메뉴 건너뛰기




Volumn 18, Issue 3, 2005, Pages 143-162

NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition

Author keywords

Laboratory animals; Metabonomics; NMR; Physiological variation

Indexed keywords

DRUG PRODUCTS; GENES; MEDICAL IMAGING; MEDICINE; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PHYSIOLOGY;

EID: 19144371287     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/nbm.935     Document Type: Review
Times cited : (424)

References (121)
  • 1
    • 0037192320 scopus 로고    scopus 로고
    • Toxicology and genetic toxicology in the new era of 'toxicogenomics': Impact of '-omics' technologies
    • Aardema MJ, MacGregor JT. Toxicology and genetic toxicology in the new era of 'toxicogenomics': impact of '-omics' technologies. Mutat. Res. 2002; 499(1): 13-25.
    • (2002) Mutat. Res. , vol.499 , Issue.1 , pp. 13-25
    • Aardema, M.J.1    MacGregor, J.T.2
  • 2
    • 0036188130 scopus 로고    scopus 로고
    • Strategic importance of research support through pathology
    • Cockerell GL, McKim JM, Vonderfecht SL. Strategic importance of research support through pathology. Toxicol. Pathol. 2002; 30(1): 4-7.
    • (2002) Toxicol. Pathol. , vol.30 , Issue.1 , pp. 4-7
    • Cockerell, G.L.1    McKim, J.M.2    Vonderfecht, S.L.3
  • 4
  • 6
    • 0031426081 scopus 로고    scopus 로고
    • Use of proton NMR for determining changes in metabolite excretion profiles induced by dietary changes in the rat
    • Phipps AN, Wright B, Stewart J, Wilson ID. Use of proton NMR for determining changes in metabolite excretion profiles induced by dietary changes in the rat. Pharm. Sci. 1997; 3: 143-146.
    • (1997) Pharm. Sci. , vol.3 , pp. 143-146
    • Phipps, A.N.1    Wright, B.2    Stewart, J.3    Wilson, I.D.4
  • 7
    • 0037163864 scopus 로고    scopus 로고
    • Physiological variation in metabolic phenotyping and functional genomic studies: Use of orthogonal signal correction and PLSDA
    • Gavaghan CL, Wilson ID, Nicholson JK. Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLSDA. FEBS Lett. 2002; 530: 191-196.
    • (2002) FEBS Lett. , vol.530 , pp. 191-196
    • Gavaghan, C.L.1    Wilson, I.D.2    Nicholson, J.K.3
  • 8
    • 0043069547 scopus 로고    scopus 로고
    • Opinion: Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
    • Nicholson JK, Wilson ID. Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2003; 8: 668-676.
    • (2003) Nat. Rev. Drug Discov. , vol.8 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 12
    • 0024580448 scopus 로고
    • Investigations into the biochemical effects of region-specific nephrotoxic lesions
    • Gartland KP, Bonner FW, Nicholson JK. Investigations into the biochemical effects of region-specific nephrotoxic lesions. Mol. Pharmac. 1989; 35(2): 242-250.
    • (1989) Mol. Pharmac. , vol.35 , Issue.2 , pp. 242-250
    • Gartland, K.P.1    Bonner, F.W.2    Nicholson, J.K.3
  • 15
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999; 11: 1181-1189.
    • (1999) Xenobiotica , vol.11 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 16
  • 18
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics-the link between genotypes and phenotypes
    • Fiehn O. Metabolomics-the link between genotypes and phenotypes. Plant Mol. Biol. 2002; 48(1-2): 155-171.
    • (2002) Plant Mol. Biol. , vol.48 , Issue.1-2 , pp. 155-171
    • Fiehn, O.1
  • 19
    • 2442719174 scopus 로고    scopus 로고
    • Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
    • Lindon JC, Holmes E, Bollard ME, Stanley EG, Nicholson JK. Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers 2004; 9(1): 1-31.
    • (2004) Biomarkers , vol.9 , Issue.1 , pp. 1-31
    • Lindon, J.C.1    Holmes, E.2    Bollard, M.E.G.3    Stanley, E.G.4    Nicholson, J.K.5
  • 23
    • 0021403120 scopus 로고
    • Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine
    • Bales JR, Higham DP, Howe I, Nicholson JK, Sadler PJ. Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine. Clin. Chem. 1984; 30(3): 426-432.
    • (1984) Clin. Chem. , vol.30 , Issue.3 , pp. 426-432
    • Bales, J.R.1    Higham, D.P.2    Howe, I.3    Nicholson, J.K.4    Sadler, P.J.5
  • 25
    • 0035796127 scopus 로고    scopus 로고
    • Pattern recognition methods and applications in biomedical magnetic resonance
    • Lindon JC, Holmes E, Nicholson JK. Pattern recognition methods and applications in biomedical magnetic resonance. Prog. NMR Spectrosc. 2001; 39(1): 1-40.
    • (2001) Prog. NMR Spectrosc. , vol.39 , Issue.1 , pp. 1-40
    • Lindon, J.C.1    Holmes, E.2    Nicholson, J.K.3
  • 29
    • 0034530607 scopus 로고    scopus 로고
    • A metabonomic approach to the investigation of drug-induced phospholipidosis: A NMR spectroscopy and pattern recognition study
    • Nicholls AW, Nicholson JK, Haselden JN, Waterfield CJ. A metabonomic approach to the investigation of drug-induced phospholipidosis: a NMR spectroscopy and pattern recognition study. Biomarkers 2000; 5: 410-423.
