-
1
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp, R. et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 987-996
-
-
Stupp, R.1
-
2
-
-
48249125791
-
Malignant gliomas in adults
-
Wen, P. Y. & Kesari, S. Malignant gliomas in adults. N. Engl. J. Med. 359, 492-507 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 492-507
-
-
Wen, P.Y.1
Kesari, S.2
-
3
-
-
1642307767
-
Medulloblastoma: Signalling a change in treatment
-
Gilbertson, R. J. Medulloblastoma: signalling a change in treatment. Lancet Oncol. 5, 209-218 (2004).
-
(2004)
Lancet Oncol.
, vol.5
, pp. 209-218
-
-
Gilbertson, R.J.1
-
5
-
-
84924838884
-
A simplified classification of gliomas
-
Kernohan, J. W., Mabon, R. F. & Svien, H. J. A simplified classification of gliomas. Proc. Staff Meetings Mayo Clinic 24, 71-74 (1949).
-
(1949)
Proc. Staff Meetings Mayo Clinic
, vol.24
, pp. 71-74
-
-
Kernohan, J.W.1
Mabon, R.F.2
Svien, H.J.3
-
8
-
-
34547122001
-
The 2007 WHO classification of tumours of the central nervous system
-
Louis, D. N. et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 11 4, 97-109 (2007).
-
(2007)
Acta Neuropathol.
, vol.11
, Issue.4
, pp. 97-109
-
-
Louis, D.N.1
-
9
-
-
0029843049
-
The prognostic impact of prior low grade histology in patients with anaplastic gliomas: A case-control study
-
Dropcho, E. J. & Soong, S. J. The prognostic impact of prior low grade histology in patients with anaplastic gliomas: a case-control study. Neurology 47, 684-690 (1996).
-
(1996)
Neurology
, vol.47
, pp. 684-690
-
-
Dropcho, E.J.1
Soong, S.J.2
-
10
-
-
20344407807
-
Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
-
Ohgaki, H. & Kleihues, P. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J. Neuropathol. Exp. Neurol. 64, 479-489 (2005).
-
(2005)
J. Neuropathol. Exp. Neurol.
, vol.64
, pp. 479-489
-
-
Ohgaki, H.1
Kleihues, P.2
-
11
-
-
0032912596
-
A case history of glioma progression
-
Ohgaki, H. et al. A case history of glioma progression. Acta Neuropathol. 97, 525-532 (1999).
-
(1999)
Acta Neuropathol.
, vol.97
, pp. 525-532
-
-
Ohgaki, H.1
-
12
-
-
84949655795
-
Cerebral astrocytomas and their derivatives
-
Scherer, H. J. Cerebral astrocytomas and their derivatives. Am. J. Cancer 40, 159-198 (1940).
-
(1940)
Am. J. Cancer
, vol.40
, pp. 159-198
-
-
Scherer, H.J.1
-
13
-
-
20044371594
-
Treatment of early childhood medulloblastoma by postoperative chemotherapy alone
-
Rutkowski, S. et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N. Engl. J. Med. 352, 978-986 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 978-986
-
-
Rutkowski, S.1
-
14
-
-
0028878530
-
Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute
-
Sure, U. et al. Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute. Acta Neurochir. (Wien) 132, 59-65 (1995).
-
(1995)
Acta Neurochir. (Wien)
, vol.132
, pp. 59-65
-
-
Sure, U.1
-
15
-
-
0033791188
-
"Large cell/anaplastic" medulloblastomas: A Pediatric Oncology Group Study
-
Brown, H. G. et al. "Large cell/anaplastic" medulloblastomas: a Pediatric Oncology Group Study. J. Neuropathol. Exp. Neurol. 59, 857-865 (2000).
-
(2000)
J. Neuropathol. Exp. Neurol.
, vol.59
, pp. 857-865
-
-
Brown, H.G.1
-
16
-
-
0026663357
-
Large-cell medulloblastomas. A distinct variant with highly aggressive behavior
-
Giangaspero, F. et al. Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. Am. J. Surg. Pathol. 16, 687-693 (1992).
-
(1992)
Am. J. Surg. Pathol.
, vol.16
, pp. 687-693
-
-
Giangaspero, F.1
-
17
-
-
33745373514
-
Stratification of medulloblastoma on the basis of histopathological grading
-
Giangaspero, F. et al. Stratification of medulloblastoma on the basis of histopathological grading. Acta Neuropathol. 11 2, 5-12 (2006).
-
(2006)
Acta Neuropathol.
, vol.11
, Issue.2
, pp. 5-12
-
-
Giangaspero, F.1
-
18
-
-
0037604509
-
Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas
-
McManamy, C. S. et al. Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas. J. Neuropathol. Exp. Neurol. 62, 627-632 (2003).
-
(2003)
J. Neuropathol. Exp. Neurol.
, vol.62
, pp. 627-632
-
-
McManamy, C.S.1
-
19
-
-
0025633582
-
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
-
Malkin, D. et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250, 1233-1238 (1990).
-
(1990)
Science
, vol.250
, pp. 1233-1238
-
-
Malkin, D.1
-
20
-
-
0025648762
-
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome
-
Srivastava, S., Zou, Z. Q., Pirollo, K., Blattner, W. & Chang, E. H. Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature 348, 747-749 (1990).
-
(1990)
Nature
, vol.348
, pp. 747-749
-
-
Srivastava, S.1
Zou, Z.Q.2
Pirollo, K.3
Blattner, W.4
Chang, E.H.5
-
21
-
-
0028123442
-
The p53 gene and protein in human brain tumors
-
Louis, D. N. The p53 gene and protein in human brain tumors. J. Neuropathol. Exp. Neurol. 53, 11-21 (1994).
-
(1994)
J. Neuropathol. Exp. Neurol.
, vol.53
, pp. 11-21
-
-
Louis, D.N.1
-
22
-
-
0021932240
-
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
-
Libermann, T. A. et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 313, 144-147 (1985).
-
(1985)
Nature
, vol.313
, pp. 144-147
-
-
Libermann, T.A.1
-
23
-
-
0021363560
-
Expression of epidermal growth factor receptors in human brain tumors
-
Libermann, T. A. et al. Expression of epidermal growth factor receptors in human brain tumors. Cancer Res. 44, 753-760 (1984).
-
(1984)
Cancer Res.
