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Volumn 48, Issue 3, 2010, Pages 362-377

Recent progress in lentiviral vector mass production

Author keywords

Animal and insect cell culture engineering; Large scale production; Lentiviral vectors; Scalable processes; Viral vectors; Virus production

Indexed keywords

INSECT CELL CULTURE; LARGE-SCALE PRODUCTION; LENTIVIRAL VECTOR; VIRAL VECTORS;

EID: 75349106422     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2009.10.017     Document Type: Review
Times cited : (23)

References (191)
  • 1
    • 13644255422 scopus 로고    scopus 로고
    • Lentiviral vectors for treating and modeling human CNS disorders
    • Azzouz M., Kingsman S.M., and Mazarakis N.D. Lentiviral vectors for treating and modeling human CNS disorders. J. Gene. Med. 6 (2004) 951-962
    • (2004) J. Gene. Med. , vol.6 , pp. 951-962
    • Azzouz, M.1    Kingsman, S.M.2    Mazarakis, N.D.3
  • 2
    • 36249015420 scopus 로고    scopus 로고
    • Gene delivery by lentivirus vectors
    • Cockrell A.S., and Kafri T. Gene delivery by lentivirus vectors. Mol. Biotechnol. 36 (2007) 184-204
    • (2007) Mol. Biotechnol. , vol.36 , pp. 184-204
    • Cockrell, A.S.1    Kafri, T.2
  • 3
    • 0036968555 scopus 로고    scopus 로고
    • Lentiviral vectors for gene delivery into cells
    • Quinonez R., and Sutton R.E. Lentiviral vectors for gene delivery into cells. DNA Cell Biol. 21 (2002) 937-951
    • (2002) DNA Cell Biol. , vol.21 , pp. 937-951
    • Quinonez, R.1    Sutton, R.E.2
  • 4
    • 0036201352 scopus 로고    scopus 로고
    • Lentiviral vectors for the gene therapy of lympho-hematological disorders
    • Salmon P., and Trono D. Lentiviral vectors for the gene therapy of lympho-hematological disorders. Curr. Top. Microbiol. Immunol. 261 (2002) 211-227
    • (2002) Curr. Top. Microbiol. Immunol. , vol.261 , pp. 211-227
    • Salmon, P.1    Trono, D.2
  • 5
    • 68949202566 scopus 로고    scopus 로고
    • Transient transfection methods for clinical adeno-associated viral vector production
    • Wright J.F. Transient transfection methods for clinical adeno-associated viral vector production. Hum Gene Ther. 20 (2009) 1-9
    • (2009) Hum Gene Ther. , vol.20 , pp. 1-9
    • Wright, J.F.1
  • 7
    • 34547635063 scopus 로고    scopus 로고
    • HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications
    • Wang G.P., Ciuffi A., Leipzig J., Berry C.C., and Bushman F.D. HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications. Genome Res. 17 (2007) 1186-1194
    • (2007) Genome Res. , vol.17 , pp. 1186-1194
    • Wang, G.P.1    Ciuffi, A.2    Leipzig, J.3    Berry, C.C.4    Bushman, F.D.5
  • 8
    • 0037162715 scopus 로고    scopus 로고
    • HIV-1 integration in the human genome favors active genes and local hotspots
    • Schröder A.R.W., Shinn P., Chen H., Berry C., Ecker J.R., and Bushman F. HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110 (2002) 521-529
    • (2002) Cell , vol.110 , pp. 521-529
    • Schröder, A.R.W.1    Shinn, P.2    Chen, H.3    Berry, C.4    Ecker, J.R.5    Bushman, F.6
  • 9
    • 0033618547 scopus 로고    scopus 로고
    • Lentiviral vectors-the promise of gene therapy within reach?
    • Amado R.G., and Chen I.S. Lentiviral vectors-the promise of gene therapy within reach?. Science 285 (1999) 674-676
    • (1999) Science , vol.285 , pp. 674-676
    • Amado, R.G.1    Chen, I.S.2
  • 10
    • 0034278156 scopus 로고    scopus 로고
    • Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy
    • Vigna E., and Naldini L. Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy. J. Gene Med. 2 (2000) 308-316
    • (2000) J. Gene Med. , vol.2 , pp. 308-316
    • Vigna, E.1    Naldini, L.2
  • 11
    • 33645888418 scopus 로고    scopus 로고
    • Downstream processing of oncoretroviral and lentiviral gene therapy vectors
    • Segura M.M., Kamen A., and Garnier A. Downstream processing of oncoretroviral and lentiviral gene therapy vectors. Biotechnol. Adv. 24 (2006) 321-337
    • (2006) Biotechnol. Adv. , vol.24 , pp. 321-337
    • Segura, M.M.1    Kamen, A.2    Garnier, A.3
  • 13
    • 0035261902 scopus 로고    scopus 로고
    • Kinetic analyses of stability of simple and complex retroviral vectors
    • Higashikawa F., and Chang L.-J. Kinetic analyses of stability of simple and complex retroviral vectors. Virology 280 (2001) 124-131
    • (2001) Virology , vol.280 , pp. 124-131
    • Higashikawa, F.1    Chang, L.-J.2
  • 14
    • 0032795497 scopus 로고    scopus 로고
    • Mass determination of Rous Sarcoma Virus virions by scanning transmission electron microscopy
    • Vogt V.M., and Simon M.N. Mass determination of Rous Sarcoma Virus virions by scanning transmission electron microscopy. J. Virol. 73 (1999) 7050-7055
    • (1999) J. Virol. , vol.73 , pp. 7050-7055
    • Vogt, V.M.1    Simon, M.N.2
  • 17
    • 40649101956 scopus 로고    scopus 로고
    • Overview of the HIV-1 lentiviral vector system
    • 16. 21. 1-16. 21.15
    • Ramezani A., and Hawley R.G. Overview of the HIV-1 lentiviral vector system. Curr. Protoc. Mol. Biol. Suppl. 60 (2002) 16. 21. 1-16. 21.15
    • (2002) Curr. Protoc. Mol. Biol. Suppl. , vol.60
    • Ramezani, A.1    Hawley, R.G.2
  • 19
    • 33846160971 scopus 로고    scopus 로고
    • Lentiviral vectors ready for prime-time
    • Kohn D.B. Lentiviral vectors ready for prime-time. Nat. Biotech. 25 (2007) 65-66
    • (2007) Nat. Biotech. , vol.25 , pp. 65-66
    • Kohn, D.B.1
  • 21
    • 0036113626 scopus 로고    scopus 로고
    • Targeted transduction patterns in the mouse brain by lentivirus vectors pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV envelope proteins
    • Watson D.J., Kobinger G.P., Passini M.A., Wilson J.M., and Wolfe J.H. Targeted transduction patterns in the mouse brain by lentivirus vectors pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV envelope proteins. Mol. Ther. 5 (2002) 528-537
    • (2002) Mol. Ther. , vol.5 , pp. 528-537
    • Watson, D.J.1    Kobinger, G.P.2    Passini, M.A.3    Wilson, J.M.4    Wolfe, J.H.5
  • 22
    • 32944473438 scopus 로고    scopus 로고
    • Lentiviral vectors for use in the central nervous system
    • Jakobsson J., and Lundberg C. Lentiviral vectors for use in the central nervous system. Mol. Ther. 13 (2006) 484-493
    • (2006) Mol. Ther. , vol.13 , pp. 484-493
    • Jakobsson, J.1    Lundberg, C.2
  • 24
    • 34249111217 scopus 로고    scopus 로고
    • Lentiviral vectors for cancer immunotherapy: transforming infectious particles into therapeutics
    • Breckpot K., Aerts J.L., and Thielemans K. Lentiviral vectors for cancer immunotherapy: transforming infectious particles into therapeutics. Gene Ther. 14 (2007) 847-862
    • (2007) Gene Ther. , vol.14 , pp. 847-862
    • Breckpot, K.1    Aerts, J.L.2    Thielemans, K.3
  • 25
    • 33645229133 scopus 로고    scopus 로고
    • An effective cancer vaccine modality: lentiviral modification of dendritic cells expressing multiple cancer-specific antigens
    • Wang B., He J., Liu C., and Chang L.-J. An effective cancer vaccine modality: lentiviral modification of dendritic cells expressing multiple cancer-specific antigens. Vaccine 24 (2006) 3477-3489
    • (2006) Vaccine , vol.24 , pp. 3477-3489
    • Wang, B.1    He, J.2    Liu, C.3    Chang, L.-J.4
  • 29
    • 0035513970 scopus 로고    scopus 로고
    • A phase I open label clinical trial of the safety and tolerability of single escalating doses of autologous CD4 T cells transduced with VRX496 in HIV-positive subjects
    • MacGregor R.R. A phase I open label clinical trial of the safety and tolerability of single escalating doses of autologous CD4 T cells transduced with VRX496 in HIV-positive subjects. Hum. Gene Ther. 12 (2001) 2028-2029
    • (2001) Hum. Gene Ther. , vol.12 , pp. 2028-2029
    • MacGregor, R.R.1
  • 30
    • 33846430437 scopus 로고    scopus 로고
    • Large-scale purification of a lentiviral vector by size exclusion chromatography or Mustang Q ion exchange capsule
    • Slepushkin V., Chang N., and Cohen R. Large-scale purification of a lentiviral vector by size exclusion chromatography or Mustang Q ion exchange capsule. Bioprocess J. 2 (2003) 89-95
    • (2003) Bioprocess J. , vol.2 , pp. 89-95
    • Slepushkin, V.1    Chang, N.2    Cohen, R.3
  • 33
    • 33847205752 scopus 로고    scopus 로고
    • The genetic engineering of hematopoietic stem cells: the rise of lentiviral vectors, the conundrum of the LTR, and the promise of lineage-restricted vectors
