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Volumn 243, Issue 2, 2010, Pages 154-166

Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity

Author keywords

Heptatotoxicity; Metabolomics; Metabonomics; Nephrotoxicity

Indexed keywords

BIOLOGICAL MARKER; DRUG;

EID: 77949417518     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.11.019     Document Type: Article
Times cited : (212)

References (171)
  • 2
    • 0031819810 scopus 로고    scopus 로고
    • Serum transaminase elevations as indicators of hepatic injury following the administration of drugs
    • Amacher, D.E., Serum transaminase elevations as indicators of hepatic injury following the administration of drugs. Regul. Toxicol. Pharmacol. 27 (1998), 119–130.
    • (1998) Regul. Toxicol. Pharmacol. , vol.27 , pp. 119-130
    • Amacher, D.E.1
  • 3
    • 34548515516 scopus 로고    scopus 로고
    • Acetaminophen safety and hepatotoxicity—where do we go from here?
    • Amar, P.J., Schiff, E.R., Acetaminophen safety and hepatotoxicity—where do we go from here?. Expert Opin. Drug Saf. 6 (2007), 341–355.
    • (2007) Expert Opin. Drug Saf. , vol.6 , pp. 341-355
    • Amar, P.J.1    Schiff, E.R.2
  • 4
    • 0027972888 scopus 로고
    • Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the Fischer 344 rat
    • Anthony, M.L., Beddell, C.R., Lindon, J.C., Nicholson, J.K., Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the Fischer 344 rat. Arch. Toxicol. 69 (1994), 99–110.
    • (1994) Arch. Toxicol. , vol.69 , pp. 99-110
    • Anthony, M.L.1    Beddell, C.R.2    Lindon, J.C.3    Nicholson, J.K.4
  • 5
    • 0028918581 scopus 로고
    • Classification of toxin-induced changes in 1H NMR spectra of urine using an artificial neural network
    • Anthony, M.L., Rose, V.S., Nicholson, J.K., Lindon, J.C., Classification of toxin-induced changes in 1H NMR spectra of urine using an artificial neural network. J. Pharm. Biomed. Anal. 13 (1995), 205–211.
    • (1995) J. Pharm. Biomed. Anal. , vol.13 , pp. 205-211
    • Anthony, M.L.1    Rose, V.S.2    Nicholson, J.K.3    Lindon, J.C.4
  • 8
    • 0036174751 scopus 로고    scopus 로고
    • Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data
    • Azmi, J., Griffin, J.L., Antti, H., Shore, R.F., Johansson, E., Nicholson, J.K., Holmes, E., Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data. Analyst 127 (2002), 271–276.
    • (2002) Analyst , vol.127 , pp. 271-276
    • Azmi, J.1    Griffin, J.L.2    Antti, H.3    Shore, R.F.4    Johansson, E.5    Nicholson, J.K.6    Holmes, E.7
  • 9
    • 27944497372 scopus 로고    scopus 로고
    • Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products
    • Azmi, J., Griffin, J.L., Shore, R.F., Holmes, E., Nicholson, J.K., Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products. Xenobiotica 35 (2005), 839–852.
    • (2005) Xenobiotica , vol.35 , pp. 839-852
    • Azmi, J.1    Griffin, J.L.2    Shore, R.F.3    Holmes, E.4    Nicholson, J.K.5
  • 10
    • 2342540427 scopus 로고    scopus 로고
    • Molecular profiling approaches for identifying novel biomarkers
    • Bailey, W.J., Ulrich, R., Molecular profiling approaches for identifying novel biomarkers. Expert Opin. Drug Saf. 3 (2004), 137–151.
    • (2004) Expert Opin. Drug Saf. , vol.3 , pp. 137-151
    • Bailey, W.J.1    Ulrich, R.2
  • 12
    • 33749165575 scopus 로고    scopus 로고
    • Metabonomic models of human pancreatic cancer using 1D proton NMR spectra of lipids in plasma
    • Beger, R.D., Schnackenberg, L.K., Li, D., Dragan, Y., Metabonomic models of human pancreatic cancer using 1D proton NMR spectra of lipids in plasma. Metabolomics 2 (2006), 125–134.
    • (2006) Metabolomics , vol.2 , pp. 125-134
    • Beger, R.D.1    Schnackenberg, L.K.2    Li, D.3    Dragan, Y.4
  • 13
    • 70149102426 scopus 로고    scopus 로고
    • Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the (U-13C6)-D-glucose tracer in mice
    • Beger, R.D., Hansen, D.K., Schnackenberg, L.K., Cross, B.M., Fatollahi, J.J., Lagunero, F.T., Sarnyai, Z., Boros, L.G., Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the (U-13C6)-D-glucose tracer in mice. Metabolomics, 2009.
    • (2009) Metabolomics
    • Beger, R.D.1    Hansen, D.K.2    Schnackenberg, L.K.3    Cross, B.M.4    Fatollahi, J.J.5    Lagunero, F.T.6    Sarnyai, Z.7    Boros, L.G.8
  • 16
    • 0035132183 scopus 로고    scopus 로고
    • Paracetamol (Acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues, and protective approaches
    • Bessems, J.G.M., Vermeulen, N.P.E., Paracetamol (Acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues, and protective approaches. Crit. Rev. Toxicol. 31 (2001), 55–138.
    • (2001) Crit. Rev. Toxicol. , vol.31 , pp. 55-138
    • Bessems, J.G.M.1    Vermeulen, N.P.E.2
  • 17
    • 0033859999 scopus 로고    scopus 로고
    • The role of quantitative neurological examination in clinical neurotoxicology
    • Bleecker, M.L., The role of quantitative neurological examination in clinical neurotoxicology. Neurol. Clin. 18 (2000), 563–578.
    • (2000) Neurol. Clin. , vol.18 , pp. 563-578
    • Bleecker, M.L.1
  • 19
    • 19144371287 scopus 로고    scopus 로고
    • NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
    • Bollard, M.E., Stanley, E.G., Lindon, J.C., Nicholson, J.K., Holmes, E., NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed. 18 (2005), 143–162.
    • (2005) NMR Biomed. , vol.18 , pp. 143-162
    • Bollard, M.E.1    Stanley, E.G.2    Lindon, J.C.3    Nicholson, J.K.4    Holmes, E.5
  • 23
    • 85099662202 scopus 로고    scopus 로고
    • De Roo, A. C., Bennette, N., Pelczer, I., Dismukes, G. C. in press. Identification and quantification of water-soluble metabolites by cryoprobe-assisted nuclear magnetic resonance spectroscopy applied to microbial fermentation. Magn. Reson. Chem.
    • Carrieri, D., McNeely, K., De Roo, A. C., Bennette, N., Pelczer, I., Dismukes, G. C. in press. Identification and quantification of water-soluble metabolites by cryoprobe-assisted nuclear magnetic resonance spectroscopy applied to microbial fermentation. Magn. Reson. Chem.
    • Carrieri, D.1    McNeely, K.2
  • 24
    • 37249093994 scopus 로고    scopus 로고
    • Metabonomics and diabetes mellitus
    • Chen, P., Liu, J., Metabonomics and diabetes mellitus. Adv. Ther. 24 (2007), 1036–1045.
    • (2007) Adv. Ther. , vol.24 , pp. 1036-1045
    • Chen, P.1    Liu, J.2
  • 26
    • 85099660628 scopus 로고    scopus 로고
    • K. in press. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc. Natl. Acad. Sci. U. S. A. in press.
    • Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R., and Nicholson, J. K. in press. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc. Natl. Acad. Sci. U. S. A. in press.
    • Clayton, T.A.1    Baker, D.2    Lindon, J.C.3    Everett, J.R.4    Nicholson, J.5
  • 27
    • 0037348405 scopus 로고    scopus 로고
    • An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy
    • Coen, M., Lenz, E.M., Nicholson, J.K., Wilson, I.D., Pognan, F., Lindon, J.C., An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy. Chem. Res. Toxicol. 16 (2003), 295–303.
    • (2003) Chem. Res. Toxicol. , vol.16 , pp. 295-303
    • Coen, M.1    Lenz, E.M.2    Nicholson, J.K.3    Wilson, I.D.4    Pognan, F.5    Lindon, J.C.6
  • 28
    • 2342520064 scopus 로고    scopus 로고
    • Application of nuclear magnetic resonance spectroscopy combined with principal component analysis in detecting inborn errors of metabolism using blood spots: a metabonomic approach
    • Constantinou, M.A., Papakonstantinou, E., Benakia, D., Spraul, M., Shulpis, K., Koupparis, M.A., Mikros, E., Application of nuclear magnetic resonance spectroscopy combined with principal component analysis in detecting inborn errors of metabolism using blood spots: a metabonomic approach. Anal. Chim. Acta 511 (2004), 303–312.
    • (2004) Anal. Chim. Acta , vol.511 , pp. 303-312
    • Constantinou, M.A.1    Papakonstantinou, E.2    Benakia, D.3    Spraul, M.4    Shulpis, K.5    Koupparis, M.A.6    Mikros, E.7
  • 30
    • 27644560273 scopus 로고    scopus 로고
    • Curve-fitting method for direct quatitation of compounds in complex biological mixtures using 1H NMR: application in metabonomic toxicology studies
    • Crockford, D.J., Keun, H.C., Smith, L.M., Holmes, E., Nicholson, J.K., Curve-fitting method for direct quatitation of compounds in complex biological mixtures using 1H NMR: application in metabonomic toxicology studies. Anal. Chem. 77 (2005), 4556–4562.
    • (2005) Anal. Chem. , vol.77 , pp. 4556-4562
    • Crockford, D.J.1    Keun, H.C.2    Smith, L.M.3    Holmes, E.4    Nicholson, J.K.5
  • 31
    • 30744443014 scopus 로고    scopus 로고
    • Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies
    • Crockford, D.J., Holmes, E., Lindon, J.C., Plumb, R.S., Zirah, S., Bruce, S.J., Rainville, P., Stumpf, C.L., Nicholson, J.K., Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies. Anal. Chem. 78 (2006), 363–371.
    • (2006) Anal. Chem. , vol.78 , pp. 363-371
    • Crockford, D.J.1    Holmes, E.2    Lindon, J.C.3    Plumb, R.S.4    Zirah, S.5    Bruce, S.J.6    Rainville, P.7    Stumpf, C.L.8    Nicholson, J.K.9
  • 32
    • 24644455146 scopus 로고    scopus 로고
    • Suppressive effect of corn bran hemicellulose on liver injury induced by D-galactosamine in rats
    • Daizo, A., Egashira, Y., Sanada, H., Suppressive effect of corn bran hemicellulose on liver injury induced by D-galactosamine in rats. Nutrition 21 (2005), 1044–1051.
    • (2005) Nutrition , vol.21 , pp. 1044-1051
    • Daizo, A.1    Egashira, Y.2    Sanada, H.3
  • 33
    • 0022868951 scopus 로고
    • Chemometrics: an overview
    • Deming, S.N., Chemometrics: an overview. Clin. Chem. 32 (1986), 1702–1706.
    • (1986) Clin. Chem. , vol.32 , pp. 1702-1706
    • Deming, S.N.1
  • 34
    • 0018645607 scopus 로고
    • Decreased aminotransferase activity of serum and various tissues in the rat after cefazolin treatment
    • Dhami, M.S., Drangova, R., Farkas, R., Balaza, T., Feuer, G., Decreased aminotransferase activity of serum and various tissues in the rat after cefazolin treatment. Clin. Chem. 25 (1979), 1263–1266.
    • (1979) Clin. Chem. , vol.25 , pp. 1263-1266
    • Dhami, M.S.1    Drangova, R.2    Farkas, R.3    Balaza, T.4    Feuer, G.5
  • 35
    • 0033638414 scopus 로고    scopus 로고
    • Diagnosis and monitoring of hepatic injury: II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring
    • Dufour, D.R., Lott, J.A., Nolte, F.S., Gretch, D.R., Koff, R.S., Seeff, L.B., Diagnosis and monitoring of hepatic injury: II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring. Clin. Chem. 46 (2000), 2050–2068.
    • (2000) Clin. Chem. , vol.46 , pp. 2050-2068
    • Dufour, D.R.1    Lott, J.A.2    Nolte, F.S.3    Gretch, D.R.4    Koff, R.S.5    Seeff, L.B.6
  • 38
    • 16244402990 scopus 로고    scopus 로고
    • Metabolomics: current analytical platforms and methodologies
    • Dunn, W.B., Ellis, D.I., Metabolomics: current analytical platforms and methodologies. Trends Anal. Chem. 24 (2005), 285–294.
    • (2005) Trends Anal. Chem. , vol.24 , pp. 285-294
    • Dunn, W.B.1    Ellis, D.I.2
  • 40
    • 36348960223 scopus 로고    scopus 로고
    • Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach
    • Ebbels, T.M., Keun, H.C., Beckonert, O.P., Bollard, M.E., Lindon, J.C., Holmes, E., Nicholson, J.K., Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach. J. Proteome Res. 6 (2007), 4407–4422.
    • (2007) J. Proteome Res. , vol.6 , pp. 4407-4422
    • Ebbels, T.M.1    Keun, H.C.2    Beckonert, O.P.3    Bollard, M.E.4    Lindon, J.C.5    Holmes, E.6    Nicholson, J.K.7
  • 45
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics–The link between genotypes and phenotypes
    • Fiehn, O., Metabolomics–The link between genotypes and phenotypes. Plant Mol. Biol. 48 (2002), 155–171.
    • (2002) Plant Mol. Biol. , vol.48 , pp. 155-171
    • Fiehn, O.1
  • 47
    • 85099663773 scopus 로고    scopus 로고
    • van der Werf, M., Nikolau, B., Morrison, N., Sumner, L. W., Goodacre, R., Hardy, N. W., Taylor, C., Fostel, J., Kristal, B., Kaddurah-Daouk, R., Mendes, P., van Ommen, B., Lindon, J. C., Sansone, S. A. in press. The metabolomics standards initiative (MSI). Metabolomics.
    • Fiehn, O., Robertson, D., Griffin, J., van der Werf, M., Nikolau, B., Morrison, N., Sumner, L. W., Goodacre, R., Hardy, N. W., Taylor, C., Fostel, J., Kristal, B., Kaddurah-Daouk, R., Mendes, P., van Ommen, B., Lindon, J. C., Sansone, S. A. in press. The metabolomics standards initiative (MSI). Metabolomics.