, vol.44
, pp. 753-760
-
-
Libermann, T.A.1
-
24
-
-
0026548240
-
Structural alterations of the epidermal growth factor receptor gene in human gliomas
-
Wong, A. J. et al. Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc. Natl Acad. Sci. USA 89, 2965-2969 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 2965-2969
-
-
Wong, A.J.1
-
25
-
-
0034163550
-
Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
-
Frederick, L., Wang, X. Y., Eley, G. & James, C. D. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res. 60, 1383-1387 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 1383-1387
-
-
Frederick, L.1
Wang, X.Y.2
Eley, G.3
James, C.D.4
-
26
-
-
0025114687
-
Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
-
Sugawa, N., Ekstrand, A. J., James, C. D. & Collins, V. P. Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc. Natl Acad. Sci. USA 87, 8602-8606 (1990).
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, pp. 8602-8606
-
-
Sugawa, N.1
Ekstrand, A.J.2
James, C.D.3
Collins, V.P.4
-
27
-
-
0032494479
-
Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas
-
Cairncross, J. G. et al. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J. Natl Cancer Inst. 90, 1473-1479 (1998).
-
(1998)
J. Natl Cancer Inst.
, vol.90
, pp. 1473-1479
-
-
Cairncross, J.G.1
-
28
-
-
0028006633
-
Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p
-
Reifenberger, G. et al. Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am. J. Pathol. 145, 1175-1190 (1994).
-
(1994)
Am. J. Pathol.
, vol.145
, pp. 1175-1190
-
-
Reifenberger, G.1
-
29
-
-
0033566061
-
Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype
-
Smith, J. S. et al. Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype. Oncogene 18, 4144-4152 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 4144-4152
-
-
Smith, J.S.1
-
30
-
-
12944314946
-
Allelic losses at 1p36 and 19q13 in gliomas: Correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene
-
Barbashina, V., Salazar, P., Holland, E. C., Rosenblum, M. K. & Ladanyi, M. Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene. Clin. Cancer Res. 11, 1119-1128 (2005).
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 1119-1128
-
-
Barbashina, V.1
Salazar, P.2
Holland, E.C.3
Rosenblum, M.K.4
Ladanyi, M.5
-
31
-
-
0030982897
-
Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA
-
Costello, J. F. et al. Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res. 57, 1250-1254 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 1250-1254
-
-
Costello, J.F.1
-
32
-
-
0027943938
-
The retinoblastoma gene is involved in the malignant progression of astrocytomas
-
Henson, J. W. et al. The retinoblastoma gene is involved in the malignant progression of astrocytomas. Ann. Neurol. 36, 714-721 (1994).
-
(1994)
Ann. Neurol.
, vol.36
, pp. 714-721
-
-
Henson, J.W.1
-
33
-
-
0027978368
-
Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4 SAS and MDM2
-
Reifenberger, G., Reifenberger, J., Ichimura, K., Meltzer, P. S. & Collins, V. P. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res. 54, 4299-4303 (1994).
-
(1994)
Cancer Res.
, vol.54
, pp. 4299-4303
-
-
Reifenberger, G.1
Reifenberger, J.2
Ichimura, K.3
Meltzer, P.S.4
Collins, V.P.5
-
34
-
-
0035213384
-
Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendroglioma
-
Watanabe, T. et al. Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendroglioma. J. Neuropathol. Exp. Neurol. 60, 1181-1190 (2001).
-
(2001)
J. Neuropathol. Exp. Neurol.
, vol.60
, pp. 1181-1190
-
-
Watanabe, T.1
-
35
-
-
68149180890
-
Genome-wide association study identifies five susceptibility loci for glioma
-
Shete, S. et al. Genome-wide association study identifies five susceptibility loci for glioma. Nature Genet. 41, 899-904 (2009).
-
(2009)
Nature Genet.
, vol.41
, pp. 899-904
-
-
Shete, S.1
-
36
-
-
68149180891
-
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility
-
Wrensch, M. et al. Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nature Genet. 41, 905-908 (2009).
-
(2009)
Nature Genet.
, vol.41
, pp. 905-908
-
-
Wrensch, M.1
-
37
-
-
0035425048
-
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
-
Dai, C. et al. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev. 15, 1913-1925 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 1913-1925
-
-
Dai, C.1
-
38
-
-
18644377225
-
Et al. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma
-
Hu, X. et al. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia 7, 356-368 (2005).
-
(2005)
Neoplasia
, vol.7
, pp. 356-368
-
-
Hu, X.1
-
39
-
-
9144251024
-
Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
-
Uhrbom, L., Nerio, E. & Holland, E. C. Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. Nature Med. 10, 1257-1260 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 1257-1260
-
-
Uhrbom, L.1
Nerio, E.2
Holland, E.C.3
-
40
-
-
0034656212
-
Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
-
Marino, S., Vooijs, M., van Der Gulden, H., Jonkers, J. & Berns, A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes D e v. 14, 994-1004 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 994-1004
-
-
Marino, S.1
Vooijs, M.2
Van Der Gulden, H.3
Jonkers, J.4
Berns, A.5
-
41
-
-
0033812187
-
Nf1; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
-
Reilly, K. M., Loisel, D. A., Bronson, R. T., McLaughlin, M. E. & Jacks, T. Nf1; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nature Genet. 26, 109-113 (2000).
-
(2000)
Nature Genet.
, vol.26
, pp. 109-113
-
-
Reilly, K.M.1
Loisel, D.A.2
Bronson, R.T.3
McLaughlin, M.E.4
Jacks, T.5
-
42
-
-
0037382205
-
Genetic determinants of malignancy in a mouse model for oligodendroglioma
-
Weiss, W. A. et al. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res. 63, 1589-1595 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 1589-1595
-
-
Weiss, W.A.1
-
43
-
-
0036490954
-
Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation
-
Xiao, A., Wu, H., Pandolfi, P. P., Louis, D. N. & Van Dyke, T. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell 1,157-168 (2002).
-
(2002)
Cancer Cell
, vol.1
, pp. 157-168
-
-
Xiao, A.1
Wu, H.2
Pandolfi, P.P.3
Louis, D.N.4
Van Dyke, T.5
-
44
-
-
20444484560
-
Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation
-
Xiao, A. et al. Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. Cancer Res. 65, 5172-5180 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 5172-5180
-
-
Xiao, A.1
-
45
-
-
54549095950
-
Et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
-
Zheng, H. et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455, 1129-1133 (2008).
-
(2008)
Nature
, vol.455
, pp. 1129-1133
-
-
Zheng, H.1
-
46
-
-
23644443053
-
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
-
Zhu, Y. et al. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8, 119-130 (2005).
-
(2005)
Cancer Cell
, vol.8
, pp. 119-130
-
-
Zhu, Y.1
-
47
-
-
0031951740
-
Platelet-derived growth factor and its receptor expression in human oligodendrogliomas
-
Di Rocco, F., Carroll, R. S., Zhang, J. & Black, P. M. Platelet-derived growth factor and its receptor expression in human oligodendrogliomas. Neurosurgery 42, 341-346 (1998).