    • Chang A.H., and Sadelain M. The genetic engineering of hematopoietic stem cells: the rise of lentiviral vectors, the conundrum of the LTR, and the promise of lineage-restricted vectors. Mol. Ther. 15 (2007) 445-456
    • (2007) Mol. Ther. , vol.15 , pp. 445-456
    • Chang, A.H.1    Sadelain, M.2
  • 34
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L., Blomer U., Gallay P., Ory D., Mulligan R., Gage F.H., Verma I.M., and Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272 (1996) 263-267
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3    Ory, D.4    Mulligan, R.5    Gage, F.H.6    Verma, I.M.7    Trono, D.8
  • 35
    • 0029993858 scopus 로고    scopus 로고
    • Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
    • Naldini L., Blomer U., Gage F.H., Trono D., and Verma I.M. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 11382-11388
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 11382-11388
    • Naldini, L.1    Blomer, U.2    Gage, F.H.3    Trono, D.4    Verma, I.M.5
  • 36
  • 40
    • 0346242699 scopus 로고    scopus 로고
    • Certification assays for HIV-1-based vectors: frequent passage of gag sequences without evidence of replication-competent viruses
    • Sastry L., Xu Y., Johnson T., Desai K., Rissing D., Marsh J., and Cornetta K. Certification assays for HIV-1-based vectors: frequent passage of gag sequences without evidence of replication-competent viruses. Mol. Ther. 8 (2003) 830-839
    • (2003) Mol. Ther. , vol.8 , pp. 830-839
    • Sastry, L.1    Xu, Y.2    Johnson, T.3    Desai, K.4    Rissing, D.5    Marsh, J.6    Cornetta, K.7
  • 42
    • 0041854294 scopus 로고    scopus 로고
    • Development of a sensitive assay for detection of replication-competent recombinant lentivirus in large-scale HIV-based vector preparations
    • Escarpe P., Zayek N., Chin P., Borellini F., Zufferey R., Veres G., and Kiermer V. Development of a sensitive assay for detection of replication-competent recombinant lentivirus in large-scale HIV-based vector preparations. Mol. Ther. 8 (2003) 332-341
    • (2003) Mol. Ther. , vol.8 , pp. 332-341
    • Escarpe, P.1    Zayek, N.2    Chin, P.3    Borellini, F.4    Zufferey, R.5    Veres, G.6    Kiermer, V.7
  • 43
    • 22744455256 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors-design, biosafety, and production
    • Sinn P.L., Sauter S.L., and McCray P.B. Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors-design, biosafety, and production. Gene Ther. 12 (2005) 1089-1098
    • (2005) Gene Ther. , vol.12 , pp. 1089-1098
    • Sinn, P.L.1    Sauter, S.L.2    McCray, P.B.3
  • 44
    • 63949087408 scopus 로고    scopus 로고
    • Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken [beta]-globin locus HS4 insulator element
    • Hanawa H., Yamamoto M., Zhao H., Shimada T., and Persons D.A. Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken [beta]-globin locus HS4 insulator element. Mol. Ther. 17 (2009) 667-674
    • (2009) Mol. Ther. , vol.17 , pp. 667-674
    • Hanawa, H.1    Yamamoto, M.2    Zhao, H.3    Shimada, T.4    Persons, D.A.5
  • 45
    • 61949341072 scopus 로고    scopus 로고
    • Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants
    • Nielsen T., Jakobsson J., Rosenqvist N., and Lundberg C. Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants. BMC Biotechnol. 9 (2009) 13
    • (2009) BMC Biotechnol. , vol.9 , pp. 13
    • Nielsen, T.1    Jakobsson, J.2    Rosenqvist, N.3    Lundberg, C.4
  • 46
    • 0036467996 scopus 로고    scopus 로고
    • Insulators: many functions, many mechanisms
    • West A.G., Gaszner M., and Felsenfeld G. Insulators: many functions, many mechanisms. Genes Dev. 16 (2002) 271-288
    • (2002) Genes Dev. , vol.16 , pp. 271-288
    • West, A.G.1    Gaszner, M.2    Felsenfeld, G.3
  • 48
    • 0032796643 scopus 로고    scopus 로고
    • Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells
    • Bukovsky A.A., Song J.P., and Naldini L. Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells. J. Virol. 73 (1999) 7087-7092
    • (1999) J. Virol. , vol.73 , pp. 7087-7092
    • Bukovsky, A.A.1    Song, J.P.2    Naldini, L.3
  • 49
    • 0035088135 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at Low pH no longer require Nef for optimal infectivity
    • Chazal N., Singer G., Aiken C., Hammarskjold M.-L., and Rekosh D. Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at Low pH no longer require Nef for optimal infectivity. J. Virol. 75 (2001) 4014-4018
    • (2001) J. Virol. , vol.75 , pp. 4014-4018
    • Chazal, N.1    Singer, G.2    Aiken, C.3    Hammarskjold, M.-L.4    Rekosh, D.5
  • 50
    • 0030835321 scopus 로고    scopus 로고
    • Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A
    • Aiken C. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A. J. Virol. 71 (1997) 5871-5877
    • (1997) J. Virol. , vol.71 , pp. 5871-5877
    • Aiken, C.1
  • 51
    • 0032520144 scopus 로고    scopus 로고
    • Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: implications for HIV-based gene transfer systems
    • Luo T., Douglas J.L., Livingston R.L., and Garcia J.V. Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: implications for HIV-based gene transfer systems. Virology 241 (1998) 224-233
    • (1998) Virology , vol.241 , pp. 224-233
    • Luo, T.1    Douglas, J.L.2    Livingston, R.L.3    Garcia, J.V.4
  • 52
    • 0023954154 scopus 로고
    • Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism
    • McClure M.O., Marsh M., and Weiss R.A. Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism. EMBO J. 7 (1988) 513-518
    • (1988) EMBO J. , vol.7 , pp. 513-518
    • McClure, M.O.1    Marsh, M.2    Weiss, R.A.3
  • 53
    • 0029872245 scopus 로고    scopus 로고
    • High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein G
    • Akkina R.K., Walton R.M., Chen M.L., Li Q.X., Planelles V., and Chen I.S. High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein G. J. Virol. 70 (1996) 2581-2585
    • (1996) J. Virol. , vol.70 , pp. 2581-2585
    • Akkina, R.K.1    Walton, R.M.2    Chen, M.L.3    Li, Q.X.4    Planelles, V.5    Chen, I.S.6
  • 54
    • 4644294989 scopus 로고    scopus 로고
    • Phosphatidylserine is not the cell surface receptor for vesicular stomatitis virus
    • Coil D.A., and Miller A.D. Phosphatidylserine is not the cell surface receptor for vesicular stomatitis virus. J. Virol. 78 (2004) 10920-10926
    • (2004) J. Virol. , vol.78 , pp. 10920-10926
    • Coil, D.A.1    Miller, A.D.2
  • 57
    • 4444226558 scopus 로고    scopus 로고
    • Surface-engineering of lentiviral vectors
    • Verhoeyen E., and Cosset F.-L. Surface-engineering of lentiviral vectors. J. Gene Med. 6 (2004) S83-S94
    • (2004) J. Gene Med. , vol.6
    • Verhoeyen, E.1    Cosset, F.-L.2
  • 58
    • 22944458202 scopus 로고    scopus 로고
    • Altering the tropism of lentiviral vectors through pseudotyping
    • Cronin J., Zhang X.Y., and Reiser J. Altering the tropism of lentiviral vectors through pseudotyping. Curr. Gene Ther. 5 (2005) 387-398
    • (2005) Curr. Gene Ther. , vol.5 , pp. 387-398
    • Cronin, J.1    Zhang, X.Y.2    Reiser, J.3
  • 59
    • 58149380748 scopus 로고    scopus 로고
    • Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteins
    • Frecha C., Costa C., Negre D., Gauthier E., Russell S.J., Cosset F.-L., and Verhoeyen E. Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteins. Blood 112 (2008) 4843-4852
    • (2008) Blood , vol.112 , pp. 4843-4852
    • Frecha, C.1    Costa, C.2    Negre, D.3    Gauthier, E.4    Russell, S.J.5    Cosset, F.-L.6    Verhoeyen, E.7
  • 64
    • 0033566372 scopus 로고    scopus 로고
    • Self-inactivating lentiviral vectors with U3 and U5 modifications
    • Iwakuma T., Cui Y., and Chang L.J. Self-inactivating lentiviral vectors with U3 and U5 modifications. Virology 261 (1999) 120-132
    • (1999) Virology , vol.261 , pp. 120-132
    • Iwakuma, T.1    Cui, Y.2    Chang, L.J.3
  • 65
    • 0032978712 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
    • Zufferey R., Donello J.E., Trono D., and Hope T.J. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J. Virol. 73 (1999) 2886-2892
    • (1999) J. Virol. , vol.73 , pp. 2886-2892
    • Zufferey, R.1    Donello, J.E.2    Trono, D.3    Hope, T.J.4
  • 68
    • 0034672356 scopus 로고    scopus 로고