    • Fiehn, O.1    Robertson, D.2    Griffin, J.3
  • 48
    • 33645717628 scopus 로고    scopus 로고
    • GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks
    • Gambus, A., Jones, R.C., Sanchez-Diaz, A., Kanemaki, M., van Deursen, F., Edmondson, R.D., Labib, K., GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat. Cell Biol. 8 (2006), 358–366.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 358-366
    • Gambus, A.1    Jones, R.C.2    Sanchez-Diaz, A.3    Kanemaki, M.4    van Deursen, F.5    Edmondson, R.D.6    Labib, K.7
  • 50
    • 0024580448 scopus 로고
    • Investigations into the biochemical effects of region-specific nephrotoxins
    • Gartland, K.P., Bonner, F.W., Nicholson, J.K., Investigations into the biochemical effects of region-specific nephrotoxins. Mol. Pharmacol. 35 (1989), 242–250.
    • (1989) Mol. Pharmacol. , vol.35 , pp. 242-250
    • Gartland, K.P.1    Bonner, F.W.2    Nicholson, J.K.3
  • 51
    • 0034634448 scopus 로고    scopus 로고
    • An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse
    • Gavaghan, C.L., Holmes, E., Lenz, E., Wilson, I.D., Nicholson, J.K., An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse. FEBS Lett. 484 (2000), 169–174.
    • (2000) FEBS Lett. , vol.484 , pp. 169-174
    • Gavaghan, C.L.1    Holmes, E.2    Lenz, E.3    Wilson, I.D.4    Nicholson, J.K.5
  • 52
    • 33845289736 scopus 로고    scopus 로고
    • Aminoglycoside-associated Fanconi syndrome. Am. J
    • Ghiculescu, R.A., Kubler, P.A., Aminoglycoside-associated Fanconi syndrome. Am. J. Kidney Dis. 48 (2006), e89–93.
    • (2006) Kidney Dis. , vol.48 , pp. e89-93
    • Ghiculescu, R.A.1    Kubler, P.A.2
  • 54
    • 34548146614 scopus 로고    scopus 로고
    • Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine
    • Gika, H.G., Theodoridis, G.A., Wingate, J.E., Wilson, I.D., Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine. J. Proteome Res. 6 (2007), 3291–3303.
    • (2007) J. Proteome Res. , vol.6 , pp. 3291-3303
    • Gika, H.G.1    Theodoridis, G.A.2    Wingate, J.E.3    Wilson, I.D.4
  • 56
    • 0142138236 scopus 로고    scopus 로고
    • Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis
    • Griffin, J.L., Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis. Curr. Opin. Chem. Biol. 7 (2003), 648–654.
    • (2003) Curr. Opin. Chem. Biol. , vol.7 , pp. 648-654
    • Griffin, J.L.1
  • 57
    • 0037454669 scopus 로고    scopus 로고
    • Cellular environment of metabolites and a metabonomic study of tamoxifen in endometrial cells using gradient high resolution magic angle spinning 1H NMR spectroscopy
    • Griffin, J.L., Pole, J.C., Nicholson, J.K., Carmichael, P.L., Cellular environment of metabolites and a metabonomic study of tamoxifen in endometrial cells using gradient high resolution magic angle spinning 1H NMR spectroscopy. Biochim. Biophys. Acta 1619 (2003), 151–158.
    • (2003) Biochim. Biophys. Acta , vol.1619 , pp. 151-158
    • Griffin, J.L.1    Pole, J.C.2    Nicholson, J.K.3    Carmichael, P.L.4
  • 60
    • 0031201762 scopus 로고    scopus 로고
    • Long-term effects of water-soluble corn bran hemicellulose on glucose tolderance in obese and non-obese patients, improved insulin sensitivity and glucose metabolism in obese subjects
    • Hanai, H., Ikuma, M., Sato, Y., Iida, T., Hosoda, Y., Matsushita, I., Nogaki, A., Yamada, M., Kaneko, E., Long-term effects of water-soluble corn bran hemicellulose on glucose tolderance in obese and non-obese patients, improved insulin sensitivity and glucose metabolism in obese subjects. Biosci. Biotechnol. Biochem. 61 (1997), 1358–1361.
    • (1997) Biosci. Biotechnol. Biochem. , vol.61 , pp. 1358-1361
    • Hanai, H.1    Ikuma, M.2    Sato, Y.3    Iida, T.4    Hosoda, Y.5    Matsushita, I.6    Nogaki, A.7    Yamada, M.8    Kaneko, E.9
  • 61
    • 34748891078 scopus 로고    scopus 로고
    • A roadmap for the establishment of standard data exchange structures for metabolomics
    • Hardy, N.W., Taylor, C.F., A roadmap for the establishment of standard data exchange structures for metabolomics. Metabolomics 3 (2007), 243–248.
    • (2007) Metabolomics , vol.3 , pp. 243-248
    • Hardy, N.W.1    Taylor, C.F.2
  • 62
    • 33644944111 scopus 로고    scopus 로고
    • High-throughput screening, metabolomics and drug discovery
    • Harrigan, G.G., Yates, L.A., High-throughput screening, metabolomics and drug discovery. IDrugs 9 (2006), 188–192.
    • (2006) IDrugs , vol.9 , pp. 188-192
    • Harrigan, G.G.1    Yates, L.A.2
  • 63
    • 0242288522 scopus 로고    scopus 로고
    • Dietary effects on drug metabolism and transport
    • Harris, R.Z., Jang, G.R., Tsunoda, S., Dietary effects on drug metabolism and transport. Clin. Pharmacokinet. 42 (2003), 1071–1088.
    • (2003) Clin. Pharmacokinet. , vol.42 , pp. 1071-1088
    • Harris, R.Z.1    Jang, G.R.2    Tsunoda, S.3
  • 64
    • 33646563442 scopus 로고    scopus 로고
    • Personalized medicine progresses
    • Haselden, J.N., Nicholls, A.W., Personalized medicine progresses. Nat. Med. 12 (2006), 510–511.
    • (2006) Nat. Med. , vol.12 , pp. 510-511
    • Haselden, J.N.1    Nicholls, A.W.2
  • 66
    • 0027052705 scopus 로고
    • Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine
    • Holmes, E., Bonner, F.W., Sweatman, B.C., Lindon, J.C., Beddell, C.R., Rahr, E., Nicholson, J.K., Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine. Mol. Pharmacol. 42 (1992), 922–930.
    • (1992) Mol. Pharmacol. , vol.42 , pp. 922-930
    • Holmes, E.1    Bonner, F.W.2    Sweatman, B.C.3    Lindon, J.C.4    Beddell, C.R.5    Rahr, E.6    Nicholson, J.K.7
  • 67
    • 33745673138 scopus 로고    scopus 로고
    • The application of NMR-based metabonomics in neurological disorders
    • Holmes, E., Tsang, T.M., Tabrizi, S.J., The application of NMR-based metabonomics in neurological disorders. NeuroRx 3 (2006), 358–372.
    • (2006) NeuroRx , vol.3 , pp. 358-372
    • Holmes, E.1    Tsang, T.M.2    Tabrizi, S.J.3
  • 68
    • 50249099816 scopus 로고    scopus 로고
    • Metabolomic phenotyping in health and disease
    • Holmes, E., Wilson, I.D., Nicholson, J.K., Metabolomic phenotyping in health and disease. Cell 134 (2008), 714–717.
    • (2008) Cell , vol.134 , pp. 714-717
    • Holmes, E.1    Wilson, I.D.2    Nicholson, J.K.3
  • 69
    • 0022189601 scopus 로고
    • Use of proton nuclear magnetic resonance spectroscopy in detection and study of organic acidurias
    • Iles, R.A., Hind, A.J., Chalmers, R.A., Use of proton nuclear magnetic resonance spectroscopy in detection and study of organic acidurias. Clin. Chem. 31 (1985), 1795–1801.