    • (2000) Biomarkers , vol.5 , pp. 410-423
    • Nicholls, A.W.1    Nicholson, J.K.2    Haselden, J.N.3    Waterfield, C.J.4
  • 32
    • 0023107578 scopus 로고
    • Predictive value of random sample urine bile acids corrected by creatinine in liver disease
    • Simko V, Michael S, Kelley RE. Predictive value of random sample urine bile acids corrected by creatinine in liver disease. Hepatology 1987; 7(1): 115-121.
    • (1987) Hepatology , vol.7 , Issue.1 , pp. 115-121
    • Simko, V.1    Michael, S.2    Kelley, R.E.3
  • 33
    • 0027511147 scopus 로고
    • The correlation between urinary and liver taurine levels and between predose urinary taurine and liver damage
    • Waterfield CJ, Turton JA, Scales MD, Timbrell JA. The correlation between urinary and liver taurine levels and between predose urinary taurine and liver damage. Toxicology 1993; 77(1-2): 1-5.
    • (1993) Toxicology , vol.77 , Issue.1-2 , pp. 1-5
    • Waterfield, C.J.1    Turton, J.A.2    Scales, M.D.3    Timbrell, J.A.4
  • 37
    • 0034306770 scopus 로고    scopus 로고
    • Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development
    • Lindon JC, Nicholson JK, Wilson ID. Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development. J. Chromatogr B Biomed. Sci. Applic. 2000; 748(1): 233-258.
    • (2000) J. Chromatogr. B. Biomed. Sci. Applic. , vol.748 , Issue.1 , pp. 233-258
    • Lindon, J.C.1    Nicholson, J.K.2    Wilson, I.D.3
  • 38
    • 0034306635 scopus 로고    scopus 로고
    • Use of directly coupled ion-exchange liquid chromatography-mass spectrometry and liquid chromatography-nuclear magnetic resonance spectroscopy as a strategy for polar metabolite identification
    • Dear GJ, Plumb RS, Sweatman BC, Parry PS, Roberts AD, Lindon JC, Nicholson JK, Ismail IM. Use of directly coupled ion-exchange liquid chromatography-mass spectrometry and liquid chromatography-nuclear magnetic resonance spectroscopy as a strategy for polar metabolite identification. J. Chromatogr. B. Biomed. Sci. Applic. 2000; 748(1): 295-309.
    • (2000) J. Chromatogr. B. Biomed. Sci. Applic. , vol.748 , Issue.1 , pp. 295-309
    • Dear, G.J.1    Plumb, R.S.2    Sweatman, B.C.3    Parry, P.S.4    Roberts, A.D.5    Lindon, J.C.6    Nicholson, J.K.7    Ismail, I.M.8
  • 39
    • 0034306734 scopus 로고    scopus 로고
    • Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography-mass spectrometry-nuclear magnetic resonance spectroscopy
    • Dear GJ, Plumb RS, Sweatman BC, Ayrton J, Lindon JC, Nicholson JK, Ismail IM. Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography-mass spectrometry-nuclear magnetic resonance spectroscopy. J. Chromatogr B. Biomed. Sci. Applic. 2000; 748(1): 281-293.
    • (2000) J. Chromatogr. B. Biomed. Sci. Applic. , vol.748 , Issue.1 , pp. 281-293
    • Dear, G.J.1    Plumb, R.S.2    Sweatman, B.C.3    Ayrton, J.4    Lindon, J.C.5    Nicholson, J.K.6    Ismail, I.M.7
  • 42
    • 0019855502 scopus 로고
    • Classification of human cancer cells by means of capillary gas chromatography and pattern recognition analysis
    • Jellum E, Bjornson I, Nesbakken R, Johansson E, Wold S. Classification of human cancer cells by means of capillary gas chromatography and pattern recognition analysis. J. Chromatogr. 1981; 217: 231-237.
    • (1981) J. Chromatogr. , vol.217 , pp. 231-237
    • Jellum, E.1    Bjornson, I.2    Nesbakken, R.3    Johansson, E.4    Wold, S.5
  • 44
    • 0019952006 scopus 로고
    • Some observations on the urinary excretion of glycine conjugates by laboratory animals
    • Jones AR. Some observations on the urinary excretion of glycine conjugates by laboratory animals. Xenobiotica 1982; 12: 387-395.
    • (1982) Xenobiotica , vol.12 , pp. 387-395
    • Jones, A.R.1
  • 46
    • 3042619232 scopus 로고    scopus 로고
    • Comparative biochemical effects of low doses of mercury II chloride in the F344 rat and the Multimammate mouse (Mastomys natalensis)
    • Holmes E, Bonner FW, Nicholson JK. Comparative biochemical effects of low doses of mercury II chloride in the F344 rat and the Multimammate mouse (Mastomys natalensis). Comp. Biochem. Physiol. 1996; 114C(1): 7-15.
