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Volumn 10, Issue 5, 2010, Pages 319-331

Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; PROTEIN TYROSINE KINASE; RAS PROTEIN; WNT PROTEIN;

EID: 77951599543     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2818     Document Type: Review
Times cited : (630)

References (186)
  • 1
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp, R. et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 987-996
    • Stupp, R.1
  • 2
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen, P. Y. & Kesari, S. Malignant gliomas in adults. N. Engl. J. Med. 359, 492-507 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 3
    • 1642307767 scopus 로고    scopus 로고
    • Medulloblastoma: Signalling a change in treatment
    • Gilbertson, R. J. Medulloblastoma: signalling a change in treatment. Lancet Oncol. 5, 209-218 (2004).
    • (2004) Lancet Oncol. , vol.5 , pp. 209-218
    • Gilbertson, R.J.1
  • 8
    • 34547122001 scopus 로고    scopus 로고
    • The 2007 WHO classification of tumours of the central nervous system
    • Louis, D. N. et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 11 4, 97-109 (2007).
    • (2007) Acta Neuropathol. , vol.11 , Issue.4 , pp. 97-109
    • Louis, D.N.1
  • 9
    • 0029843049 scopus 로고    scopus 로고
    • The prognostic impact of prior low grade histology in patients with anaplastic gliomas: A case-control study
    • Dropcho, E. J. & Soong, S. J. The prognostic impact of prior low grade histology in patients with anaplastic gliomas: a case-control study. Neurology 47, 684-690 (1996).
    • (1996) Neurology , vol.47 , pp. 684-690
    • Dropcho, E.J.1    Soong, S.J.2
  • 10
    • 20344407807 scopus 로고    scopus 로고
    • Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    • Ohgaki, H. & Kleihues, P. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J. Neuropathol. Exp. Neurol. 64, 479-489 (2005).
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 479-489
    • Ohgaki, H.1    Kleihues, P.2
  • 11
    • 0032912596 scopus 로고    scopus 로고
    • A case history of glioma progression
    • Ohgaki, H. et al. A case history of glioma progression. Acta Neuropathol. 97, 525-532 (1999).
    • (1999) Acta Neuropathol. , vol.97 , pp. 525-532
    • Ohgaki, H.1
  • 12
    • 84949655795 scopus 로고
    • Cerebral astrocytomas and their derivatives
    • Scherer, H. J. Cerebral astrocytomas and their derivatives. Am. J. Cancer 40, 159-198 (1940).
    • (1940) Am. J. Cancer , vol.40 , pp. 159-198
    • Scherer, H.J.1
  • 13
    • 20044371594 scopus 로고    scopus 로고
    • Treatment of early childhood medulloblastoma by postoperative chemotherapy alone
    • Rutkowski, S. et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N. Engl. J. Med. 352, 978-986 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 978-986
    • Rutkowski, S.1
  • 14
    • 0028878530 scopus 로고
    • Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute
    • Sure, U. et al. Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute. Acta Neurochir. (Wien) 132, 59-65 (1995).
    • (1995) Acta Neurochir. (Wien) , vol.132 , pp. 59-65
    • Sure, U.1
  • 15
    • 0033791188 scopus 로고    scopus 로고
    • "Large cell/anaplastic" medulloblastomas: A Pediatric Oncology Group Study
    • Brown, H. G. et al. "Large cell/anaplastic" medulloblastomas: a Pediatric Oncology Group Study. J. Neuropathol. Exp. Neurol. 59, 857-865 (2000).
    • (2000) J. Neuropathol. Exp. Neurol. , vol.59 , pp. 857-865
    • Brown, H.G.1
  • 16
    • 0026663357 scopus 로고
    • Large-cell medulloblastomas. A distinct variant with highly aggressive behavior
    • Giangaspero, F. et al. Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. Am. J. Surg. Pathol. 16, 687-693 (1992).
    • (1992) Am. J. Surg. Pathol. , vol.16 , pp. 687-693
    • Giangaspero, F.1
  • 17
    • 33745373514 scopus 로고    scopus 로고
    • Stratification of medulloblastoma on the basis of histopathological grading
    • Giangaspero, F. et al. Stratification of medulloblastoma on the basis of histopathological grading. Acta Neuropathol. 11 2, 5-12 (2006).
    • (2006) Acta Neuropathol. , vol.11 , Issue.2 , pp. 5-12
    • Giangaspero, F.1
  • 18
    • 0037604509 scopus 로고    scopus 로고
    • Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas
    • McManamy, C. S. et al. Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas. J. Neuropathol. Exp. Neurol. 62, 627-632 (2003).
    • (2003) J. Neuropathol. Exp. Neurol. , vol.62 , pp. 627-632
    • McManamy, C.S.1
  • 19
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    • Malkin, D. et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250, 1233-1238 (1990).
    • (1990) Science , vol.250 , pp. 1233-1238
    • Malkin, D.1
  • 20
    • 0025648762 scopus 로고
    • Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome
    • Srivastava, S., Zou, Z. Q., Pirollo, K., Blattner, W. & Chang, E. H. Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature 348, 747-749 (1990).
    • (1990) Nature , vol.348 , pp. 747-749
    • Srivastava, S.1    Zou, Z.Q.2    Pirollo, K.3    Blattner, W.4    Chang, E.H.5
  • 21
    • 0028123442 scopus 로고
    • The p53 gene and protein in human brain tumors
    • Louis, D. N. The p53 gene and protein in human brain tumors. J. Neuropathol. Exp. Neurol. 53, 11-21 (1994).
    • (1994) J. Neuropathol. Exp. Neurol. , vol.53 , pp. 11-21
    • Louis, D.N.1
  • 22
    • 0021932240 scopus 로고
    • Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
    • Libermann, T. A. et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 313, 144-147 (1985).
    • (1985) Nature , vol.313 , pp. 144-147
    • Libermann, T.A.1
  • 23
    • 0021363560 scopus 로고
    • Expression of epidermal growth factor receptors in human brain tumors
    • Libermann, T. A. et al. Expression of epidermal growth factor receptors in human brain tumors. Cancer Res. 44, 753-760 (1984).