    • The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells
    • Sirven A., Pflumio F., Zennou V., Titeux M., Vainchenker W., Coulombel L., Dubart-Kupperschmitt A., and Charneau P. The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells. Blood 96 (2000) 4103-4110
    • (2000) Blood , vol.96 , pp. 4103-4110
    • Sirven, A.1    Pflumio, F.2    Zennou, V.3    Titeux, M.4    Vainchenker, W.5    Coulombel, L.6    Dubart-Kupperschmitt, A.7    Charneau, P.8
  • 69
    • 0034040751 scopus 로고    scopus 로고
    • Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences
    • Follenzi A., Ailles L.E., Bakovic S., Geuna M., and Naldini L. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat. Genet. 25 (2000) 217-222
    • (2000) Nat. Genet. , vol.25 , pp. 217-222
    • Follenzi, A.1    Ailles, L.E.2    Bakovic, S.3    Geuna, M.4    Naldini, L.5
  • 73
    • 42049091745 scopus 로고    scopus 로고
    • From retroviral vector production to gene transfer: spontaneous inactivation is caused by loss of reverse transcription capacity
    • Carmo M., Panet A., Carrondo M.J.T., Alves P.M., and Cruz P.E. From retroviral vector production to gene transfer: spontaneous inactivation is caused by loss of reverse transcription capacity. J. Gene Med. 10 (2008) 383-391
    • (2008) J. Gene Med. , vol.10 , pp. 383-391
    • Carmo, M.1    Panet, A.2    Carrondo, M.J.T.3    Alves, P.M.4    Cruz, P.E.5
  • 74
    • 5444246755 scopus 로고    scopus 로고
    • Transient production of retroviral- and lentiviral-based vectors for the transduction of Mammalian cells
    • Tonini T., Claudio P.P., Giordano A., and Romano G. Transient production of retroviral- and lentiviral-based vectors for the transduction of Mammalian cells. Methods Mol. Biol. 285 (2004) 141-148
    • (2004) Methods Mol. Biol. , vol.285 , pp. 141-148
    • Tonini, T.1    Claudio, P.P.2    Giordano, A.3    Romano, G.4
  • 75
    • 0036713630 scopus 로고    scopus 로고
    • Titering lentiviral vectors: comparison of DNA, RNA and marker expression methods
    • Sastry L., Johnson T., Hobson M.J., Smucker B., and Cornetta K. Titering lentiviral vectors: comparison of DNA, RNA and marker expression methods. Gene Ther. 9 (2002) 1155-1162
    • (2002) Gene Ther. , vol.9 , pp. 1155-1162
    • Sastry, L.1    Johnson, T.2    Hobson, M.J.3    Smucker, B.4    Cornetta, K.5
  • 76
    • 0026448387 scopus 로고
    • A new method for measuring reverse transcriptase activity by ELISA
    • Eberle J., and Seibl R. A new method for measuring reverse transcriptase activity by ELISA. J. Virol. Methods 40 (1992) 347-356
    • (1992) J. Virol. Methods , vol.40 , pp. 347-356
    • Eberle, J.1    Seibl, R.2
  • 78
    • 46749136445 scopus 로고    scopus 로고
    • Optimized lentiviral transduction of mouse bone marrow-derived mesenchymal stem cells
    • Ricks D.M., Kutner R., Zhang X.-Y., Welsh D.A., and Reiser J. Optimized lentiviral transduction of mouse bone marrow-derived mesenchymal stem cells. Stem Cells Dev. 17 (2008) 441-450
    • (2008) Stem Cells Dev. , vol.17 , pp. 441-450
    • Ricks, D.M.1    Kutner, R.2    Zhang, X.-Y.3    Welsh, D.A.4    Reiser, J.5
  • 79
    • 27644457706 scopus 로고    scopus 로고
    • Upscaling of lentiviral vector production by tangential flow filtration
    • Geraerts M., Michiels M., Baekelandt V., Debyser Z., and Gijsbers R. Upscaling of lentiviral vector production by tangential flow filtration. J. Gene Med. 7 (2005) 1299-1310
    • (2005) J. Gene Med. , vol.7 , pp. 1299-1310
    • Geraerts, M.1    Michiels, M.2    Baekelandt, V.3    Debyser, Z.4    Gijsbers, R.5
  • 80
    • 0036145392 scopus 로고    scopus 로고
    • Oncoretrovirus and lentivirus vectors pseudotyped with lymphocytic choriomeningitis virus glycoprote: generation, concentration, and broad host range
    • Beyer W.R., Westphal M., Ostertag W., and von Laer D. Oncoretrovirus and lentivirus vectors pseudotyped with lymphocytic choriomeningitis virus glycoprote: generation, concentration, and broad host range. J. Virol. 76 (2002) 1488-1495
    • (2002) J. Virol. , vol.76 , pp. 1488-1495
    • Beyer, W.R.1    Westphal, M.2    Ostertag, W.3    von Laer, D.4
  • 82
    • 28444441522 scopus 로고    scopus 로고
    • Detailed design and comparative analysis of protocols for optimized production of high-performance HIV-1-derived lentiviral particles
    • Mitta B., Rimann M., and Fussenegger M. Detailed design and comparative analysis of protocols for optimized production of high-performance HIV-1-derived lentiviral particles. Metab. Eng. 7 (2005) 426-436
    • (2005) Metab. Eng. , vol.7 , pp. 426-436
    • Mitta, B.1    Rimann, M.2    Fussenegger, M.3
  • 83
    • 0033046030 scopus 로고    scopus 로고
    • Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system
    • Chang L., Urlacher V., Iwakuma T., Cui Y., and Zucali J. Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system. Gene Ther. 6 (1999) 715-728
    • (1999) Gene Ther. , vol.6 , pp. 715-728
    • Chang, L.1    Urlacher, V.2    Iwakuma, T.3    Cui, Y.4    Zucali, J.5
  • 84
    • 34447563815 scopus 로고    scopus 로고
    • Quantitative polymerase chain reaction as a reliable method to determine functional lentiviral titer after ex vivo gene transfer in human mesenchymal stem cells
    • Böcker W., Rossmann O., Docheva D., Malterer G., Mutschler W., and Schieker M. Quantitative polymerase chain reaction as a reliable method to determine functional lentiviral titer after ex vivo gene transfer in human mesenchymal stem cells. J. Gene Med. 9 (2007) 585-595
    • (2007) J. Gene Med. , vol.9 , pp. 585-595
    • Böcker, W.1    Rossmann, O.2    Docheva, D.3    Malterer, G.4    Mutschler, W.5    Schieker, M.6
  • 85
    • 16344370550 scopus 로고    scopus 로고
    • The significance of controlled conditions in lentiviral vector titration and in the use of multiplicity of infection (MOI) for predicting gene transfer events
    • Zhang B., Metharom P., Jullie H., Ellem K., Cleghorn G., West M., and Wei M. The significance of controlled conditions in lentiviral vector titration and in the use of multiplicity of infection (MOI) for predicting gene transfer events. Genet. Vaccines Ther. 2 (2004) 6
    • (2004) Genet. Vaccines Ther. , vol.2 , pp. 6
    • Zhang, B.1    Metharom, P.2    Jullie, H.3    Ellem, K.4    Cleghorn, G.5    West, M.6    Wei, M.7
  • 86
    • 64749107970 scopus 로고    scopus 로고
    • Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors
    • Kutner R.H., Zhang X.-Y., and Reiser J. Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors. Nat. Protoc. 4 (2009) 495-505
    • (2009) Nat. Protoc. , vol.4 , pp. 495-505
    • Kutner, R.H.1    Zhang, X.-Y.2    Reiser, J.3
  • 87
    • 4344634285 scopus 로고    scopus 로고
    • HIV-1 gene expression: lessons from provirus and non-integrated DNA
    • Wu Y. HIV-1 gene expression: lessons from provirus and non-integrated DNA. Retrovirology 1 (2004) 13
    • (2004) Retrovirology , vol.1 , pp. 13
    • Wu, Y.1
  • 89
    • 0037384693 scopus 로고    scopus 로고
    • Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction
    • Van Maele B., De Rijck J., De Clercq E., and Debyser Z. Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction. J. Virol. 77 (2003) 4685-4694
    • (2003) J. Virol. , vol.77 , pp. 4685-4694
    • Van Maele, B.1    De Rijck, J.2    De Clercq, E.3    Debyser, Z.4
  • 90
    • 0035025888 scopus 로고    scopus 로고
    • A quantitative assay for HIV DNA integration in vivo
    • Butler S.L., Hansen M.S.T., and Bushman F.D. A quantitative assay for HIV DNA integration in vivo. Nat. Med. 7 (2001) 631-634
    • (2001) Nat. Med. , vol.7 , pp. 631-634
    • Butler, S.L.1    Hansen, M.S.T.2    Bushman, F.D.3
  • 91
    • 0029843990 scopus 로고    scopus 로고
    • Proteoglycans secreted by packaging cell lines inhibit retrovirus infection
    • Le Doux J.M., Morgan J.R., Snow R.G., and Yarmush M.L. Proteoglycans secreted by packaging cell lines inhibit retrovirus infection. J. Virol. 70 (1996) 6468-6473
    • (1996) J. Virol. , vol.70 , pp. 6468-6473
    • Le Doux, J.M.1    Morgan, J.R.2    Snow, R.G.3    Yarmush, M.L.4
  • 92
    • 27544437703 scopus 로고    scopus 로고
    • Real-time quantitative PCR for the design of lentiviral vector analytical assays
    • C. Delenda, C. Gaillard, Real-time quantitative PCR for the design of lentiviral vector analytical assays, Gene Ther (2005) (12) S36-S50.