    • (1996) Comp. Biochem. Physiol. , vol.114 C , Issue.1 , pp. 7-15
    • Holmes, E.1    Bonner, F.W.2    Nicholson, J.K.3
  • 47
    • 0030612030 scopus 로고    scopus 로고
    • 1H NMR spectroscopic and histopathological studies on propyleneimine-induced renal papillary necrosis in the rat and the multimammate desert mouse (Mastomys natalensis)
    • 1H NMR spectroscopic and histopathological studies on propyleneimine-induced renal papillary necrosis in the rat and the multimammate desert mouse (Mastomys natalensis). Comp. Biochem. Physiol. C. Pharmac. Toxicol. Endocrinol. 1997; 116(2): 125-134.
    • (1997) Comp. Biochem. Physiol. C. Pharmac. Toxicol. Endocrinol. , vol.116 , Issue.2 , pp. 125-134
    • Holmes, E.1    Bonner, F.W.2    Nicholson, J.K.3
  • 48
    • 0020033788 scopus 로고
    • Mitochondrial bioenergetics during the initiation of mercuric chloride induced renal injury
    • Weinberg JM, Harding PG, Humes HD. Mitochondrial bioenergetics during the initiation of mercuric chloride induced renal injury. J. Biol. Chem. 1982; 257: 60-67.
    • (1982) J. Biol. Chem. , vol.257 , pp. 60-67
    • Weinberg, J.M.1    Harding, P.G.2    Humes, H.D.3
  • 49
    • 0029565805 scopus 로고
    • Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis)
    • Holmes E, Bonner FW, Nicholson JK. Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis). Arch. Toxicol. 1995; 70(2): 89-95.
    • (1995) Arch. Toxicol. , vol.70 , Issue.2 , pp. 89-95
    • Holmes, E.1    Bonner, F.W.2    Nicholson, J.K.3
  • 50
    • 0024362124 scopus 로고
    • Experimental renal papilliary necrosis in the Syrian hamster
    • Carlton WW, Engelhardt JA. Experimental renal papilliary necrosis in the Syrian hamster. Food Chem. Toxicol. 1989; 27(5): 331-340.
    • (1989) Food Chem. Toxicol. , vol.27 , Issue.5 , pp. 331-340
    • Carlton, W.W.1    Engelhardt, J.A.2
  • 52
    • 0033743932 scopus 로고    scopus 로고
    • NMR spectroscopy based metabonomic studies on the comparative biochemistry of the kidney and urine of the bank vole (Clethrionomys glareolus), wood mouse (Apodemus sylvaticus), white toothed shrew (Crocidura suaveolens) and the laboratory rat
    • Griffin JL, Walker LA, Garrod S, Holmes E, Shore RE, Nicholson JK. NMR spectroscopy based metabonomic studies on the comparative biochemistry of the kidney and urine of the bank vole (Clethrionomys glareolus), wood mouse (Apodemus sylvaticus), white toothed shrew (Crocidura suaveolens) and the laboratory rat. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 2000; 127(3): 357-367.
    • (2000) Comp. Biochem. Physiol. B. Biochem. Mol. Biol. , vol.127 , Issue.3 , pp. 357-367
    • Griffin, J.L.1    Walker, L.A.2    Garrod, S.3    Holmes, E.4    Shore, R.E.5    Nicholson, J.K.6
  • 53
    • 0020308552 scopus 로고
    • Strain differences in the tryptophan metabolite excretion and enzyme activities along the kynurenine pathway in rats
    • Costa C, DeAntoni A, Baccichetti F, Vanzan S, Appodia M, Allegri G. Strain differences in the tryptophan metabolite excretion and enzyme activities along the kynurenine pathway in rats. Ital. J. Biochem. 1982; 31(6): 412-418.
    • (1982) Ital. J. Biochem. , vol.31 , Issue.6 , pp. 412-418
    • Costa, C.1    DeAntoni, A.2    Baccichetti, F.3    Vanzan, S.4    Appodia, M.5    Allegri, G.6
  • 54
    • 0021678429 scopus 로고
    • Metabolites and enzyme activities involved in tryptophan metabolism in two strains of mouse
    • Costa C, DeAntoni A, Baccichetti F, Biasiolo M, Allegri G. Metabolites and enzyme activities involved in tryptophan metabolism in two strains of mouse. Ital. J. Biochem. 1984; 33(5): 319-324.
    • (1984) Ital. J. Biochem. , vol.33 , Issue.5 , pp. 319-324
    • Costa, C.1    DeAntoni, A.2    Baccichetti, F.3    Biasiolo, M.4    Allegri, G.5
  • 55
    • 0021318933 scopus 로고
    • Sex and strain differences in mouse kidney: Bowman's capsule morphology and susceptibility to chloroform
    • Ahmadizadeh M, Echt R, Kuo CH, Hook JB. Sex and strain differences in mouse kidney: Bowman's capsule morphology and susceptibility to chloroform. Toxicol. Lett. 1984; 20(2): 161-171.
    • (1984) Toxicol. Lett. , vol.20 , Issue.2 , pp. 161-171
    • Ahmadizadeh, M.1    Echt, R.2    Kuo, C.H.3    Hook, J.B.4
  • 56
    • 0036300913 scopus 로고    scopus 로고
    • Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats
    • Harstad EB, Klaassen CD. Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats. Toxicol. Sci. 2002; 67(2): 329-340.
