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Volumn 25, Issue 2, 2000, Pages 217-222

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 9; VIRUS VECTOR;

EID: 0034040751     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/76095     Document Type: Article
Times cited : (805)

References (30)
  • 1
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini, L. et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272, 263-267 (1996).
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1
  • 2
    • 0032191380 scopus 로고    scopus 로고
    • Lentiviruses as gene transfer agents for delivery to non-dividing cells
    • Naldini, L. Lentiviruses as gene transfer agents for delivery to non-dividing cells. Curr. Opin. Biotechnol. 9, 457-463 (1998).
    • (1998) Curr. Opin. Biotechnol. , vol.9 , pp. 457-463
    • Naldini, L.1
  • 3
    • 0027376309 scopus 로고
    • A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells
    • Bukrinsky, M.I. et al. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature 365, 666-669 (1993).
    • (1993) Nature , vol.365 , pp. 666-669
    • Bukrinsky, M.I.1
  • 4
    • 0028821383 scopus 로고
    • HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator
    • Gallay, P., Swingler, S., Aiken, C. & Trono, D. HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. Cell 80, 379-388 (1995).
    • (1995) Cell , vol.80 , pp. 379-388
    • Gallay, P.1    Swingler, S.2    Aiken, C.3    Trono, D.4
  • 5
    • 18844468523 scopus 로고    scopus 로고
    • Viral protein R regulates nuclear import of the HIV-1 preintegration complex
    • Popov, S. et al. Viral protein R regulates nuclear import of the HIV-1 preintegration complex. EMBO J. 17, 909-917 (1998).
    • (1998) EMBO J. , vol.17 , pp. 909-917
    • Popov, S.1
  • 6
    • 0026506252 scopus 로고
    • A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication
    • Charneau, P., Alizon, M. & Clavel, F. A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication. J. Virol. 66, 2814-2820 (1992).
    • (1992) J. Virol. , vol.66 , pp. 2814-2820
    • Charneau, P.1    Alizon, M.2    Clavel, F.3
  • 7
    • 0027965903 scopus 로고
    • HIV-1 reverse transcription. A termination step at the center of the genome
    • Charneau, P. et al. HIV-1 reverse transcription. A termination step at the center of the genome. J. Mol. Biol. 241, 651-662 (1994).
    • (1994) J. Mol. Biol. , vol.241 , pp. 651-662
    • Charneau, P.1
  • 8
    • 0032125698 scopus 로고    scopus 로고
    • Identification of a sequence element immediately upstream of the polypurine tract that is essential for replication of simian immunodeficiency virus
    • Ilyinskii, P.O. & Desrosiers, R.C. Identification of a sequence element immediately upstream of the polypurine tract that is essential for replication of simian immunodeficiency virus. EMBO J. 17, 3766-3774 (1998).
    • (1998) EMBO J. , vol.17 , pp. 3766-3774
    • Ilyinskii, P.O.1    Desrosiers, R.C.2
  • 9
    • 0029955712 scopus 로고    scopus 로고
    • Sequence and structural determinants required for priming of plus-strand DNA synthesis by the human immunodeficiency virus type 1 polypurine tract
    • Powell, M.D. & Levin, J.G. Sequence and structural determinants required for priming of plus-strand DNA synthesis by the human immunodeficiency virus type 1 polypurine tract. J. Virol. 70, 5288-5296 (1996).
    • (1996) J. Virol. , vol.70 , pp. 5288-5296
    • Powell, M.D.1    Levin, J.G.2
  • 10
    • 0031743608 scopus 로고    scopus 로고
    • Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
    • Zufferey, R. et al. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J. Virol. 72, 9873-9880 (1998).
    • (1998) J. Virol. , vol.72 , pp. 9873-9880
    • Zufferey, R.1
  • 11
    • 0030819379 scopus 로고    scopus 로고
    • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
    • Zufferey, R., Nagy, D., Mandel, R.J., Naldini, L. & Trono, D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nature Biotechnol. 15, 871-875 (1997).