    • (1984) Cancer Res. , vol.44 , pp. 753-760
    • Libermann, T.A.1
  • 24
    • 0026548240 scopus 로고
    • Structural alterations of the epidermal growth factor receptor gene in human gliomas
    • Wong, A. J. et al. Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc. Natl Acad. Sci. USA 89, 2965-2969 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 2965-2969
    • Wong, A.J.1
  • 25
    • 0034163550 scopus 로고    scopus 로고
    • Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
    • Frederick, L., Wang, X. Y., Eley, G. & James, C. D. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res. 60, 1383-1387 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 1383-1387
    • Frederick, L.1    Wang, X.Y.2    Eley, G.3    James, C.D.4
  • 26
    • 0025114687 scopus 로고
    • Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
    • Sugawa, N., Ekstrand, A. J., James, C. D. & Collins, V. P. Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc. Natl Acad. Sci. USA 87, 8602-8606 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 8602-8606
    • Sugawa, N.1    Ekstrand, A.J.2    James, C.D.3    Collins, V.P.4
  • 27
    • 0032494479 scopus 로고    scopus 로고
    • Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas
    • Cairncross, J. G. et al. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J. Natl Cancer Inst. 90, 1473-1479 (1998).
    • (1998) J. Natl Cancer Inst. , vol.90 , pp. 1473-1479
    • Cairncross, J.G.1
  • 28
    • 0028006633 scopus 로고
    • Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p
    • Reifenberger, G. et al. Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am. J. Pathol. 145, 1175-1190 (1994).
    • (1994) Am. J. Pathol. , vol.145 , pp. 1175-1190
    • Reifenberger, G.1
  • 29
    • 0033566061 scopus 로고    scopus 로고
    • Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype
    • Smith, J. S. et al. Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype. Oncogene 18, 4144-4152 (1999).
    • (1999) Oncogene , vol.18 , pp. 4144-4152
    • Smith, J.S.1
  • 30
    • 12944314946 scopus 로고    scopus 로고
    • Allelic losses at 1p36 and 19q13 in gliomas: Correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene
    • Barbashina, V., Salazar, P., Holland, E. C., Rosenblum, M. K. & Ladanyi, M. Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene. Clin. Cancer Res. 11, 1119-1128 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1119-1128
    • Barbashina, V.1    Salazar, P.2    Holland, E.C.3    Rosenblum, M.K.4    Ladanyi, M.5
  • 31
    • 0030982897 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA
    • Costello, J. F. et al. Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res. 57, 1250-1254 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 1250-1254
    • Costello, J.F.1
  • 32
    • 0027943938 scopus 로고
    • The retinoblastoma gene is involved in the malignant progression of astrocytomas
    • Henson, J. W. et al. The retinoblastoma gene is involved in the malignant progression of astrocytomas. Ann. Neurol. 36, 714-721 (1994).
    • (1994) Ann. Neurol. , vol.36 , pp. 714-721
    • Henson, J.W.1
  • 33
    • 0027978368 scopus 로고
    • Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4 SAS and MDM2
    • Reifenberger, G., Reifenberger, J., Ichimura, K., Meltzer, P. S. & Collins, V. P. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res. 54, 4299-4303 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 4299-4303
    • Reifenberger, G.1    Reifenberger, J.2    Ichimura, K.3    Meltzer, P.S.4    Collins, V.P.5
  • 34
    • 0035213384 scopus 로고    scopus 로고
    • Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendroglioma
    • Watanabe, T. et al. Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendroglioma. J. Neuropathol. Exp. Neurol. 60, 1181-1190 (2001).
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 1181-1190
    • Watanabe, T.1
  • 35
    • 68149180890 scopus 로고    scopus 로고
    • Genome-wide association study identifies five susceptibility loci for glioma
    • Shete, S. et al. Genome-wide association study identifies five susceptibility loci for glioma. Nature Genet. 41, 899-904 (2009).
    • (2009) Nature Genet. , vol.41 , pp. 899-904
    • Shete, S.1
  • 36
    • 68149180891 scopus 로고    scopus 로고
    • Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility
    • Wrensch, M. et al. Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nature Genet. 41, 905-908 (2009).
    • (2009) Nature Genet. , vol.41 , pp. 905-908
    • Wrensch, M.1
  • 37
    • 0035425048 scopus 로고    scopus 로고
    • PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    • Dai, C. et al. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev. 15, 1913-1925 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 1913-1925
    • Dai, C.1
  • 38
    • 18644377225 scopus 로고    scopus 로고
    • Et al. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma
    • Hu, X. et al. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia 7, 356-368 (2005).
    • (2005) Neoplasia , vol.7 , pp. 356-368
    • Hu, X.1
  • 39
    • 9144251024 scopus 로고    scopus 로고
    • Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
    • Uhrbom, L., Nerio, E. & Holland, E. C. Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. Nature Med. 10, 1257-1260 (2004).
    • (2004) Nature Med. , vol.10 , pp. 1257-1260
    • Uhrbom, L.1    Nerio, E.2    Holland, E.C.3
  • 40
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • Marino, S., Vooijs, M., van Der Gulden, H., Jonkers, J. & Berns, A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes D e v. 14, 994-1004 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 994-1004
    • Marino, S.1    Vooijs, M.2    Van Der Gulden, H.3    Jonkers, J.4    Berns, A.5
  • 41
    • 0033812187 scopus 로고    scopus 로고
    • Nf1; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
    • Reilly, K. M., Loisel, D. A., Bronson, R. T., McLaughlin, M. E. & Jacks, T. Nf1; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nature Genet. 26, 109-113 (2000).
    • (2000) Nature Genet. , vol.26 , pp. 109-113
    • Reilly, K.M.1    Loisel, D.A.2    Bronson, R.T.3    McLaughlin, M.E.4    Jacks, T.5
  • 42
    • 0037382205 scopus 로고    scopus 로고
    • Genetic determinants of malignancy in a mouse model for oligodendroglioma
    • Weiss, W. A. et al. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res. 63, 1589-1595 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 1589-1595
    • Weiss, W.A.1
  • 43
    • 0036490954 scopus 로고    scopus 로고
    • Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation
    • Xiao, A., Wu, H., Pandolfi, P. P., Louis, D. N. & Van Dyke, T. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell 1,157-168 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 157-168
    • Xiao, A.1    Wu, H.2    Pandolfi, P.P.3    Louis, D.N.4    Van Dyke, T.5
  • 44
    • 20444484560 scopus 로고    scopus 로고
    • Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation
    • Xiao, A. et al. Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. Cancer Res. 65, 5172-5180 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 5172-5180
    • Xiao, A.1
  • 45
    • 54549095950 scopus 로고    scopus 로고
    • Et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    • Zheng, H. et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455, 1129-1133 (2008).