    • (2002) Toxicol. Sci. , vol.67 , Issue.2 , pp. 329-340
    • Harstad, E.B.1    Klaassen, C.D.2
  • 57
    • 0024542035 scopus 로고
    • Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F344 rat
    • Gartland KP, Bonner FW, Timbrell JA, Nicholson JK. Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F344 rat. Arch. Toxicol. 1989; 63(2): 97-106.
    • (1989) Arch. Toxicol. , vol.63 , Issue.2 , pp. 97-106
    • Gartland, K.P.1    Bonner, F.W.2    Timbrell, J.A.3    Nicholson, J.K.4
  • 58
    • 0025092255 scopus 로고
    • Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat
    • Gartland KP, Eason CT, Bonner FW, Nicholson JK. Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat. Arch. Toxicol. 1990; 64(1): 14-25.
    • (1990) Arch. Toxicol. , vol.64 , Issue.1 , pp. 14-25
    • Gartland, K.P.1    Eason, C.T.2    Bonner, F.W.3    Nicholson, J.K.4
  • 59
    • 0022492563 scopus 로고
    • Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity
    • Elfarra AA, Jakobson I, Anders MW. Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. Biochem. Pharmac. 1986; 35(2): 283-288.
    • (1986) Biochem. Pharmac. , vol.35 , Issue.2 , pp. 283-288
    • Elfarra, A.A.1    Jakobson, I.2    Anders, M.W.3
  • 60
    • 0020534793 scopus 로고
    • Acetaminophen nephrotoxicity in the rat. II. Strain differences in nephrotoxicity and metabolism of p-aminophenol, a metabolite of acetaminophen
    • Newton JF, Yoshimoto M, Bernstein J, Rush GF, Hook JB. Acetaminophen nephrotoxicity in the rat. II. Strain differences in nephrotoxicity and metabolism of p-aminophenol, a metabolite of acetaminophen. Toxicol. Appl. Pharmac. 1983; 69(2): 307-318.
    • (1983) Toxicol. Appl. Pharmac. , vol.69 , Issue.2 , pp. 307-318
    • Newton, J.F.1    Yoshimoto, M.2    Bernstein, J.3    Rush, G.F.4    Hook, J.B.5
  • 61
    • 0035107971 scopus 로고    scopus 로고
    • Metabonomic characterisation of genetic variation in toxicological and metabolic responses using probabalistic neural networks
    • Holmes E, Nicholson JK, Tranter G. Metabonomic characterisation of genetic variation in toxicological and metabolic responses using probabalistic neural networks. Chem. Res. Toxicol. 2001; 24: 182-191.
    • (2001) Chem. Res. Toxicol. , vol.24 , pp. 182-191
    • Holmes, E.1    Nicholson, J.K.2    Tranter, G.3
  • 62
    • 0034634448 scopus 로고    scopus 로고
    • An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: Application to the C57BL10J and A1pk:ApfCD mouse
    • Gavaghan CL, Holmes E, Lenz E, Wilson ID, Nicholson JK. An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and A1pk:ApfCD mouse. FEBS Lett. 2000; 484(3): 169-174.
    • (2000) FEBS Lett. , vol.484 , Issue.3 , pp. 169-174
    • Gavaghan, C.L.1    Holmes, E.2    Lenz, E.3    Wilson, I.D.4    Nicholson, J.K.5
  • 63
    • 19144371598 scopus 로고    scopus 로고
    • Metabolic profiles to define the genome: Can we hear the silent phenotypes
    • on-line
    • Griffin JL. Metabolic profiles to define the genome: can we hear the silent phenotypes. Phil. Trans. Biol. Sci. R. Soc. Lond. B 2004; 2: 1471-2970 on-line.
    • (2004) Phil. Trans. Biol. Sci. R. Soc. Lond. B , vol.2 , pp. 1471-2970
    • Griffin, J.L.1
  • 66
    • 0031710040 scopus 로고    scopus 로고
    • Regeneration and myogerric cell proliferation correlate with taurine levels in dystrophin- and MyoD-deficient muscles
    • McIntosh LM, Garrett KL, Megeney L, Rudnicki MA, Anderson JE. Regeneration and myogerric cell proliferation correlate with taurine levels in dystrophin- and MyoD-deficient muscles. Anat. Rec. 1998; 252(2): 311-324.
    • (1998) Anat. Rec. , vol.252 , Issue.2 , pp. 311-324
    • McIntosh, L.M.1    Garrett, K.L.2    Megeney, L.3    Rudnicki, M.A.4    Anderson, J.E.5
  • 67
    • 0034894692 scopus 로고    scopus 로고
    • Abnormal lipid profile of dystrophic cardiac tissue as demonstrated by one- and two-dimensional magic-angle spinning (1)H NMR spectroscopy
    • Griffin JL, Williams HJ, Sang E, Nicholson JK. Abnormal lipid profile of dystrophic cardiac tissue as demonstrated by one- and two-dimensional magic-angle spinning (1)H NMR spectroscopy. Magn. Reson. Med. 2001; 46(2): 249-255.