    • (1985) Clin. Chem. , vol.31 , pp. 1795-1801
    • Iles, R.A.1    Hind, A.J.2    Chalmers, R.A.3
  • 70
    • 33747877512 scopus 로고    scopus 로고
    • A metabonomics study of the hepatotoxicants galactosamine, methylene dianiline and clofibrate in rats
    • Ishihara, K., Katsutani, N., Aoki, T., A metabonomics study of the hepatotoxicants galactosamine, methylene dianiline and clofibrate in rats. Basic Clin. Pharmacol. Toxicol. 99 (2006), 251–260.
    • (2006) Basic Clin. Pharmacol. Toxicol. , vol.99 , pp. 251-260
    • Ishihara, K.1    Katsutani, N.2    Aoki, T.3
  • 71
    • 0034950046 scopus 로고    scopus 로고
    • Drug-induced liver disorders: implications for drug development and regulation
    • Kaplowitz, N., Drug-induced liver disorders: implications for drug development and regulation. Drug Safety 24 (2001), 483–490.
    • (2001) Drug Safety , vol.24 , pp. 483-490
    • Kaplowitz, N.1
  • 72
    • 20844444779 scopus 로고    scopus 로고
    • Idiosyncratic drug hepatotoxicity
    • Kaplowitz, N., Idiosyncratic drug hepatotoxicity. Nat. Rev. Drug Discov. 4 (2005), 489–499.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 489-499
    • Kaplowitz, N.1
  • 73
    • 34247175019 scopus 로고    scopus 로고
    • Nutrigenomics: concepts and applications to pharmacogenomics and clinical medicine
    • Kaput, J., Perlina, A., Hatipoglu, B., Bartholomew, A., Nikolsky, Y., Nutrigenomics: concepts and applications to pharmacogenomics and clinical medicine. Pharmacogenomics 8 (2007), 369–390.
    • (2007) Pharmacogenomics , vol.8 , pp. 369-390
    • Kaput, J.1    Perlina, A.2    Hatipoglu, B.3    Bartholomew, A.4    Nikolsky, Y.5
  • 76
    • 28444480986 scopus 로고    scopus 로고
    • Metabonomic modeling of drug toxicity
    • Keun, H., Metabonomic modeling of drug toxicity. Pharmacol. Ther. 109 (2006), 92–106.
    • (2006) Pharmacol. Ther. , vol.109 , pp. 92-106
    • Keun, H.1
  • 78
    • 45249086603 scopus 로고    scopus 로고
    • Chemometrics
    • Lavine, B., Workman, J., Chemometrics. Anal. Chem. 80 (2008), 4519–4531.
    • (2008) Anal. Chem. , vol.80 , pp. 4519-4531
    • Lavine, B.1    Workman, J.2
  • 79
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies
    • Lazarou, J., Pomeranz, B.H., Corey, P.N., Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 279 (1998), 1200–1205.
    • (1998) JAMA , vol.279 , pp. 1200-1205
    • Lazarou, J.1    Pomeranz, B.H.2    Corey, P.N.3
  • 80
    • 3042738919 scopus 로고    scopus 로고
    • Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure.
    • Lee, W.M., Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. Hepatology 40 (2004), 6–9.
    • (2004) Hepatology , vol.40 , pp. 6-9
    • Lee, W.M.1
  • 81
    • 0022470534 scopus 로고
    • Possibilities of selective screening for inborn errors of metabolism using high-resolution 1H-FT-NMR spectrometry
    • Lehnert, W., Hunkler, D., Possibilities of selective screening for inborn errors of metabolism using high-resolution 1H-FT-NMR spectrometry. Eur. J. Pediatr. 145 (1986), 260–266.
    • (1986) Eur. J. Pediatr. , vol.145 , pp. 260-266
    • Lehnert, W.1    Hunkler, D.2
  • 82
    • 0034530684 scopus 로고    scopus 로고
    • A 1H NMR spectroscopic study of the biochemical effects of ifosfamide in the rat: evaluation of potential biomarkers
    • Lenz, E.M., Nicholson, J.K., Wilson, I.D., Timbrell, J.A., A 1H NMR spectroscopic study of the biochemical effects of ifosfamide in the rat: evaluation of potential biomarkers. Biomarkers 5 (2000), 424–435.
    • (2000) Biomarkers , vol.5 , pp. 424-435
    • Lenz, E.M.1    Nicholson, J.K.2    Wilson, I.D.3    Timbrell, J.A.4
  • 83
    • 2342483689 scopus 로고    scopus 로고
    • Cyclosporin A-induced changes in endogenous metabolites in rat urine: a metabonomic investigation using high field 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics
    • Lenz, E.M., Bright, J., Knight, R., Wilson, I.D., Major, H., Cyclosporin A-induced changes in endogenous metabolites in rat urine: a metabonomic investigation using high field 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics. J. Pharm. Biomed. Anal. 35 (2004), 599–608.
    • (2004) J. Pharm. Biomed. Anal. , vol.35 , pp. 599-608
    • Lenz, E.M.1    Bright, J.2    Knight, R.3    Wilson, I.D.4    Major, H.5
  • 84
    • 3042517107 scopus 로고    scopus 로고
    • A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity
    • Lenz, E.M., Bright, J., Knight, R., Wilson, I.D., Major, H., A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity. Analyst 129 (2004), 535–541.
    • (2004) Analyst , vol.129 , pp. 535-541
    • Lenz, E.M.1    Bright, J.2    Knight, R.3    Wilson, I.D.4    Major, H.5
  • 85
    • 21444445989 scopus 로고    scopus 로고
    • Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat
    • Lenz, E.M., Bright, J., Knight, R., Westwood, F.R., Davies, D., Major, H., Wilson, I.D., Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat. Biomarkers 10 (2005), 173–187.
    • (2005) Biomarkers , vol.10 , pp. 173-187
    • Lenz, E.M.1    Bright, J.2    Knight, R.3    Westwood, F.R.4    Davies, D.5    Major, H.6    Wilson, I.D.7
  • 86
    • 33847358695 scopus 로고    scopus 로고
    • Analytical strategies in metabonomics
    • Lenz, E.M., Wilson, I.D., Analytical strategies in metabonomics. J. Proteome Res. 6 (2007), 443–458.
    • (2007) J. Proteome Res. , vol.6 , pp. 443-458
    • Lenz, E.M.1    Wilson, I.D.2
  • 87
    • 0021339475 scopus 로고
    • Hepatic toxicity of nonsteroidal anti-inflammatory drugs
    • Lewis, J.H., Hepatic toxicity of nonsteroidal anti-inflammatory drugs. Clin. Pharm. 3 (1984), 128–138.
    • (1984) Clin. Pharm. , vol.3 , pp. 128-138
    • Lewis, J.H.1
  • 90
    • 2442719174 scopus 로고    scopus 로고
    • Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
    • Lindon, J.C., Holmes, E., Bollard, M.E., Stanley, E.G., Nicholson, J.K., Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers 9 (2004), 1–31.
    • (2004) Biomarkers , vol.9 , pp. 1-31
    • Lindon, J.C.1    Holmes, E.2    Bollard, M.E.3    Stanley, E.G.4    Nicholson, J.K.5
  • 93
    • 33645449734 scopus 로고    scopus 로고
    • Urinary metabolites and antioxidant products of exogenous melatonin in the mouse
    • Ma, X., Idle, J.R., Krausz, K.W., Tan, D.X., Ceraulo, L, Gonzalez, F.J., Urinary metabolites and antioxidant products of exogenous melatonin in the mouse. J. Pineal Res. 40 (2006), 343–349.