    • (1997) Nature Biotechnol. , vol.15 , pp. 871-875
    • Zufferey, R.1    Nagy, D.2    Mandel, R.J.3    Naldini, L.4    Trono, D.5
  • 12
    • 0031710033 scopus 로고    scopus 로고
    • A third-generation lentivirus vector with a conditional packaging system
    • Dull, T. et al. A third-generation lentivirus vector with a conditional packaging system. J. Virol. 72, 8463-6471 (1998).
    • (1998) J. Virol. , vol.72 , pp. 8463-16471
    • Dull, T.1
  • 13
    • 0026654682 scopus 로고
    • Human immunodeficiency virus infection of cells arrested in the cell cycle
    • Lewis, P., Hensel, M. & Emerman, M. Human immunodeficiency virus infection of cells arrested in the cell cycle. EMBO J. 11, 3053-3058 (1992).
    • (1992) EMBO J. , vol.11 , pp. 3053-3058
    • Lewis, P.1    Hensel, M.2    Emerman, M.3
  • 14
    • 0031967149 scopus 로고    scopus 로고
    • The putative α helix 2 of human immunodeficiency virus type 1 Vpr contains a determinant which is responsible for the nuclear translocation of proviral DNA in growth-arrested cells
    • Nie, Z. et al. The putative α helix 2 of human immunodeficiency virus type 1 Vpr contains a determinant which is responsible for the nuclear translocation of proviral DNA in growth-arrested cells. J. Virol. 72, 4104-4115 (1998).
    • (1998) J. Virol. , vol.72 , pp. 4104-4115
    • Nie, Z.1
  • 15
    • 0031980211 scopus 로고    scopus 로고
    • Role of matrix in an early postentry step in the human immunodeficiency virus type 1 life cycle
    • Kiernan, R.E., Ono, A., Englund, G. & Freed, E.O. Role of matrix in an early postentry step in the human immunodeficiency virus type 1 life cycle. J. Virol. 72, 4116-4126 (1998).
    • (1998) J. Virol. , vol.72 , pp. 4116-4126
    • Kiernan, R.E.1    Ono, A.2    Englund, G.3    Freed, E.O.4
  • 16
    • 0031924466 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4-and CXCR4-mediated pathway: Replication is restricted at a postentry level
    • Schmidtmayerova, H., Alfano, M., Nuovo, G. & Bukrinsky, M. Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4-and CXCR4-mediated pathway: replication is restricted at a postentry level. J. Virol. 72, 4633-4642 (1998).
    • (1998) J. Virol. , vol.72 , pp. 4633-4642
    • Schmidtmayerova, H.1    Alfano, M.2    Nuovo, G.3    Bukrinsky, M.4
  • 17
    • 0033021533 scopus 로고    scopus 로고
    • Integration complexes derived from HIV vectors for rapid assays in vitro
    • Hansen, M.S. et al. Integration complexes derived from HIV vectors for rapid assays in vitro. Nature Biotechnol. 17, 578-582 (1999).
    • (1999) Nature Biotechnol. , vol.17 , pp. 578-582
    • Hansen, M.S.1
  • 18
    • 0030972160 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 preintegration complexes: Studies of organization and composition
    • Miller, M.D., Farnet, C.M. & Bushman, F.D. Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition. J. Virol. 71, 5382-5390 (1997).
    • (1997) J. Virol. , vol.71 , pp. 5382-5390
    • Miller, M.D.1    Farnet, C.M.2    Bushman, F.D.3
  • 19
    • 0029872245 scopus 로고    scopus 로고
    • High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein G
    • Akkina, R.K. et al. High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein G. J. Virol. 70, 2581-2585 (1996).
    • (1996) J. Virol. , vol.70 , pp. 2581-2585
    • Akkina, R.K.1
  • 20
    • 13044309472 scopus 로고    scopus 로고
    • Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors
    • Case, S.S. et al. Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc. Natl Acad. Sci. USA 96, 2988-2993 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 2988-2993
    • Case, S.S.1
  • 21
    • 0033613827 scopus 로고    scopus 로고
    • Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors
    • Miyoshi, H., Smith, K.A., Mosier, D.E., Verma, I.M. & Torbett, B.E. Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science 283, 682-686 (1999).