    • (2001) Magn. Reson. Med. , vol.46 , Issue.2 , pp. 249-255
    • Griffin, J.L.1    Williams, H.J.2    Sang, E.3    Nicholson, J.K.4
  • 69
    • 0029665960 scopus 로고    scopus 로고
    • 1H-NMR detectable fatty acy1 chain unsaturation in excised leiomyosarcoma correlate with grade and mitotic activity
    • 1H-NMR detectable fatty acy1 chain unsaturation in excised leiomyosarcoma correlate with grade and mitotic activity. J. Clin. Invest. 1996; 98(2): 244-250.
    • (1996) J. Clin. Invest. , vol.98 , Issue.2 , pp. 244-250
    • Singer, S.1    Sivaraja, M.2    Souza, K.3    Millis, K.4    Corson, J.M.5
  • 70
    • 0036773296 scopus 로고    scopus 로고
    • Is a mouse like any other mouse?
    • Hintze TH, Shesely EG. Is a mouse like any other mouse? J. Mol. Cell Cardiol. 2002; 34(10): 1283-1286.
    • (2002) J. Mol. Cell Cardiol. , vol.34 , Issue.10 , pp. 1283-1286
    • Hintze, T.H.1    Shesely, E.G.2
  • 71
    • 0035348633 scopus 로고    scopus 로고
    • The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases
    • Linder CC. The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases. Lab. Anim. (NY) 2001; 30(5): 34-39.
    • (2001) Lab. Anim. (NY) , vol.30 , Issue.5 , pp. 34-39
    • Linder, C.C.1
  • 73
    • 0001336169 scopus 로고
    • Citric acid excretion in normal adults and in patients with renal calculus
    • Hodgkinson A. Citric acid excretion in normal adults and in patients with renal calculus. Clin. Sci. 1962; 23: 203-205.
    • (1962) Clin. Sci. , vol.23 , pp. 203-205
    • Hodgkinson, A.1
  • 75
    • 12344276593 scopus 로고    scopus 로고
    • 1H NMR spectroscopic and chemometric studies on endogenous physiological variation in rats
    • Ph.D. thesis, University of London
    • 1H NMR spectroscopic and chemometric studies on endogenous physiological variation in rats. Ph.D. thesis, University of London, 2002; 43-67.
    • (2002) , pp. 43-67
    • Stanley, E.G.1
  • 76
    • 0026091233 scopus 로고
    • Gender-related differences in xenobiotic metabolism
    • Bonate PL. Gender-related differences in xenobiotic metabolism. J. Clin. Pharmac. 1991; 31: 684-690.
    • (1991) J. Clin. Pharmac. , vol.31 , pp. 684-690
    • Bonate, P.L.1
  • 79
    • 0019126560 scopus 로고
    • Sex difference of mercuric chloride-induced renal tubular necrosis in rats from the aspect of sex differences in renal mercury concentration and sulfhydryl levels
    • Muraoka Y, Itoh F. Sex difference of mercuric chloride-induced renal tubular necrosis in rats from the aspect of sex differences in renal mercury concentration and sulfhydryl levels. J. Toxicol. Sci. 1980; 5(3): 203-214.
    • (1980) J. Toxicol. Sci. , vol.5 , Issue.3 , pp. 203-214
    • Muraoka, Y.1    Itoh, F.2
  • 80
    • 0018765817 scopus 로고
    • Liver injury and lipid metabolism: Sex differences in the fatty liver induced by d-galactosamine
    • Kattermann R, Sirowej H. Liver injury and lipid metabolism: sex differences in the fatty liver induced by d-galactosamine. Acta Hepatogastroenterol. (Stuttg.) 1979; 26: 112-121.
    • (1979) Acta Hepatogastroenterol. (Stuttg.) , vol.26 , pp. 112-121
    • Kattermann, R.1    Sirowej, H.2
  • 81
    • 0026716863 scopus 로고
    • Sex-specific cytochrome P450 as a cause of sex and species related differences in drug toxicity
    • Kato R, Yamazoe Y. Sex-specific cytochrome P450 as a cause of sex and species related differences in drug toxicity. Toxicol. Lett. 1992; 64-65: 661-667.
    • (1992) Toxicol. Lett. , vol.64-65 , pp. 661-667
    • Kato, R.1    Yamazoe, Y.2
  • 82
    • 0034933916 scopus 로고    scopus 로고
    • Gender-based differences in pharmacokinetics in laboratory animal models
    • Czerniak R. Gender-based differences in pharmacokinetics in laboratory animal models. Int. J. Toxicol. 2001; 20(3): 161-163.
    • (2001) Int. J. Toxicol. , vol.20 , Issue.3 , pp. 161-163
    • Czerniak, R.1
  • 85
    • 0023760883 scopus 로고
    • Mechanisms of hypercholesterolemia and atherosclerosis
    • Joossen JV. Mechanisms of hypercholesterolemia and atherosclerosis. Acta Cardiol. Suppl. 1988; 29: 63-83.
    • (1988) Acta Cardiol. Suppl. , vol.29 , pp. 63-83
    • Joossen, J.V.1
  • 86
    • 0031882555 scopus 로고    scopus 로고
    • Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats
    • Moser VC, Padilla S. Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats. Toxicol. Appl. Pharmac. 1998; 149(1): 107-119.