-
(1998)
Neurosurgery
, vol.42
, pp. 341-346
-
-
Di Rocco, F.1
Carroll, R.S.2
Zhang, J.3
Black, P.M.4
-
48
-
-
0029401049
-
Platelet-derived growth factor in human glioma
-
Westermark, B., Heldin, C. H. & Nister, M. Platelet-derived growth factor in human glioma. Glia 15, 257-263 (1995).
-
(1995)
Glia
, vol.15
, pp. 257-263
-
-
Westermark, B.1
Heldin, C.H.2
Nister, M.3
-
49
-
-
0037421971
-
A human brain tumor-derived PDGFR-α deletion mutant is transforming
-
Clarke, I. D. & Dirks, P. B. A human brain tumor-derived PDGFR-α deletion mutant is transforming. Oncogene 22, 722-733 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 722-733
-
-
Clarke, I.D.1
Dirks, P.B.2
-
50
-
-
27644543354
-
Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
-
Abounader, R. & Laterra, J. Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro Oncol. 7, 436-451 (2005).
-
(2005)
Neuro Oncol.
, vol.7
, pp. 436-451
-
-
Abounader, R.1
Laterra, J.2
-
51
-
-
0031465906
-
Proliferation of human malignant astrocytomas is dependent on Ras activation
-
Guha, A., Feldkamp, M. M., Lau, N., Boss, G. & Pawson, A. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene 15, 2755-2765 (1997).
-
(1997)
Oncogene
, vol.15
, pp. 2755-2765
-
-
Guha, A.1
Feldkamp, M.M.2
Lau, N.3
Boss, G.4
Pawson, A.5
-
52
-
-
3543056884
-
Analysis of the activation status of Akt NFkB, and Stat3 in human diffuse gliomas
-
Wang, H. et al. Analysis of the activation status of Akt, NFkB, and Stat3 in human diffuse gliomas. Lab. Invest. 84, 941-951 (2004).
-
(2004)
Lab. Invest.
, vol.84
, pp. 941-951
-
-
Wang, H.1
-
53
-
-
0023708370
-
Clonal genomic alterations in glioma malignancy stages
-
James, C. D. et al. Clonal genomic alterations in glioma malignancy stages. Cancer Res. 48, 5546-5551 (1988).
-
(1988)
Cancer Res.
, vol.48
, pp. 5546-5551
-
-
James, C.D.1
-
54
-
-
0037374550
-
Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model
-
Ding, H. et al. Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res. 63, 1106-1113 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 1106-1113
-
-
Ding, H.1
-
55
-
-
3142713010
-
Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis
-
Shih, A. H. et al. Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis. Cancer Res. 64, 4783-4789 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 4783-4789
-
-
Shih, A.H.1
-
56
-
-
0036791177
-
Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt
-
Uhrbom, L. et al. Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. Cancer Res. 62, 5551-5558 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 5551-5558
-
-
Uhrbom, L.1
-
57
-
-
0032401819
-
Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus
-
Uhrbom, L., Hesselager, G., Nister, M. & Westermark, B. Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus. Cancer Res. 58, 5275-5279 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 5275-5279
-
-
Uhrbom, L.1
Hesselager, G.2
Nister, M.3
Westermark, B.4
-
58
-
-
33747885901
-
High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model
-
Wei, Q. et al. High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Res. 66, 7429-7437 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 7429-7437
-
-
Wei, Q.1
-
59
-
-
62449252775
-
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis
-
Zhu, H. et al. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc. Natl Acad. Sci. USA 106, 2712-2716 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 2712-2716
-
-
Zhu, H.1
-
60
-
-
0035328722
-
Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas
-
Ding, H. et al. Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas. Cancer Res. 61, 3826-3836 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 3826-3836
-
-
Ding, H.1
-
61
-
-
0034020459
-
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
-
Holland, E. C. et al. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nature Genet. 25, 55-57 (2000).
-
(2000)
Nature Genet.
, vol.25
, pp. 55-57
-
-
Holland, E.C.1
-
62
-
-
44849089702
-
Pten haploinsufficiency accelerates formation of high-grade astrocytomas
-
Kwon, C. H. et al. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 68, 3286-3294 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 3286-3294
-
-
Kwon, C.H.1
-
63
-
-
57849109837
-
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
-
Llaguno, S. A. et al. Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 15, 45-56 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 45-56
-
-
Llaguno, S.A.1
-
64
-
-
0036828260
-
Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma
-
Burton, E. C. et al. Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma. Cancer Res. 62, 6205-6210 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 6205-6210
-
-
Burton, E.C.1
-
65
-
-
0034998193
-
Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization
-
Hui, A. B., Lo, K. W., Yin, X. L., Poon, W. S. & Ng, H. K. Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization. Lab. Invest. 81, 717-723 (2001).
-
(2001)
Lab. Invest.
, vol.81
, pp. 717-723
-
-
Hui, A.B.1
Lo, K.W.2
Yin, X.L.3
Poon, W.S.4
Ng, H.K.5
-
66
-
-
33845807801
-
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities
-
Maher, E. A. et al. Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res. 66, 11502-11513 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 11502-11513
-
-
Maher, E.A.1
-
67
-
-
17144376016
-
Array comparative genomic hybridization identifies genetic subgroups in grade 4 human astrocytoma
-
Misra, A. et al. Array comparative genomic hybridization identifies genetic subgroups in grade 4 human astrocytoma. Clin. Cancer Res. 11, 2907-2918 (2005).
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 2907-2918
-
-
Misra, A.1
-
68
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
The Cancer Genome Atlas Research Network
-
The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
69
-
-
20144389740
-
Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma
-
Nigro, J. M. et al. Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res. 65, 1678-1686 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 1678-1686
-
-
Nigro, J.M.1
-
70
-
-
0034105136
-
Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization
-
Nishizaki, T. et al. Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization. Hum. Pathol. 31, 608-614 (2000).
-
(2000)
Hum. Pathol.
, vol.31
, pp. 608-614
-
-
Nishizaki, T.1
-
71
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812 (2008).
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
-
72
-
-
67651039919
-
A network model of a cooperative genetic landscape in brain tumors
-
Bredel, M. et al. A network model of a cooperative genetic landscape in brain tumors. JAMA 302, 261-275 (2009).
-
(2009)
JAMA
, vol.302
, pp. 261-275
-
-
Bredel, M.1
-
73
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765-773 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 765-773
-
-
Yan, H.1
-
74
-
-
69949114447
-
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: A study of 1,010 diffuse gliomas
-
Hartmann, C. et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol. 11 8, 469-474 (2009).
-
(2009)
Acta Neuropathol.
