Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins

Chemical Research in Toxicology

Volumn 11, Issue 4, 1998, Pages 260-272

  Beckwith Hall, B M ^a   Nicholson, J K ^a   Nicholls, A W ^a   Foxall, P J D ^a   Lindon, J C ^a   Connor, S C ^b   Abdi, M ^b   Connelly, J ^b   Holmes, E ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; 2 OXOGLUTARIC ACID; ACETIC ACID; BETAINE; BILE ACID; BIOCHEMICAL MARKER; BUTYLCRESOL; CITRIC ACID; CREATINE; GALACTOSAMINE; GLUTAMIC ACID; TAURINE; THREONINE; TYROSINE; UROCANIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIRUBIN BLOOD LEVEL; BIOAVAILABILITY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HISTOPATHOLOGY; KIDNEY INJURY; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRINCIPAL COMPONENT ANALYSIS; RAT; TOXIN ANALYSIS; UREA BLOOD LEVEL; URINARY EXCRETION;

1-NAPHTHYLISOTHIOCYANATE; ANIMALS; BUTYLATED HYDROXYTOLUENE; GALACTOSAMINE; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0031949067     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9700679     Document Type: Article

References (40)

1. Nicbolson, J. K., and Wilson, I. D. (1989) High-resolution proton magnetic resonance spectroscopy of biological fluids. Prog. NMR Spectrosc. 21, 449-501.
2. Gartland, K. P. R., Bonner, F. W., and Nicholson, J. K. (1989) Investigations into the biochemical effects of region-specific nephrotoxins. Mol. Pharmacol. 35, 242-250.
3. Nicholson, J. K., Higham, D. P., Timbrell, J. A., and Sadler, P. J. (1989) Quantitative high-resolution NMR urinalysis studies of the biochemical effects of cadmium in the rat. Mol. Pharmaco. 36, 398-404.
4. 1H NMR spectroscopy as a means of monitoring nephrotoxicity as exemplified by studies with cephaloridine. Hum. Exp. Toxicol. 11, 35-41.
5. 1H NMR spectroscopy. Biochem. PharmacoL 41, 2045-2049.
6. Sanins, S. M., Nicholson, J. K., Elcombe, C., and Timbrell, J. A. (1990) Hepatotoxin-induced hypertaurinuria: a proton NMR study. Arch. Toxicol. 64, 407-411.
7. Ilies, R. A., Hind, A. J., and Chalmers, R. A. (1985) Use of proton magnetic resonance spectroscopy in detection of organic acidurias. Clin. Chem. 31 (11), 1795-1801.
8. Videen, J. S., and Ross, B. D. (1994). Proton nuclear magnetic reosonance urinalysis-coming of age. Kid. Int. 46, S122-S128.
9. Bell, J. D., Lee, H. A., Lee, J. A., Sadler, P. J., Wilkie, D. R., and Woodham, R. H. (1991) Nuclear magnetic resonance studies of blood plasma and urine from subjects with chronic renal failure: identification of trimethylamine-N-oxide. Biochim. Biophys. Acta 1096, 101-107.
10. Gartland, K. P. R., Beddell, C. R., Lindon, J. C., and Nicholson, J. K. (1991) Application of pattern recognition methods to the analysis and classification of toxicological data derived from proton nuclear magnetic resonance spectroscopy of urine. Mol. PharmacoL 39, 629-642.
11. 1H nuclear magnetic resonance spectra of human urine from normal and pathological states. Anal. Biochem. 220, 284-296.
12. Holmes, E., Bonner, F. W., Sweatman, B. C., Lindon, J. C., Beddell, C. R., Rahr, E., and Nicholson, J. K. (1992) Nuclear magnetic resonance spectroscopy and pattern-recognition analysis of the biochemical processes associated with the progression and recovery from nephrotoxic lesions in the rat induced by Mercury II chloride and 2-bromoethanamine. Mol. Pharmacol. 42 (5), 922-930.
13. Kossor, D. C., Meunier, P. C., Handler, J. A., Sozio, R. S., and Goldstein, R. S. (1993) Temporal relationship of changes in hepatobiliary function and morphology in rats following α-naph-thylisothiocyanate (ANIT) administration. Toxicol. Appl. Pharmacol. 119, 108-114.
14. Waterfield, C. J., Turton, J. A., Scales, M. D. C., and Timbrell, J. A. (1993) Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats. Arch. Toxicol. 67, 244-254.
15. Connolly, A. K., Price, S. C., Connelly, J. C., and Hinton, R. H. (1988) Early changes in bile duct lining cells and hepatocytes in rats treated with anaphthylisothiocyanate. Toxicol. Appl. Pharmacol. 93, 208-219.
16. Nakagawa, Y., Tayama, K., Nakao, T., and Hiraga, K. (1985) On the mechanism of butylated hydroxytoluene induced hepatic toxicity in rats. Biochem. Pharmacol. 33, 2669-2674.