    • (2005) Gene Ther , vol.12
    • Delenda, C.1    Gaillard, C.2
  • 93
    • 0036634929 scopus 로고    scopus 로고
    • Development and characterization of a minimal inducible packaging cell line for simian immunodeficiency virus-based lentiviral vectors
    • Kuate S., Wagner R., and Überla K. Development and characterization of a minimal inducible packaging cell line for simian immunodeficiency virus-based lentiviral vectors. J. Gene Med. 4 (2002) 347-355
    • (2002) J. Gene Med. , vol.4 , pp. 347-355
    • Kuate, S.1    Wagner, R.2    Überla, K.3
  • 94
    • 0347003599 scopus 로고    scopus 로고
    • Transduction of bone-marrow-derived mesenchymal stem cells by using lentivirus vectors pseudotyped with modified RD114 envelope glycoproteins
    • Zhang X.-Y., La Russa V.F., and Reiser J. Transduction of bone-marrow-derived mesenchymal stem cells by using lentivirus vectors pseudotyped with modified RD114 envelope glycoproteins. J. Virol. 78 (2004) 1219-1229
    • (2004) J. Virol. , vol.78 , pp. 1219-1229
    • Zhang, X.-Y.1    La Russa, V.F.2    Reiser, J.3
  • 95
    • 2942705682 scopus 로고    scopus 로고
    • Green fluorescent protein: green cells do not always indicate gene expression
    • Nash K.L., and Lever A.M.L. Green fluorescent protein: green cells do not always indicate gene expression. Gene Ther. 11 (2004) 882-883
    • (2004) Gene Ther. , vol.11 , pp. 882-883
    • Nash, K.L.1    Lever, A.M.L.2
  • 97
    • 0029931982 scopus 로고    scopus 로고
    • Pseudotransduction of hepatocytes by using concentrated pseudotyped vesicular stomatitis virus G glycoprotein (VSV-G)-Moloney murine leukemia virus-derived retrovirus vectors: comparison of VSV-G and amphotropic vectors for hepatic gene transfer
    • Liu M.L., Winther B.L., and Kay M.A. Pseudotransduction of hepatocytes by using concentrated pseudotyped vesicular stomatitis virus G glycoprotein (VSV-G)-Moloney murine leukemia virus-derived retrovirus vectors: comparison of VSV-G and amphotropic vectors for hepatic gene transfer. J. Virol. 70 (1996) 2497-2502
    • (1996) J. Virol. , vol.70 , pp. 2497-2502
    • Liu, M.L.1    Winther, B.L.2    Kay, M.A.3
  • 99
    • 0034244658 scopus 로고    scopus 로고
    • A stable system for the high-titer production of multiply attenuated lentiviral vectors
    • Klages N., Zufferey R., and Trono D. A stable system for the high-titer production of multiply attenuated lentiviral vectors. Mol. Ther. 2 (2000) 170-176
    • (2000) Mol. Ther. , vol.2 , pp. 170-176
    • Klages, N.1    Zufferey, R.2    Trono, D.3
  • 101
    • 72449162211 scopus 로고    scopus 로고
    • Development of a scalable process for high-yield lentiviral vector production by transient transfection of HEK293 suspension cultures
    • Ansorge S., Lanthier S., Transfiguracion J., Durocher Y., Henry O., and Kamen A. Development of a scalable process for high-yield lentiviral vector production by transient transfection of HEK293 suspension cultures. J. Gene Med. 11 (2009) 868-876
    • (2009) J. Gene Med. , vol.11 , pp. 868-876
    • Ansorge, S.1    Lanthier, S.2    Transfiguracion, J.3    Durocher, Y.4    Henry, O.5    Kamen, A.6
  • 102
    • 33845935849 scopus 로고    scopus 로고
    • Large-scale transfection of mammalian cells for the fast production of recombinant protein
    • Pham P.L., Kamen A., and Durocher Y. Large-scale transfection of mammalian cells for the fast production of recombinant protein. Mol. Biotechnol. 34 (2006) 225-237
    • (2006) Mol. Biotechnol. , vol.34 , pp. 225-237
    • Pham, P.L.1    Kamen, A.2    Durocher, Y.3
  • 104
    • 0033039916 scopus 로고    scopus 로고
    • Large-scale transient expression in mammalian cells for recombinant protein production
    • Wurm F., and Bernard A. Large-scale transient expression in mammalian cells for recombinant protein production. Curr. Opin. Biotechnol. 10 (1999) 156-159
    • (1999) Curr. Opin. Biotechnol. , vol.10 , pp. 156-159
    • Wurm, F.1    Bernard, A.2
  • 106
    • 0037082158 scopus 로고    scopus 로고
    • High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells
    • Durocher Y., Perret S., and Kamen A. High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells. Nucleic Acids Res. 30 (2002) E9
    • (2002) Nucleic Acids Res. , vol.30
    • Durocher, Y.1    Perret, S.2    Kamen, A.3
  • 107
    • 26444612689 scopus 로고    scopus 로고
    • Large-scale transient transfection of mammalian cells: a newly emerging attractive option for recombinant protein production
    • Geisse S., and Henke M. Large-scale transient transfection of mammalian cells: a newly emerging attractive option for recombinant protein production. J. Struct. Funct. Genomics 6 (2005) 165-170
    • (2005) J. Struct. Funct. Genomics , vol.6 , pp. 165-170
    • Geisse, S.1    Henke, M.2
  • 108
    • 33646543920 scopus 로고    scopus 로고
    • Scalable production of adeno-associated virus type 2 vectors via suspension transfection
    • Park J.Y., Lim B.P., Lee K., Kim Y.G., and Jo E.C. Scalable production of adeno-associated virus type 2 vectors via suspension transfection. Biotechnol. Bioeng. 94 (2006) 416-430
    • (2006) Biotechnol. Bioeng. , vol.94 , pp. 416-430
    • Park, J.Y.1    Lim, B.P.2    Lee, K.3    Kim, Y.G.4    Jo, E.C.5
  • 109
    • 34848876973 scopus 로고    scopus 로고
    • High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells
    • Hildinger M., Baldi L., Stettler M., and Wurm F. High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells. Biotechnol. Lett. (2007)
    • (2007) Biotechnol. Lett.