    • (2008) Nature , vol.455 , pp. 1129-1133
    • Zheng, H.1
  • 46
    • 23644443053 scopus 로고    scopus 로고
    • Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    • Zhu, Y. et al. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8, 119-130 (2005).
    • (2005) Cancer Cell , vol.8 , pp. 119-130
    • Zhu, Y.1
  • 47
    • 0031951740 scopus 로고    scopus 로고
    • Platelet-derived growth factor and its receptor expression in human oligodendrogliomas
    • Di Rocco, F., Carroll, R. S., Zhang, J. & Black, P. M. Platelet-derived growth factor and its receptor expression in human oligodendrogliomas. Neurosurgery 42, 341-346 (1998).
    • (1998) Neurosurgery , vol.42 , pp. 341-346
    • Di Rocco, F.1    Carroll, R.S.2    Zhang, J.3    Black, P.M.4
  • 48
    • 0029401049 scopus 로고
    • Platelet-derived growth factor in human glioma
    • Westermark, B., Heldin, C. H. & Nister, M. Platelet-derived growth factor in human glioma. Glia 15, 257-263 (1995).
    • (1995) Glia , vol.15 , pp. 257-263
    • Westermark, B.1    Heldin, C.H.2    Nister, M.3
  • 49
    • 0037421971 scopus 로고    scopus 로고
    • A human brain tumor-derived PDGFR-α deletion mutant is transforming
    • Clarke, I. D. & Dirks, P. B. A human brain tumor-derived PDGFR-α deletion mutant is transforming. Oncogene 22, 722-733 (2003).
    • (2003) Oncogene , vol.22 , pp. 722-733
    • Clarke, I.D.1    Dirks, P.B.2
  • 50
    • 27644543354 scopus 로고    scopus 로고
    • Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
    • Abounader, R. & Laterra, J. Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro Oncol. 7, 436-451 (2005).
    • (2005) Neuro Oncol. , vol.7 , pp. 436-451
    • Abounader, R.1    Laterra, J.2
  • 51
    • 0031465906 scopus 로고    scopus 로고
    • Proliferation of human malignant astrocytomas is dependent on Ras activation
    • Guha, A., Feldkamp, M. M., Lau, N., Boss, G. & Pawson, A. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene 15, 2755-2765 (1997).
    • (1997) Oncogene , vol.15 , pp. 2755-2765
    • Guha, A.1    Feldkamp, M.M.2    Lau, N.3    Boss, G.4    Pawson, A.5
  • 52
    • 3543056884 scopus 로고    scopus 로고
    • Analysis of the activation status of Akt NFkB, and Stat3 in human diffuse gliomas
    • Wang, H. et al. Analysis of the activation status of Akt, NFkB, and Stat3 in human diffuse gliomas. Lab. Invest. 84, 941-951 (2004).
    • (2004) Lab. Invest. , vol.84 , pp. 941-951
    • Wang, H.1
  • 53
    • 0023708370 scopus 로고
    • Clonal genomic alterations in glioma malignancy stages
    • James, C. D. et al. Clonal genomic alterations in glioma malignancy stages. Cancer Res. 48, 5546-5551 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 5546-5551
    • James, C.D.1
  • 54
    • 0037374550 scopus 로고    scopus 로고
    • Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model
    • Ding, H. et al. Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res. 63, 1106-1113 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 1106-1113
    • Ding, H.1
  • 55
    • 3142713010 scopus 로고    scopus 로고
    • Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis
    • Shih, A. H. et al. Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis. Cancer Res. 64, 4783-4789 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 4783-4789
    • Shih, A.H.1
  • 56
    • 0036791177 scopus 로고    scopus 로고
    • Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt
    • Uhrbom, L. et al. Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. Cancer Res. 62, 5551-5558 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 5551-5558
    • Uhrbom, L.1
  • 57
    • 0032401819 scopus 로고    scopus 로고
    • Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus
    • Uhrbom, L., Hesselager, G., Nister, M. & Westermark, B. Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus. Cancer Res. 58, 5275-5279 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 5275-5279
    • Uhrbom, L.1    Hesselager, G.2    Nister, M.3    Westermark, B.4
  • 58
    • 33747885901 scopus 로고    scopus 로고
    • High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model
    • Wei, Q. et al. High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Res. 66, 7429-7437 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 7429-7437
    • Wei, Q.1
  • 59
    • 62449252775 scopus 로고    scopus 로고
    • Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis
    • Zhu, H. et al. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc. Natl Acad. Sci. USA 106, 2712-2716 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 2712-2716
    • Zhu, H.1
  • 60
    • 0035328722 scopus 로고    scopus 로고
    • Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas
    • Ding, H. et al. Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas. Cancer Res. 61, 3826-3836 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 3826-3836
    • Ding, H.1
  • 61
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    • Holland, E. C. et al. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nature Genet. 25, 55-57 (2000).
    • (2000) Nature Genet. , vol.25 , pp. 55-57
    • Holland, E.C.1
  • 62
    • 44849089702 scopus 로고    scopus 로고
    • Pten haploinsufficiency accelerates formation of high-grade astrocytomas
    • Kwon, C. H. et al. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 68, 3286-3294 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 3286-3294
    • Kwon, C.H.1
  • 63
    • 57849109837 scopus 로고    scopus 로고
    • Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
    • Llaguno, S. A. et al. Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 15, 45-56 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 45-56
    • Llaguno, S.A.1
  • 64
    • 0036828260 scopus 로고    scopus 로고
    • Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma
    • Burton, E. C. et al. Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma. Cancer Res. 62, 6205-6210 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 6205-6210
    • Burton, E.C.1
  • 65
    • 0034998193 scopus 로고    scopus 로고
    • Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization
    • Hui, A. B., Lo, K. W., Yin, X. L., Poon, W. S. & Ng, H. K. Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization. Lab. Invest. 81, 717-723 (2001).
    • (2001) Lab. Invest. , vol.81 , pp. 717-723
    • Hui, A.B.1    Lo, K.W.2    Yin, X.L.3    Poon, W.S.4    Ng, H.K.5
  • 66
    • 33845807801 scopus 로고    scopus 로고
    • Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities
    • Maher, E. A. et al. Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res. 66, 11502-11513 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 11502-11513
    • Maher, E.A.1
  • 67
    • 17144376016 scopus 로고    scopus 로고
    • Array comparative genomic hybridization identifies genetic subgroups in grade 4 human astrocytoma
    • Misra, A. et al. Array comparative genomic hybridization identifies genetic subgroups in grade 4 human astrocytoma. Clin. Cancer Res. 11, 2907-2918 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2907-2918
    • Misra, A.1
  • 68
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • The Cancer Genome Atlas Research Network
    • The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 69
    • 20144389740 scopus 로고    scopus 로고
    • Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma
    • Nigro, J. M. et al. Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res. 65, 1678-1686 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 1678-1686
    • Nigro, J.M.1
  • 70
    • 0034105136 scopus 로고    scopus 로고
    • Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization
    • Nishizaki, T. et al. Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization. Hum. Pathol. 31, 608-614 (2000).
