Detailed design and comparative analysis of protocols for optimized production of high-performance HIV-1-derived lentiviral particles

Metabolic Engineering

Volumn 7, Issue 5-6, 2005, Pages 426-436

  Mitta, Barbara ^a   Rimann, Markus ^a   Fussenegger, Martin ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Gene therapy; Lentiviral particle production; Lentivirus

Indexed keywords

CHOLESTEROL; GENES; GENETIC ENGINEERING; LIPIDS;

GENE THERAPY; LENTIVIRAL PARTICLE PRODUCTION; LENTIVIRUS;

VIRUSES;

CALCIUM PHOSPHATE; CHOLESTEROL; LENTIVIRUS VECTOR; LIPID; PHOSPHATIDYLCHOLINE;

ARTICLE; CELL DENSITY; CELL STRAIN HEK293; CHEMICAL COMPOSITION; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; EMBRYO; EXPRESSION VECTOR; FETAL CALF SERUM; GENE EXPRESSION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LARGE SCALE PRODUCTION; LENTIVIRINAE; NONHUMAN; PARAMETER; PERFORMANCE; PLASMID; POLYADENYLATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; TEMPERATURE; TRANSGENE; VIRUS PARTICLE;

CELL CULTURE TECHNIQUES; CELL LINE; GENETIC ENHANCEMENT; GENETIC VECTORS; HIV-1; HUMANS; KIDNEY; LENTIVIRUS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; TRANSFECTION; VIRION;

HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; MAMMALIA;

EID: 28444441522     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2005.06.006     Document Type: Article

References (62)