    • (1998) Toxicol. Appl. Pharmac. , vol.149 , Issue.1 , pp. 107-119
    • Moser, V.C.1    Padilla, S.2
  • 87
    • 0028152478 scopus 로고
    • Carbon tetrachloride hepatotoxicity as a function of age in female Fischer 344 rats
    • Rikans LE, Hornbrook KR, Cai Y. Carbon tetrachloride hepatotoxicity as a function of age in female Fischer 344 rats. Mech. Ageing Dev. 1994; 76(2-3): 89-99.
    • (1994) Mech. Ageing Dev. , vol.76 , Issue.2-3 , pp. 89-99
    • Rikans, L.E.1    Hornbrook, K.R.2    Cai, Y.3
  • 88
    • 0031839564 scopus 로고    scopus 로고
    • Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity
    • Phipps AN, Stewart J, Wright B, Wilson ID. Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity. Xenobiotica 1998; 28(5): 527-537.
    • (1998) Xenobiotica , vol.28 , Issue.5 , pp. 527-537
    • Phipps, A.N.1    Stewart, J.2    Wright, B.3    Wilson, I.D.4
  • 89
    • 0025305943 scopus 로고
    • Alteration of plasma sex hormone levels associated with old age and its effect on hepatic drug metabolism in rats
    • Fujita,S, Chiba M, Ohta M, Kitani K, Suzuki T, Alteration of plasma sex hormone levels associated with old age and its effect on hepatic drug metabolism in rats. J. Pharmac. Exp. Ther. 1990; 253(1): 369-374.
    • (1990) J. Pharmac. Exp. Ther. , vol.253 , Issue.1 , pp. 369-374
    • Fujita, S.1    Chiba, M.2    Ohta, M.3    Kitani, K.4    Suzuki, T.5
  • 90
    • 0022876096 scopus 로고
    • Age-dependent phagocytosis of erythrocytes by the isolated perfused rat liver after galactosamine hepatitis and alpha-naphthylisothiocyanate cholestasis
    • Vömel T, Platt D. Age-dependent phagocytosis of erythrocytes by the isolated perfused rat liver after galactosamine hepatitis and alpha-naphthylisothiocyanate cholestasis. Arch. Gerontol. Geriat. 1986; 5(4): 351-359.
    • (1986) Arch. Gerontol. Geriat. , vol.5 , Issue.4 , pp. 351-359
    • Vömel, T.1    Platt, D.2
  • 91
    • 19144367665 scopus 로고    scopus 로고
    • NMR spectroscopic studies on hepatotoxic processes
    • Ph.D. Thesis, University of London
    • Beckwith Hall BM. NMR spectroscopic studies on hepatotoxic processes. Ph.D. Thesis, University of London, 1998; 88-90.
    • (1998) , pp. 88-90
    • Beckwith Hall, B.M.1
  • 92
    • 0027765518 scopus 로고
    • Conjugation of benzoic acid with glycine in human liver and kidney: A study on the interindividual variability
    • Temellini A, Mogavero S, Giulianotti PC, Pietrabissa A, Mosca F, Pacifici GM. Conjugation of benzoic acid with glycine in human liver and kidney: a study on the interindividual variability. Xenobiotica 1993; 23(12): 1427-1433.
    • (1993) Xenobiotica , vol.23 , Issue.12 , pp. 1427-1433
    • Temellini, A.1    Mogavero, S.2    Giulianotti, P.C.3    Pietrabissa, A.4    Mosca, F.5    Pacifici, G.M.6
  • 93
    • 0028233223 scopus 로고
    • Age-related reference values for organic acids in a healthy Turkish pediatric population
    • Guneral F, Bachmann C. Age-related reference values for organic acids in a healthy Turkish pediatric population. Clin. Chem. 1994; 40(6): 862-868.
    • (1994) Clin. Chem. , vol.40 , Issue.6 , pp. 862-868
    • Guneral, F.1    Bachmann, C.2
  • 94
    • 0004240821 scopus 로고
    • Organic acids in blood and urine
    • Nordmann J, Nordmann R. Organic acids in blood and urine. Adv. Clin. Chem. 1961; 4: 53-120.
    • (1961) Adv. Clin. Chem. , vol.4 , pp. 53-120
    • Nordmann, J.1    Nordmann, R.2
  • 96
    • 0018090054 scopus 로고
    • The effect of sex hormones on the proximal tubules in the rat kidney
    • Schiebler TH, Danner KG. The effect of sex hormones on the proximal tubules in the rat kidney. Cell Tissue Res. 1978; 192(3): 527-549.
    • (1978) Cell Tissue Res. , vol.192 , Issue.3 , pp. 527-549
    • Schiebler, T.H.1    Danner, K.G.2
  • 97
    • 1842594589 scopus 로고
    • The effect of pregnancy on the renal handling of glucose
    • Davison JM, Hytten FE. The effect of pregnancy on the renal handling of glucose. Br. J. Obstet. Gynaecol. 1975; 82(5): 374-381.
    • (1975) Br. J. Obstet. Gynaecol. , vol.82 , Issue.5 , pp. 374-381
    • Davison, J.M.1    Hytten, F.E.2
  • 98
    • 0019229722 scopus 로고
    • Effects of pregnancy on glucose handling by rat kidneys
    • Bishop JH, Green R. Effects of pregnancy on glucose handling by rat kidneys. J. Physiol. 1980; 307: 491-502.
