brain that enhances neurite outgrowth in central, neurons
74. Sp1 binding elements in the promoter of RAGE are essential, for amphoterin-mediated gene expression in cultured neuroblastoma cells
75. Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides: Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation
76. Blockade of amphoterin/RAGE signalling suppresses tumor growth and metastases
77. Enhanced cellular oxidant stress by the interaction of advanced glycation endproducts with their receptors/binding proteins
78. Activation of the receptor for advanced glycation endproducts triggers a MAP kinase pathway regulated by oxidant stress
79. RAGE-mediated neurite outgrowth and activation of NF-kB require the cytosolic domain of the receptor but different downstream signalling pathways
80. Diabetes-associated sustained activation of the transcription factor nuclear factor-kappa B
81. Requirement for p38 and p44/42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional, activation and cytokine secretion
82. Restenosis: Central, role of RAGE-dependent neointimal, expansion