    • (1999) Science , vol.283 , pp. 682-686
    • Miyoshi, H.1    Smith, K.A.2    Mosier, D.E.3    Verma, I.M.4    Torbett, B.E.5
  • 22
    • 0032578385 scopus 로고    scopus 로고
    • HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/g1 human hematopoietic stem cells
    • Uchida, N. et al. HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells. Proc. Natl Acad. Sci. USA 95, 11939-11944 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 11939-11944
    • Uchida, N.1
  • 23
    • 0031747965 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells
    • Sutton, R.E., Wu, H.T., Rigg, R., Bohnlein, E. & Brown, P.O. Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells. J. Virol. 72, 5781-5788 (1998).
    • (1998) J. Virol. , vol.72 , pp. 5781-5788
    • Sutton, R.E.1    Wu, H.T.2    Rigg, R.3    Bohnlein, E.4    Brown, P.O.5
  • 24
    • 0032056367 scopus 로고    scopus 로고
    • Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential
    • Conneally, E., Eaves, C.J. & Humphries, R.K. Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential. Blood 91, 3487-3493 (1998).
    • (1998) Blood , vol.91 , pp. 3487-3493
    • Conneally, E.1    Eaves, C.J.2    Humphries, R.K.3
  • 25
    • 0032126897 scopus 로고    scopus 로고
    • Retrovirus-mediated gene transfer into human CD34+38low primitive cells capable of reconstituting long-term cultures in vitro and nonobese diabetic-severe combined immunodeficiency mice in vivo
    • Marandin, A. et al. Retrovirus-mediated gene transfer into human CD34+38low primitive cells capable of reconstituting long-term cultures in vitro and nonobese diabetic-severe combined immunodeficiency mice in vivo. Hum. Gene Ther. 9, 1497-1511 (1998).
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1497-1511
    • Marandin, A.1
  • 26
    • 0033621122 scopus 로고    scopus 로고
    • Gene therapy for the hemophilias
    • Kay, M.A. & High, K. Gene therapy for the hemophilias. Proc. Natl Acad. Sci. USA 96, 9973-9975 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 9973-9975
    • Kay, M.A.1    High, K.2
  • 27
    • 0030865201 scopus 로고    scopus 로고
    • Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours
    • Andreadis, S.T., Brott, D., Fuller, A.O. & Palsson, B.O. Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours. J. Virol. 71, 7541-7548 (1997).
    • (1997) J. Virol. , vol.71 , pp. 7541-7548
    • Andreadis, S.T.1    Brott, D.2    Fuller, A.O.3    Palsson, B.O.4
  • 28
    • 2642670312 scopus 로고    scopus 로고
    • Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1
    • Schwartz, O., Marechal, V., Friguet, B., Arenzana-Seisdedos, F & Heard, J.M. Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1. J. Virol. 72, 3845-3850 (1998).
    • (1998) J. Virol. , vol.72 , pp. 3845-3850
    • Schwartz, O.1    Marechal, V.2    Friguet, B.3    Arenzana-Seisdedos, F.4    Heard, J.M.5
  • 29
    • 0025915560 scopus 로고
    • A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract
    • Charneau, P. & Clavel, F. A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract. J. Virol. 65, 2415-2421 (1991).
    • (1991) J. Virol. , vol.65 , pp. 2415-2421
    • Charneau, P.1    Clavel, F.2
  • 30
    • 0031775745 scopus 로고    scopus 로고
    • Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton
    • Bukrinskaya, A., Brichacek, B., Mann, A. & Stevenson, M. Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton. J. Exp. Med. 188, 2113-2125 (1998).
    • (1998) J. Exp. Med. , vol.188 , pp. 2113-2125
    • Bukrinskaya, A.1    Brichacek, B.2    Mann, A.3    Stevenson, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.