    • Hildinger, M.1    Baldi, L.2    Stettler, M.3    Wurm, F.4
  • 110
    • 2342446492 scopus 로고    scopus 로고
    • Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer
    • Blesch A. Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer. Methods 33 (2004) 164-172
    • (2004) Methods , vol.33 , pp. 164-172
    • Blesch, A.1
  • 111
    • 33845935849 scopus 로고    scopus 로고
    • Large-scale transfection of mammalian cells for the fast production of recombinant protein
    • Pham P., Kamen A., and Durocher Y. Large-scale transfection of mammalian cells for the fast production of recombinant protein. Mol. Biotechnol. 34 (2006) 225-237
    • (2006) Mol. Biotechnol. , vol.34 , pp. 225-237
    • Pham, P.1    Kamen, A.2    Durocher, Y.3
  • 112
    • 0035858332 scopus 로고    scopus 로고
    • Recent progress in gene delivery using non-viral transfer complexes
    • Godbey W.T., and Mikos A.G. Recent progress in gene delivery using non-viral transfer complexes. J. Control. Release 72 (2001) 115-125
    • (2001) J. Control. Release , vol.72 , pp. 115-125
    • Godbey, W.T.1    Mikos, A.G.2
  • 113
    • 0037437033 scopus 로고    scopus 로고
    • Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine
    • Kunath K., von Harpe A., Fischer D., Petersen H., Bickel U., Voigt K., and Kissel T. Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. J. Control. Release 89 (2003) 113-125
    • (2003) J. Control. Release , vol.89 , pp. 113-125
    • Kunath, K.1    von Harpe, A.2    Fischer, D.3    Petersen, H.4    Bickel, U.5    Voigt, K.6    Kissel, T.7
  • 114
    • 33745259524 scopus 로고    scopus 로고
    • Enhancement of transient gene expression by fed-batch culture of HEK 293 EBNA1 cells in suspension
    • Sun X., Goh P.E., Wong K.T., Mori T., and Yap M.G. Enhancement of transient gene expression by fed-batch culture of HEK 293 EBNA1 cells in suspension. Biotechnol. Lett. 28 (2006) 843
    • (2006) Biotechnol. Lett. , vol.28 , pp. 843
    • Sun, X.1    Goh, P.E.2    Wong, K.T.3    Mori, T.4    Yap, M.G.5
  • 115
    • 67649531628 scopus 로고    scopus 로고
    • Polyethylenimine-based transfection method as a simple and effective way to produce recombinant lentiviral vectors
    • Toledo J.R., Prieto Y., Oramas N., and Sanchez O. Polyethylenimine-based transfection method as a simple and effective way to produce recombinant lentiviral vectors. Appl. Biochem. Biotechnol. 157 (2009) 538-544
    • (2009) Appl. Biochem. Biotechnol. , vol.157 , pp. 538-544
    • Toledo, J.R.1    Prieto, Y.2    Oramas, N.3    Sanchez, O.4
  • 116
    • 0029993519 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control
    • Bartz S.R., Rogel M.E., and Emerman M. Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control. J. Virol 70 (1996) 2324-2331
    • (1996) J. Virol , vol.70 , pp. 2324-2331
    • Bartz, S.R.1    Rogel, M.E.2    Emerman, M.3
  • 117
    • 0036370361 scopus 로고    scopus 로고
    • Generation of HIV-1 derived lentiviral vectors
    • Follenzi A., and Naldini L. Generation of HIV-1 derived lentiviral vectors. Methods Enzymol. 346 (2002) 454-465
    • (2002) Methods Enzymol. , vol.346 , pp. 454-465
    • Follenzi, A.1    Naldini, L.2
  • 119
    • 60849119249 scopus 로고    scopus 로고
    • Advantages of COS-1 monkey kidney epithelial cells as packaging host for small-volume production of high-quality recombinant lentiviruses
    • Smith S.L., and Shioda T. Advantages of COS-1 monkey kidney epithelial cells as packaging host for small-volume production of high-quality recombinant lentiviruses. J. Virol. Methods 157 (2009) 47-54
    • (2009) J. Virol. Methods , vol.157 , pp. 47-54
    • Smith, S.L.1    Shioda, T.2
  • 120
    • 2642647059 scopus 로고    scopus 로고
    • Serum-free production of recombinant proteins and adenoviral vectors by 293SF-3F6 cells
    • Côté J., Garnier A., Massie B., and Kamen A. Serum-free production of recombinant proteins and adenoviral vectors by 293SF-3F6 cells. Biotechnol. Bioeng. 59 (1998) 567-575
    • (1998) Biotechnol. Bioeng. , vol.59 , pp. 567-575
    • Côté, J.1    Garnier, A.2    Massie, B.3    Kamen, A.4
  • 121
    • 0028696562 scopus 로고
    • Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells
    • Garnier A., Cote J., Nadeau I., Kamen A., and Massie B. Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells. Cytotechnology 15 (1994) 145-155
    • (1994) Cytotechnology , vol.15 , pp. 145-155
    • Garnier, A.1    Cote, J.2    Nadeau, I.3    Kamen, A.4    Massie, B.5
  • 122
    • 0034083194 scopus 로고    scopus 로고
    • Production and concentration of pseudotyped HIV-1-based gene transfer vectors
    • Reiser J. Production and concentration of pseudotyped HIV-1-based gene transfer vectors. Gene Ther. 7 (2000) 910-913
    • (2000) Gene Ther. , vol.7 , pp. 910-913
    • Reiser, J.1
  • 123
    • 61849181323 scopus 로고    scopus 로고
    • Simplified lentivirus vector production in protein-free media using polyethylenimine-mediated transfection
    • Kuroda H., Kutner R.H., Bazan N.G., and Reiser J. Simplified lentivirus vector production in protein-free media using polyethylenimine-mediated transfection. J. Virol. Methods 157 (2009) 113-121
    • (2009) J. Virol. Methods , vol.157 , pp. 113-121
    • Kuroda, H.1    Kutner, R.H.2    Bazan, N.G.3    Reiser, J.4
  • 124
    • 35648981154 scopus 로고    scopus 로고
    • Production of lentiviral vectors by large-scale transient transfection of suspension cultures and affinity chromatography purification
    • Segura M.M., Garnier A., Durocher Y., Coelho H., and Kamen A. Production of lentiviral vectors by large-scale transient transfection of suspension cultures and affinity chromatography purification. Biotechnol. Bioeng. 98 (2007) 789-799
    • (2007) Biotechnol. Bioeng. , vol.98 , pp. 789-799
    • Segura, M.M.1    Garnier, A.2    Durocher, Y.3    Coelho, H.4    Kamen, A.5
  • 125
    • 0141650595 scopus 로고    scopus 로고
    • Comparison of transfection conditions for a lentivirus vector produced in large volumes
    • Karolewski B.A., Watson D.J., Parente M.K., and Wolfe J.H. Comparison of transfection conditions for a lentivirus vector produced in large volumes. Hum. Gene Ther. 14 (2003) 1287-1296
    • (2003) Hum. Gene Ther. , vol.14 , pp. 1287-1296
    • Karolewski, B.A.1    Watson, D.J.2    Parente, M.K.3    Wolfe, J.H.4
  • 127
    • 75349107971 scopus 로고    scopus 로고
    • G. Backliwal, M. Hildinger, V. Hasija, F.M. Wurm, High density transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI, Biotechnology and Bioengineering 9999 (2007) n/a.
    • G. Backliwal, M. Hildinger, V. Hasija, F.M. Wurm, High density transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI, Biotechnology and Bioengineering 9999 (2007) n/a.
