Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system

Gene Therapy

Volumn 6, Issue 5, 1999, Pages 715-728

  Chang, L J ^a   Urlacher, V ^a   Iwakuma, T ^a   Cui, Y ^a   Zucali, J ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

HIV; Lentivirus; MLV; Vector; VSV G

Indexed keywords

CD34 ANTIGEN; EXTRACHROMOSOMAL DNA; GAG PROTEIN; NEF PROTEIN; POL PROTEIN; RNA; SIGNAL PEPTIDE; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIVISION; CELL LINE; CONTROLLED STUDY; DNA INTEGRATION; DNA PACKAGING; ENVELOPE GENE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; LENTIVIRINAE; LIVER CELL; LONG TERMINAL REPEAT; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; MUSCLE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION; RISK ASSESSMENT; ROUS SARCOMA ONCOVIRUS; TRANSGENE; VESICULAR STOMATITIS VIRUS; VIRUS REPLICATION;

ANIMALS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; GENE THERAPY; GENETIC VECTORS; HELA CELLS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; RATS; RATS, SPRAGUE-DAWLEY; TUMOR CELLS, CULTURED;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; ONCOVIRINAE; RICE STRIPE VIRUS; ROUS SARCOMA VIRUS; VESICULAR STOMATITIS VIRUS;

EID: 0033046030     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300895     Document Type: Article

References (30)

1. Yang Y, Ertl HC, Wilson JM. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1994; 1: 433-142.
2. + CTLs in vivo. J Immunol 1995; 155: 2564-2570.
3. Yang Y et al. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Therapy 1996; 3: 137-144.
4. DeMatteo RP et al. Immunologic barriers to hepatic adenoviral gene therapy for transplantation. Transplantation 1997; 63: 315-319.
5. Jooss K, Ertl HC, Wilson JM. Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver. J Virol 1998; 72: 2945-2954.
6. Worgall S, Wolff G, Falck-Pedersen E, Crystal RG. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum Gene Ther 1997; 8: 37-44.
7. Nelson JE, Kay MA. Persistence of recombinant adenovirus in vivo is not dependent on vector DNA replication. J Virol 1997; 71: 8902-8907.
8. Gupta S, Irani AN, Gorla GR. Hepatocyte transplantation: emerging insights into mechanisms of liver repopulation and their relevance to potential therapies. J Hepatol 1999 (in press).
9. Rajvanshi P et al. Studies of liver repopulation using the dipeptidyl peptidase IV deficient rat and other rodent recipients: cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobule. Hepatology 1996; 23: 482-496.
10. Lieber A et al. Adenovirus-mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo. Proc Natl Acad Sci USA 1995; 92: 6210-6214.
11. Castell JV et al. Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells. Gene Therapy 1997; 4: 455-464.
12. Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA 1994; 91: 6196-6200.
13. Gao GP, Yang Y, Wilson JM. Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy. J Virol 1996; 70: 8934-8943.
14. Brough DE et al. Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo. J Virol 1997; 71: 9206-9213.
15. DeMatteo RP et al. Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion. Gene Therapy 1996; 3: 4-12.
16. Lei D et al. Nondepleting anti-CD4 antibody treatment prolongs lung-directed E1-deleted adenovirus-mediated gene expression in rats. Hum Gene Ther 1996; 7: 2273-2279.
17. Yang Y et al. Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues. J Virol 1996; 70: 6370-6377.
18. Ilan Y et al. Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats. J Clin Invest 1996; 98: 2640-2647.
19. Jooss K, Turka LA, Wilson JM. Blunting of immune responses to adenoviral vectors in mouse liver and lung with CTLA4Ig. Gene Therapy 1998; 5: 309-319.
20. Efrat S, Fejer G, Brownlee M, Horwitz MS. Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes. Proc Natl Acad Sci USA 1995; 92: 6947-6951.
21. Bruder JT, Jie T, McVey DL, Kovesdi I. Expression of gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver. J Virol 1997; 71: 7623-7628.
22. Polier W et al. Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host. Gene Therapy 1996; 3: 521-530.
23. Jooss K, Yang Y, Wilson JM. Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung. Hum Gene Ther 1996; 7: 1555-1566.
24. Anton E. Ultrastructural changes of stromal cells of bone marrow and liver after cyclophosphamide treatment in mice. Tissue Cell 1997; 29: 1-9.
25. Kondo T et al. Essential roles of the Fas ligand in the development of hepatitis. Nature Med 1997; 3: 409-413.
26. Denizot F, Lang R. Rapid calorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Meth 1986; 89: 271-277.
27. Rajvanshi P et al. Efficacy and safety of repeated hepatocyte transplantation for significant liver repopulation in rodents. Gastroenterology 1996; 111: 1092-1102.
28. Ott M et al. Simultaneous upregulation of viral receptor expression and DNA synthesis is required for increasing efficiency of retroviral hepatic gene transfer. J Biol Chem 1998; 273: 11954-11961.
29. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
30. Gupta S et al. Position-specific gene expression in the liver lobule is directed by the microenvironment and not by the previous cell differentiation state. J Biol Chem 1999; 274: 2157-2165.