, vol.11
, Issue.8
, pp. 469-474
-
-
Hartmann, C.1
-
75
-
-
70249097408
-
Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas
-
Sanson, M. et al. Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J. Clin. Oncol. 27, 4150-4154 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 4150-4154
-
-
Sanson, M.1
-
76
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α
-
Zhao, S. et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science 324, 261-265 (2009).
-
(2009)
Science
, vol.324
, pp. 261-265
-
-
Zhao, S.1
-
77
-
-
65249131228
-
Brain tumor hypoxia: Tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target
-
Jensen, R. L. Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target. J. Neurooncol. 92, 317-335 (2009).
-
(2009)
J. Neurooncol.
, vol.92
, pp. 317-335
-
-
Jensen, R.L.1
-
78
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739-744 (2009).
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
-
79
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis, E. R. et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N. Engl. J. Med. 361, 1058-1066 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
-
80
-
-
66149173789
-
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
-
Huse, J. T. et al. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev. 23, 1327-1337 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 1327-1337
-
-
Huse, J.T.1
-
81
-
-
76649130555
-
Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship
-
Kim, H. et al. Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc. Natl Acad. Sci. USA 107, 2183-2188 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 2183-2188
-
-
Kim, H.1
-
82
-
-
70350221952
-
MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
-
Li, Y. et al. MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res. 69, 7569-7576 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 7569-7576
-
-
Li, Y.1
-
83
-
-
67649202155
-
MicroRNA involvement in glioblastoma pathogenesis
-
Novakova, J., Slaby, O., Vyzula, R. & Michalek, J. MicroRNA involvement in glioblastoma pathogenesis. Biochem. Biophys. Res. Commun. 386, 1-5 (2009).
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.386
, pp. 1-5
-
-
Novakova, J.1
Slaby, O.2
Vyzula, R.3
Michalek, J.4
-
84
-
-
0142157702
-
Classification of human astrocytic gliomas on the basis of gene expression: A correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes
-
Godard, S. et al. Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res. 63, 6613-6625 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 6613-6625
-
-
Godard, S.1
-
85
-
-
0037381008
-
Gene expression-based classification of malignant gliomas correlates better with survival than histological classification
-
Nutt, C. L. et al. Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res. 63, 1602-1607 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 1602-1607
-
-
Nutt, C.L.1
-
86
-
-
62449321780
-
Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes
-
Li, A. et al. Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes. Cancer Res. 69, 2091-2099 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 2091-2099
-
-
Li, A.1
-
87
-
-
20244387732
-
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
-
Liang, Y. et al. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc. Natl Acad. Sci. USA 102, 5814-5819 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 5814-5819
-
-
Liang, Y.1
-
88
-
-
33644820339
-
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
-
Phillips, H. S. et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9, 157-173 (2006).
-
(2006)
Cancer Cell
, vol.9
, pp. 157-173
-
-
Phillips, H.S.1
-
89
-
-
33751208636
-
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target
-
Horvath, S. et al. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc. Natl Acad. Sci. USA 103, 17402-17407 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 17402-17407
-
-
Horvath, S.1
-
90
-
-
70849122697
-
Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
-
Brennan, C. et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS ONE 4, e7752 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Brennan, C.1
-
91
-
-
73649123907
-
An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak, R. G. W. et al. An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17, 98-110 (2009).
-
(2009)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.W.1
-
92
-
-
75149195336
-
The transcriptional network for mesenchymal transformation of brain tumours
-
Carro, M. S. et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463, 318-325 (2010).
-
(2010)
Nature
, vol.463
, pp. 318-325
-
-
Carro, M.S.1
-
93
-
-
48849110181
-
Medulloblastoma: What is the role of molecular genetics? Expert Rev
-
Entz-Werle, N. et al. Medulloblastoma: what is the role of molecular genetics? Expert Rev. Anticancer Ther. 8, 1169-1181 (2008).
-
(2008)
Anticancer Ther.
, vol.8
, pp. 1169-1181
-
-
Entz-Werle, N.1
-
94
-
-
0030913169
-
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched
-
Pietsch, T. et al. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res. 57, 2085-2088 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 2085-2088
-
-
Pietsch, T.1
-
95
-
-
0031036694
-
Sporadic medulloblastomas contain PTCH mutations
-
Raffel, C. et al. Sporadic medulloblastomas contain PTCH mutations. Cancer Res. 57, 842-845 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 842-845
-
-
Raffel, C.1
-
96
-
-
0032080853
-
Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
-
Reifenberger, J. et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 58, 1798-1803 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 1798-1803
-
-
Reifenberger, J.1
-
97
-
-
0036648241
-
Mutations in SUFU predispose to medulloblastoma
-
Taylor, M. D. et al. Mutations in SUFU predispose to medulloblastoma. Nature Genet. 31, 306-310 (2002).
-
(2002)
Nature Genet.
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
-
98
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
Hahn, H. et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85, 841-851 (1996).
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
-
99
-
-
1642496855
-
Molecular biology of medulloblastoma therapy
-
Pomeroy, S. L. & Sturla, L. M. Molecular biology of medulloblastoma therapy. Pediatr. Neurosurg. 39, 299-304 (2003).
-
(2003)
Pediatr. Neurosurg.
, vol.39
, pp. 299-304
-
-
Pomeroy, S.L.1
Sturla, L.M.2
-
100
-
-
48449105147
-
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
-
Schuller, U. et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14, 123-134 (2008).
-
(2008)
Cancer Cell
, vol.14
, pp. 123-134
-
-
Schuller, U.1
-
101
-
-
48449101742
-
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
-
Yang, Z. J. et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14, 135-145 (2008).
-
(2008)
Cancer Cell
, vol.14
, pp. 135-145
-
-
Yang, Z.J.1
-
102
-
-
33645094926
-
N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma
-
Browd, S. R. et al. N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma. Cancer Res. 66, 2666-2672 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 2666-2672
-
-
Browd, S.R.1
-
103
-
-
0030866154
-
Altered neural cell fates and medulloblastoma in mouse patched mutants
-
Goodrich, L. V., Milenkovic, L., Higgins, K. M. & Scott, M. P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113 (1997).
