Mechanisms and biomarkers of cardiovascular injury induced by phosphodiesterase inhibitor III SK&F 95654 in the spontaneously hypertensive rat

Toxicologic Pathology

Volumn 34, Issue 2, 2006, Pages 152-163

  Zhang, Jun ^a   Herman, Eugene H ^a   Robertson, Donald G ^b   Reily, Michael D ^b   Knapton, Alan ^a   Ratajczak, Helen V ^c   Rifai, Nader ^d   Honchel, Ronald ^a   Blanchard, Kerry T ^c   Stoll, Raymond E ^c   Sistare, Frank D ^a,e  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b PFIZER INC   (United States)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cardiac troponin T; CD63; Endothelial cell activation; Inducible nitric oxide synthase; Mast cell degranulation; Nitrotyrosine

Indexed keywords

3 NITROTYROSINE; 6 [4 (1,4 DIHYDRO 4 OXO 1 PYRIDYL)PHENYL] 4,5 DIHYDRO 5 METHYL 3(2H) PYRIDAZINONE; ACUTE PHASE PROTEIN; ALPHA 2 MACROGLOBULIN; BIOLOGICAL MARKER; CD63 ANTIGEN; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; NITRIC OXIDE; PEROXIDASE; PHOSPHODIESTERASE III INHIBITOR; TROPONIN T;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTERITIS; ARTICLE; BLEEDING; CARDIOVASCULAR DISEASE; CELL ACTIVATION; CELL DAMAGE; CONTROLLED STUDY; DEGRANULATION; DRUG MECHANISM; DRUG SELECTIVITY; EDEMA; ESSENTIAL HYPERTENSION; HEART MUSCLE INJURY; HEART MUSCLE NECROSIS; IMMUNOPEROXIDASE STAINING; INFLAMMATION; LEYDIG CELL; MALE; MAST CELL DEGRANULATION; MESENTERIC ARTERY; NECROSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SMOOTH MUSCLE FIBER; SPONTANEOUSLY HYPERTENSIVE RAT; URINALYSIS; VASCULAR SMOOTH MUSCLE;

ALANINE TRANSAMINASE; ALPHA-MACROGLOBULINS; ANIMALS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CREATINE; ENDOTHELIAL CELLS; HIPPURATES; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; MALE; MAST CELLS; MYOCYTES, CARDIAC; PHOSPHODIESTERASE INHIBITORS; PYRIDAZINES; PYRIDINES; RATS; RATS, INBRED SHR; TAURINE; TROPONIN; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 33644999719     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1080/01926230600588562     Document Type: Article

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