메뉴 건너뛰기




Volumn , Issue , 2009, Pages 997-1021

Novel oximes

Author keywords

[No Author keywords available]

Indexed keywords


EID: 72049117857     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012374484-5.00066-3     Document Type: Chapter
Times cited : (23)

References (121)
  • 1
    • 38549145987 scopus 로고    scopus 로고
    • In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages
    • Acharya, J., Gupta, A.K., Mazumder, A., Dubey, D.K. (2008a). In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages. Toxicol. In Vitro22: 525-30.
    • (2008) Toxicol. In Vitro , vol.22 , pp. 525-30
    • Acharya, J.1    Gupta, A.K.2    Mazumder, A.3    Dubey, D.K.4
  • 2
    • 60549114749 scopus 로고    scopus 로고
    • Synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase
    • doi:10.1016/jejmech.2008.02.029.
    • Acharya, J., Gupta, A.K., Dubey, D.K., Raza, S.K. (2008b). Synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase. Eur. J. Med. Chem. doi:10.1016/jejmech.2008.02.029.
    • (2008) Eur. J. Med. Chem.
    • Acharya, J.1    Gupta, A.K.2    Dubey, D.K.3    Raza, S.K.4
  • 3
    • 60549087001 scopus 로고    scopus 로고
    • In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker
    • doi:10.1016/jejmech.2008.02.020.
    • Acharya, J., Gupta, A.K., Mazumder, A., Dubey, D.K. (2008c) In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker. Eur. J. Med. Chem. doi:10.1016/jejmech.2008.02.020.
    • (2008) Eur. J. Med. Chem.
    • Acharya, J.1    Gupta, A.K.2    Mazumder, A.3    Dubey, D.K.4
  • 4
    • 10044275708 scopus 로고    scopus 로고
    • Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment
    • Bajgar J. Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Adv. Clin. Chem. 2004, 38:151-216.
    • (2004) Adv. Clin. Chem. , vol.38 , pp. 151-216
    • Bajgar, J.1
  • 5
    • 22444440950 scopus 로고    scopus 로고
    • Laboratory diagnosis of organophosphates/nerve agent poisoning
    • Bajgar J. Laboratory diagnosis of organophosphates/nerve agent poisoning. Klin. Bioch. Metab. 2005, 13:40-47.
    • (2005) Klin. Bioch. Metab. , vol.13 , pp. 40-47
    • Bajgar, J.1
  • 6
    • 34249796659 scopus 로고    scopus 로고
    • Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction
    • Bajgar J., Fusek J., Kuca K., Bartosova L., Jun D. Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction. Mini Rev. Med. Chem. 2007, 7:461-466.
    • (2007) Mini Rev. Med. Chem. , vol.7 , pp. 461-466
    • Bajgar, J.1    Fusek, J.2    Kuca, K.3    Bartosova, L.4    Jun, D.5
  • 8
    • 0025642471 scopus 로고
    • Ligand exclusion on acetylcholinesterase
    • Berman H.A., Leonard K. Ligand exclusion on acetylcholinesterase. Biochemistry 1990, 29:10640-10649.
    • (1990) Biochemistry , vol.29 , pp. 10640-10649
    • Berman, H.A.1    Leonard, K.2
  • 9
    • 0028294045 scopus 로고
    • Application of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry to the analysis of chemical warfare samples, found to contain residues of the nerve agent sarin, sulphur mustard and their degradation products
    • Black R.M., Clark R.J., Read R.W., Reid M.T.J. Application of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry to the analysis of chemical warfare samples, found to contain residues of the nerve agent sarin, sulphur mustard and their degradation products. J. Chromatogr. 1994, 662:301-321.
    • (1994) J. Chromatogr. , vol.662 , pp. 301-321
    • Black, R.M.1    Clark, R.J.2    Read, R.W.3    Reid, M.T.J.4
  • 11
    • 0037413712 scopus 로고    scopus 로고
    • Structural insight into ligand interactions at the acetylcholinesterase peripheral anionic site
    • Bourne Y., Taylor P., Radic Z., Marchot P. Structural insight into ligand interactions at the acetylcholinesterase peripheral anionic site. EMBO J 2003, 22:1-12.
    • (2003) EMBO J , vol.22 , pp. 1-12
    • Bourne, Y.1    Taylor, P.2    Radic, Z.3    Marchot, P.4
  • 12
    • 0026620018 scopus 로고
    • Adamantane derivatives as potential reactivators of acetylcholinesterase inhibited by organophosphorous compounds