-
(1997)
Science
, vol.277
, pp. 1109-1113
-
-
Goodrich, L.V.1
Milenkovic, L.2
Higgins, K.M.3
Scott, M.P.4
-
104
-
-
7444228699
-
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas
-
Hallahan, A. R. et al. The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res. 64, 7794-7800 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 7794-7800
-
-
Hallahan, A.R.1
-
105
-
-
40949158954
-
The Smo/Smo model: Hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread
-
Hatton, B. A. et al. The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread. Cancer Res. 68, 1768-1776 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 1768-1776
-
-
Hatton, B.A.1
-
106
-
-
33746879125
-
Patched2 modulates tumorigenesis in patched1 heterozygous mice
-
Lee, Y. et al. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res. 66, 6964-6971 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 6964-6971
-
-
Lee, Y.1
-
107
-
-
34347241369
-
Apoptosis suppression by somatic cell transfer of Bcl-2 promotes Sonic hedgehog-dependent medulloblastoma formation in mice
-
McCall, T. D., Pedone, C. A. & Fults, D. W. Apoptosis suppression by somatic cell transfer of Bcl-2 promotes Sonic hedgehog-dependent medulloblastoma formation in mice. Cancer Res. 67, 5179-5185 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 5179-5185
-
-
McCall, T.D.1
Pedone, C.A.2
Fults, D.W.3
-
108
-
-
0037168206
-
High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice
-
Pazzaglia, S. et al. High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice. Oncogene 21, 7580-7584 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 7580-7584
-
-
Pazzaglia, S.1
-
109
-
-
33644529131
-
Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice
-
Pazzaglia, S. et al. Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice. Oncogene 25, 1165-1173 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 1165-1173
-
-
Pazzaglia, S.1
-
110
-
-
4444273153
-
Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice
-
Rao, G. et al. Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Oncogene 23, 6156-6162 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 6156-6162
-
-
Rao, G.1
-
111
-
-
33644877965
-
Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells
-
Rao, R. D. et al. Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells. Neoplasia 7, 921-929 (2005).
-
(2005)
Neoplasia
, vol.7
, pp. 921-929
-
-
Rao, R.D.1
-
112
-
-
0035863498
-
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
-
Wetmore, C., Eberhart, D. E. & Curran, T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res. 61, 513-516 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 513-516
-
-
Wetmore, C.1
Eberhart, D.E.2
Curran, T.3
-
113
-
-
0034123010
-
Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice
-
Zurawel, R. H., Allen, C., Wechsler-Reya, R., Scott, M. P. & Raffel, C. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chromosom. Cancer 28, 77-81 (2000).
-
(2000)
Genes Chromosom. Cancer
, vol.28
, pp. 77-81
-
-
Zurawel, R.H.1
Allen, C.2
Wechsler-Reya, R.3
Scott, M.P.4
Raffel, C.5
-
114
-
-
0034033921
-
Nuclear localization and mutation of beta-catenin in medulloblastomas
-
Eberhart, C. G., Tihan, T. & Burger, P. C. Nuclear localization and mutation of beta-catenin in medulloblastomas. J. Neuropathol. Exp. Neurol. 59, 333-337 (2000).
-
(2000)
J. Neuropathol. Exp. Neurol.
, vol.59
, pp. 333-337
-
-
Eberhart, C.G.1
Tihan, T.2
Burger, P.C.3
-
115
-
-
39749116268
-
Medulloblastoma: From molecular pathology to therapy
-
Rossi, A., Caracciolo, V., Russo, G., Reiss, K. & Giordano, A. Medulloblastoma: from molecular pathology to therapy. Clin. Cancer Res. 14, 971-976 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 971-976
-
-
Rossi, A.1
Caracciolo, V.2
Russo, G.3
Reiss, K.4
Giordano, A.5
-
116
-
-
0037473082
-
AXIN1 mutations but not deletions in cerebellar medulloblastomas
-
Baeza, N., Masuoka, J., Kleihues, P. & Ohgaki, H. AXIN1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 22, 632-636 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 632-636
-
-
Baeza, N.1
Masuoka, J.2
Kleihues, P.3
Ohgaki, H.4
-
117
-
-
0033883092
-
APC mutations in sporadic medulloblastomas
-
Huang, H. et al. APC mutations in sporadic medulloblastomas. Am. J. Pathol. 156, 433-437 (2000).
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 433-437
-
-
Huang, H.1
-
118
-
-
34250341789
-
Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas
-
Koch, A. et al. Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas. Int. J. Cancer 121, 284-291 (2007).
-
(2007)
Int. J. Cancer
, vol.121
, pp. 284-291
-
-
Koch, A.1
-
119
-
-
0035427076
-
Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors
-
Koch, A. et al. Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors. Int. J. Cancer 93, 445-449 (2001).
-
(2001)
Int. J. Cancer
, vol.93
, pp. 445-449
-
-
Koch, A.1
-
120
-
-
0032030894
-
Sporadic medulloblastomas contain oncogenic β-catenin mutations
-
Zurawel, R. H., Chiappa, S. A., Allen, C. & Raffel, C. Sporadic medulloblastomas contain oncogenic β-catenin mutations. Cancer Res. 58, 896-899 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 896-899
-
-
Zurawel, R.H.1
Chiappa, S.A.2
Allen, C.3
Raffel, C.4
-
121
-
-
32944461274
-
Beta-catenin status predicts a favorable outcome in childhood medulloblastoma: The United Kingdom Children's Cancer Study Group Brain Tumour Committee
-
Ellison, D. W. et al. β-catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. J. Clin. Oncol. 23, 7951-7957 (2005).
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 7951-7957
-
-
Ellison, D.W.1
-
122
-
-
45749109850
-
C. c-Myc and β-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice
-
Momota, H., Shih, A. H., Edgar, M. A. & Holland, E. C. c-Myc and β-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice. Oncogene 27, 4392-4401 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 4392-4401
-
-
Momota, H.1
Shih, A.H.2
Edgar, M.A.3
Holland, E.4
-
123
-
-
0030988932
-
Prognostic significance of chromosome 17p deletions in childhood primitive neuroectodermal tumors (medulloblastomas) of the central nervous system
-
Biegel, J. A. et al. Prognostic significance of chromosome 17p deletions in childhood primitive neuroectodermal tumors (medulloblastomas) of the central nervous system. Clin. Cancer Res. 3, 473-478 (1997).
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 473-478
-
-
Biegel, J.A.1
-
124
-
-
0023847681
-
Structural chromosomal abnormalities in human medulloblastoma
-
DOI 10.1016/0165-4608(88)90096-9
-
Bigner, S. H., Mark, J., Friedman, H. S., Biegel, J. A. & Bigner, D. D. Structural chromosomal abnormalities in human medulloblastoma. Cancer Genet. Cytogenet. 30, 91-101 (1988). (Pubitemid 18033792)
-
(1988)
Cancer Genetics and Cytogenetics
, vol.30
, Issue.1
, pp. 91-101
-
-
Bigner, S.H.1
Mark, J.2
Friedman, H.S.3
Biegel, J.A.4
Bigner, D.D.5
-
125
-
-
0029944362
-
Tumor suppressor genes and medulloblastoma
-
Cogen, P. H. & McDonald, J. D. Tumor suppressor genes and medulloblastoma. J. Neurooncol. 29, 103-112 (1996).
