Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: Comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine

Journal of Controlled Release

Volumn 89, Issue 1, 2003, Pages 113-125

  Kunath, Klaus ^a   Von Harpe, Anke ^a   Fischer, Dagmar ^a   Petersen, Holger ^a   Bickel, Ulrich ^b   Voigt, Karlheinz ^a   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Biodistribution; Cytotoxicity; Molecular weight; PEI; Pharmacokinetics; Polyethylenimine; Transfection efficiency

Indexed keywords

DNA; LIGHT SCATTERING; MOLECULAR WEIGHT; RING OPENING POLYMERIZATION; SIZE EXCLUSION CHROMATOGRAPHY; SYNTHESIS (CHEMICAL);

HYDRODYNAMIC DIAMETERS;

POLYOLEFINS;

HIGH MOLECULAR WEIGHT POLYETHYLENEIMINE; IODINE 125; LOW MOLECULAR WEIGHT POLYETHYLENEIMINE; PLASMID DNA; POLYETHYLENEIMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DRUG COMPLEX; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG SYNTHESIS; FIBROBLAST; GEL PERMEATION CHROMATOGRAPHY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDRODYNAMICS; LIGHT SCATTERING; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REPORTER GENE; RING OPENING METATHESIS POLYMERIZATION; SURFACE CHARGE; ZETA POTENTIAL;

EID: 0037437033     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(03)00076-2     Document Type: Article

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