    • (1980) J. Physiol. , vol.307 , pp. 491-502
    • Bishop, J.H.1    Green, R.2
  • 100
    • 0030472235 scopus 로고    scopus 로고
    • Exacerbation of symptoms of fish-odour syndrome during menstruation
    • Zhang AQ, Mitchell SC, Smith RL. Exacerbation of symptoms of fish-odour syndrome during menstruation. Lancet 1996; 348(9043): 1740-1741.
    • (1996) Lancet , vol.348 , Issue.9043 , pp. 1740-1741
    • Zhang, A.Q.1    Mitchell, S.C.2    Smith, R.L.3
  • 101
    • 0029133243 scopus 로고
    • Dysfunctional N-oxidation of trimethylamine and the influence of testosterone treatment in man
    • Ayesh R, Mitchell SC, Smith RL. Dysfunctional N-oxidation of trimethylamine and the influence of testosterone treatment in man. Pharmacogenetics 1995; 5: 244-246.
    • (1995) Pharmacogenetics , vol.5 , pp. 244-246
    • Ayesh, R.1    Mitchell, S.C.2    Smith, R.L.3
  • 102
    • 0001078461 scopus 로고
    • Biology and disease
    • Baker HJ, Lindsey JR, Weisbroth SH (eds). Academic Press: New York
    • Baker DEJ. Biology and disease. In The Laboratory Rat, Baker HJ, Lindsey JR, Weisbroth SH (eds). Academic Press: New York, 1979; 153-166.
    • (1979) The Laboratory Rat , pp. 153-166
    • Baker, D.E.J.1
  • 103
    • 0025938010 scopus 로고
    • Chronopharmacological study of furosemide; (VIII) influence of feeding restriction
    • Fujimura A, Ohashi, Ebihara A. Chronopharmacological study of furosemide; (VIII) influence of feeding restriction. Life Sci. 1991; 49(24): 1829-1834.
    • (1991) Life Sci. , vol.49 , Issue.24 , pp. 1829-1834
    • Fujimura, A.1    Ohashi2    Ebihara, A.3
  • 104
    • 0019215785 scopus 로고
    • Circadian rhythmns of urinary electrolyte excretion in freely moving rats
    • Roelfsema F, Van de Heide D, Smeenk D. Circadian rhythmns of urinary electrolyte excretion in freely moving rats. Life Sci. 1980; 27: 2303-2309.
    • (1980) Life Sci. , vol.27 , pp. 2303-2309
    • Roelfsema, F.1    Van de Heide, D.2    Smeenk, D.3
  • 105
    • 0035870843 scopus 로고    scopus 로고
    • Directly coupled high-performance liquid chromatography and nuclear magnetic resonance spectroscopic with chemometric studies on metabolic variation in Sprague-Dawley rats
    • Gavaghan CL, Nicholson JK, Connor SC, Wilson ID, Wright B, Holmes E. Directly coupled high-performance liquid chromatography and nuclear magnetic resonance spectroscopic with chemometric studies on metabolic variation in Sprague-Dawley rats. Anal. Biochem. 2001; 291(2): 245-252.
    • (2001) Anal. Biochem. , vol.291 , Issue.2 , pp. 245-252
    • Gavaghan, C.L.1    Nicholson, J.K.2    Connor, S.C.3    Wilson, I.D.4    Wright, B.5    Holmes, E.6
  • 107
    • 0027325748 scopus 로고
    • Effects of two weeks of feed restriction on some common toxicologic parameters in Sprague Dawley rats
    • Levin S, Semler D, Ruben Z. Effects of two weeks of feed restriction on some common toxicologic parameters in Sprague Dawley rats. Toxicol. Pathol. 1993; 21: 1-14.
    • (1993) Toxicol. Pathol. , vol.21 , pp. 1-14
    • Levin, S.1    Semler, D.2    Ruben, Z.3
  • 108
    • 0036246743 scopus 로고    scopus 로고
    • Characterisation of diet-dependent metabolic serotypes: Primary validation of male and female serotypes in independent cohorts of rats
    • Honglian S, Vigneau-Callahan KE, Shestopalov AI, Milbury PE, Matson WR, Kristal BS. Characterisation of diet-dependent metabolic serotypes: primary validation of male and female serotypes in independent cohorts of rats. J. Nutr. 2002; 132: 1039-1046.
    • (2002) J. Nutr. , vol.132 , pp. 1039-1046
    • Honglian, S.1    Vigneau-Callahan, K.E.2    Shestopalov, A.I.3    Milbury, P.E.4    Matson, W.R.5    Kristal, B.S.6
  • 109
    • 0017112487 scopus 로고
    • Influence of diet and feed restriction on kidney function of ageing male rats
    • Tucker SM, Mason RL, Beauchene RE. Influence of diet and feed restriction on kidney function of ageing male rats. J. Gerontol. 1976; 31: 264-270.