17. Powell, C. J., Connelly, J. C., Jones, S. M., Grasso, P., and Bridges, J. W. (1986) Hepatic responses to the administration of high doses of BHT to the rat: their relevance to hepatocarcinogenicity. Food Chem. Toxicol. 24, 1131-1143.
18. Koff, R. S., Gordon, G., and Sabesin, S. M. (1971) D-Galactosamine hepatitis. I. Hepatocellular injury and fatty liver following a single dose. Proc. Soc. Exp. Biol. Med. 137, 696-701.
19. Zieve, L., Anderson, W. R., and Dozeman, R. (1988) Hepatic regenerative enzyme activity after diffuse injury with galactos- amine: relationship to histological alterations. J. Lab. Clin. Med 112 (5), 575-582.
20. Cuatrecasas, P., and Segal, S. (1965) Mammalian galactokinase development and adaptivechacteristics in the liver. J. Biol. Chem 240, 2382-2386.
21. Keppler, D., Lesch, R., Reutter, W., and Decker, K. (1968) Experimental hepatitis induced by D-galactosamine. Exp. Mol. Pathol. 9, 279-290.
22. Bauer, C. H., Bachmann, W., and Reutter, W. (1966) Studies on galactosamine hepatitis: Determination of galactosamine metabolites in the developing rat liver. Hoppe-Seyler's Z. Physiol. Chem. 241, 1705-1712.
23. Decker, K., Keppler, D., Rudigier, J., and Domschke, W. (1971) Cell damage by trapping of biosynthetic intermediates. The role of uracil nucleotides in experimental hepatitis. Hoppe-Seyer's Z. Physiol. Chem. 352, 412-418.
24. Keppler, D., and Decker, K. (1969) Studies on the mechanism of galactosamine hepatitis: Accumulation of galactosamine-1-phosphate and its inhibition of UDP-lucose pyrophosphorylase. Eur. J. Biochem. 10, 219-225.
25. Capizzo, F., and Roberts, R. J. (1971) l-Naphthylisothiocyanate (ANIT)-induced hepatotoxicity and disposition in various species. Toxicol. Appl. Pharmacol. 19, 176-187.
26. Indacochea-Redmond, N., and Plaa, G. L. (1971) Functional effects of α-naphthylisothiocyanate in various species. Toxicol. Appl. Pharmacol. 19, 71-80.
27. Hausamen, T. U. (1967) Optimal conditions for the determination of serum alkaline phosphatase by a new kinetic method. Clin. Chim. Acta 15, 241.
28. McComb, R. B., and Bowers, B. N. (1972) Study of the optimal buffer conditions for measuring alkaline phosphatase activity in human serum. Clin. Chem. 18, 97-103.
29. Jaffe, M. (1886) Ueber den niederschlag, welchen pikrinsaure in normalem harn erzeugt und uber eine neue reaction des kreatinins. Z. Physiol. Chem. 10, 391.
30. Thefeld, W. (1974) Referenswerte fur die bestimmungen der transaminasen got und GPT sowie der alkalischen phosphatase im serum mit optimierten Standardmethoden. Dtsch. Med. Wschr. 99, 343.
31. Bruker Analytische Messtechnik GmbH, D76287-Rheinstetten, Silberstreifen, Germany.
32. 13C NMR spectroscopy of human blood plasma. Anal. Chem. 67 (5), 793-811.
33. Lindon, J. C., and Ferrige, A. G. (1980). Digitisation and data processing in Fourier transform NMR. Prog. NMR Spectrosc. 14, 27-66.
34. Aue, W. P., Bartholdi, E., and Ernst, R. R. (1976) Two-dimensional spectroscopy. Application to nuclear magnetic resonance. J. Chem. Phys. 64, 2229.
35. Wilson, I. D., and Ismail, I. M. (1986) A rapid method for the isolation and identification of drug metabolites from human urine using solid-phase extraction and proton NMR spectroscopy. J. Pharm. Biomed. Anal. 4, 663-665.
36. Kowalski, B. R., and Bender, C. F. (1972) Pattern recognition. A powerful approach to interpreting chemical data. J. Am. Chem. Soc. 94, 5632-5659.
37. Bell, J. D., Brown, J. C. C., Nicholson, J. K., and Sadler, P. J. (1987) Assignment of resonances for 'acute-phase' glycoproteins in high-resolution proton NMR spectra of human blood plasma. FEES Lett. 215, 311-315.
38. Vömel, T., and Platt, D. (1986) Age-dependent phagocytosis of erythrocytes by the isolated perfused rat liver after galactosamine hepatitis and alpha-naphthylisothiocyanate cholestasis. Arch. Gerontol. Geriatr. 5, 351-359.
39. Sanins, S. M., Nicholson, J. K., and Timbrell, J. A. (1986J High-resolution proton-NMR studies of the toxicity and metabolism of hydrazine. Toxicol. Lett. 31, 242.
40. Henson, P. D., Dudley, S. L., Britton, P. S., and Banks, W. L. (1976) Evidence of enhancement of hepatic pyrimidine catabolism following hydrazine or INH treatment to rats. Proc. 67th Annu. Meeting Am. Assoc. Cancer Res. 17, 144 (abstract).