-
(1996)
J. Neurooncol.
, vol.29
, pp. 103-112
-
-
Cogen, P.H.1
McDonald, J.D.2
-
126
-
-
4143081483
-
Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients
-
Lamont, J. M., McManamy, C. S., Pearson, A. D., Clifford, S. C. & Ellison, D. W. Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients. Clin. Cancer Res. 10, 5482-5493 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 5482-5493
-
-
Lamont, J.M.1
McManamy, C.S.2
Pearson, A.D.3
Clifford, S.C.4
Ellison, D.W.5
-
127
-
-
0033669529
-
Imbalances of chromosome 17 in medulloblastomas determined by comparative genomic hybridisation and fluorescence in situ hybridisation
-
Nicholson, J., Wickramasinghe, C., Ross, F., Crolla, J. & Ellison, D. Imbalances of chromosome 17 in medulloblastomas determined by comparative genomic hybridisation and fluorescence in situ hybridisation. Mol. Pathol. 53, 313-319 (2000).
-
(2000)
Mol. Pathol.
, vol.53
, pp. 313-319
-
-
Nicholson, J.1
Wickramasinghe, C.2
Ross, F.3
Crolla, J.4
Ellison, D.5
-
128
-
-
0030657926
-
Deletion mapping on chromosome 17p in medulloblastoma
-
Steichen-Gersdorf, E., Baumgartner, M., Kreczy, A., Maier, H. & Fink, F. M. Deletion mapping on chromosome 17p in medulloblastoma. Br. J. Cancer 76, 1284-1287 (1997).
-
(1997)
Br. J. Cancer
, vol.76
, pp. 1284-1287
-
-
Steichen-Gersdorf, E.1
Baumgartner, M.2
Kreczy, A.3
Maier, H.4
Fink, F.M.5
-
129
-
-
0027960780
-
Detection of i(17q) chromosome by fluorescent in situ hybridization (FISH) with interphase nuclei in medulloblastoma
-
Vagner-Capodano, A. M. et al. Detection of i(17q) chromosome by fluorescent in situ hybridization (FISH) with interphase nuclei in medulloblastoma. Cancer Genet. Cytogenet. 78, 1-6 (1994).
-
(1994)
Cancer Genet. Cytogenet.
, vol.78
, pp. 1-6
-
-
Vagner-Capodano, A.M.1
-
130
-
-
0028316608
-
Aggressive medulloblastoma with high-level N-myc amplification
-
Tomlinson, F. H. et al. Aggressive medulloblastoma with high-level N-myc amplification. Mayo Clin. Proc. 69, 359-365 (1994).
-
(1994)
Mayo Clin. Proc.
, vol.69
, pp. 359-365
-
-
Tomlinson, F.H.1
-
131
-
-
34848893044
-
Loss of suppressor-of-fused function promotes tumorigenesis
-
Lee, Y. et al. Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene 26, 6442-6447 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 6442-6447
-
-
Lee, Y.1
-
132
-
-
27744450224
-
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
-
Uziel, T. et al. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev. 19, 2656-2667 (2005).
-
(2005)
Genes Dev.
, vol.19
, pp. 2656-2667
-
-
Uziel, T.1
-
133
-
-
0036245047
-
MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group
-
Aldosari, N. et al. MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. Arch. Pathol. Lab. Med. 126, 540-544 (2002).
-
(2002)
Arch. Pathol. Lab. Med.
, vol.126
, pp. 540-544
-
-
Aldosari, N.1
-
134
-
-
41949102707
-
T. miRiad roles for the miR-17-92 cluster in development and disease
-
Mendell, J. T. miRiad roles for the miR-17-92 cluster in development and disease. Cell 133, 217-222 (2008).
-
(2008)
Cell
, vol.133
, pp. 217-222
-
-
Mendell, J.1
-
135
-
-
0037902082
-
W. c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice
-
Rao, G., Pedone, C. A., Coffin, C. M., Holland, E. C. & Fults, D. W. c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice. Neoplasia 5, 198-204 (2003).
-
(2003)
Neoplasia
, vol.5
, pp. 198-204
-
-
Rao, G.1
Pedone, C.A.2
Coffin, C.M.3
Holland, E.C.4
Fults, D.5
-
136
-
-
0034794796
-
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
-
MacDonald, T. J. et al. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nature Genet. 29, 143-152 (2001).
-
(2001)
Nature Genet.
, vol.29
, pp. 143-152
-
-
MacDonald, T.J.1
-
137
-
-
0035445646
-
Clinical and molecular stratification of disease risk in medulloblastoma
-
Gilbertson, R. et al. Clinical and molecular stratification of disease risk in medulloblastoma. Br. J. Cancer 85, 705-712 (2001).
-
(2001)
Br. J. Cancer
, vol.85
, pp. 705-712
-
-
Gilbertson, R.1
-
138
-
-
0043092165
-
Medulloblastoma sensitivity to 17-allylamino-17-demethoxygeldanamycin requires MEK/ERKM
-
Calabrese, C., Frank, A., Maclean, K. & Gilbertson, R. Medulloblastoma sensitivity to 17-allylamino-17-demethoxygeldanamycin requires MEK/ERKM. J. Biol. Chem. 278, 24951-24959 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 24951-24959
-
-
Calabrese, C.1
Frank, A.2
MacLean, K.3
Gilbertson, R.4
-
139
-
-
0037224320
-
ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma
-
Hernan, R. et al. ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma. Cancer Res. 63, 140-148 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 140-148
-
-
Hernan, R.1
-
140
-
-
0034996240
-
Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma
-
Gilbertson, R. et al. Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma. Genes Chromosom. Cancer 31, 288-294 (2001).
-
(2001)
Genes Chromosom. Cancer
, vol.31
, pp. 288-294
-
-
Gilbertson, R.1
-
141
-
-
1842614251
-
Clinical, histopathologic, and molecular markers of prognosis: Toward a new disease risk stratification system for medulloblastoma
-
Gajjar, A. et al. Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J. Clin. Oncol. 22, 984-993 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 984-993
-
-
Gajjar, A.1
-
142
-
-
0028918623
-
Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma
-
Gilbertson, R. J., Pearson, A. D., Perry, R. H., Jaros, E. & Kelly, P. J. Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma. Br. J. Cancer 71, 473-477 (1995).