    • (1976) J. Gerontol. , vol.31 , pp. 264-270
    • Tucker, S.M.1    Mason, R.L.2    Beauchene, R.E.3
  • 111
    • 0024363453 scopus 로고
    • Comparisons of urinary creatinine, skeletal muscle mass and indices of muscle protein catabolism in rats fed ad libitum, with restricted food intake and deprived of food
    • Rikimaru T, Oozeki T, Ichikawa M, Ebisawa H, Fujita Y. Comparisons of urinary creatinine, skeletal muscle mass and indices of muscle protein catabolism in rats fed ad libitum, with restricted food intake and deprived of food. J. Nutr Sci. Vitaminol. 1989; 35(3): 190-209.
    • (1989) J. Nutr. Sci. Vitaminol. , vol.35 , Issue.3 , pp. 190-209
    • Rikimaru, T.1    Oozeki, T.2    Ichikawa, M.3    Ebisawa, H.4    Fujita, Y.5
  • 112
    • 0024411677 scopus 로고
    • Effects of drinking water acidification, restriction of water supply and individual cageing on parameters of toxicological studies in rats
    • Clausing P, Gottschalk M. Effects of drinking water acidification, restriction of water supply and individual cageing on parameters of toxicological studies in rats. Z. Versuchstierkd. 1989; 32(3): 129-134.
    • (1989) Z. Versuchstierkd. , vol.32 , Issue.3 , pp. 129-134
    • Clausing, P.1    Gottschalk, M.2
  • 113
    • 0029330618 scopus 로고
    • Changes in glycolysis and glycogenolysis in tissues and level of certain hormones in blood and urine from rats with varying lengths of cold adaptation
    • Panin LE, Starova TIu, Tret'iakova TA, Kolpakov AR, Kolosova IE, Solov'ev VN. Changes in glycolysis and glycogenolysis in tissues and level of certain hormones in blood and urine from rats with varying lengths of cold adaptation. Vopr. Med. Khim. 1995; 41(4): 14-18.
    • (1995) Vopr. Med. Khim. , vol.41 , Issue.4 , pp. 14-18
    • Panin, L.E.1    Starova, T.Iu.2    Tret'iakova, T.A.3    Kolpakov, A.R.4    Kolosova, I.E.5    Solov'ev, V.N.6
  • 114
    • 0017296114 scopus 로고
    • Effects of acute heat stress on tissue carbohydrate in fasted rats
    • Harrison MH. Effects of acute heat stress on tissue carbohydrate in fasted rats. Aviation, Space Environ. Med. 1976; 47: 165-167.
    • (1976) Aviation, Space Environ. Med. , vol.47 , pp. 165-167
    • Harrison, M.H.1
  • 115
    • 0024586240 scopus 로고
    • Sleep deprivation in the rat: III. Total sleep deprivation
    • Everson CA, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: III. Total sleep deprivation. Sleep 1989; 12(1): 13-21.
    • (1989) Sleep , vol.12 , Issue.1 , pp. 13-21
    • Everson, C.A.1    Bergmann, B.M.2    Rechtschaffen, A.3
  • 117
    • 0020675765 scopus 로고
    • The effect of sleep deprivation and recovery sleep on plasma corticosterone in the rat
    • Tobler I, Murison R, Ursin R, Ursin H, Borbely AA. The effect of sleep deprivation and recovery sleep on plasma corticosterone in the rat. Neurosci. Lett. 1983; 35(3): 297-300.
    • (1983) Neurosci. Lett. , vol.35 , Issue.3 , pp. 297-300
    • Tobler, I.1    Murison, R.2    Ursin, R.3    Ursin, H.4    Borbely, A.A.5
  • 119
    • 0034090505 scopus 로고    scopus 로고
    • Development of sterotypes and polydipsia in wild caught bank voles (Clethionomys glareolus) and their laboratory-bred offspring. Is polydipsia a symptom of diabetes mellitus?
    • Schoenecker B, Heeler KE, Freimanis T. Development of sterotypes and polydipsia in wild caught bank voles (Clethionomys glareolus) and their laboratory-bred offspring. Is polydipsia a symptom of diabetes mellitus? Appl. Animal Behav. Sci. 2000; 68: 349-357.
    • (2000) Appl. Animal Behav. Sci. , vol.68 , pp. 349-357
    • Schoenecker, B.1    Heeler, K.E.2    Freimanis, T.3
  • 120
    • 0345714918 scopus 로고    scopus 로고
    • NMR spectroscopic and metabonomic studies of urinary metabolite variation in acclimatising germ free rats
    • Nicholls AW, Mortishire-Smith RJ, Nicholson JK. NMR spectroscopic and metabonomic studies of urinary metabolite variation in acclimatising germ free rats. Chem. Res. Toxicol. 2003; 16(11): 1395-1404.
    • (2003) Chem. Res. Toxicol. , vol.16 , Issue.11 , pp. 1395-1404
    • Nicholls, A.W.1    Mortishire-Smith, R.J.2    Nicholson, J.K.3
  • 121
    • 0028360586 scopus 로고
    • Gut flora and the origin of some urinary aromatic phenolic compounds
    • Goodwin BL, Ruthven CRJ, Sandler M. Gut flora and the origin of some urinary aromatic phenolic compounds. Biochem. Pharmac. 1994; 47: 2294-2297.
    • (1994) Biochem. Pharmac. , vol.47 , pp. 2294-2297
    • Goodwin, B.L.1    Ruthven, C.R.J.2    Sandler, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.