    • (2000) Hum. Pathol. , vol.31 , pp. 608-614
    • Nishizaki, T.1
  • 71
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812 (2008).
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1
  • 72
    • 67651039919 scopus 로고    scopus 로고
    • A network model of a cooperative genetic landscape in brain tumors
    • Bredel, M. et al. A network model of a cooperative genetic landscape in brain tumors. JAMA 302, 261-275 (2009).
    • (2009) JAMA , vol.302 , pp. 261-275
    • Bredel, M.1
  • 73
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765-773 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 765-773
    • Yan, H.1
  • 74
    • 69949114447 scopus 로고    scopus 로고
    • Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: A study of 1,010 diffuse gliomas
    • Hartmann, C. et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol. 11 8, 469-474 (2009).
    • (2009) Acta Neuropathol. , vol.11 , Issue.8 , pp. 469-474
    • Hartmann, C.1
  • 75
    • 70249097408 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas
    • Sanson, M. et al. Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J. Clin. Oncol. 27, 4150-4154 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4150-4154
    • Sanson, M.1
  • 76
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α
    • Zhao, S. et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science 324, 261-265 (2009).
    • (2009) Science , vol.324 , pp. 261-265
    • Zhao, S.1
  • 77
    • 65249131228 scopus 로고    scopus 로고
    • Brain tumor hypoxia: Tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target
    • Jensen, R. L. Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target. J. Neurooncol. 92, 317-335 (2009).
    • (2009) J. Neurooncol. , vol.92 , pp. 317-335
    • Jensen, R.L.1
  • 78
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739-744 (2009).
    • (2009) Nature , vol.462 , pp. 739-744
    • Dang, L.1
  • 79
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis, E. R. et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N. Engl. J. Med. 361, 1058-1066 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1058-1066
    • Mardis, E.R.1
  • 80
    • 66149173789 scopus 로고    scopus 로고
    • The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
    • Huse, J. T. et al. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev. 23, 1327-1337 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 1327-1337
    • Huse, J.T.1
  • 81
    • 76649130555 scopus 로고    scopus 로고
    • Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship
    • Kim, H. et al. Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc. Natl Acad. Sci. USA 107, 2183-2188 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 2183-2188
    • Kim, H.1
  • 82
    • 70350221952 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
    • Li, Y. et al. MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res. 69, 7569-7576 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 7569-7576
    • Li, Y.1
  • 84
    • 0142157702 scopus 로고    scopus 로고
    • Classification of human astrocytic gliomas on the basis of gene expression: A correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes
    • Godard, S. et al. Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res. 63, 6613-6625 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 6613-6625
    • Godard, S.1
  • 85
    • 0037381008 scopus 로고    scopus 로고
    • Gene expression-based classification of malignant gliomas correlates better with survival than histological classification
    • Nutt, C. L. et al. Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res. 63, 1602-1607 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 1602-1607
    • Nutt, C.L.1
  • 86
    • 62449321780 scopus 로고    scopus 로고
    • Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes
    • Li, A. et al. Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes. Cancer Res. 69, 2091-2099 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 2091-2099
    • Li, A.1
  • 87
    • 20244387732 scopus 로고    scopus 로고
    • Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
    • Liang, Y. et al. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc. Natl Acad. Sci. USA 102, 5814-5819 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 5814-5819
    • Liang, Y.1
  • 88
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips, H. S. et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9, 157-173 (2006).
    • (2006) Cancer Cell , vol.9 , pp. 157-173
    • Phillips, H.S.1
  • 89
    • 33751208636 scopus 로고    scopus 로고
    • Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target
    • Horvath, S. et al. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc. Natl Acad. Sci. USA 103, 17402-17407 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 17402-17407
    • Horvath, S.1
  • 90
    • 70849122697 scopus 로고    scopus 로고
    • Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    • Brennan, C. et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS ONE 4, e7752 (2009).
    • (2009) PLoS ONE , vol.4
    • Brennan, C.1
  • 91
    • 73649123907 scopus 로고    scopus 로고
    • An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak, R. G. W. et al. An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17, 98-110 (2009).
    • (2009) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.W.1
  • 92
    • 75149195336 scopus 로고    scopus 로고
    • The transcriptional network for mesenchymal transformation of brain tumours
    • Carro, M. S. et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463, 318-325 (2010).
    • (2010) Nature , vol.463 , pp. 318-325
    • Carro, M.S.1
  • 93
    • 48849110181 scopus 로고    scopus 로고
    • Medulloblastoma: What is the role of molecular genetics? Expert Rev
    • Entz-Werle, N. et al. Medulloblastoma: what is the role of molecular genetics? Expert Rev. Anticancer Ther. 8, 1169-1181 (2008).
    • (2008) Anticancer Ther. , vol.8 , pp. 1169-1181
    • Entz-Werle, N.1
  • 94
    • 0030913169 scopus 로고    scopus 로고
    • Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched
    • Pietsch, T. et al. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res. 57, 2085-2088 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 2085-2088
    • Pietsch, T.1
  • 95
    • 0031036694 scopus 로고    scopus 로고
    • Sporadic medulloblastomas contain PTCH mutations
    • Raffel, C. et al. Sporadic medulloblastomas contain PTCH mutations. Cancer Res. 57, 842-845 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 842-845
    • Raffel, C.1
  • 96
    • 0032080853 scopus 로고    scopus 로고
    • Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Reifenberger, J. et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 58, 1798-1803 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 1798-1803
    • Reifenberger, J.1
  • 97
    • 0036648241 scopus 로고    scopus 로고
    • Mutations in SUFU predispose to medulloblastoma
    • Taylor, M. D. et al. Mutations in SUFU predispose to medulloblastoma. Nature Genet. 31, 306-310 (2002).
    • (2002) Nature Genet. , vol.31 , pp. 306-310
    • Taylor, M.D.1
  • 98
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn, H. et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85, 841-851 (1996).