  • 128
    • 72449159695 scopus 로고    scopus 로고
    • Transient expression in HEK293-EBNA1 cells
    • Dyson M.R., and Durocher Y. (Eds), Scion Publishing Ltd., Bloxham, Oxfordshire, UK
    • Tom R., Bisson L., and Durocher Y. Transient expression in HEK293-EBNA1 cells. In: Dyson M.R., and Durocher Y. (Eds). Methods Express: Expression Systems (2007), Scion Publishing Ltd., Bloxham, Oxfordshire, UK 203-223
    • (2007) Methods Express: Expression Systems , pp. 203-223
    • Tom, R.1    Bisson, L.2    Durocher, Y.3
  • 129
    • 34447581119 scopus 로고    scopus 로고
    • Optimized production and concentration of lentiviral vectors containing large inserts
    • Al Yacoub N., Romanowska M., Haritonova N., and Foerster J. Optimized production and concentration of lentiviral vectors containing large inserts. J. Gene Med. 9 (2007) 579-584
    • (2007) J. Gene Med. , vol.9 , pp. 579-584
    • Al Yacoub, N.1    Romanowska, M.2    Haritonova, N.3    Foerster, J.4
  • 130
    • 0029080215 scopus 로고
    • The cytotoxicity of human immunodeficiency virus type 1 Rev: implications for its interaction with the nucleolar protein B23
    • Miyazaki Y., Takamatsu T., Nosaka T., Fujita S., Martin T.E., and Hatanaka M. The cytotoxicity of human immunodeficiency virus type 1 Rev: implications for its interaction with the nucleolar protein B23. Exp. Cell Res. 219 (1995) 93-101
    • (1995) Exp. Cell Res. , vol.219 , pp. 93-101
    • Miyazaki, Y.1    Takamatsu, T.2    Nosaka, T.3    Fujita, S.4    Martin, T.E.5    Hatanaka, M.6
  • 131
    • 0025828543 scopus 로고
    • Human immunodeficiency virus type 1 Gag proteins are processed in two cellular compartments
    • Kaplan A.H., and Swanstrom R. Human immunodeficiency virus type 1 Gag proteins are processed in two cellular compartments. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 4528-4532
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 4528-4532
    • Kaplan, A.H.1    Swanstrom, R.2
  • 132
    • 0034991066 scopus 로고    scopus 로고
    • Generation of a flexible cell line with regulatable, high-level expression of HIV Gag/Pol particles capable of packaging HIV-derived vectors
    • Sparacio S., Pfeiffer T., Schaal H., and Bosch V. Generation of a flexible cell line with regulatable, high-level expression of HIV Gag/Pol particles capable of packaging HIV-derived vectors. Mol. Ther. 3 (2001) 602-612
    • (2001) Mol. Ther. , vol.3 , pp. 602-612
    • Sparacio, S.1    Pfeiffer, T.2    Schaal, H.3    Bosch, V.4
  • 135
    • 33745664380 scopus 로고    scopus 로고
    • A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectors
    • Cockrell A.S., Ma H., Fu K., McCown T.J., and Kafri T. A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectors. Mol. Ther. 14 (2006) 276-284
    • (2006) Mol. Ther. , vol.14 , pp. 276-284
    • Cockrell, A.S.1    Ma, H.2    Fu, K.3    McCown, T.J.4    Kafri, T.5
  • 136
    • 0034988922 scopus 로고    scopus 로고
    • Generation of a stable cell line producing high-titer self-inactivating lentiviral vectors
    • Xu K., Ma H., McCown T.J., Verma I.M., and Kafri T. Generation of a stable cell line producing high-titer self-inactivating lentiviral vectors. Mol. Ther. 3 (2001) 97-104
    • (2001) Mol. Ther. , vol.3 , pp. 97-104
    • Xu, K.1    Ma, H.2    McCown, T.J.3    Verma, I.M.4    Kafri, T.5
  • 137
    • 0036634929 scopus 로고    scopus 로고
    • Development and characterization of a minimal inducible packaging cell line for simian immunodeficiency virus-based lentiviral vectors
    • Seraphin K., Ralf W., and Klaus U. Development and characterization of a minimal inducible packaging cell line for simian immunodeficiency virus-based lentiviral vectors. J. Gene Med. 4 (2002) 347-355
    • (2002) J. Gene Med. , vol.4 , pp. 347-355
    • Seraphin, K.1    Ralf, W.2    Klaus, U.3
  • 138
    • 0035970319 scopus 로고    scopus 로고
    • An inducible packaging cell system for safe, efficient lentiviral vector production in the absence of HIV-1 accessory proteins
    • Pacchia A.L., Adelson M.E., Kaul M., Ron Y., and Dougherty J.P. An inducible packaging cell system for safe, efficient lentiviral vector production in the absence of HIV-1 accessory proteins. Virology 282 (2001) 77-86
    • (2001) Virology , vol.282 , pp. 77-86
    • Pacchia, A.L.1    Adelson, M.E.2    Kaul, M.3    Ron, Y.4    Dougherty, J.P.5
  • 139
    • 0020025385 scopus 로고
    • Effects of sodium butyrate, a new pharmacological agent, on cells in culture
    • Kruh J. Effects of sodium butyrate, a new pharmacological agent, on cells in culture. Mol. Cell. Biochem. 42 (1981) 65-82
    • (1981) Mol. Cell. Biochem. , vol.42 , pp. 65-82
    • Kruh, J.1
  • 140
    • 0017090381 scopus 로고
    • Modification of the phenotype of murine sarcoma virus-transformed cells by sodium butyrate: effects on morphology and cytoskeletal elements
    • Altenburg B.C., Via D.P., and Steiner S.H. Modification of the phenotype of murine sarcoma virus-transformed cells by sodium butyrate: effects on morphology and cytoskeletal elements. Exp. Cell Res. 102 (1976) 223-231
    • (1976) Exp. Cell Res. , vol.102 , pp. 223-231
    • Altenburg, B.C.1    Via, D.P.2    Steiner, S.H.3
  • 141
    • 0021857602 scopus 로고
    • Regulation of Moloney murine leukemia virus replication in chronically infected cells arrested at the G0/G1 phase
    • Gloger I., Arad G., and Panet A. Regulation of Moloney murine leukemia virus replication in chronically infected cells arrested at the G0/G1 phase. J. Virol. 54 (1985) 844-850
    • (1985) J. Virol. , vol.54 , pp. 844-850
    • Gloger, I.1    Arad, G.2    Panet, A.3
  • 142
    • 0032982140 scopus 로고    scopus 로고
    • Requirements for efficient production and transduction of human immunodeficiency virus type 1-based vectors
    • Gasmi M., Glynn J., Jin M.-J., Jolly D.J., Yee J.-K., and Chen S.-T. Requirements for efficient production and transduction of human immunodeficiency virus type 1-based vectors. J. Virol. 73 (1999) 1828-1834
    • (1999) J. Virol. , vol.73 , pp. 1828-1834
    • Gasmi, M.1    Glynn, J.2    Jin, M.-J.3    Jolly, D.J.4    Yee, J.-K.5    Chen, S.-T.6
  • 143
    • 33745801803 scopus 로고    scopus 로고
    • Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors
    • Jaalouk D., Crosato M., Brodt P., and Galipeau J. Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors. Virol. J. 3 (2006) 27
    • (2006) Virol. J. , vol.3 , pp. 27
    • Jaalouk, D.1    Crosato, M.2    Brodt, P.3    Galipeau, J.4
  • 144
    • 0034083194 scopus 로고    scopus 로고
    • Production and concentration of pseudotyped HIV-1-based gene transfer vectors
    • Reiser J. Production and concentration of pseudotyped HIV-1-based gene transfer vectors. Gene. Ther. 7 (2000) 910-913
    • (2000) Gene. Ther. , vol.7 , pp. 910-913
    • Reiser, J.1
  • 145
    • 0033986340 scopus 로고    scopus 로고
    • Efficient lentiviral transduction of liver requires cell cycling in vivo
    • Park F., Ohashi K., Chiu W., Naldini L., and Kay M.A. Efficient lentiviral transduction of liver requires cell cycling in vivo. Nat. Genet. 24 (2000) 49-52
    • (2000) Nat. Genet. , vol.24 , pp. 49-52
    • Park, F.1    Ohashi, K.2    Chiu, W.3    Naldini, L.4    Kay, M.A.5
  • 146
    • 0038314400 scopus 로고    scopus 로고
    • Virus entry, assembly, budding, and membrane rafts
    • table of contents
    • Chazal N., and Gerlier D. Virus entry, assembly, budding, and membrane rafts. Microbiol. Mol. Biol. Rev. 67 (2003) 226-237 table of contents
    • (2003) Microbiol. Mol. Biol. Rev. , vol.67 , pp. 226-237
    • Chazal, N.1    Gerlier, D.2
  • 147
    • 0035923525 scopus 로고    scopus 로고
    • Plasma membrane rafts play a critical role in HIV-1 assembly and release
    • Ono A., and Freed E.O. Plasma membrane rafts play a critical role in HIV-1 assembly and release. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 13925-13930
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 13925-13930
    • Ono, A.1    Freed, E.O.2
  • 148
    • 0036239931 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4+ T cells