    • (2006) J. Pineal Res. , vol.40 , pp. 343-349
    • Ma, X.1    Idle, J.R.2    Krausz, K.W.3    Tan, D.X.4    Ceraulo, L.5    Gonzalez, F.J.6
  • 94
    • 0025824971 scopus 로고
    • Aminoaciduria is an earlier index of renal tubular damage than conventional renal disease markers in the gentamicin-rat model of acute renal failure
    • Macpherson, N.A., Moscarello, M.A., Goldberg, D.M., Aminoaciduria is an earlier index of renal tubular damage than conventional renal disease markers in the gentamicin-rat model of acute renal failure. Clin. Invest. Med. 14 (1991), 101–110.
    • (1991) Clin. Invest. Med. , vol.14 , pp. 101-110
    • Macpherson, N.A.1    Moscarello, M.A.2    Goldberg, D.M.3
  • 95
    • 0037225665 scopus 로고    scopus 로고
    • Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism
    • Moolenaar, S.H., Engelke, U.F., Wevers, R.A., Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism. Ann. Clin. Biochem. 40 (2003), 16–24.
    • (2003) Ann. Clin. Biochem. , vol.40 , pp. 16-24
    • Moolenaar, S.H.1    Engelke, U.F.2    Wevers, R.A.3
  • 96
    • 34548602369 scopus 로고    scopus 로고
    • Serious adverse drug events reported to the Food and Drug Administration, 1998–2005
    • Moore, T.J., Cohen, M.R., Furberg, C.D., Serious adverse drug events reported to the Food and Drug Administration, 1998–2005. Arch. Intern. Med. 167 (2007), 1752–1759.
    • (2007) Arch. Intern. Med. , vol.167 , pp. 1752-1759
    • Moore, T.J.1    Cohen, M.R.2    Furberg, C.D.3
  • 99
    • 0022338946 scopus 로고
    • In vivo and in vitro inhibition of hepatic microsomal drug metabolism by ketoconazole
    • Mosca, P., Bonazzi, P., Novelli, G., Jezequel, A.M., Orlandi, F., In vivo and in vitro inhibition of hepatic microsomal drug metabolism by ketoconazole. Br. J. Exp. Pathol. 66 (1985), 737–742.
    • (1985) Br. J. Exp. Pathol. , vol.66 , pp. 737-742
    • Mosca, P.1    Bonazzi, P.2    Novelli, G.3    Jezequel, A.M.4    Orlandi, F.5
  • 100
    • 33644851228 scopus 로고    scopus 로고
    • Altered CYP expression and function in response to dietary factors: potential roles in disease pathogenesis
    • Murray, M., Altered CYP expression and function in response to dietary factors: potential roles in disease pathogenesis. Curr. Drug Metab. 7 (2006), 67–81.
    • (2006) Curr. Drug Metab. , vol.7 , pp. 67-81
    • Murray, M.1
  • 101
    • 33845543658 scopus 로고    scopus 로고
    • Cytochrome P450: decision-making tools for personalized therapeutics
    • Murray, M., Petrovic, N., Cytochrome P450: decision-making tools for personalized therapeutics. Curr. Opin. Mol. Ther. 8 (2006), 480–486.
    • (2006) Curr. Opin. Mol. Ther. , vol.8 , pp. 480-486
    • Murray, M.1    Petrovic, N.2
  • 102
  • 103
    • 34748833701 scopus 로고    scopus 로고
    • Interactions of food and dietary supplements with drug metabolising cytochrome P450 enzymes
    • Nekvindova, J., Anzenbacher, P., Interactions of food and dietary supplements with drug metabolising cytochrome P450 enzymes. Ceska Slov. Farm. 56 (2007), 165–173.
    • (2007) Ceska Slov. Farm. , vol.56 , pp. 165-173
    • Nekvindova, J.1    Anzenbacher, P.2
  • 104
    • 0032694577 scopus 로고    scopus 로고
    • ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson, J.K., Lindon, J.C., Holmes, E., ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29 (1999), 1181–1189.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 105
  • 106
    • 17844404232 scopus 로고    scopus 로고
    • Gut microbes, mammalian metabolism and personalized healthcare
    • Nicholson, J.K., Holmes, E., Wilson, I.D., Gut microbes, mammalian metabolism and personalized healthcare. Nat. Rev. Microbiol. 3 (2005), 2–8.
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 2-8
    • Nicholson, J.K.1    Holmes, E.2    Wilson, I.D.3
  • 107
    • 36349020905 scopus 로고    scopus 로고
    • COMET and the challenge of drug safety screening
    • Nicholson, J., Keun, H., Ebbels, T., COMET and the challenge of drug safety screening. J. Proteome Res. 6 (2007), 4098–4099.
    • (2007) J. Proteome Res. , vol.6 , pp. 4098-4099
    • Nicholson, J.1    Keun, H.2    Ebbels, T.3
  • 108
    • 85047685525 scopus 로고    scopus 로고
    • Biochemical mechanisms of nephrotoxicity: application for metabolomics
    • Niemann, C.U., Serkova, N.J., Biochemical mechanisms of nephrotoxicity: application for metabolomics. Exp. Opin. Drug Metab. Toxicol. 3 (2007), 527–544.
    • (2007) Exp. Opin. Drug Metab. Toxicol. , vol.3 , pp. 527-544
    • Niemann, C.U.1    Serkova, N.J.2
  • 109
    • 30844432659 scopus 로고    scopus 로고
    • Increased serum bile acids as a possible biomarker of hepatotoxicity in Brazilian workers exposed to solvents in car repainting shops
    • Nunes De Paiva, M.J., Pereira Bastos De Siqueira, M.E., Increased serum bile acids as a possible biomarker of hepatotoxicity in Brazilian workers exposed to solvents in car repainting shops. Biomarkers 10 (2005), 456–463.
    • (2005) Biomarkers , vol.10 , pp. 456-463
    • Nunes De Paiva, M.J.1    Pereira Bastos De Siqueira, M.E.2
  • 110
    • 0000799968 scopus 로고
    • Antioxidative activity of corn bran hemicellulose fragments
    • Ohta, T., Yamasaki, S., Egashira, Y., Sanada, H., Antioxidative activity of corn bran hemicellulose fragments. J. Agric. Food Chem. 42 (1994), 653–656.
    • (1994) J. Agric. Food Chem. , vol.42 , pp. 653-656
    • Ohta, T.1    Yamasaki, S.2    Egashira, Y.3    Sanada, H.4
  • 111
    • 33846064843 scopus 로고    scopus 로고
    • Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism
    • Pan, Z., Gu, H., Talaty, N., Chen, H., Shanaiah, N., Hainline, B.E., Cooks, R.G., Raftery, D., Principal component analysis of urine metabolites detected by NMR and DESI-MS in patients with inborn errors of metabolism. Anal. Bioanal. Chem. 387 (2006), 539–549.
    • (2006) Anal. Bioanal. Chem. , vol.387 , pp. 539-549
    • Pan, Z.1    Gu, H.2    Talaty, N.3    Chen, H.4    Shanaiah, N.5    Hainline, B.E.6    Cooks, R.G.7    Raftery, D.8
  • 113
    • 21144435518 scopus 로고    scopus 로고
    • A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice
    • Plumb, R.S., Granger, J.H., Stumpf, C.L., Johnson, K.A., Smith, B.W., Gaulitz, S., Wilson, I.D., Castro-Perez, J., A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice. Analyst 130 (2005), 844–849.