    • (1996) Cell , vol.85 , pp. 841-851
    • Hahn, H.1
  • 99
    • 1642496855 scopus 로고    scopus 로고
    • Molecular biology of medulloblastoma therapy
    • Pomeroy, S. L. & Sturla, L. M. Molecular biology of medulloblastoma therapy. Pediatr. Neurosurg. 39, 299-304 (2003).
    • (2003) Pediatr. Neurosurg. , vol.39 , pp. 299-304
    • Pomeroy, S.L.1    Sturla, L.M.2
  • 100
    • 48449105147 scopus 로고    scopus 로고
    • Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
    • Schuller, U. et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14, 123-134 (2008).
    • (2008) Cancer Cell , vol.14 , pp. 123-134
    • Schuller, U.1
  • 101
    • 48449101742 scopus 로고    scopus 로고
    • Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    • Yang, Z. J. et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14, 135-145 (2008).
    • (2008) Cancer Cell , vol.14 , pp. 135-145
    • Yang, Z.J.1
  • 102
    • 33645094926 scopus 로고    scopus 로고
    • N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma
    • Browd, S. R. et al. N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma. Cancer Res. 66, 2666-2672 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 2666-2672
    • Browd, S.R.1
  • 103
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich, L. V., Milenkovic, L., Higgins, K. M. & Scott, M. P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113 (1997).
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 104
    • 7444228699 scopus 로고    scopus 로고
    • The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas
    • Hallahan, A. R. et al. The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res. 64, 7794-7800 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 7794-7800
    • Hallahan, A.R.1
  • 105
    • 40949158954 scopus 로고    scopus 로고
    • The Smo/Smo model: Hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread
    • Hatton, B. A. et al. The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread. Cancer Res. 68, 1768-1776 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 1768-1776
    • Hatton, B.A.1
  • 106
    • 33746879125 scopus 로고    scopus 로고
    • Patched2 modulates tumorigenesis in patched1 heterozygous mice
    • Lee, Y. et al. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res. 66, 6964-6971 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 6964-6971
    • Lee, Y.1
  • 107
    • 34347241369 scopus 로고    scopus 로고
    • Apoptosis suppression by somatic cell transfer of Bcl-2 promotes Sonic hedgehog-dependent medulloblastoma formation in mice
    • McCall, T. D., Pedone, C. A. & Fults, D. W. Apoptosis suppression by somatic cell transfer of Bcl-2 promotes Sonic hedgehog-dependent medulloblastoma formation in mice. Cancer Res. 67, 5179-5185 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 5179-5185
    • McCall, T.D.1    Pedone, C.A.2    Fults, D.W.3
  • 108
    • 0037168206 scopus 로고    scopus 로고
    • High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice
    • Pazzaglia, S. et al. High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice. Oncogene 21, 7580-7584 (2002).
    • (2002) Oncogene , vol.21 , pp. 7580-7584
    • Pazzaglia, S.1
  • 109
    • 33644529131 scopus 로고    scopus 로고
    • Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice
    • Pazzaglia, S. et al. Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice. Oncogene 25, 1165-1173 (2006).
    • (2006) Oncogene , vol.25 , pp. 1165-1173
    • Pazzaglia, S.1
  • 110
    • 4444273153 scopus 로고    scopus 로고
    • Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice
    • Rao, G. et al. Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Oncogene 23, 6156-6162 (2004).
    • (2004) Oncogene , vol.23 , pp. 6156-6162
    • Rao, G.1
  • 111
    • 33644877965 scopus 로고    scopus 로고
    • Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells
    • Rao, R. D. et al. Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells. Neoplasia 7, 921-929 (2005).
    • (2005) Neoplasia , vol.7 , pp. 921-929
    • Rao, R.D.1
  • 112
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore, C., Eberhart, D. E. & Curran, T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res. 61, 513-516 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 114
    • 0034033921 scopus 로고    scopus 로고
    • Nuclear localization and mutation of beta-catenin in medulloblastomas
    • Eberhart, C. G., Tihan, T. & Burger, P. C. Nuclear localization and mutation of beta-catenin in medulloblastomas. J. Neuropathol. Exp. Neurol. 59, 333-337 (2000).
    • (2000) J. Neuropathol. Exp. Neurol. , vol.59 , pp. 333-337
    • Eberhart, C.G.1    Tihan, T.2    Burger, P.C.3
  • 116
    • 0037473082 scopus 로고    scopus 로고
    • AXIN1 mutations but not deletions in cerebellar medulloblastomas
    • Baeza, N., Masuoka, J., Kleihues, P. & Ohgaki, H. AXIN1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 22, 632-636 (2003).
    • (2003) Oncogene , vol.22 , pp. 632-636
    • Baeza, N.1    Masuoka, J.2    Kleihues, P.3    Ohgaki, H.4
  • 117
    • 0033883092 scopus 로고    scopus 로고
    • APC mutations in sporadic medulloblastomas
    • Huang, H. et al. APC mutations in sporadic medulloblastomas. Am. J. Pathol. 156, 433-437 (2000).
    • (2000) Am. J. Pathol. , vol.156 , pp. 433-437
    • Huang, H.1
  • 118
    • 34250341789 scopus 로고    scopus 로고
    • Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas
    • Koch, A. et al. Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas. Int. J. Cancer 121, 284-291 (2007).
    • (2007) Int. J. Cancer , vol.121 , pp. 284-291
    • Koch, A.1
  • 119
    • 0035427076 scopus 로고    scopus 로고
    • Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors
    • Koch, A. et al. Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors. Int. J. Cancer 93, 445-449 (2001).
    • (2001) Int. J. Cancer , vol.93 , pp. 445-449
    • Koch, A.1
  • 120
    • 0032030894 scopus 로고    scopus 로고
    • Sporadic medulloblastomas contain oncogenic β-catenin mutations
    • Zurawel, R. H., Chiappa, S. A., Allen, C. & Raffel, C. Sporadic medulloblastomas contain oncogenic β-catenin mutations. Cancer Res. 58, 896-899 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 896-899
    • Zurawel, R.H.1    Chiappa, S.A.2    Allen, C.3    Raffel, C.4
  • 121
    • 32944461274 scopus 로고    scopus 로고
    • Beta-catenin status predicts a favorable outcome in childhood medulloblastoma: The United Kingdom Children's Cancer Study Group Brain Tumour Committee
    • Ellison, D. W. et al. β-catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. J. Clin. Oncol. 23, 7951-7957 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 7951-7957
    • Ellison, D.W.1
  • 122
    • 45749109850 scopus 로고    scopus 로고
    • C. c-Myc and β-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice
    • Momota, H., Shih, A. H., Edgar, M. A. & Holland, E. C. c-Myc and β-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice. Oncogene 27, 4392-4401 (2008).
