Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat

Biomarkers

Volumn 10, Issue 2-3, 2005, Pages 173-187

  Lenz, E M ^a   Bright, J ^a   Knight, R ^a   Westwood, F R ^a   Davies, D ^a   Major, H ^b   Wilson, Ian D ^a  

^a ASTRAZENECA   (United Kingdom)

^b WATERS CORPORATION   (United States)

Author keywords

Gentamicin; Metabonomics; Nephrotoxicity; Pattern Recognition

Indexed keywords

GENTAMICIN; GLUCOSE; N ACETYL BETA GLUCOSAMINIDASE; PROTON; TRIMETHYLAMINE OXIDE; ACETYLGLUCOSAMINIDASE; BIOLOGICAL MARKER; LACTATE DEHYDROGENASE; PROTEIN SYNTHESIS INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; KIDNEY TUBULE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NEPHROTOXICITY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RAT STRAIN; TIME OF FLIGHT MASS SPECTROMETRY; URINALYSIS; URINARY EXCRETION; ANIMAL; CHEMICALLY INDUCED DISORDER; GLUCOSURIA; KIDNEY; KIDNEY DISEASE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; STATISTICAL ANALYSIS; URINE; WISTAR RAT; X RAY CRYSTALLOGRAPHY;

ANIMALIA;

ACETYLGLUCOSAMINIDASE; ANIMALS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; DATA INTERPRETATION, STATISTICAL; GENTAMICINS; GLYCOSURIA; KIDNEY; KIDNEY DISEASES; L-LACTATE DEHYDROGENASE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 21444445989     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.1080/13547500500094034     Document Type: Article

References (18)

1. Anthony ML, Lindon JC, Beddell CR, Nicholson JK. 1994. Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from proton nuclear magnetic resonance spectra of urine. Molecular Pharmacology 46:199-211.
2. Beckwith-Hall BM, Nicholson JK, Nicholls AW, Foxall PJ, Linden JC, Connor SC, Abdi M, Conelly J, Holmes E. 1998. Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chemical Research in Toxicology 11:260-272.
3. Foxall PJD, Lenz EM, Neild GH, Lindon JC, Wilson ID, Nicholson JK. 1996. Nuclear magnetic resonance and high-performance liquid chromatography-nuclear magnetic resonance studies on the toxicity and metabolism of ifosfamide. Therapeutic Drug Monitoring 18:498-505.
4. Gartland KPR, Bonner FW, Nicholson JK. 1989. Investigations into the biochemical effects of region-specific nephrotoxins. Molecular Pharmacology 35:242-250.
5. Holmes E, Antti H. 2002. Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterising and interpreting complex biological NMR spectra. Analyst 127:1549-1557.
6. Idborg-Bjorkman H, Edlund P-O, Kvalheim OM, Schuppe-Koistinen SP. Jacobsson. 2003. Screening of biomarkers in rat urine using LC/electrospray ionization-MS and two-way data analysis. Analytical Chemistry 75: 4784-4792.
7. Lafaye A, Junot C, Ramounet-Le Gall B, Fritsch P, Tabet. J-C, Ezan E. 2003. Metabolite profiling in rat urine by liquid chromatography/electrospray ion trap mass spectrometry. Application to the study of heavy metal toxicity. Rapid Communications in Mass Spectrometry 17:2541-2549.
8. 1H-NMR spectroscopy, HPLC-TOF/MS and chemometrics. Journal of Pharmacology and Biomedical Analysis 32:599-608.
9. 1H-NMR and HPLC-TOF/MS: Time dependant changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity. Analyst 129:535-541.
10. Lindon JC, Nicholson JK, Holmes E, Antti H, Bollard ME, Keun H, Beckonert O, Ebbels TM, Reily MD, Robertson D, et al. 2003. Contemporary issues in toxicology: the role of metabonomics in toxicology and its evaluation by the COMET project. Toxicology and Applied Pharmacology 187:137-146.
11. Phipps AN, Wright B, Stewart J, Wilson ID. 1997. Use of proton NMR for determining changes in metabolite excretion profiles induced by dietary changes in the rat. Pharmaceutical Sciences 3:143-146.
12. Phipps AN, Wright B, Stewart J, Wilson ID. 1998. Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity. Xenobiotica 28:527-537.
13. Plumb RS, Stumpf CLMV, Gorenstein MV, Castro-Perez JM, Dear GJM, Anthony M, Sweatman BC, Haselden JN. 2002. Metabonomics: the use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development. Rapid Communications in Mass Spectrometry 16:1991-1996.
14. Plumb R, Granger J, Stumpf C, Wilson ID, Evans JA, Lenz EM. 2003. Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences. Analyst 128:819-823.
15. Robertson DG, Reily MD, Sigler RE, Wells DF, Paterson DA, Braden TK. 2000. Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. Toxicological Sciences 57:326-337.
16. Waters N, Holmes E, Wiliams A, Waterfield CJ, Farrant RD, Nicholson JK. 2001. NMR and pattern recognition studies on the time-related metabolic effects of α-napthylisothiocyanate on liver, urine and plasma in the rat: an integrative metabonomic approach. Chemical Research in Toxicology 14:1401-1412.
17. Whiting PH, Brown PAJ. 1996. The relationship between enzymuria and kidney enzyme activities in experimental gentamicin nephrotoxicity. Renal Failure 18:899-909.
18. 1H-nuclear magnetic resonance spectroscopy study. Xenobiotica 32:783-794.