    • Popik W., Alce T.M., and Au W.-C. Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4+ T cells. J. Virol. 76 (2002) 4709-4722
    • (2002) J. Virol. , vol.76 , pp. 4709-4722
    • Popik, W.1    Alce, T.M.2    Au, W.-C.3
  • 150
    • 0037384986 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 assembly and lipid rafts: Pr55gag associates with membrane domains that are largely resistant to Brij98 but sensitive to Triton X-100
    • Holm K., Weclewicz K., Hewson R., and Suomalainen M. Human immunodeficiency virus type 1 assembly and lipid rafts: Pr55gag associates with membrane domains that are largely resistant to Brij98 but sensitive to Triton X-100. J. Virol. 77 (2003) 4805-4817
    • (2003) J. Virol. , vol.77 , pp. 4805-4817
    • Holm, K.1    Weclewicz, K.2    Hewson, R.3    Suomalainen, M.4
  • 151
    • 61449223487 scopus 로고    scopus 로고
    • Cholesterol supplementation during production increases the infectivity of retroviral and lentiviral vectors pseudotyped with the vesicular stomatitis virus glycoprotein (VSV-G)
    • Chen Y., Ott C.J., Townsend K., Subbaiah P., Aiyar A., and Miller W.M. Cholesterol supplementation during production increases the infectivity of retroviral and lentiviral vectors pseudotyped with the vesicular stomatitis virus glycoprotein (VSV-G). Biochem. Eng. J. 44 (2009) 199-207
    • (2009) Biochem. Eng. J. , vol.44 , pp. 199-207
    • Chen, Y.1    Ott, C.J.2    Townsend, K.3    Subbaiah, P.4    Aiyar, A.5    Miller, W.M.6
  • 153
    • 4644323951 scopus 로고    scopus 로고
    • State-of-the-art of the production of retroviral vectors
    • Merten O.W. State-of-the-art of the production of retroviral vectors. J. Gene Med. 6 (2004) S105-S124
    • (2004) J. Gene Med. , vol.6
    • Merten, O.W.1
  • 155
    • 33744474819 scopus 로고    scopus 로고
    • Effect of osmotic pressure on the production of retroviral vectors: enhancement in vector stability
    • Coroadinha A.S., Silva A.C., Pires E., Coelho A., Alves P.M., and Carrondo M.J.T. Effect of osmotic pressure on the production of retroviral vectors: enhancement in vector stability. Biotechnol. Bioeng. 94 (2006) 322-329
    • (2006) Biotechnol. Bioeng. , vol.94 , pp. 322-329
    • Coroadinha, A.S.1    Silva, A.C.2    Pires, E.3    Coelho, A.4    Alves, P.M.5    Carrondo, M.J.T.6
  • 156
    • 0037473315 scopus 로고    scopus 로고
    • The temperature stability of mouse retroviruses depends on the cholesterol levels of viral lipid shell and cellular plasma membrane
    • Beer C., Meyer A., Muller K., and Wirth M. The temperature stability of mouse retroviruses depends on the cholesterol levels of viral lipid shell and cellular plasma membrane. Virology 308 (2003) 137-146
    • (2003) Virology , vol.308 , pp. 137-146
    • Beer, C.1    Meyer, A.2    Muller, K.3    Wirth, M.4
  • 158
    • 61849135619 scopus 로고    scopus 로고
    • Simplified production and concentration of HIV-1-based lentiviral vectors using HYPERFlask vessels and anion exchange membrane chromatography
    • Kutner R., Puthli S., Marino M., and Reiser J. Simplified production and concentration of HIV-1-based lentiviral vectors using HYPERFlask vessels and anion exchange membrane chromatography. BMC Biotechnol. 9 (2009) 10
    • (2009) BMC Biotechnol. , vol.9 , pp. 10
    • Kutner, R.1    Puthli, S.2    Marino, M.3    Reiser, J.4
  • 159
    • 0034052029 scopus 로고    scopus 로고
    • Modeling retrovirus production for gene therapy. 1. Determination of optimal bioreaction mode and harvest strategy
    • Cruz P.E., Almeida J.S., Murphy P.N., Moreira J.L., and Carrondo M.J.T. Modeling retrovirus production for gene therapy. 1. Determination of optimal bioreaction mode and harvest strategy. Biotechnol. Prog. 16 (2000) 213-221
    • (2000) Biotechnol. Prog. , vol.16 , pp. 213-221
    • Cruz, P.E.1    Almeida, J.S.2    Murphy, P.N.3    Moreira, J.L.4    Carrondo, M.J.T.5
  • 160
    • 33746215805 scopus 로고    scopus 로고
    • Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia
    • Torashima T., Yamada N., Itoh M., Yamamoto A., and Hirai H. Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia. Eur. J. Neurosci. 24 (2006) 371-380
    • (2006) Eur. J. Neurosci. , vol.24 , pp. 371-380
    • Torashima, T.1    Yamada, N.2    Itoh, M.3    Yamamoto, A.4    Hirai, H.5
  • 161
    • 0034281468 scopus 로고    scopus 로고
    • Effects of culture parameters on the production of retroviral vectors by a human packaging cell line
    • McTaggart S., and Al-Rubeai M. Effects of culture parameters on the production of retroviral vectors by a human packaging cell line. Biotechnol. Prog. 16 (2000) 859-865
    • (2000) Biotechnol. Prog. , vol.16 , pp. 859-865
    • McTaggart, S.1    Al-Rubeai, M.2
  • 162
    • 33750562780 scopus 로고    scopus 로고
    • Retroviral vector production using suspension-adapted 293GPG cells in a 3L acoustic filter-based perfusion bioreactor
    • Ghani K., Garnier A., Coelho H., Transfiguracion J., Trudel P., and Kamen A. Retroviral vector production using suspension-adapted 293GPG cells in a 3L acoustic filter-based perfusion bioreactor. Biotechnol. Bioeng. 95 (2006) 653-660
    • (2006) Biotechnol. Bioeng. , vol.95 , pp. 653-660
    • Ghani, K.1    Garnier, A.2    Coelho, H.3    Transfiguracion, J.4    Trudel, P.5    Kamen, A.6
  • 163
    • 34248526597 scopus 로고    scopus 로고
    • Purification of retroviral vectors for clinical application: biological implications and technological challenges
    • Rodrigues T., Carrondo M.J.T., Alves P.M., and Cruz P.E. Purification of retroviral vectors for clinical application: biological implications and technological challenges. J. Biotechnol. 127 (2007) 520-541
    • (2007) J. Biotechnol. , vol.127 , pp. 520-541
    • Rodrigues, T.1    Carrondo, M.J.T.2    Alves, P.M.3    Cruz, P.E.4
  • 164
    • 0030437534 scopus 로고    scopus 로고
    • Strategies for the isolation and purification of retroviral vectors for gene therapy
    • Braas G., Searle P., Slater N., and Lyddiatt A. Strategies for the isolation and purification of retroviral vectors for gene therapy. Bioseparation 6 (1996) 211-228
    • (1996) Bioseparation , vol.6 , pp. 211-228
    • Braas, G.1    Searle, P.2    Slater, N.3    Lyddiatt, A.4
  • 165
    • 0031923947 scopus 로고    scopus 로고
    • Biochemical recovery and purification of gene therapy vectors
    • Lyddiatt A., and O'Sullivan D.A. Biochemical recovery and purification of gene therapy vectors. Curr. Opin. Biotechnol. 9 (1998) 177-185
    • (1998) Curr. Opin. Biotechnol. , vol.9 , pp. 177-185
    • Lyddiatt, A.1    O'Sullivan, D.A.2
  • 166
    • 0038666499 scopus 로고    scopus 로고
    • Lentivirus vector purification using anion exchange HPLC leads to improved gene transfer
    • Yamada K., McCarty D.M., Madden V.J., and Walsh C.E. Lentivirus vector purification using anion exchange HPLC leads to improved gene transfer. Biotechniques 34 (2003) 1074-1078
    • (2003) Biotechniques , vol.34 , pp. 1074-1078
    • Yamada, K.1    McCarty, D.M.2    Madden, V.J.3    Walsh, C.E.4
  • 167
    • 0036957811 scopus 로고    scopus 로고
    • Efficient gene transfer into the CNS by lentiviral vectors purified by anion exchange chromatography
    • Scherr M., Battmer K., Eder M., Schule S., Hohenberg H., Ganser A., Grez M., and Blomer U. Efficient gene transfer into the CNS by lentiviral vectors purified by anion exchange chromatography. Gene Ther. 9 (2002) 1708-1714
    • (2002) Gene Ther. , vol.9 , pp. 1708-1714
    • Scherr, M.1    Battmer, K.2    Eder, M.3    Schule, S.4    Hohenberg, H.5    Ganser, A.6    Grez, M.7    Blomer, U.8
  • 168
    • 33044492347 scopus 로고    scopus 로고
    • Development of scalable purification protocols for lentiviral vectors
    • Marino M., Kutner R., Lajmi A., Nocumson S., and Reiser J. Development of scalable purification protocols for lentiviral vectors. Mol. Ther. 7 (2003) S178
    • (2003) Mol. Ther. , vol.7
    • Marino, M.1    Kutner, R.2    Lajmi, A.3    Nocumson, S.4    Reiser, J.5
  • 169
    • 0043269712 scopus 로고    scopus 로고