    • (2008) Oncogene , vol.27 , pp. 4392-4401
    • Momota, H.1    Shih, A.H.2    Edgar, M.A.3    Holland, E.4
  • 123
    • 0030988932 scopus 로고    scopus 로고
    • Prognostic significance of chromosome 17p deletions in childhood primitive neuroectodermal tumors (medulloblastomas) of the central nervous system
    • Biegel, J. A. et al. Prognostic significance of chromosome 17p deletions in childhood primitive neuroectodermal tumors (medulloblastomas) of the central nervous system. Clin. Cancer Res. 3, 473-478 (1997).
    • (1997) Clin. Cancer Res. , vol.3 , pp. 473-478
    • Biegel, J.A.1
  • 125
    • 0029944362 scopus 로고    scopus 로고
    • Tumor suppressor genes and medulloblastoma
    • Cogen, P. H. & McDonald, J. D. Tumor suppressor genes and medulloblastoma. J. Neurooncol. 29, 103-112 (1996).
    • (1996) J. Neurooncol. , vol.29 , pp. 103-112
    • Cogen, P.H.1    McDonald, J.D.2
  • 126
    • 4143081483 scopus 로고    scopus 로고
    • Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients
    • Lamont, J. M., McManamy, C. S., Pearson, A. D., Clifford, S. C. & Ellison, D. W. Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients. Clin. Cancer Res. 10, 5482-5493 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5482-5493
    • Lamont, J.M.1    McManamy, C.S.2    Pearson, A.D.3    Clifford, S.C.4    Ellison, D.W.5
  • 127
    • 0033669529 scopus 로고    scopus 로고
    • Imbalances of chromosome 17 in medulloblastomas determined by comparative genomic hybridisation and fluorescence in situ hybridisation
    • Nicholson, J., Wickramasinghe, C., Ross, F., Crolla, J. & Ellison, D. Imbalances of chromosome 17 in medulloblastomas determined by comparative genomic hybridisation and fluorescence in situ hybridisation. Mol. Pathol. 53, 313-319 (2000).
    • (2000) Mol. Pathol. , vol.53 , pp. 313-319
    • Nicholson, J.1    Wickramasinghe, C.2    Ross, F.3    Crolla, J.4    Ellison, D.5
  • 129
    • 0027960780 scopus 로고
    • Detection of i(17q) chromosome by fluorescent in situ hybridization (FISH) with interphase nuclei in medulloblastoma
    • Vagner-Capodano, A. M. et al. Detection of i(17q) chromosome by fluorescent in situ hybridization (FISH) with interphase nuclei in medulloblastoma. Cancer Genet. Cytogenet. 78, 1-6 (1994).
    • (1994) Cancer Genet. Cytogenet. , vol.78 , pp. 1-6
    • Vagner-Capodano, A.M.1
  • 130
    • 0028316608 scopus 로고
    • Aggressive medulloblastoma with high-level N-myc amplification
    • Tomlinson, F. H. et al. Aggressive medulloblastoma with high-level N-myc amplification. Mayo Clin. Proc. 69, 359-365 (1994).
    • (1994) Mayo Clin. Proc. , vol.69 , pp. 359-365
    • Tomlinson, F.H.1
  • 131
    • 34848893044 scopus 로고    scopus 로고
    • Loss of suppressor-of-fused function promotes tumorigenesis
    • Lee, Y. et al. Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene 26, 6442-6447 (2007).
    • (2007) Oncogene , vol.26 , pp. 6442-6447
    • Lee, Y.1
  • 132
    • 27744450224 scopus 로고    scopus 로고
    • The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
    • Uziel, T. et al. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev. 19, 2656-2667 (2005).
    • (2005) Genes Dev. , vol.19 , pp. 2656-2667
    • Uziel, T.1
  • 133
    • 0036245047 scopus 로고    scopus 로고
    • MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group
    • Aldosari, N. et al. MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. Arch. Pathol. Lab. Med. 126, 540-544 (2002).
    • (2002) Arch. Pathol. Lab. Med. , vol.126 , pp. 540-544
    • Aldosari, N.1
  • 134
    • 41949102707 scopus 로고    scopus 로고
    • T. miRiad roles for the miR-17-92 cluster in development and disease
    • Mendell, J. T. miRiad roles for the miR-17-92 cluster in development and disease. Cell 133, 217-222 (2008).
    • (2008) Cell , vol.133 , pp. 217-222
    • Mendell, J.1
  • 135
    • 0037902082 scopus 로고    scopus 로고
    • W. c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice
    • Rao, G., Pedone, C. A., Coffin, C. M., Holland, E. C. & Fults, D. W. c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice. Neoplasia 5, 198-204 (2003).
    • (2003) Neoplasia , vol.5 , pp. 198-204
    • Rao, G.1    Pedone, C.A.2    Coffin, C.M.3    Holland, E.C.4    Fults, D.5
  • 136
    • 0034794796 scopus 로고    scopus 로고
    • Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
    • MacDonald, T. J. et al. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nature Genet. 29, 143-152 (2001).
    • (2001) Nature Genet. , vol.29 , pp. 143-152
    • MacDonald, T.J.1
  • 137
    • 0035445646 scopus 로고    scopus 로고
    • Clinical and molecular stratification of disease risk in medulloblastoma
    • Gilbertson, R. et al. Clinical and molecular stratification of disease risk in medulloblastoma. Br. J. Cancer 85, 705-712 (2001).
    • (2001) Br. J. Cancer , vol.85 , pp. 705-712
    • Gilbertson, R.1
  • 138
    • 0043092165 scopus 로고    scopus 로고
    • Medulloblastoma sensitivity to 17-allylamino-17-demethoxygeldanamycin requires MEK/ERKM
    • Calabrese, C., Frank, A., Maclean, K. & Gilbertson, R. Medulloblastoma sensitivity to 17-allylamino-17-demethoxygeldanamycin requires MEK/ERKM. J. Biol. Chem. 278, 24951-24959 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 24951-24959
    • Calabrese, C.1    Frank, A.2    MacLean, K.3    Gilbertson, R.4
  • 139
    • 0037224320 scopus 로고    scopus 로고
    • ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma
    • Hernan, R. et al. ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma. Cancer Res. 63, 140-148 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 140-148
    • Hernan, R.1
  • 140
    • 0034996240 scopus 로고    scopus 로고
    • Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma
    • Gilbertson, R. et al. Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma. Genes Chromosom. Cancer 31, 288-294 (2001).
