NMR-based metabolomics

Drug and Chemical Toxicology

Volumn 25, Issue 4, 2002, Pages 375-382

  Reo, Nicholas V ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

Author keywords

Metabolomics; Metabonomics; NMR

Indexed keywords

BIOLOGICAL MARKER;

ANALYTIC METHOD; BODY FLUID; CELL FUNCTION; CELL METABOLISM; CONFERENCE PAPER; METABOLOMICS; PROTON NUCLEAR MAGNETIC RESONANCE; TOXICITY; TOXICOLOGY; URINALYSIS;

ANIMALS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLISM; PATTERN RECOGNITION, AUTOMATED; RISK ASSESSMENT; TOXICOLOGY; XENOBIOTICS;

EID: 0036384102     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.1081/DCT-120014789     Document Type: Conference Paper

References (9)

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2. Lindon, J.C.; Nicholson, J.K.; Everett, J.R. NMR Spectroscopy of Biofluids. In Annual Reports on NMR Spectroscopy; Webb, G.A., Ed.; Academic Press: New York, 1999; Vol. 38, 1-88.
3. Gartland, K.P.R.; Beddell, C.R.; Lindon, J.C.; Nicholson, J.K. Application of Pattern Recognition Methods to the Analysis and Classification of Toxicological Data Derived from Proton Nuclear Magnetic Resonance Spectroscopy of Urine. Mol. Pharmacol. 1991, 39, 629-642.
4. 1HNMR Spectra of Urine. A Nonlinear Mapping Approach to the Classification of Toxicological Data. NMR Biomed. 1990, 3, 166-172.
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6. Gavaghan, C.L.; Holmes, E.; Lenz, E.; Wilson, I.D.; Nicholson, J.K. An NMR-based Metabonomics Approach to Investigate the Biochemical Consequences of Genetic Strain Differences: Application to the C57BL10J and Alpk:ApfCD Mouse. FEBS Lett. 2000, 484, 169-174.
7. Griffin, J.L.; Walker, L.A.; Garrod, S.; Holmes, E.; Shore, R.F.; Nicholson, J.K. NMR Spectroscopy Based Metabonomic Studies on the Comparative Biochemistry of the Kidney and Urine of the Bank Vole (Clethrionomys glareolus), Wood Mouse (Apodemus sylvaticus), White Toothed Shrew (Crocidura suaveolens) and the Laboratory Rat. Comp. Biochem. Physiol. 2000, B127, 357-367.
8. Robertson, D.G.; Bulera, S.J. High-throughput Toxicology: Practical Considerations. Cur. Opin. Drug Disc. Develop. 2000, 3, 42-47.
9. Becker, E.D. High Resolution NMR: Theory and Chemical Applications, 3rd Ed.; Academic Press: New York, 2000; 334-339.