A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: Time dependant changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity

Analyst

Volumn 129, Issue 6, 2004, Pages 535-541

  Lenz, E M ^a   Bright, J ^a   Knight, R ^a   Wilson, I D ^a   Major, H ^b  

^a ASTRAZENECA   (United Kingdom)

^b WATERS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; 7 METHYLGUANINE; ACETIC ACID; ALANINE; CITRIC ACID; GLUCOSE; KYNURENIC ACID; LACTIC ACID; MERCURIC CHLORIDE; PANTOTHENIC ACID; SUCCINIC ACID; TROMETAMOL; XANTHURENIC ACID;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE MARKER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NEPHROTOXICITY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TIME OF FLIGHT MASS SPECTROMETRY; URINALYSIS; URINARY EXCRETION;

EID: 3042517107     PISSN: 00032654     EISSN: None     Source Type: Journal    
DOI: 10.1039/b400159c     Document Type: Article

References (22)

1. K. P. R. Gartland, F. W. Bonner and J. K. Nicholson, Mol. Pharmacol., 1988, 35, 242-250.
2. M. L. Anthony, J. C. Lindon, C. R. Beddell and J. K. Nicholson, Mol. Pharmacol., 1994, 46, 199-211.
3. B. M. Beckwith-Hall, J. K. Nicholson, A. W. Nicholls, P. J. Foxall, J. C. Lindon, S. C. Connor, M. Abdi, J. Conelly and E. Holmes, Chem. Res. Toxicol., 1998, 11, 260-272.
4. E. Holmes and J. Shockcor, Curr. Opin.: Drug Discovery Dev., 2000, 3, 72-78.
5. P. J. D. Foxall, E. M. Lenz, G. H. Neild, J. C. Lindon, I. D. Wilson and J. K. Nicholson, Ther. Drug Monit., 1996, 18, 498-505.
6. P. J. D. Foxall, J. M. Singer, J. M. Hartley, G. H. Neild, M. Lapsley, J. K. Nicholson and R. L. Souhami, Clin. Cancer Res., 1997, 3, 1507-1518.
7. J. K. Nicholson, D. P. Higham, J. A. Timbrell and P. J. Sadler, Mol. Pharmacol., 1989, 36, 398-404.
8. J. A. Timbrell, R. Draper and C. J. Waterfield, Toxicol. Ecotoxicol. News, 1994, 1, 4-15.
9. J. A. Timbrell, C. J. Waterfield and R. P. Draper, Comp. Haematology. Int., 1995, 5, 112-119.
10. D. G. Robertson, M. D. Reily, R. E. Sigler, D. F. Wells, D. A. Paterson and T. K. Braden, Toxicol. Sci., 2000, 57, 326-337.
11. E. M. Lenz, I. D. Wilson, J. A. Timbrell and J. K. Nicholson, Biomarkers, 2000, 5, 424-435.
12. E. Holmes and H. Anti, Analyst, 2002, 127, 1549-1557.
13. O. Fiehn, J. Kopka, P. Dormann, T. Altmann, R. N. Trethewey and L. Willmitzer, Nat. Biotechnol., 2000, 18, 1157-1161.
14. Metabolic Profiling: its Role in Biomarker Discovery and Gene Function Analysis, ed. G. C. Harrigan and R. Goodacre, Kluwer Academic Publishers, Boston, 2003.
15. R. S. Plumb, C. L. Stumpf, N. V. Gorenstein, J. M. Castro-Perez, G. J. Dear, M. Anthony, B. C. Sweatman, S. C. Connor and J. N. Haselden, Rapid Commun. Mass Spectrom., 2002, 16, 1991-1996.
16. H. Idborg-Bjorkman, P.-O. Edlund, O. M. Kvalheim, I. Schuppe-Koistinen and S. P. Jacobsson, Anal. Chem., 2003, 75, 4784-4792.
17. A. Lafaye, C. Junot, B. Ramounet-Le Gall, P. Fritsch, J.-C. Tabet and E. Ezan, Rapid Commun. Mass Spectrom, 2003, 17, 2541-2549.
18. A. N. Phipps, B. Wright, J. Stewart and I. D. Wilson, Pharm. Sci., 1997, 3, 143-146.
19. A. N. Phipps, J. Stewart, B. Wright and I. D. Wilson, Xenobiotica, 1998, 28, 527-537.
20. R. E. Williams, H. W. Eyton-Jones, M. J. Farnworth, R. Gallagher and M. W. Provan, Xenobiotica, 2002, 32, 783-794.
21. J. K. Nicholson, J. A. Timbrell and P. J. Sadler, Mol. Pharmacol., 1985, 127, 644-651.
22. E. Holmes, F. W. Bonner and J. K. Nicholson. Comp. Biochem. Physiol., 1996, 114C, 7-11.