-
(1995)
Br. J. Cancer
, vol.71
, pp. 473-477
-
-
Gilbertson, R.J.1
Pearson, A.D.2
Perry, R.H.3
Jaros, E.4
Kelly, P.J.5
-
143
-
-
0030741967
-
Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma
-
Gilbertson, R. J., Perry, R. H., Kelly, P. J., Pearson, A. D. & Lunec, J. Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma. Cancer Res. 57, 3272-3280 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 3272-3280
-
-
Gilbertson, R.J.1
Perry, R.H.2
Kelly, P.J.3
Pearson, A.D.4
Lunec, J.5
-
144
-
-
0037165140
-
Prediction of central nervous system embryonal tumour outcome based on gene expression
-
Pomeroy, S. L. et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415, 436-442 (2002).
-
(2002)
Nature
, vol.415
, pp. 436-442
-
-
Pomeroy, S.L.1
-
145
-
-
52449119078
-
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
-
Kool, M. et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS ONE 3, e3088 (2008).
-
(2008)
PLoS ONE
, vol.3
-
-
Kool, M.1
-
146
-
-
33646362581
-
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
-
Thompson, M. C. et al. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J. Clin. Oncol. 24, 1924-1931 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 1924-1931
-
-
Thompson, M.C.1
-
147
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature 414, 105-111 (2001).
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
148
-
-
4944250781
-
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
-
Galli, R. et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 64, 7011-7021 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 7011-7021
-
-
Galli, R.1
-
149
-
-
0141842674
-
Identification of a cancer stem cell in human brain tumors
-
Singh, S. K. et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 63, 5821-5828 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 5821-5828
-
-
Singh, S.K.1
-
150
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396-401 (2004).
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
-
151
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao, S. et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756-760 (2006).
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
-
152
-
-
33845621982
-
Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133-cells, and the CD133+ sector is enlarged by hypoxia
-
Blazek, E. R., Foutch, J. L. & Maki, G. Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133-cells, and the CD133+ sector is enlarged by hypoxia. Int. J. Radiat. Oncol. Biol. Phys. 67, 1-5 (2007).
-
(2007)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.67
, pp. 1-5
-
-
Blazek, E.R.1
Foutch, J.L.2
Maki, G.3
-
153
-
-
41749118669
-
Identification of A2B5+CD133-tumor-initiating cells in adult human gliomas
-
Ogden, A. T. et al. Identification of A2B5+CD133-tumor-initiating cells in adult human gliomas. Neurosurgery 62, 505-515 (2008).
-
(2008)
Neurosurgery
, vol.62
, pp. 505-515
-
-
Ogden, A.T.1
-
154
-
-
38349075007
-
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
-
Wang, J. et al. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int. J. Cancer 122, 761-768 (2008).
-
(2008)
Int. J. Cancer
, vol.122
, pp. 761-768
-
-
Wang, J.1
-
155
-
-
67849099254
-
How powerful is CD133 as a cancer stem cell marker in brain tumors?
-
Cheng, J. X., Liu, B. L. & Zhang, X. How powerful is CD133 as a cancer stem cell marker in brain tumors? Cancer Treat Rev. 35, 403-408 (2009).
-
(2009)
Cancer Treat Rev.
, vol.35
, pp. 403-408
-
-
Cheng, J.X.1
Liu, B.L.2
Zhang, X.3
-
156
-
-
34648821254
-
Making a tumour's bed: Glioblastoma stem cells and the vascular niche
-
Gilbertson, R. J. & Rich, J. N. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nature Rev. Cancer 7, 733-736 (2007).
-
(2007)
Nature Rev. Cancer
, vol.7
, pp. 733-736
-
-
Gilbertson, R.J.1
Rich, J.N.2
-
157
-
-
0013784893
-
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
-
Altman, J. & Das, G. D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol. 124, 319-335 (1965).
-
(1965)
J. Comp. Neurol.
, vol.124
, pp. 319-335
-
-
Altman, J.1
Das, G.D.2
-
158
-
-
0027406459
-
Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons an glia
-
Lois, C. & Alvarez-Buylla, A. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons an glia. Proc. Natl Acad. Sci. USA 90, 2074-2077 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 2074-2077
-
-
Lois, C.1
Alvarez-Buylla, A.2
-
159
-
-
36448982477
-
Brain micro-ecologies: Neural stem cell niches in the adult mammalian brain
-
Riquelme, P. A., Drapeau, E. & Doetsch, F. Brain micro-ecologies: neural stem cell niches in the adult mammalian brain. Philos. Trans. R. Soc. Lond. B Biol. Sci. 363, 123-137 (2008).
-
(2008)
Philos. Trans. R. Soc. Lond. B Biol. Sci.
, vol.363
, pp. 123-137
-
-
Riquelme, P.A.1
Drapeau, E.2
Doetsch, F.3
-
160
-
-
33846029123
-
A perivascular niche for brain tumor stem cells
-
Calabrese, C. et al. A perivascular niche for brain tumor stem cells. Cancer Cell 11, 69-82 (2007).
-
(2007)
Cancer Cell
, vol.11
, pp. 69-82
-
-
Calabrese, C.1
-
161
-
-
33748051406
-
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
-
Bao, S. et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 66, 7843-7848 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 7843-7848
-
-
Bao, S.1
-
162
-
-
67649118749
-
Turning cancer stem cells inside out: An exploration of glioma stem cell signaling pathways
-
Li, Z., Wang, H., Eyler, C. E., Hjelmeland, A. B. & Rich, J. N. Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J. Biol. Chem. 284, 16705-16709 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 16705-16709
-
-
Li, Z.1
Wang, H.2
Eyler, C.E.3
Hjelmeland, A.B.4
Rich, J.N.5
-
163
-
-
42049108822
-
Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas
-
Becher, O. J. et al. Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas. Cancer Res. 68, 2241-2249 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 2241-2249
-
-
Becher, O.J.1
-
164
-
-
65749106405
-
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
-
Li, Z. et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15, 501-513 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 501-513
-
-
Li, Z.1
-
165
-
-
33644747418
-
HIF-2α regulates Oct-4: Effects of hypoxia on stem cell function, embryonic development, and tumor growth
-
Covello, K. L. et al. HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 20, 557-570 (2006).
-
(2006)
Genes Dev.
, vol.20
, pp. 557-570
-
-
Covello, K.L.1
-
166
-
-
70350225829
-
The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
-
Heddleston, J. M., Li, Z., McLendon, R. E., Hjelmeland, A. B. & Rich, J. N. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle 8, 3274-3284 (2009).
-
(2009)
Cell Cycle
, vol.8
, pp. 3274-3284
-
-
Heddleston, J.M.1
Li, Z.2
McLendon, R.E.3
Hjelmeland, A.B.4
Rich, J.N.5
-
167
-
-
67349193226
-
Emerging role of Notch in stem cells and cancer
-
Wang, Z., Li, Y., Banerjee, S. & Sarkar, F. H. Emerging role of Notch in stem cells and cancer. Cancer Lett. 279, 8-12 (2009).