    • (2005) Analyst , vol.130 , pp. 844-849
    • Plumb, R.S.1    Granger, J.H.2    Stumpf, C.L.3    Johnson, K.A.4    Smith, B.W.5    Gaulitz, S.6    Wilson, I.D.7    Castro-Perez, J.8
  • 115
    • 40449140169 scopus 로고    scopus 로고
    • A rapid simple approach to screening pharmaceutical products using ultra-performance LC couple to time-of-flight mass spectrometry and pattern recognition
    • Plumb, R.S., Jones, M.D., Rainville, P.D., Nicholson, J.K., A rapid simple approach to screening pharmaceutical products using ultra-performance LC couple to time-of-flight mass spectrometry and pattern recognition. J. Chromatogr. Sci. 46 (2008), 193–198.
    • (2008) J. Chromatogr. Sci. , vol.46 , pp. 193-198
    • Plumb, R.S.1    Jones, M.D.2    Rainville, P.D.3    Nicholson, J.K.4
  • 116
    • 66749102638 scopus 로고    scopus 로고
    • Application of ultra performance liquid chromatography-mass spectrometry to profiling rat and dog bile
    • Plumb, R.S., Rainville, P.D., Potts, W.B., Johnson, K.A., Gika, E., Wilson, I.D., Application of ultra performance liquid chromatography-mass spectrometry to profiling rat and dog bile. J. Proteome Res. 8 (2009), 2495–2500.
    • (2009) J. Proteome Res. , vol.8 , pp. 2495-2500
    • Plumb, R.S.1    Rainville, P.D.2    Potts, W.B.3    Johnson, K.A.4    Gika, E.5    Wilson, I.D.6
  • 119
    • 33749173659 scopus 로고    scopus 로고
    • DFTMP, an NMR Reagent for assessing the near-neutral pH of biological samples
    • Reily, M.D., Robosky, L.C., Manning, M.L., Butler, A., Baker, J.D., Winters, R.T., DFTMP, an NMR Reagent for assessing the near-neutral pH of biological samples. JACS 126 (2006), 12360–12361.
    • (2006) JACS , vol.126 , pp. 12360-12361
    • Reily, M.D.1    Robosky, L.C.2    Manning, M.L.3    Butler, A.4    Baker, J.D.5    Winters, R.T.6
  • 120
    • 0036384102 scopus 로고    scopus 로고
    • NMR-based metabolomics
    • Reo, N.V., NMR-based metabolomics. Drug Chem. Toxicol. 25 (2002), 375–382.
    • (2002) Drug Chem. Toxicol. , vol.25 , pp. 375-382
    • Reo, N.V.1
  • 121
    • 0033795182 scopus 로고    scopus 로고
    • Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants
    • Robertson, D.G., Reily, M.D., Sigler, R.E., Wells, D.F., Paterson, D.A., Braden, T.K., Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. Toxicol. Sci. 57 (2000), 326–337.
    • (2000) Toxicol. Sci. , vol.57 , pp. 326-337
    • Robertson, D.G.1    Reily, M.D.2    Sigler, R.E.3    Wells, D.F.4    Paterson, D.A.5    Braden, T.K.6
  • 123
    • 20544466649 scopus 로고    scopus 로고
    • Metabonomics in toxicology: a review
    • Robertson, D.G., Metabonomics in toxicology: a review. Toxicol. Sci. 85 (2005), 809–822.
    • (2005) Toxicol. Sci. , vol.85 , pp. 809-822
    • Robertson, D.G.1
  • 126
    • 33645920855 scopus 로고    scopus 로고
    • NMR-based metabonomic evaluation of livers from rats chronically treated with tamoxifen, mestranol, and phenobarbital
    • Schnackenberg, L., Beger, R.D., Dragan, Y., NMR-based metabonomic evaluation of livers from rats chronically treated with tamoxifen, mestranol, and phenobarbital. Metabonomics 1 (2005), 87–94.
    • (2005) Metabonomics , vol.1 , pp. 87-94
    • Schnackenberg, L.1    Beger, R.D.2    Dragan, Y.3
  • 128
    • 34249027854 scopus 로고    scopus 로고
    • Evaluation of NMR spectral data of urine in conjunction with measured clinical chemistry and histopathology parameters to assess the effects of liver and kidney toxicants
    • Schnackenberg, L.K., Dragan, Y.P., Reily, M.D., Robertson, D.G., Beger, R.D., Evaluation of NMR spectral data of urine in conjunction with measured clinical chemistry and histopathology parameters to assess the effects of liver and kidney toxicants. Metabolomics 2 (2007), 87–100.
    • (2007) Metabolomics , vol.2 , pp. 87-100
    • Schnackenberg, L.K.1    Dragan, Y.P.2    Reily, M.D.3    Robertson, D.G.4    Beger, R.D.5
  • 129
    • 38549095644 scopus 로고    scopus 로고
    • Metabonomics evaluations of age-related changes in the urinary compositions of male Sprague–Dawley rats and effects of data normalization methods on statistical and quantitative analysis
    • Schnackenberg, L.K., Sun, J., Espandiari, P., Holland, R.D., Hanig, J., Beger, R.D., Metabonomics evaluations of age-related changes in the urinary compositions of male Sprague–Dawley rats and effects of data normalization methods on statistical and quantitative analysis. BMC Bioinformatics(Suppl. 7), 2007, S3.
    • (2007) BMC Bioinformatics , pp. S3
    • Schnackenberg, L.K.1    Sun, J.2    Espandiari, P.3    Holland, R.D.4    Hanig, J.5    Beger, R.D.6
  • 132
    • 28044449855 scopus 로고    scopus 로고
    • Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood
    • Serkova, N.J., Christians, U., Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood. Ther. Drug Monit. 27 (2005), 733–737.
    • (2005) Ther. Drug Monit. , vol.27 , pp. 733-737
    • Serkova, N.J.1    Christians, U.2
  • 133
    • 0025965404 scopus 로고
    • Alanine aminotransferase in clinical practice. A review
    • Sherman, K.E., Alanine aminotransferase in clinical practice. A review. Arch. Intern. Med. 151 (1991), 260–265.
    • (1991) Arch. Intern. Med. , vol.151 , pp. 260-265
    • Sherman, K.E.1
  • 134
    • 34548547257 scopus 로고    scopus 로고
    • NMR-spectroscopy-based metabonomic approach to the analysis of Bay41-4109, a novel anti-HBV compound, induced hepatotoxicity in rats
    • Shi, C., Wu, C.Q., Cao, A.M., Sheng, H.Z., Yan, X.Z., Liao, M.Y., NMR-spectroscopy-based metabonomic approach to the analysis of Bay41-4109, a novel anti-HBV compound, induced hepatotoxicity in rats. Toxicol. Lett. 173 (2007), 161–167.
    • (2007) Toxicol. Lett. , vol.173 , pp. 161-167
    • Shi, C.1    Wu, C.Q.2    Cao, A.M.3    Sheng, H.Z.4    Yan, X.Z.5    Liao, M.Y.6
  • 135
    • 0036406930 scopus 로고    scopus 로고
    • Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats
    • Slim, R.M., Robertson, D.G., Albassam, M., Reily, M.D., Robosky, L., Dethloff, L.A., Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats. Toxicol. Appl. Pharmacol. 183 (2002), 108–116.
