Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation

Cancer Cell

Volumn 1, Issue 2, 2002, Pages 157-168

  Xiao, Andrew ^a   Wu, Hua ^a   Pandolfi, Pier Paolo ^b   Louis, David N ^c   Van Dyke, Terry ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN; ONCOPROTEIN; PHOSPHATASE; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTOMA; ASTROCYTOSIS; CANCER GRADING; CANCER GROWTH; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; GENE INACTIVATION; INDUCED MUTATION; MALIGNANT TRANSFORMATION; MOUSE; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSGENICS; AGING; ANIMAL; ANTIBODY SPECIFICITY; APOPTOSIS; BRAIN; CELL DIVISION; CONGENITAL MALFORMATION; ENZYME ACTIVATION; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE; METABOLISM; MUTATION; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

AGING; ANIMALS; APOPTOSIS; ASTROCYTES; ASTROCYTOMA; BRAIN; CELL DIVISION; ENZYME ACTIVATION; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; MICE; MICE, TRANSGENIC; MUTATION; ORGAN SPECIFICITY; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0036490954     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(02)00029-6     Document Type: Article

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