1. W.F. Anderson Gene therapy scores against cancer Nat. Med. 6 2000 862 863
2. M. Azzouz, S.M. Kingsman, and N.D. Mazarakis Lentiviral vectors for treating and modeling human CNS disorders J. Gene Med. 6 2004 951 962
3. S.R. Bartz, and M.A. Vodicka Production of high-titer human immunodeficiency virus type 1 pseudotyped with vesicular stomatitis virus glycoprotein Methods 12 1997 337 342
4. W.R. Beyer, M. Westphal, W. Ostertag, and D. von Laer Oncoretrovirus and lentivirus vectors pseudotyped with lymphocytic choriomeningitis virus glycoprotein: generation, concentration, and broad host range J. Virol. 76 2002 1488 1495
5. A. Blesch Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer Methods 33 2004 164 172
6. U. Blomer, I. Gruh, H. Witschel, A. Haverich, and U. Martin Shuttle of lentiviral vectors via transplanted cells in vivo Gene Ther. 2004
7. N. Chazal, and D. Gerlier Virus entry, assembly, budding, and membrane rafts Microbiol. Mol. Biol. Rev. 67 2003 226 237 (table of contents)
8. J.M. Coffin, S.H. Hughes, and H.E. Varmus Retroviruses 1997 Cold Spring Harbor Laboratory Press New York
9. J.E. Coleman, M.J. Huentelman, S. Kasparov, B.L. Metcalfe, J.F. Paton, M.J. Katovich, S.L. Semple-Rowland, and M.K. Raizada Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo Physiol. Genom. 12 2003 221 228
10. R. Condiotti, M.A. Curran, G.P. Nolan, H. Giladi, M. Ketzinel-Gilad, E. Gross, and E. Galun Prolonged liver-specific transgene expression by a non-primate lentiviral vector Biochem. Biophys. Res. Commun. 320 2004 998 1006
11. T.D. Copeland, M.A. Morgan, and S. Oroszlan Complete amino acid sequence of the nucleic acid-binding protein of bovine leukemia virus FEBS Lett. 156 1983 37 40
12. R.G. Crystal Transfer of genes to humans: early lessons and obstacles to success Science 270 1995 404 410
13. J. D'Costa, J. Harvey-White, P. Qasba, A. Limaye, C.R. Kaneski, A. Davis-Warren, R.O. Brady, K.S. Bankiewicz, E.O. Major, and S.K. Arya HIV-2 derived lentiviral vectors: gene transfer in Parkinson's and Fabry disease models in vitro J. Med. Virol. 71 2003 173 182
14. M. De Palma, and L. Naldini Transduction of a gene expression cassette using advanced generation lentiviral vectors Methods Enzymol. 346 2002 514 529
15. N. Deglon, J.L. Tseng, J.C. Bensadoun, A.D. Zurn, Y. Arsenijevic, L. Pereira de Almeida, R. Zufferey, D. Trono, and P. Aebischer Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease Hum. Gene Ther. 11 2000 179 190
16. M. Derouazi, P. Girard, F. Van Tilborgh, K. Iglesias, N. Muller, M. Bertschinger, and F.M. Wurm Serum-free large-scale transient transfection of CHO cells Biotechnol. Bioeng. 87 2004 537 545
17. G. Duisit, H. Conrath, S. Saleun, S. Folliot, N. Provost, F.L. Cosset, V. Sandrin, P. Moullier, and F. Rolling Five recombinant simian immunodeficiency virus pseudotypes lead to exclusive transduction of retinal pigmented epithelium in rat Mol. Ther. 6 2002 446 454
18. T. Dull, R. Zufferey, M. Kelly, R.J. Mandel, M. Nguyen, D. Trono, and L. Naldini A third-generation lentivirus vector with a conditional packaging system J. Virol. 72 1998 8463 8471
19. O.B. Engler, R.A. Schwendener, W.J. Dai, B. Wolk, W. Pichler, D. Moradpour, T. Brunner, and A. Cerny A liposomal peptide vaccine inducing CD8+ T cells in HLA-A2.1 transgenic mice, which recognise human cells encoding hepatitis C virus (HCV) proteins Vaccine 23 2004 58 68
20. C. Fux, B. Mitta, B.P. Kramer, and M. Fussenegger Dual-regulated expression of C/EBP-alpha and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblasts Nucl. Acids Res. 32 2004 e1
21. C. Fux, S. Moser, S. Schlatter, M. Rimann, J.E. Bailey, and M. Fussenegger Streptogramin- and tetracycline-responsive dual regulated expression of p27(Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells Nucl. Acids Res. 29 2001 E19
22. F. Higashikawa, and L. Chang Kinetic analyses of stability of simple and complex retroviral vectors Virology 280 2001 124 131