    • (2002) Toxicol. Appl. Pharmacol. , vol.183 , pp. 108-116
    • Slim, R.M.1    Robertson, D.G.2    Albassam, M.3    Reily, M.D.4    Robosky, L.5    Dethloff, L.A.6
  • 138
    • 48749108374 scopus 로고    scopus 로고
    • Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS
    • Sun, J., Schnackenberg, L.K., Holland, R.D., Schmitt, T.C., Cantor, G.H., Dragan, Y.P., Beger, R.D., Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. J. Chromatogr. B 871 (2008), 328–340.
    • (2008) J. Chromatogr. B , vol.871 , pp. 328-340
    • Sun, J.1    Schnackenberg, L.K.2    Holland, R.D.3    Schmitt, T.C.4    Cantor, G.H.5    Dragan, Y.P.6    Beger, R.D.7
  • 139
    • 85099659417 scopus 로고    scopus 로고
    • in press. Pharmacokinetic studies of acetaminophen and metabolites and their correlations with toxicity using metabonomics. Drug Metab. Lett.
    • Sun J., Schnackenberg, L. K., Beger, R. D. in press. Pharmacokinetic studies of acetaminophen and metabolites and their correlations with toxicity using metabonomics. Drug Metab. Lett.
    • Sun, J.1    Schnackenberg, L.K.2    Beger, R.D.3
  • 140
    • 85099667526 scopus 로고    scopus 로고
    • submitted for publication. A study of valproic acid-induced endogenous and exogenous metabolite alterations using LC/MS-based metabolomics. Bioanalysis.
    • Sun, J., Schnackenberg, L. K., Hansen, D. K., and Beger, R. D. submitted for publication. A study of valproic acid-induced endogenous and exogenous metabolite alterations using LC/MS-based metabolomics. Bioanalysis.
    • Sun, J.1    Schnackenberg, L.K.2    Hansen, D.K.3    Beger, R.D.4
  • 141
    • 1542380037 scopus 로고    scopus 로고
    • Toxicogenomics in predictive toxicology in drug development
    • Suter, L., Babiss, L.E., Wheeldon, E.B., Toxicogenomics in predictive toxicology in drug development. Chem. Biol. 11 (2004), 161–172.
    • (2004) Chem. Biol. , vol.11 , pp. 161-172
    • Suter, L.1    Babiss, L.E.2    Wheeldon, E.B.3
  • 142
    • 34347384910 scopus 로고    scopus 로고
    • Normalization method for metabolomics data using optimal selection of multiple internal standards
    • Sysi-Aho, M., Katajamaa, M., Yetukuri, L., Oresic, M., Normalization method for metabolomics data using optimal selection of multiple internal standards. BMC Bioinformatics, 8, 2007, 93.
    • (2007) BMC Bioinformatics , vol.8 , pp. 93
    • Sysi-Aho, M.1    Katajamaa, M.2    Yetukuri, L.3    Oresic, M.4
  • 143
    • 0026632689 scopus 로고
    • Comparison of screening approaches
    • Tilson, H.A., Moser, V.C., Comparison of screening approaches. Neurotoxicology 13 (1992), 1–13.
    • (1992) Neurotoxicology , vol.13 , pp. 1-13
    • Tilson, H.A.1    Moser, V.C.2
  • 144
  • 147
    • 33144456906 scopus 로고    scopus 로고
    • Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis
    • Wagner, S., Scholz, K., Donegan, M., Burton, L., Wingate, J., Völkel, W., Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis. Anal. Chem. 78 (2006), 1296–1305.
    • (2006) Anal. Chem. , vol.78 , pp. 1296-1305
    • Wagner, S.1    Scholz, K.2    Donegan, M.3    Burton, L.4    Wingate, J.5    Völkel, W.6
  • 148
    • 34247115128 scopus 로고    scopus 로고
    • Tools in metabonomics: an integrated validation approach for LC-MS metabolic profiling of mercapturic acids in human urine
    • Wagner, S., Scholz, K., Sieber, M., Kellert, M., Voelkel, W., Tools in metabonomics: an integrated validation approach for LC-MS metabolic profiling of mercapturic acids in human urine. Anal. Chem. 79 (2007), 2918–2926.
    • (2007) Anal. Chem. , vol.79 , pp. 2918-2926
    • Wagner, S.1    Scholz, K.2    Sieber, M.3    Kellert, M.4    Voelkel, W.5
  • 149
    • 18844373318 scopus 로고    scopus 로고
    • Role of metabolism in drug-induced idiosyncratic hepatotoxicity
    • Walgren, J.L., Mitchell, M.D., Thompson, D.C., Role of metabolism in drug-induced idiosyncratic hepatotoxicity. Crit. Rev. Toxicol. 35 (2005), 325–361.
    • (2005) Crit. Rev. Toxicol. , vol.35 , pp. 325-361
    • Walgren, J.L.1    Mitchell, M.D.2    Thompson, D.C.3
  • 150
    • 0029978949 scopus 로고    scopus 로고
    • Influence of diet and nutritional status on drug metabolism
    • Walter-Sack, I., Klotz, U., Influence of diet and nutritional status on drug metabolism. Clin. Pharmacokinet. 31 (1996), 47–64.
    • (1996) Clin. Pharmacokinet. , vol.31 , pp. 47-64
    • Walter-Sack, I.1    Klotz, U.2
  • 151
    • 0026031011 scopus 로고
    • The toxicological significance of decreased activities of blood alanine and aspartate aminotransferase
    • Waner, T., Nyska, A., The toxicological significance of decreased activities of blood alanine and aspartate aminotransferase. Vet. Res. Commun. 15 (1991), 73–78.
    • (1991) Vet. Res. Commun. , vol.15 , pp. 73-78
    • Waner, T.1    Nyska, A.2
  • 153
    • 0034775361 scopus 로고    scopus 로고
    • NMR and pattern recognition studies on the time-related metabolic effects of -naphthylisothiocyante on liver, urine, and plasma in the rat: an integrative metabonomic approach
    • Waters, N.J., Holmes, E., Williams, A., Waterfield, C.J., Farrant, R.D., Nicholson, J.K., NMR and pattern recognition studies on the time-related metabolic effects of -naphthylisothiocyante on liver, urine, and plasma in the rat: an integrative metabonomic approach. Chem. Res. Toxicol. 14 (2001), 1401–1412.
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 1401-1412
    • Waters, N.J.1    Holmes, E.2    Williams, A.3    Waterfield, C.J.4    Farrant, R.D.5    Nicholson, J.K.6
  • 154
    • 33745005962 scopus 로고    scopus 로고
    • Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis
    • Waters, N.J., Waterfield, C.J., Farrant, R.D., Holmes, E., Nicholson, J.K., Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis. J. Proteome Res. 5 (2006), 1448–1459.
    • (2006) J. Proteome Res. , vol.5 , pp. 1448-1459
    • Waters, N.J.1    Waterfield, C.J.2    Farrant, R.D.3    Holmes, E.4    Nicholson, J.K.5
  • 155
    • 0142169963 scopus 로고    scopus 로고
    • 1H NMR pattern recognition and 31P NMR studies with D-serine in rat urine and kidney, time- and dose-related metabolic effects
    • Williams, R.E., Jacobsen, M., Lock, E.A., 1H NMR pattern recognition and 31P NMR studies with D-serine in rat urine and kidney, time- and dose-related metabolic effects. Chem. Res. Toxicol. 16 (2003), 1207–1216.
