Modeling retrovirus production for gene therapy. 1. Determination of optimal bioreaction mode and harvest strategy

Biotechnology Progress

Volumn 16, Issue 2, 2000, Pages 213-221

  Cruz, Pedro E ^a   Almeida, Jonas S ^a   Murphy, Patrick N ^a   Moreira, José L ^a   Carrondo, Manuel J T ^a,b  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BATCH CELL CULTURE; BIOENGINEERING; BIOREACTION KINETICS; CELL CULTURE; CELL GROWTH; DOWNSTREAM PROCESSING; GENE THERAPY; HARVEST; MATHEMATICAL MODEL; PERFUSION; REACTION OPTIMIZATION; RETROVIRUS; STIRRED REACTOR; TEMPERATURE;

ADDITIVES; BATCH CELL CULTURE; BIOREACTORS; BIOSYNTHESIS; MATHEMATICAL MODELS; OPTIMIZATION; PATIENT TREATMENT; VIRUSES;

GENE THERAPY; OPTIMAL BIOREACTION MODE; RETROVIRUS;

GENETIC ENGINEERING;

ANIMALS; BIOREACTORS; BIOTECHNOLOGY; BUTYRATES; CELL CULTURE TECHNIQUES; CELL DIVISION; CELLS, CULTURED; DEXAMETHASONE; GENE THERAPY; HALF-LIFE; MODELS, BIOLOGICAL; MOLONEY MURINE LEUKEMIA VIRUS; REPRODUCIBILITY OF RESULTS; RETROVIRIDAE; SENSITIVITY AND SPECIFICITY; TEMPERATURE;

RNA VIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 0034052029     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp9901466     Document Type: Article

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