    • Size-exclusion chromatography purification of high-titer vesicular stomatitis virus G glycoprotein-pseudotyped retrovectors for cell and gene therapy applications
    • Transfiguracion J., Jaalouk D.E., Ghani K., Galipeau J., and Kamen A. Size-exclusion chromatography purification of high-titer vesicular stomatitis virus G glycoprotein-pseudotyped retrovectors for cell and gene therapy applications. Hum. Gene Ther. 14 (2003) 1139-1153
    • (2003) Hum. Gene Ther. , vol.14 , pp. 1139-1153
    • Transfiguracion, J.1    Jaalouk, D.E.2    Ghani, K.3    Galipeau, J.4    Kamen, A.5
  • 171
    • 16344377051 scopus 로고    scopus 로고
    • Good manufacturing practice production of adenoviral vectors for clinical trials
    • Lusky M. Good manufacturing practice production of adenoviral vectors for clinical trials. Hum. Gene Ther. 16 (2005) 281-291
    • (2005) Hum. Gene Ther. , vol.16 , pp. 281-291
    • Lusky, M.1
  • 172
    • 74949114697 scopus 로고    scopus 로고
    • Manufacturing recombinant adeno-associated viral vectors from producer cell clones
    • Thorne B.A., Takeya R.K., and Peluso R.W. Manufacturing recombinant adeno-associated viral vectors from producer cell clones. Hum. Gene Ther. 20 (2009) 707-714
    • (2009) Hum. Gene Ther. , vol.20 , pp. 707-714
    • Thorne, B.A.1    Takeya, R.K.2    Peluso, R.W.3
  • 173
    • 37549054118 scopus 로고    scopus 로고
    • Viral vectors for in vivo gene transfer in Parkinson's disease: properties and clinical grade production
    • Mandel R.J., Burger C., and Snyder R.O. Viral vectors for in vivo gene transfer in Parkinson's disease: properties and clinical grade production. Exp. Neurol. 209 (2008) 58-71
    • (2008) Exp. Neurol. , vol.209 , pp. 58-71
    • Mandel, R.J.1    Burger, C.2    Snyder, R.O.3
  • 174
    • 0034694022 scopus 로고    scopus 로고
    • Lentivirus vector mobilization and spread by human immunodeficiency virus
    • Evans J.T., and Garcia J.V. Lentivirus vector mobilization and spread by human immunodeficiency virus. Hum. Gene Ther. 11 (2000) 2331-2339
    • (2000) Hum. Gene Ther. , vol.11 , pp. 2331-2339
    • Evans, J.T.1    Garcia, J.V.2
  • 175
    • 0032796643 scopus 로고    scopus 로고
    • Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells
    • Bukovsky A.A., Song J.-P., and Naldini L. Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells. J. Virol. 73 (1999) 7087-7092
    • (1999) J. Virol. , vol.73 , pp. 7087-7092
    • Bukovsky, A.A.1    Song, J.-P.2    Naldini, L.3
  • 176
    • 30344434648 scopus 로고    scopus 로고
    • Integration site selection by HIV-based vectors in dividing and growth-arrested IMR-90 lung fibroblasts
    • Ciuffi A., Mitchell R.S., Hoffmann C., Leipzig J., Shinn P., Ecker J.R., and Bushman F.D. Integration site selection by HIV-based vectors in dividing and growth-arrested IMR-90 lung fibroblasts. Mol. Ther. 13 (2006) 366-373
    • (2006) Mol. Ther. , vol.13 , pp. 366-373
    • Ciuffi, A.1    Mitchell, R.S.2    Hoffmann, C.3    Leipzig, J.4    Shinn, P.5    Ecker, J.R.6    Bushman, F.D.7
  • 178
    • 67349132909 scopus 로고    scopus 로고
    • Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells
    • Wang G.P., Levine B.L., Binder G.K., Berry C.C., Malani N., McGarrity G., Tebas P., June C.H., and Bushman F.D. Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells. Mol. Ther. 17 (2009) 844-850
    • (2009) Mol. Ther. , vol.17 , pp. 844-850
    • Wang, G.P.1    Levine, B.L.2    Binder, G.K.3    Berry, C.C.4    Malani, N.5    McGarrity, G.6    Tebas, P.7    June, C.H.8    Bushman, F.D.9
  • 180
    • 65449186706 scopus 로고    scopus 로고
    • Dotting the I/'s and crossing the T/'s: integration analyses in transduced patient T cells
    • Rossi J.J. Dotting the I/'s and crossing the T/'s: integration analyses in transduced patient T cells. Mol. Ther. 17 (2009) 756-757
    • (2009) Mol. Ther. , vol.17 , pp. 756-757
    • Rossi, J.J.1
  • 182
    • 3042704538 scopus 로고    scopus 로고
    • Development and optimization of an adenovirus production process
    • Kamen A., and Henry O. Development and optimization of an adenovirus production process. J. Gene Med. 6 (2004) S184-S192
    • (2004) J. Gene Med. , vol.6
    • Kamen, A.1    Henry, O.2
  • 183
    • 36348930054 scopus 로고    scopus 로고
    • Critical assessment of current adeno-associated viral vector production and quantification methods
    • Aucoin M.G., Perrier M., and Kamen A.A. Critical assessment of current adeno-associated viral vector production and quantification methods. Biotechnol. Adv. 26 (2008) 73-88
    • (2008) Biotechnol. Adv. , vol.26 , pp. 73-88
    • Aucoin, M.G.1    Perrier, M.2    Kamen, A.A.3
  • 184
    • 30344435302 scopus 로고    scopus 로고
    • Intracellular trafficking of plasmids during transfection is mediated by microtubules
    • Vaughan E.E., and Dean D.A. Intracellular trafficking of plasmids during transfection is mediated by microtubules. Mol. Ther. 13 (2006) 422-428
    • (2006) Mol. Ther. , vol.13 , pp. 422-428
    • Vaughan, E.E.1    Dean, D.A.2
  • 185
    • 14044250982 scopus 로고    scopus 로고
    • Formation and intracellular trafficking of lipoplexes and polyplexes
    • Elouahabi A., and Ruysschaert J.-M. Formation and intracellular trafficking of lipoplexes and polyplexes. Mol. Ther. 11 (2005) 336-347
    • (2005) Mol. Ther. , vol.11 , pp. 336-347
    • Elouahabi, A.1    Ruysschaert, J.-M.2
  • 186
    • 33746410712 scopus 로고    scopus 로고
    • Nonviral vectors
    • Collins L. Nonviral vectors. Methods Mol. Biol. 333 (2006) 201-226
    • (2006) Methods Mol. Biol. , vol.333 , pp. 201-226
    • Collins, L.1
  • 187
    • 0035949826 scopus 로고    scopus 로고
    • Validation of a high-performance liquid chromatographic assay for the quantification of adenovirus type 5 particles
    • Transfiguracion J., Bernier A., Arcand N., Chahal P., and Kamen A. Validation of a high-performance liquid chromatographic assay for the quantification of adenovirus type 5 particles. J. Chromatogr. B Biomed. Sci. Appl. 761 (2001) 187-194
    • (2001) J. Chromatogr. B Biomed. Sci. Appl. , vol.761 , pp. 187-194
    • Transfiguracion, J.1    Bernier, A.2    Arcand, N.3    Chahal, P.4    Kamen, A.5
  • 188
    • 53249154286 scopus 로고    scopus 로고
    • Rapid and reliable quantification of reovirus type 3 by high performance liquid chromatography during manufacturing of Reolysin
    • Transfiguracion J., Bernier A., Voyer R., Coelho H., Coffey M., and Kamen A. Rapid and reliable quantification of reovirus type 3 by high performance liquid chromatography during manufacturing of Reolysin. J. Pharm. Biomed. Anal. 48 (2008) 598-605
    • (2008) J. Pharm. Biomed. Anal. , vol.48 , pp. 598-605
    • Transfiguracion, J.1    Bernier, A.2    Voyer, R.3    Coelho, H.4    Coffey, M.5    Kamen, A.6
  • 189
    • 8844268430 scopus 로고    scopus 로고
    • High-performance liquid chromatographic total particles quantification of retroviral vectors pseudotyped with vesicular stomatitis virus-G glycoprotein
    • Transfiguracion J., Coelho H., and Kamen A. High-performance liquid chromatographic total particles quantification of retroviral vectors pseudotyped with vesicular stomatitis virus-G glycoprotein. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 813 (2004) 167-173
    • (2004) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.813 , pp. 167-173
    • Transfiguracion, J.1    Coelho, H.2    Kamen, A.3
  • 190
    • 0036710633 scopus 로고    scopus 로고
    • Quantitation of baculovirus particles by flow cytometry
    • Shen C.F., Meghrous J., and Kamen A. Quantitation of baculovirus particles by flow cytometry. J. Virol. Methods 105 (2002) 321-330
    • (2002) J. Virol. Methods , vol.105 , pp. 321-330
    • Shen, C.F.1    Meghrous, J.2    Kamen, A.3
  • 191
    • 68249112926 scopus 로고    scopus 로고
    • Integration-deficient lentiviral vectors: a slow coming of age
    • Wanisch K., and Yanez-Munoz R.J. Integration-deficient lentiviral vectors: a slow coming of age. Mol. Ther. (2009)
    • (2009) Mol. Ther.
    • Wanisch, K.1    Yanez-Munoz, R.J.2


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