Use of Metabonomics to Identify Impaired Fatty Acid Metabolism as the Mechanism of a Drug-Induced Toxicity

Chemical Research in Toxicology

Volumn 17, Issue 2, 2004, Pages 165-173

  Mortishire Smith, Russell J ^a   Skiles, Gary L ^b,d   Lawrence, Jeffrey W ^b   Spence, Stan ^b   Nicholls, Andrew W ^c   Johnson, Bruce A ^b   Nicholson, Jeremy K ^c  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; DICARBOXYLIC ACID; FATTY ACID; N [3 [[4 (3 BENZYL 1 ETHYL 1H PYRAZOL 5 YL)PIPERIDIN 1 YL]METHYL] 4 (3 FLUOROPHENYL)CYCLOPENTYL] N METHYLVALINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACIDURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SAFETY; DRUG SYNTHESIS; DRUG TARGETING; EVALUATION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; LIVER LEVEL; LIVER TOXICITY; MALE; METABONOMICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STATISTICAL ANALYSIS; TECHNIQUE; TOXICITY TESTING; URINALYSIS; URINE LEVEL;

ANIMALS; FATTY ACIDS; FEMALE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; TOXICOLOGY;

ANIMALIA;

EID: 1342310587     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx034123j     Document Type: Article

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