CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells

European Journal of Immunology

Volumn 33, Issue 3, 2003, Pages 579-587

  Wing, Kajsa ^a   Lindgren, Susanne ^a   Kollberg, Gittan ^a   Lundgren, Anna ^a   Harris, Robert A ^b   Rudin, Anna ^a   Lundin, Samuel ^a   Suri Payer, Elisabeth ^a,c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

CD25+ regulatory T cell; Cord blood; Myelin oligodendrocyte glycoprotein

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PADGEM PROTEIN; POLYCLONAL ANTIBODY;

ADULT; ANTIGEN EXPRESSION; ANTIGEN PURIFICATION; ANTIGEN SPECIFICITY; CELL MATURATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MEMORY CELL; NEWBORN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; UMBILICAL CORD BLOOD;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FETAL BLOOD; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MYELIN-ASSOCIATED GLYCOPROTEIN; RECEPTORS, INTERLEUKIN-2; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES, REGULATORY;

EID: 0037348923     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200323701     Document Type: Review

References (37)

1. Stockinger, B., T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms. Adv. Immunol. 1999. 71: 229-265.
2. Shevach, E. M., Regulatory T cells in autoimmmunity*. Annu. Rev. Immunol. 2000. 18: 423-449.
3. Diaz-Villoslada, P., Shih, A., Shao, L., Genain, C. P. and Hauser, S. L., Autoreactivity to myelin antigens: myelin/oligodendrocyte glycoprotein is a prevalent autoantigen. J. Neuroimmunol. 1999. 99: 36-43.
4. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 2001. 182: 18-32.
5. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2002. 2: 389-400.
6. Apostolou, I., Sarukhan, A., Klein, L. and von Boehmer, H., Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 2002. 3: 756-763.
7. - regulatory T cells. Proc. Natl. Acad. Sci. USA 2002. 99: 13031-13036.
8. Furtado, G. C., Olivares-Villagomez, D., Curotto de Lafaille, M. A., Wensky, A. K., Latkowski, J. A. and Lafaille, J. J., Regulatory T cells in spontaneous autoimmune encephalomyelitis. Immunol. Rev. 2001. 182: 122-134.
9. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 2000. 164: 183-190.
10. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-incluced TNF receptor. Immunity 2002. 16: 311-323.
11. + T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int. Immunol. 2000. 12: 1145-1155.
12. +CD25high regulatory cells in human peripheral blood. J. Immunol. 2001. 167: 1245-1253.
13. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 1999. 162: 5317-5326.
14. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2001. 2: 301-306.
15. + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 2002. 169: 4712-4716.
16. + T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 2001. 193: 1285-1294.
17. + thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. 2001. 31: 1247-1254.
18. Traggiai, E., Biagioli, T., Rosati, E., Ballerini, C., Mazzanti, B., Ben Nun, A., Massacesi, L. and Vergelli, M., IL-7-enhanced T cell response to myelin proteins in multiple sclerosis. J. Neuroimmunol. 2001. 121: 111-119.
19. Hellings, N., Baree, M., Verhoeven, C., D'Hooghe M. B., Medaer, R., Bernard, C. C., Raus, J. and Stinissen, P., T cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls. J. Neurosci. Res. 2001. 63: 290-302.
20. Dosch, H., Cheung, R. K., Karges, W., Pietropaolo, M. and Becker, D. J., Persistent T cell anergy in human type 1 diabetes. J. Immunol. 1999. 163: 6933-6940.
21. Viglietta, V., Kent, S. C., Orban, T and Hafler, D. A., GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J. Clin. Invest. 2002. 109: 895-903.
22. Roep, B. O., Atkinson, M. A., van Endert, P. M., Gottlieb, P. A., Wilson, S. B. and Sachs, J. A., Autoreactive T cell responses in insulin-dependent (type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays. J. Autoimmun. 1999. 13: 267-282.
23. + T cells in thymus, cord and adult blood. Immunology 2002. 106: 190-199.
24. + cells: a naturally occurring population of regulatory T cells. Blood 2001. 98: 2736-2744.
25. Lucivero, G., Dalla Mora, L., Bresciano, E., Loria, M. P., Pezone, L. and Mancino, D., Functional characteristics of cord blood T lymphocytes after lectin and anti-CD3 stimulation. Differences in the way T cells express activation molecules and proliferate. Int. J. Clin. Lab. Res. 1996. 26: 255-261.
26. + regulatory T cells. Eur. J. Immunol. 2002. 32: 1621-1630.
27. Asano, M., Toda, M., Sakaguchi, N. and Sakaguchi, S., Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 1996. 184: 387-396.
28. Suri-Payer, E., Amar, A. Z., McHugh, R., Natarajan, K., Margulies, D. H. and Shevach, E. M., Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells. Eur. J. Immunol. 1999. 29: 669-677.
29. Scheinecker, C., McHugh, R., Shevach, E. M. and Germain, R. N., Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 2002. 196: 1079-1090.
30. Fredrikson, S., Sun, J. B., Huang, W. X., Li, B. L., Olsson, T. and Link, H., Cord blood contains high numbers of autoimmune T cells recognizing multiple myelin proteins and acetylcholine receptor. J. Immunol. 1993. 151: 2217-2224.
31. Ludvigsson, J. and Wahlberg, J., Diabetes-related autoantibodies in cord blood from children of healthy mothers have disappeared by the time the child is one year old. Ann. N. Y. Acad. Sci. 2002. 958: 289-292.
32. Kukreja, A., Cost, G., Marker, J., Zhang, C., Sun, Z., Lin-Su, K., Ten, S., Sanz, M., Exley, M., Wilson, B., Porcelli, S. and Maclaren, N., Multiple immuno-regulatory defects in type-1 diabetes. J. Clin. Invest. 2002. 109: 131-140.
33. + subpopulations. J. Immunol. 2000. 165: 3105-3110.
34. + human thymocytes. J. Exp. Med. 2002. 196: 379-387.
35. Derbinski, J., Schulte, A., Kyewski, B. and Klein, L., Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2001. 2: 1032-1039.
36. Heath, V. L., Moore, N. C., Parnell, S. M. and Mason, D. W., Intrathymic expression of genes involved in organ specific autoimmune disease. J. Autoimmun. 1998. 11: 309-318.
37. Seddon, B. and Mason, D., Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J. Exp. Med. 1999. 189: 877-882.