Cyclosporin A-induced changes in endogenous metabolites in rat urine: A metabonomic investigation using high field 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics

Journal of Pharmaceutical and Biomedical Analysis

Volumn 35, Issue 3, 2004, Pages 599-608

  Lenz, E M ^a   Bright, J ^a   Knight, R ^a   Wilson, I D ^a   Major, H ^b  

^a ASTRAZENECA   (United Kingdom)

^b WATERS CORPORATION   (United States)

Author keywords

1H NMR spectroscopy; Biomarkers; Cyclosporin A; HPLC TOF MS; Metabonomics; MS MS; Nephrotoxicity; Pattern recognition

Indexed keywords

ACETIC ACID; CITRIC ACID; CYCLOSPORIN A; DRUG METABOLITE; GLUCOSE; KYNURENIC ACID; MACROGOL; RIBOFLAVIN; SUCCINIC ACID; TRIMETHYLAMINE; TRIMETHYLAMINE OXIDE; XANTHURENIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOMETRIC ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG METABOLISM; DRUG URINE LEVEL; GLUCOSE URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOLECULAR WEIGHT; MULTIVARIATE ANALYSIS; NEPHROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATTERN RECOGNITION; PRIORITY JOURNAL; RAT; TIME OF FLIGHT MASS SPECTROMETRY; URINALYSIS; URINE LEVEL;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOSPORINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, WISTAR;

EID: 2342483689     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2004.02.013     Document Type: Article

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