    • (2003) Chem. Res. Toxicol. , vol.16 , pp. 1207-1216
    • Williams, R.E.1    Jacobsen, M.2    Lock, E.A.3
  • 156
    • 19544374744 scopus 로고    scopus 로고
    • A combined 1H NMR and HPLC-MC-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats
    • Williams, R.E., Lenz, E.M., Evans, J.A., Wilson, I.D., Granger, J.H., Plumb, R.S., Stumpf, C.L., A combined 1H NMR and HPLC-MC-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats. J. Pharm. Biomed. Anal. 38 (2005), 465–471.
    • (2005) J. Pharm. Biomed. Anal. , vol.38 , pp. 465-471
    • Williams, R.E.1    Lenz, E.M.2    Evans, J.A.3    Wilson, I.D.4    Granger, J.H.5    Plumb, R.S.6    Stumpf, C.L.7
  • 157
    • 32344432945 scopus 로고    scopus 로고
    • The metabonomics of aging and development in the rat: an investigation into the effect of age on the profile of endogenous metabolites in the urine of male rats using 1H NMR and HPLC-TOF MS
    • Williams, R.E., Lenz, E.M., Lowden, J.S., Rantalainen, M., Wilson, I.D., The metabonomics of aging and development in the rat: an investigation into the effect of age on the profile of endogenous metabolites in the urine of male rats using 1H NMR and HPLC-TOF MS. Mol. Biosyst. 1 (2005), 166–175.
    • (2005) Mol. Biosyst. , vol.1 , pp. 166-175
    • Williams, R.E.1    Lenz, E.M.2    Lowden, J.S.3    Rantalainen, M.4    Wilson, I.D.5
  • 158
    • 33644849267 scopus 로고    scopus 로고
    • The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats
    • Williams, R.E., Lenz, E.M., Rantalainen, M., Wilson, I.D., The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats. Mol. Biosyst. 2 (2006), 193–202.
    • (2006) Mol. Biosyst. , vol.2 , pp. 193-202
    • Williams, R.E.1    Lenz, E.M.2    Rantalainen, M.3    Wilson, I.D.4
  • 159
    • 17444404226 scopus 로고    scopus 로고
    • High resolution “ultra performance” liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies
    • Wilson, I.D., Nicholson, J.K., Castro-Perez, J., Granger, J.H., Johnson, K.A., Smith, B.W., Plumb, R.S., High resolution “ultra performance” liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J. Proteome Res. 4 (2005), 591–598.
    • (2005) J. Proteome Res. , vol.4 , pp. 591-598
    • Wilson, I.D.1    Nicholson, J.K.2    Castro-Perez, J.3    Granger, J.H.4    Johnson, K.A.5    Smith, B.W.6    Plumb, R.S.7
  • 161
    • 38749150308 scopus 로고    scopus 로고
    • Gas chromatography-mass spectrometry based on metabonomics study of carbon tetrachloride-induced acute liver injury in mice
    • Xin, H., Yi-Fei, G., Ke Y., Yi-Yu, C., Gas chromatography-mass spectrometry based on metabonomics study of carbon tetrachloride-induced acute liver injury in mice. Chinese, J. Anal. Chem. 35 (2007), 1736–1740.
    • (2007) Chinese, J. Anal. Chem. , vol.35 , pp. 1736-1740
    • Xin, H.1    Yi-Fei, G.2    Ke, Y.3    Yi-Yu, C.4
  • 162
    • 48149101956 scopus 로고    scopus 로고
    • Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells
    • Xu, F., Papanayotou, I., Putt, D.A., Wang, J., Lash, L.H., Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells. Biochem. Pharmacol. 76 (2008), 552–567.
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 552-567
    • Xu, F.1    Papanayotou, I.2    Putt, D.A.3    Wang, J.4    Lash, L.H.5
  • 163
    • 0021235966 scopus 로고
    • “In vivo” inhibition of murine liver aspartate aminotransferase by isoniazid
    • Yamada, R., Wakabayashi, Y., Iwashima, A., “In vivo” inhibition of murine liver aspartate aminotransferase by isoniazid. Acta Vitaminol. Enzymol. 6 (1984), 29–39.
    • (1984) Acta Vitaminol. Enzymol. , vol.6 , pp. 29-39
    • Yamada, R.1    Wakabayashi, Y.2    Iwashima, A.3
  • 164
    • 0021707993 scopus 로고
    • Inhibition of serum aspartate aminotransferase induced by isoniazid administration in mice
    • Yamada, R.H., Wakabayashi, Y., Iwashima, A., Inhibition of serum aspartate aminotransferase induced by isoniazid administration in mice. Acta Vitaminol. Enzymol. 6 (1984), 289–293.
    • (1984) Acta Vitaminol. Enzymol. , vol.6 , pp. 289-293
    • Yamada, R.H.1    Wakabayashi, Y.2    Iwashima, A.3
  • 165
    • 22044449913 scopus 로고    scopus 로고
    • Strategy for metabonomics research based on high-performance liquid chromatography and liquid chromatography coupled with tandem mass spectrometry
    • Yang, J., Xu, G., Zheng, Y., Kong, H., Wang, C., Zhao, X., Pang, T., Strategy for metabonomics research based on high-performance liquid chromatography and liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr. A 1084 (2005), 214–221.
    • (2005) J. Chromatogr. A , vol.1084 , pp. 214-221
    • Yang, J.1    Xu, G.2    Zheng, Y.3    Kong, H.4    Wang, C.5    Zhao, X.6    Pang, T.7
  • 166
    • 58149087636 scopus 로고    scopus 로고
    • Bile acids metabonomic study on the CCL4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry
    • Yang, L., Xiong, A., He, Y., Wang, Z., Wang, C., Wang, Z., Li, W., Yang, L., Hu, Z., Bile acids metabonomic study on the CCL4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry. Chem. Res. Toxicol. 21 (2008), 2280–2288.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 2280-2288
    • Yang, L.1    Xiong, A.2    He, Y.3    Wang, Z.4    Wang, C.5    Wang, Z.6    Li, W.7    Yang, L.8    Hu, Z.9
  • 168
    • 15244345388 scopus 로고    scopus 로고
    • Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a D-galactosamine-induced rat liver failure model
    • Yokoyama, T., Banta, S., Berthiaume, F., Nagrath, D., Tompkins, R.G., Yarmush, M.L., Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a D-galactosamine-induced rat liver failure model. Metab. Eng. 7 (2005), 88–103.
    • (2005) Metab. Eng. , vol.7 , pp. 88-103
    • Yokoyama, T.1    Banta, S.2    Berthiaume, F.3    Nagrath, D.4    Tompkins, R.G.5    Yarmush, M.L.6
  • 171
    • 36949014801 scopus 로고    scopus 로고
    • Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chrominum
    • Zhou, Y., Vaidya, V.S., Brown, R.P., Zhang, J., Rosenweig, B.A., Thompson, K.L., Miller, T.J., Bonventre, J.V., Goering, P.L., Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chrominum. Toxicol. Sci. 101 (2008), 159–170.
    • (2008) Toxicol. Sci. , vol.101 , pp. 159-170
    • Zhou, Y.1    Vaidya, V.S.2    Brown, R.P.3    Zhang, J.4    Rosenweig, B.A.5    Thompson, K.L.6    Miller, T.J.7    Bonventre, J.V.8    Goering, P.L.9


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