    • (2001) Genes Chromosom. Cancer , vol.31 , pp. 288-294
    • Gilbertson, R.1
  • 141
    • 1842614251 scopus 로고    scopus 로고
    • Clinical, histopathologic, and molecular markers of prognosis: Toward a new disease risk stratification system for medulloblastoma
    • Gajjar, A. et al. Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J. Clin. Oncol. 22, 984-993 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 984-993
    • Gajjar, A.1
  • 142
    • 0028918623 scopus 로고
    • Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma
    • Gilbertson, R. J., Pearson, A. D., Perry, R. H., Jaros, E. & Kelly, P. J. Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma. Br. J. Cancer 71, 473-477 (1995).
    • (1995) Br. J. Cancer , vol.71 , pp. 473-477
    • Gilbertson, R.J.1    Pearson, A.D.2    Perry, R.H.3    Jaros, E.4    Kelly, P.J.5
  • 143
    • 0030741967 scopus 로고    scopus 로고
    • Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma
    • Gilbertson, R. J., Perry, R. H., Kelly, P. J., Pearson, A. D. & Lunec, J. Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma. Cancer Res. 57, 3272-3280 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 3272-3280
    • Gilbertson, R.J.1    Perry, R.H.2    Kelly, P.J.3    Pearson, A.D.4    Lunec, J.5
  • 144
    • 0037165140 scopus 로고    scopus 로고
    • Prediction of central nervous system embryonal tumour outcome based on gene expression
    • Pomeroy, S. L. et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415, 436-442 (2002).
    • (2002) Nature , vol.415 , pp. 436-442
    • Pomeroy, S.L.1
  • 145
    • 52449119078 scopus 로고    scopus 로고
    • Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
    • Kool, M. et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS ONE 3, e3088 (2008).
    • (2008) PLoS ONE , vol.3
    • Kool, M.1
  • 146
    • 33646362581 scopus 로고    scopus 로고
    • Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    • Thompson, M. C. et al. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J. Clin. Oncol. 24, 1924-1931 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1924-1931
    • Thompson, M.C.1
  • 147
  • 148
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • Galli, R. et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 64, 7011-7021 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 7011-7021
    • Galli, R.1
  • 149
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh, S. K. et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 63, 5821-5828 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 5821-5828
    • Singh, S.K.1
  • 150
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396-401 (2004).
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1
  • 151
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao, S. et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756-760 (2006).
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1
  • 152
    • 33845621982 scopus 로고    scopus 로고
    • Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133-cells, and the CD133+ sector is enlarged by hypoxia
    • Blazek, E. R., Foutch, J. L. & Maki, G. Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133-cells, and the CD133+ sector is enlarged by hypoxia. Int. J. Radiat. Oncol. Biol. Phys. 67, 1-5 (2007).
    • (2007) Int. J. Radiat. Oncol. Biol. Phys. , vol.67 , pp. 1-5
    • Blazek, E.R.1    Foutch, J.L.2    Maki, G.3
  • 153
    • 41749118669 scopus 로고    scopus 로고
    • Identification of A2B5+CD133-tumor-initiating cells in adult human gliomas
    • Ogden, A. T. et al. Identification of A2B5+CD133-tumor-initiating cells in adult human gliomas. Neurosurgery 62, 505-515 (2008).
    • (2008) Neurosurgery , vol.62 , pp. 505-515
    • Ogden, A.T.1
  • 154
    • 38349075007 scopus 로고    scopus 로고
    • CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
    • Wang, J. et al. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int. J. Cancer 122, 761-768 (2008).
    • (2008) Int. J. Cancer , vol.122 , pp. 761-768
    • Wang, J.1
  • 155
    • 67849099254 scopus 로고    scopus 로고
    • How powerful is CD133 as a cancer stem cell marker in brain tumors?
    • Cheng, J. X., Liu, B. L. & Zhang, X. How powerful is CD133 as a cancer stem cell marker in brain tumors? Cancer Treat Rev. 35, 403-408 (2009).
    • (2009) Cancer Treat Rev. , vol.35 , pp. 403-408
    • Cheng, J.X.1    Liu, B.L.2    Zhang, X.3
  • 156
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: Glioblastoma stem cells and the vascular niche
    • Gilbertson, R. J. & Rich, J. N. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nature Rev. Cancer 7, 733-736 (2007).
    • (2007) Nature Rev. Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 157
    • 0013784893 scopus 로고
    • Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
    • Altman, J. & Das, G. D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol. 124, 319-335 (1965).
    • (1965) J. Comp. Neurol. , vol.124 , pp. 319-335
    • Altman, J.1    Das, G.D.2
  • 158
    • 0027406459 scopus 로고
    • Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons an glia
    • Lois, C. & Alvarez-Buylla, A. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons an glia. Proc. Natl Acad. Sci. USA 90, 2074-2077 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 2074-2077
    • Lois, C.1    Alvarez-Buylla, A.2
  • 160
    • 33846029123 scopus 로고    scopus 로고
    • A perivascular niche for brain tumor stem cells
    • Calabrese, C. et al. A perivascular niche for brain tumor stem cells. Cancer Cell 11, 69-82 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 69-82
    • Calabrese, C.1
  • 161
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao, S. et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 66, 7843-7848 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 7843-7848
    • Bao, S.1
  • 162
    • 67649118749 scopus 로고    scopus 로고
    • Turning cancer stem cells inside out: An exploration of glioma stem cell signaling pathways
    • Li, Z., Wang, H., Eyler, C. E., Hjelmeland, A. B. & Rich, J. N. Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J. Biol. Chem. 284, 16705-16709 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 16705-16709
    • Li, Z.1    Wang, H.2    Eyler, C.E.3    Hjelmeland, A.B.4    Rich, J.N.5
  • 163
    • 42049108822 scopus 로고    scopus 로고
    • Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas
    • Becher, O. J. et al. Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas. Cancer Res. 68, 2241-2249 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 2241-2249
    • Becher, O.J.1
  • 164
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • Li, Z. et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15, 501-513 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 501-513
    • Li, Z.1
  • 165
    • 33644747418 scopus 로고    scopus 로고
    • HIF-2α regulates Oct-4: Effects of hypoxia on stem cell function, embryonic development, and tumor growth
    • Covello, K. L. et al. HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 20, 557-570 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 557-570
    • Covello, K.L.1
  • 166
    • 70350225829 scopus 로고    scopus 로고
    • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
    • Heddleston, J. M., Li, Z., McLendon, R. E., Hjelmeland, A. B. & Rich, J. N. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle 8, 3274-3284 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 3274-3284
    • Heddleston, J.M.1    Li, Z.2    McLendon, R.E.3    Hjelmeland, A.B.4    Rich, J.N.5
  • 167
    • 67349193226 scopus 로고    scopus 로고
    • Emerging role of Notch in stem cells and cancer
    • Wang, Z., Li, Y., Banerjee, S. & Sarkar, F. H. Emerging role of Notch in stem cells and cancer. Cancer Lett. 279, 8-12 (2009).