23. K. Holm, K. Weclewicz, R. Hewson, and M. Suomalainen Human immunodeficiency virus type 1 assembly and lipid rafts: Pr55(gag) associates with membrane domains that are largely resistant to Brij98 but sensitive to Triton X-100 J. Virol. 77 2003 4805 4817
24. M.B. Huang, M. Khan, M. Garcia-Barrio, M. Powell, and V.C. Bond Apoptotic effects in primary human umbilical vein endothelial cell cultures caused by exposure to virion-associated and cell membrane-associated HIV-1 gp120 J. Acq. Immun. Def. Synd. 27 2001 213 221
25. L.M. Humeau, G.K. Binder, X. Lu, V. Slepushkin, R. Merling, P. Echeagaray, M. Pereira, T. Slepushkina, S. Barnett, L.K. Dropulic, R. Carroll, B.L. Levine, C.H. June, and B. Dropulic Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load Mol. Ther. 9 2004 902 913
26. Y. Ikeda, M.K. Collins, P.A. Radcliffe, K.A. Mitrophanous, and Y. Takeuchi Gene transduction efficiency in cells of different species by HIV and EIAV vectors Gene Ther. 9 2002 932 938
27. J.C. Johnston, M. Gasmi, L.E. Lim, J.H. Elder, J.K. Yee, D.J. Jolly, K.P. Campbell, B.L. Davidson, and S.L. Sauter Minimum requirements for efficient transduction of dividing and nondividing cells by feline immunodeficiency virus vectors J. Virol. 73 1999 4991 5000
28. M. Jordan, and F. Wurm Transfection of adherent and suspended cells by calcium phosphate Methods 33 2004 136 143
29. T. Kafri, H. van Praag, L. Ouyang, F.H. Gage, and I.M. Verma A packaging cell line for lentivirus vectors J. Virol. 73 1999 576 584
30. Y. Kang, C.S. Stein, J.A. Heth, P.L. Sinn, A.K. Penisten, P.D. Staber, K.L. Ratliff, H. Shen, C.K. Barker, I. Martins, C.M. Sharkey, D.A. Sanders, P.B. McCray Jr., and B.L. Davidson In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins J. Virol. 76 2002 9378 9388
31. L.C. Kaptein, A.E. Greijer, D. Valerio, and V.W. van Beusechem Optimized conditions for the production of recombinant amphotropic retroviral vector preparations Gene Ther. 4 1997 172 176
32. H. Kaufmann, X. Mazur, R. Marone, J.E. Bailey, and M. Fussenegger Comparative analysis of two controlled proliferation strategies regarding product quality, influence on tetracycline-regulated gene expression, and productivity Biotechnol. Bioeng. 72 2001 592 602
33. M. Kaul, H. Yu, Y. Ron, and J.P. Dougherty Regulated lentiviral packaging cell line devoid of most viral cis-acting sequences Virology 249 1998 167 174
34. M.A. Kay, J.C. Glorioso, and L. Naldini Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics Nat. Med. 7 2001 33 40
35. N. Klages, R. Zufferey, and D. Trono A stable system for the high-titer production of multiply attenuated lentiviral vectors Mol. Ther. 2 2000 170 176
36. J.K. Koponen, H. Kankkonen, J. Kannasto, T. Wirth, W. Hillen, H. Bujard, and S. Yla-Herttuala Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo Gene Ther. 10 2003 459 466
37. J.H. Kordower, M.E. Emborg, J. Bloch, S.Y. Ma, Y. Chu, L. Leventhal, J. McBride, E.Y. Chen, S. Palfi, B.Z. Roitberg, W.D. Brown, J.E. Holden, R. Pyzalski, M.D. Taylor, P. Carvey, Z. Ling, D. Trono, P. Hantraye, N. Deglon, and P. Aebischer Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease Science 290 2000 767 773
38. S.P. Layne, M.J. Merges, M. Dembo, J.L. Spouge, S.R. Conley, J.P. Moore, J.L. Raina, H. Renz, H.R. Gelderblom, and P.L. Nara Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus Virology 189 1992 695 714
39. J.M. Le Doux, H.E. Davis, J.R. Morgan, and M.L. Yarmush Kinetics of retrovirus production and decay Biotechnol. Bioeng. 63 1999 654 662
40. B. Mangeat, P. Turelli, G. Caron, M. Friedli, L. Perrin, and D. Trono Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts Nature 424 2003 99 103
41. L. Maranga, A. Cunha, J. Clemente, P. Cruz, and M.J. Carrondo Scale-up of virus-like particles production: effects of sparging, agitation and bioreactor scale on cell growth, infection kinetics and productivity J. Biotechnol. 107 2004 55 64