-
(2009)
Cancer Lett.
, vol.279
, pp. 8-12
-
-
Wang, Z.1
Li, Y.2
Banerjee, S.3
Sarkar, F.H.4
-
168
-
-
33845595633
-
Notch signaling enhances nestin expression in gliomas
-
Shih, A. H. & Holland, E. C. Notch signaling enhances nestin expression in gliomas. Neoplasia 8, 1072-1082 (2006).
-
(2006)
Neoplasia
, vol.8
, pp. 1072-1082
-
-
Shih, A.H.1
Holland, E.C.2
-
169
-
-
34548253014
-
Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling
-
Bhattacharya, S., Das, A., Mallya, K. & Ahmad, I. Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling. J. Cell Sci. 120, 2652-2662 (2007).
-
(2007)
J. Cell Sci.
, vol.120
, pp. 2652-2662
-
-
Bhattacharya, S.1
Das, A.2
Mallya, K.3
Ahmad, I.4
-
170
-
-
33747874155
-
Notch pathway inhibition depletes stemlike cells and blocks engraftment in embryonal brain tumors
-
Fan, X. et al. Notch pathway inhibition depletes stemlike cells and blocks engraftment in embryonal brain tumors. Cancer Res. 66, 7445-7452 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 7445-7452
-
-
Fan, X.1
-
171
-
-
60849117508
-
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
-
Bleau, A. M. et al. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 4, 226-235 (2009).
-
(2009)
Cell Stem Cell
, vol.4
, pp. 226-235
-
-
Bleau, A.M.1
-
172
-
-
75349091751
-
Nitric oxide drives notch signaling and stem cell-like character via PKG in the perivascular niche of PDGF gliomas
-
Charles, N. et al. Nitric oxide drives notch signaling and stem cell-like character via PKG in the perivascular niche of PDGF gliomas. Cell Stem Cell. 6, 141-152 (2010).
-
(2010)
Cell Stem Cell.
, vol.6
, pp. 141-152
-
-
Charles, N.1
-
173
-
-
39449135834
-
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
-
Hambardzumyan, D. et al. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev. 22, 436-448 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 436-448
-
-
Hambardzumyan, D.1
-
174
-
-
70349291126
-
Modeling adult gliomas using RCAS/t-va technology
-
Hambardzumyan, D., Amankulor, N. M., Helmy, K. Y., Becher, O. J. & Holland, E. C. Modeling Adult Gliomas Using RCAS/t-va Technology. Transl. Oncol. 2, 89-95 (2009).
-
(2009)
Transl. Oncol.
, vol.2
, pp. 89-95
-
-
Hambardzumyan, D.1
Amankulor, N.M.2
Helmy, K.Y.3
Becher, O.J.4
Holland, E.C.5
-
175
-
-
67349108288
-
Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma
-
Lindberg, N., Kastemar, M., Olofsson, T., Smits, A. & Uhrbom, L. Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma. Oncogene 28, 2266-2275 (2009).
-
(2009)
Oncogene
, vol.28
, pp. 2266-2275
-
-
Lindberg, N.1
Kastemar, M.2
Olofsson, T.3
Smits, A.4
Uhrbom, L.5
-
176
-
-
33745778950
-
Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses
-
Assanah, M. et al. Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. J. Neurosci. 26, 6781-6790 (2006).
-
(2006)
J. Neurosci.
, vol.26
, pp. 6781-6790
-
-
Assanah, M.1
-
177
-
-
70349296853
-
The ABCG2 resistance network of glioblastoma
-
Bleau, A. M., Huse, J. T. & Holland, E. C. The ABCG2 resistance network of glioblastoma. Cell Cycle 8, 2936-2944 (2009).
-
(2009)
Cell Cycle
, vol.8
, pp. 2936-2944
-
-
Bleau, A.M.1
Huse, J.T.2
Holland, E.C.3
-
178
-
-
61449171080
-
New (alternative) temozolomide regimens for the treatment of glioma
-
Wick, W., Platten, M. & Weller, M. New (alternative) temozolomide regimens for the treatment of glioma. Neuro Oncol. 11, 69-79 (2009).
-
(2009)
Neuro Oncol.
, vol.11
, pp. 69-79
-
-
Wick, W.1
Platten, M.2
Weller, M.3
-
179
-
-
27744606737
-
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
-
Mellinghoff, I. K. et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. 353, 2012-2024 (2005).
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 2012-2024
-
-
Mellinghoff, I.K.1
-
180
-
-
70350496540
-
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
-
Yauch, R. L. et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 326, 572-574 (2009).
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
-
181
-
-
57449096198
-
Genetically engineered mouse models of brain cancer and the promise of preclinical testing
-
Huse, J. T. & Holland, E. C. Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol. 19, 132-143 (2009).
-
(2009)
Brain Pathol.
, vol.19
, pp. 132-143
-
-
Huse, J.T.1
Holland, E.C.2
-
182
-
-
33747887175
-
ROS fusion tyrosine kinase activates a SH2 domain-containing phospatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice
-
Charest, A. et al. ROS fusion tyrosine kinase activates a SH2 domain-containing phospatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 66, 7473-7481 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 7473-7481
-
-
Charest, A.1
-
183
-
-
27744506881
-
Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: Tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01
-
Lassman, A. B. et al. Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01. Clin. Cancer Res. 11, 7841-7850 (2005).
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 7841-7850
-
-
Lassman, A.B.1
-
184
-
-
0033938847
-
Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme
-
Liebner, S. et al. Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme. Acta Neuropathol. 100, 323-331 (2000).
-
(2000)
Acta Neuropathol.
, vol.100
, pp. 323-331
-
-
Liebner, S.1
-
185
-
-
33747151335
-
Blood-brain barrier and chemotherapeutic treatment of brain tumors
-
de Vries, N. A., Beijnen, J. H., Boogerd, W. & van Tellingen, O. Blood-brain barrier and chemotherapeutic treatment of brain tumors. Expert Rev. Neurother 6, 1199-1209 (2006).
-
(2006)
Expert Rev. Neurother
, vol.6
, pp. 1199-1209
-
-
De Vries, N.A.1
Beijnen, J.H.2
Boogerd, W.3
Van Tellingen, O.4
-
186
-
-
70349408777
-
New strategies to deliver anticancer drugs to brain tumors
-
Laquintana, V. et al. New strategies to deliver anticancer drugs to brain tumors. Expert Opin. Drug Deliv. 6, 1017-1032 (2009).
-
(2009)
Expert Opin. Drug Deliv.
, vol.6
, pp. 1017-1032
-
-
Laquintana, V.1
|