Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 46, 2006, Pages 17402-17407

  Horvath, S ^a   Zhang, B ^a   Carlson, M ^a   Lu, K V ^a   Zhu, S ^a   Felciano, R M ^c   Laurence, M F ^c   Zhao, W ^a   Qi, S ^a   Chen, Z ^a   Lee, Y ^a   Schecks, A C ^d   Liau, L M ^a   Wu, H ^a   Geschwind, D H ^a,b   Febbo, P G ^e   Kornblum, H I ^a,b   Cloughesy, T F ^a   Nelson, S F ^a   Mischel, P S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Ingenuity Systems Inc   (United States)

^d BARROW NEUROLOGICAL INSTITUTE   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Epidermal growth factor receptor VIII; Glioblastoma; Modules; Network based screening; Weighted gene coexpression network analysis

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 8; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASPM GENE; BREAST CANCER; CANCER SURVIVAL; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC ANALYSIS; GLIOBLASTOMA; MOUSE; NEURAL STEM CELL; NONHUMAN; ONCOGENE; PRIORITY JOURNAL;

ANIMALS; BREAST NEOPLASMS; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; MICE; NERVE TISSUE PROTEINS; ONCOGENE PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 33751208636     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0608396103     Document Type: Article

References (46)

1. Sawyers C (2004) Nature 432:294-297.
2. Mellinghoff IK, Wang MY, Vivanco I, Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Yoshiraoto K, Huang JH, Chute DJ, et al. (2005) N Engl J Med 353:2012-2024.
3. Liu ET, Karuturi KR (2004) N Engl J Med 350:1595-1597.
4. Ebert BL, Golub TR (2004) Blood 104:923-932.
5. Hood L, Heath JR, Phelps ME, Lin B (2004) Science 306:640-643.
6. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP (2005) Proc Natl Acad Sci USA 102:15545-15550.
7. Segal E, Friedman N, Koller D, Regev A (2004) Nat Genet 36:1090-1098.
8. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, et al. (2003) Nat Genet 34:267-273.
9. Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, Joshi MB, Harpole D, Lancaster JM, Berchuck A, et al. (2006) Nature 439:353-357.
10. Lamb J, Ramaswamy S, Ford HL, Contreras B, Martinez RV, Kittrell FS, Zahnow CA, Patterson N, Golub TR, Ewen ME (2003) Cell 114:323-334.
11. Kang Y (2005) Expert Rev Mol Diagn 5:385-395.
12. Freije WA, Castro-Vargas FE, Fang Z, Horvath S, Cloughesy T, Liau LM, Mischel PS, Nelson SF (2004) Cancer Res 64:6503-6510.
13. Zhang B, Horvath S (2005) Stat Appl Genet Mol Biol 4:17.
14. van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, et al. (2002) Nature 415:530-536.
15. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, Chinnaiyan AM (2004) Proc Natl Acad Sci USA 101:9309-9314.
16. Alter O, Brown PO, Botstein D (2000) Proc Natl Acad Sci USA 97:10101-10106.
17. Quinones-Hinojosa A, Sanai N, Smith JS, McDermott MW (2005) J Neurooncol 74:19-30.
18. Han JD, Bertin N, Hao T, Goldberg DS, Berriz GF, Zhang LV, Dupuy D, Walhout AJ, Cusick ME, Roth FP, Vidal M (2004) Nature 430:88-93.
19. Jeong H, Mason SP, Barabasi AL, Oltvai ZN (2001) Nature 411:41-42.
20. Carlson MR, Zhang B, Fang Z, Mischel PS, Horvath S, Nelson SF (2006) BMC Genomics 7:40.
21. Barabasi AL, Albert R (1999) Science 286:509-512.
22. Barabasi AL, Oltvai ZN (2004) Nat Rev Genet 5:101-113.
23. Hamid T, Malik MT, Kakar SS (2005) Mol Cancer 4:3.
24. Larsen AK, Gobert C (1999) Pathol Oncol Res 5:171-178.
25. Sellers WR, Loda M (2002) Cancer Cell 2:349-350.
26. Andrews PD (2005) Oncogene 24:5005-5015.
27. Altieri DC (2003) Oncogene 22:8581-8589.
28. Bond J, Roberts E, Mochida GH, Hampshire DJ, Scott S, Askham JM, Springell K, Mahadevan M, Crow YJ, Markham AF, et al. (2002) Nat Genet 32:316-320.
29. Bond J, Scott S, Hampshire DJ, Springell K, Corry P, Abramowicz MJ, Mochida GH, Hennekam RC, Maher ER, Fryns JP, et al. (2003) Am J Hum Genet 73:1170-1177.
30. Woods CG, Bond J, Enard W (2005) Am J Hum Genet 76:717-728.
31. Mekel-Bobrov N, Gilbert SL, Evans PD, Vallender EJ, Anderson JR, Hudson RR, Tishkoff SA, Lahn BT (2005) Science 309:1720-1722.
32. Ponting C, Jackson AP (2005) Curr Opin Genet Dev 15:241-248.
33. Kouprina N, Pavlicek A, Mochida GH, Solomon G, Gersch W, Yoon YH, Collura R, Ruvolo M, Barrett JC, Woods CG, et al. (2004) PLoS Biol 2:E126.
34. Kouprina N, Pavlicek A, Collins NK, Nakano M, Noskov VN, Ohzeki J, Mochida GH, Risinger JI, Goldsmith P, Gunsior M, et al. (2005) Hum Mol Genet 14:2155-2165.
35. Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith BL, Sawyers CL, Mischel PS (2003) Cancer Res 63:2742-2746.
36. Ermoian RP, Furniss CS, Lamborn KR, Basila D, Berger MS, Gottschalk AR, Nicholas MK, Stokoe D, Haas-Kogan DA (2002) Clin Cancer Res 8:1100-1106.
37. Smith JS, Tachibana I, Passe SM, Huntley BK, Borell TJ, Iturria N, O'Fallon JR, Schaefer PL, Scheithauer BW, James CD, et al. (2001) J Natl Cancer Inst 93:1246-1256.
38. Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI (2003) Proc Natl Acad Scei USA 100:15178-15183.
39. Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB (2003) Cancer Res 63:5821-5828.
40. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB (2004) Nature 432:396-401.
41. Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, Fiocco R, Foroni C, Dimeco F, Vescovi A (2004) Cancer Res 64:7011-7021.
42. Bae I, Rih JK, Kim HJ, Kang HJ, Haddad B, Kirilyuk A, Fan S, Avantaggiati ML, Rosen EM (2005) Cell Cycle 4:1641-1666.
43. Rosty C, Sheffer M, Tsafrir D, Stransky N, Tsafrir I, Peter M, de Cremoux P, de La Rochefordiereqq A, Salmon R, Dorval T, et al. (2005) Oncogene 24:7094-7104.
44. Sotiriou C, Wirapati P, Loi S, Harris A, Fox S, Smeds J, Nordgren H, Farmer P, Praz V, Haibe-Kains B, et al. (2006) J Natl Cancer Inst 98:262-272.
45. Fish JL, Kosodo Y, Enard W, Paabo S, Huttner WB (2006) Proc Natl Acad Sci USA 103:10438-10443.
46. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, et al (2005) Nature 437:1032-1037.