42. O.W. Merten State-of-the-art of the production of retroviral vectors J. Gene Med. 6 1 2004 S105 S124
43. B. Mitta, M. Rimann, M.U. Ehrengruber, M. Ehrbar, V. Djonov, J. Kelm, and M. Fussenegger Advanced modular self-inactivating lentiviral expression vectors for multigene interventions in mammalian cells and in vivo transduction Nucl. Acids Res. 30 2002 e113
44. B. Mitta, C.C. Weber, M. Rimann, and M. Fussenegger Design and in vivo characterization of self-inactivating human and non-human lentiviral expression vectors engineered for streptogramin-adjustable transgene expression Nucl. Acids Res. 32 2004 e106
45. Mitta, B., Weber, C.C., Fussenegger, M., 2005. In-Vivo Transduction of HIV-1-Derived Lentiviral Particles Engineered For Macrolide-Adjustable Transgene Expression. J. Gene Med., in press.
46. H. Mochizuki, J.P. Schwartz, K. Tanaka, R.O. Brady, and J. Reiser High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells J. Virol. 72 1998 8873 8883
47. K. Morizono, G. Bristol, Y.M. Xie, S.K. Kung, and I.S. Chen Antibody-directed targeting of retroviral vectors via cell surface antigens J. Virol. 75 2001 8016 8020
48. L. Naldini, U. Blomer, P. Gallay, D. Ory, R. Mulligan, F.H. Gage, I.M. Verma, and D. Trono In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector Science 272 1996 263 267
49. M. Nishikawa, and L. Huang Nonviral vectors in the new millennium: delivery barriers in gene transfer Hum. Gene Ther. 12 2001 861 870
50. S. Oroszlan, T.D. Copeland, L.E. Henderson, J.R. Stephenson, and R.V. Gilden Amino-terminal sequence of bovine leukemia virus major internal protein: homology with mammalian type C virus p30 structural proteins Proc. Natl. Acad. Sci. USA 76 1979 2996 3000
51. J. Reiser, G. Harmison, S. Kluepfel-Stahl, R.O. Brady, S. Karlsson, and M. Schubert Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles Proc. Natl. Acad. Sci. USA 93 1996 15266 15271
52. J. Reiser, Z. Lai, X.Y. Zhang, and R.O. Brady Development of multigene and regulated lentivirus vectors J. Virol. 74 2000 10589 10599
53. J.B. Rohll, K.A. Mitrophanous, E. Martin-Rendon, F.M. Ellard, P.A. Radcliffe, N.D. Mazarakis, and S.M. Kingsman Design, production, safety, evaluation, and clinical applications of nonprimate lentiviral vectors Methods Enzymol. 346 2002 466 500
54. N. Somia, and I.M. Verma Gene therapy: trials and tribulations Nat. Rev. Genet. 1 2000 91 99
55. A. Ventura, A. Meissner, C.P. Dillon, M. McManus, P.A. Sharp, L. Van Parijs, R. Jaenisch, and T. Jacks Cre-lox-regulated conditional RNA interference from transgenes Proc. Natl. Acad. Sci. USA 101 2004 10380 10385
56. J.B. Wechuck, A. Ozuer, W.F. Goins, D. Wolfe, T. Oligino, J.C. Glorioso, and M.M. Ataai Effect of temperature, medium composition, and cell passage on production of hepes-based viral vectors Biotechnol. Bioeng. 79 2002 112 119
57. R.S. Williams Human gene therapy - of tortoises and hares Nat. Med. 1 1995 1137 1138
58. H. Yu, A.B. Rabson, M. Kaul, Y. Ron, and J.P. Dougherty Inducible human immunodeficiency virus type 1 packaging cell lines J. Virol. 70 1996 4530 4537
59. M. Zahn-Zabal, M. Kobr, P.A. Girod, M. Imhof, P. Chatellard, M. de Jesus, F. Wurm, and N. Mermod Development of stable cell lines for production or regulated expression using matrix attachment regions J. Biotechnol. 87 2001 29 42
60. V. Zaric, D. Weltin, P. Erbacher, J.S. Remy, J.P. Behr, and D. Stephan Effective polyethylenimine-mediated gene transfer into human endothelial cells J. Gene Med. 6 2004 176 184
61. J. Zhao, G.J. Pettigrew, J. Thomas, J.I. Vandenberg, L. Delriviere, E.M. Bolton, A. Carmichael, J.L. Martin, M.S. Marber, and A.M. Lever Lentiviral vectors for delivery of genes into neonatal and adult ventricular cardiac myocytes in vitro and in vivo Basic Res. Cardiol. 97 2002 348 358
62. R. Zufferey, D. Nagy, R.J. Mandel, L. Naldini, and D. Trono Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo Nat. Biotechnol. 15 1997 871 875