    • (2009) Cancer Lett. , vol.279 , pp. 8-12
    • Wang, Z.1    Li, Y.2    Banerjee, S.3    Sarkar, F.H.4
  • 168
    • 33845595633 scopus 로고    scopus 로고
    • Notch signaling enhances nestin expression in gliomas
    • Shih, A. H. & Holland, E. C. Notch signaling enhances nestin expression in gliomas. Neoplasia 8, 1072-1082 (2006).
    • (2006) Neoplasia , vol.8 , pp. 1072-1082
    • Shih, A.H.1    Holland, E.C.2
  • 169
    • 34548253014 scopus 로고    scopus 로고
    • Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling
    • Bhattacharya, S., Das, A., Mallya, K. & Ahmad, I. Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling. J. Cell Sci. 120, 2652-2662 (2007).
    • (2007) J. Cell Sci. , vol.120 , pp. 2652-2662
    • Bhattacharya, S.1    Das, A.2    Mallya, K.3    Ahmad, I.4
  • 170
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stemlike cells and blocks engraftment in embryonal brain tumors
    • Fan, X. et al. Notch pathway inhibition depletes stemlike cells and blocks engraftment in embryonal brain tumors. Cancer Res. 66, 7445-7452 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 7445-7452
    • Fan, X.1
  • 171
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau, A. M. et al. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 4, 226-235 (2009).
    • (2009) Cell Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1
  • 172
    • 75349091751 scopus 로고    scopus 로고
    • Nitric oxide drives notch signaling and stem cell-like character via PKG in the perivascular niche of PDGF gliomas
    • Charles, N. et al. Nitric oxide drives notch signaling and stem cell-like character via PKG in the perivascular niche of PDGF gliomas. Cell Stem Cell. 6, 141-152 (2010).
    • (2010) Cell Stem Cell. , vol.6 , pp. 141-152
    • Charles, N.1
  • 173
    • 39449135834 scopus 로고    scopus 로고
    • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
    • Hambardzumyan, D. et al. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev. 22, 436-448 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 436-448
    • Hambardzumyan, D.1
  • 175
    • 67349108288 scopus 로고    scopus 로고
    • Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma
    • Lindberg, N., Kastemar, M., Olofsson, T., Smits, A. & Uhrbom, L. Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma. Oncogene 28, 2266-2275 (2009).
    • (2009) Oncogene , vol.28 , pp. 2266-2275
    • Lindberg, N.1    Kastemar, M.2    Olofsson, T.3    Smits, A.4    Uhrbom, L.5
  • 176
    • 33745778950 scopus 로고    scopus 로고
    • Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses
    • Assanah, M. et al. Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. J. Neurosci. 26, 6781-6790 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 6781-6790
    • Assanah, M.1
  • 177
    • 70349296853 scopus 로고    scopus 로고
    • The ABCG2 resistance network of glioblastoma
    • Bleau, A. M., Huse, J. T. & Holland, E. C. The ABCG2 resistance network of glioblastoma. Cell Cycle 8, 2936-2944 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 2936-2944
    • Bleau, A.M.1    Huse, J.T.2    Holland, E.C.3
  • 178
    • 61449171080 scopus 로고    scopus 로고
    • New (alternative) temozolomide regimens for the treatment of glioma
    • Wick, W., Platten, M. & Weller, M. New (alternative) temozolomide regimens for the treatment of glioma. Neuro Oncol. 11, 69-79 (2009).
    • (2009) Neuro Oncol. , vol.11 , pp. 69-79
    • Wick, W.1    Platten, M.2    Weller, M.3
  • 179
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • Mellinghoff, I. K. et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. 353, 2012-2024 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1
  • 180
    • 70350496540 scopus 로고    scopus 로고
    • Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
    • Yauch, R. L. et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 326, 572-574 (2009).
    • (2009) Science , vol.326 , pp. 572-574
    • Yauch, R.L.1
  • 181
    • 57449096198 scopus 로고    scopus 로고
    • Genetically engineered mouse models of brain cancer and the promise of preclinical testing
    • Huse, J. T. & Holland, E. C. Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol. 19, 132-143 (2009).
    • (2009) Brain Pathol. , vol.19 , pp. 132-143
    • Huse, J.T.1    Holland, E.C.2
  • 182
    • 33747887175 scopus 로고    scopus 로고
    • ROS fusion tyrosine kinase activates a SH2 domain-containing phospatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice
    • Charest, A. et al. ROS fusion tyrosine kinase activates a SH2 domain-containing phospatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 66, 7473-7481 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 7473-7481
    • Charest, A.1
  • 183
    • 27744506881 scopus 로고    scopus 로고
    • Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: Tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01
    • Lassman, A. B. et al. Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01. Clin. Cancer Res. 11, 7841-7850 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7841-7850
    • Lassman, A.B.1
  • 184
    • 0033938847 scopus 로고    scopus 로고
    • Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme
    • Liebner, S. et al. Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme. Acta Neuropathol. 100, 323-331 (2000).
    • (2000) Acta Neuropathol. , vol.100 , pp. 323-331
    • Liebner, S.1
  • 186
    • 70349408777 scopus 로고    scopus 로고
    • New strategies to deliver anticancer drugs to brain tumors
    • Laquintana, V. et al. New strategies to deliver anticancer drugs to brain tumors. Expert Opin. Drug Deliv. 6, 1017-1032 (2009).
    • (2009) Expert Opin. Drug Deliv. , vol.6 , pp. 1017-1032
    • Laquintana, V.1


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