Bile acids metabonomic study on the CCl4- and α-naphthylisothiocyanate-induced animal models: Quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry

Chemical Research in Toxicology

Volumn 21, Issue 12, 2008, Pages 2280-2288

  Yang, Li ^a,b   Xiong, Aizhen ^a   He, Yuqi ^a   Wang, Zaiyong ^b   Wang, Changhong ^a,b   Wang, Zhengtao ^a,b   Li, Wei ^c   Yang, Ling ^c   Hu, Zhibi ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

^c DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; ACETIC ACID; ALANINE AMINOTRANSFERASE; ALCOHOL; AMMONIUM ACETATE; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILE ACID CONJUGATE; CARBON TETRACHLORIDE; CHENODEOXYCHOLIC ACID; CHOLIC ACID; CHOLIC ACID DERIVATIVE; DEOXYCHOLIC ACID; GLYCHODEOXYCHOLIC ACID; GLYCHOLITHOCHOLIC ACID; GLYCINE DERIVATIVE; HYODEOXYCHOLIC ACID; LITHOCHOLIC ACID; TAURINE DERIVATIVE; TAURO ALPHA MURICHOLIC ACID; TAURO BETA MURICHOLIC ACID; TAUROCHENODEOXYCHOLIC ACID; TAURODEOXYCHOLIC ACID; TAUROHYODEOXYCHOLIC ACID; TAUROLITHOCHOLIC ACID; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID BLOOD LEVEL; BLOOD SAMPLING; CHEMOMETRIC ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION MONITORING; LIVER FAILURE; LIVER INJURY; LIVER TOXICITY; MALE; MASS SPECTROMETRY; METABOLOMICS; NONHUMAN; PRECIPITATION; RAT;

1-NAPHTHYLISOTHIOCYANATE; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILE ACIDS AND SALTS; CARBON TETRACHLORIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISCRIMINANT ANALYSIS; DISEASE MODELS, ANIMAL; HEPATITIS, TOXIC; LIVER; LIVER FAILURE; MALE; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANIMALIA; RATTUS;

EID: 58149087636     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx800225q     Document Type: Article

References (21)

1. Burkard, I., Eckardstein, A. V., and Rentsch, K. M. (2005) Differentiated quantification of human BAs in serum by high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 826, 147-159.
2. Meng, L. J., Reyes, H., Palma, J., Hernandez, I., Ribalta, J., and Sjovall, J. (1997) Profiles of BAs and progesterone metabolites in the urine and serum of women with intrahepatic cholestasis of pregnancy. J. Hepatol. 27, 346-357.
3. Palmeira, C. M., and Rolo, A. P. (2004) Mitochondrially-mediated toxicity of BAs.Toxicology. Toxicology 203, 1-15.
4. Ye, L., Liu, S. Y., Wang, M., Shao, S., and Ding, M. (2007) High-performance liquid chromatography-tandem mass spectrometry for the analysis of bile acid profiles in serum of women with intrahepatic cholestasis of pregnancy. J. Chromatogr. B 860, 10-17.
5. Roda, A., Piazza, F., and Baraldini, M. (1998) Separation techniques for bile salts analysis. J. Chromatogr. B 717, 263-278.
6. Batta, A. K., and Salen, G. (1999) Gas chromatography of BAs. J. Chromatogr. B 723, 1-16.
7. Keller, S., and Jahreis, G. (2004) Determination of underivatised sterols and bile acid trimethyl silyl ether methyl esters by gas chromatography-mass spectrometry-single ion monitoring in faeces. J. Chromatogr. B 813, 199-207.
8. 27 bile acids in plasma and blood samples by tandem mass spectrometry. J. Lipid Res. 42, 9-16.
9. Gatti, R., Roda, A., Cerre, C., Bonazzi, D., and Cavrini, V. (1997) HPLC-fluorescence determination of individual free and conjugated BAs in human serum. Biomed. Chromatogr. 11, 11-15.
10. Perwaiz, S., Tuchweber, B., Mignault, D., Gilat, T., and Yousef, I. M. (2001) Determination of BAs in biological fluids by liquid chromatography- electrospray tandem mass spectrometry. J. Lipid Res. 42, 114-119.
11. Sakakura, H., Suzuki, M., Kimura, N., Takeda, H., Nagata, S., and Maeda, M. (1993) Simultaneous determination of BAs in rat bile and serum by high-performance liquid chromatography. J. Chromatogr. 621, 123-131.
12. Ando, M., Kaneko, T., Watanabe, R., Kikuchi, S., Goto, T., Iida, T., Hishinuma, T., Mano, N., and Goto, J. (2006) High sensitive analysis of rat serum BAs by liquid chromatography/electrospray ionization tandem mass spectrometry. J. Pharm. Biomed. Anal. 40, 1179-1186.
13. Liu, M., Liu, Y. G., Chou, G. X., Cheng, X. M., Zhang, M., and Wang, Z. T. (2007) Extraction and ultra-performance liquid chromatography of hydrophilic and lipophilic bioactive components in a Chinese herb Radix Salviae Miltiorrhizae. J. Chromatogr. A 1157, 51-55.
14. Hartley, D. P., Kolaja, K. L., Reichard, J., and Petersen, D. R. (1999) 4-Hydroxynonenal and malondialdehyde hepatic protein adducts in rats treated with carbon tetrachloride: immunochemical detection and lobular localization. Toxicol. Appl. Pharmacol. 161, 23-33.
15. 4-induced hepatotoxicity in Cyp2e1-null mice. Toxicology 228, 310-322.
16. Zhao, Y., Zhai, D., Chen, X., Yang, J., Song, X., He, H., Yu, Q., and Xing, Y. (2007) Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats. Toxicology 230, 145-150.
17. U.S. Department of Health and Human Services, Food and Drug Administration, Centre for Drug Evaluation and Research (2001) Guidance for Industry, Bioanalytical Method Validation, U.S. Department of Health and Human Services, Rockville, MD, http://www.fda.gov/CDER/GUIDANCE/4252fnl.pdf.
18. Bonfiglio, R., King, R. C., Olah, T. V., and Merkle, K. (1999) The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Commun. Mass Spectrom. 13, 1175-1185.
19. Annesley, T. M. (2003) Ion suppression in mass spectrometry. Clin. Chem. 49, 1041-1044.
20. Matuszewski, B. K., Constanzer, M. L., and Chavez-Eng, C. M. (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 75, 3019-3030.
21. Kurihara, H., Sano, N, and Takikawa, H. (2005) Biliary excretion of taurocholate, organic anions and vinblastine in rats with alpha- naphthylisothiocyanate-induced cholestasis. J. Gastroenterol. Hepatol. 20, 1069-1074.