Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

Nature Genetics

Volumn 29, Issue 2, 2001, Pages 143-152

  MacDonald, Tobey J ^a   Brown, Kevin M ^b,c   Lafleur, Bonnie ^d   Peterson, Katia ^a   Lawlor, Christopher ^a   Chen, Yidong ^e   Packer, Roger J ^a   Cogen, Philip ^d   Stephan, Dietrich A ^b  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c GEORGE WASHINGTON UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CATHEPSIN D; DIPEPTIDYL PEPTIDASE I; GAMMA INTERFERON; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; GUANINE NUCLEOTIDE BINDING PROTEIN; HEAT SHOCK PROTEIN 70; IMATINIB; INTERLEUKIN 10; ISOENZYME; LONAFARNIB; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 2K1; MITOGEN ACTIVATED PROTEIN KINASE 2K2; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROTROPHIN 3; NEUTRALIZING ANTIBODY; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN C MYB; PROTEIN P53; PROTEIN TYROSINE KINASE; RAS PROTEIN; RETINOBLASTOMA PROTEIN; TIPIFARNIB; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER INVASION; CELL ADHESION; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE CONTROL; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MEDULLOBLASTOMA; METASTASIS; METASTASIS POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BUTADIENES; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; MAP KINASE SIGNALING SYSTEM; MEDULLOBLASTOMA; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM METASTASIS; NITRILES; PHENOTYPE; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA;

EID: 0034794796     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng731     Document Type: Article

References (38)

1. Childhood medulloblastoma: Progress and future challenges
2. Brain tumors in children
3. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medullobiastoma in children: Conclusions from the Children's Cancer Group 921 randomized phase III study
4. TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors
5. Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas
6. C-MYC expression in medulloblastoma and its prognostic value
7. Prognostic significance of chromosome 17p deletions in childhood primitive neuroectodermal tumors (medulloblastomas) of the central nervous system
8. Prognostic implications of chromosome 17p deletions in human medulloblastomas
9. Correlation of chromosome 17p loss with clinical outcome in medulloblastoma
10. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
11. Molecular classification of cutaneous malignant melanoma by gene expression profiling
12. Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study
13. "Large cell/anaplastic" medulloblastomas: A Pediatric Oncology Group Study
14. Molecular heterogeneity in medulloblastoma with implications for differing tumor biology
15. Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA
16. Multiple competition reactions for RPA order the assembly of the DNA polymerase delta holoenzyme
17. Genomic analysis of metastasis reveals an essential role for RhoC
18. Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin
19. Rab3B regulates ZO-1 targeting and actin organization in PC12 neuroendocrine cells
20. Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells
21. A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis
22. Integrin activation controls metastasis in human breast cancer
23. Differential expression of osteonectin/SPARC during human prostate cancer progression
24. High levels of TIMP-2 correlate with adverse prognosis in breast cancer
25. The endothelial receptor tyrosine kinase tie-1 is upregulated by hypoxia and vascular endothelial growth factor
26. Differential patterns of HOX gene expression are associated with specific integrin and ICAM profiles in clonal populations isolated from a single human melanoma metastasis
27. N-myc gene expression and oncoprotein characterisation in medulloblastoma
28. Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma
29. Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma
30. Gene expression profiling of low-grade diffuse astrocytomas by cDNA array
31. Differential gene expression profiling in human brain tumors
32. Platelet-derived growth factor is expressed by cells in the early oligodendrocyte lineage
33. Platelet-derived growth factor (PDGF) receptor-alpha activates c-Jun NH2-terminal kinase-1 and antagonizes PDGF receptor-beta-induced phenotypic transformation
34. FAK integrates growth-factor and integrin signals to promote cell migration
35. Specific activation of a c-Jun NH2-terminal kinase isoform and induction of neurite outgrowth in PC-12 cells by staurosporine
36. DNA microarray technology: The anticipated impact on the study of human disease
37. Cluster analysis and display of genome-wide expression patterns