    • Bregovec I., Maksimovic M., Kilibarda V., Binenfeld Z. Adamantane derivatives as potential reactivators of acetylcholinesterase inhibited by organophosphorous compounds. Acta Pharm. 1992, 42:251-253.
    • (1992) Acta Pharm. , vol.42 , pp. 251-253
    • Bregovec, I.1    Maksimovic, M.2    Kilibarda, V.3    Binenfeld, Z.4
  • 13
    • 4744354029 scopus 로고    scopus 로고
    • Specification of the structure of oximes able to reactivate tabun inhibited acetylcholinesterase
    • Cabal J., Kuca K., Kassa J. Specification of the structure of oximes able to reactivate tabun inhibited acetylcholinesterase. Bas. Clin. Pharmacol. Toxicol. 2004, 95:81-86.
    • (2004) Bas. Clin. Pharmacol. Toxicol. , vol.95 , pp. 81-86
    • Cabal, J.1    Kuca, K.2    Kassa, J.3
  • 14
    • 31044442395 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun-and soman-poisoned mice and their cytotoxicity
    • Calic M., Lucic-Vrdoljak A., Radic B., Jelic D., Jun D., Kuca K., Kovarik Z. In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun-and soman-poisoned mice and their cytotoxicity. Toxicology 2006, 219:85-96.
    • (2006) Toxicology , vol.219 , pp. 85-96
    • Calic, M.1    Lucic-Vrdoljak, A.2    Radic, B.3    Jelic, D.4    Jun, D.5    Kuca, K.6    Kovarik, Z.7
  • 15
    • 0000811597 scopus 로고
    • Synthesis of 1-methyl-2-hydroxyiminomethyl-aryl-pyridinium salts with potential as acetyl-cholinesterase reactivators
    • Carvalho I., Miller J. Synthesis of 1-methyl-2-hydroxyiminomethyl-aryl-pyridinium salts with potential as acetyl-cholinesterase reactivators. Heterocycl. Commun. 1995, 1:403-410.
    • (1995) Heterocycl. Commun. , vol.1 , pp. 403-410
    • Carvalho, I.1    Miller, J.2
  • 16
    • 19844367066 scopus 로고    scopus 로고
    • Quaternary salts of 4,30 and 4,40bis-pyridinium monooximes: synthesis and biological activity
    • Chennamaneni S.R., Vobalaboina V., Garlapati A. Quaternary salts of 4,30 and 4,40bis-pyridinium monooximes: synthesis and biological activity. Bioorg. Med. Chem. Lett. 2005, 15:3076-3080.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 3076-3080
    • Chennamaneni, S.R.1    Vobalaboina, V.2    Garlapati, A.3
  • 18
    • 37849018256 scopus 로고    scopus 로고
    • Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex
    • Da Silva A.P., Farina M., Franco J.L., Dafre A.L., Kassa J., Kuca K. Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex. Neurotoxicology 2008, 29:184-189.
    • (2008) Neurotoxicology , vol.29 , pp. 184-189
    • Da Silva, A.P.1    Farina, M.2    Franco, J.L.3    Dafre, A.L.4    Kassa, J.5    Kuca, K.6
  • 19
    • 0028132872 scopus 로고
    • Review of oximes available for treatment of nerve agent poisoning
    • Dawson R.M. Review of oximes available for treatment of nerve agent poisoning. J. Appl. Toxicol. 1994, 14:317-331.
    • (1994) J. Appl. Toxicol. , vol.14 , pp. 317-331
    • Dawson, R.M.1
  • 20
    • 0026660593 scopus 로고
    • Reactivators of AChE inhibited by organophosphorous compounds. Butenylenic and tetramethylenic heterocyclic oximes. IV
    • Deljac V., Deljac A., Mesic M., Kilibarda V., Maksimovic M., Binenfeld Z. Reactivators of AChE inhibited by organophosphorous compounds. Butenylenic and tetramethylenic heterocyclic oximes. IV. Acta Pharm. 1992, 42:173-179.
    • (1992) Acta Pharm. , vol.42 , pp. 173-179
    • Deljac, V.1    Deljac, A.2    Mesic, M.3    Kilibarda, V.4    Maksimovic, M.5    Binenfeld, Z.6
  • 21
    • 33746765583 scopus 로고    scopus 로고
    • Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates
    • Ekström F., Pang Y.P., Boman M., Artursson E., Akfur C., Börjegren S. Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates. Biochem. Pharmacol. 2006, 72:597-607.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 597-607
    • Ekström, F.1    Pang, Y.P.2    Boman, M.3    Artursson, E.4    Akfur, C.5    Börjegren, S.6
  • 22
    • 34547866680 scopus 로고    scopus 로고
    • Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes
    • Ekström F.J., Astot C., Pang Y.P. Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes. Clin. Pharmacol. Ther. 2007, 82:282-293.
    • (2007) Clin. Pharmacol. Ther. , vol.82 , pp. 282-293
    • Ekström, F.J.1    Astot, C.2    Pang, Y.P.3
  • 25
    • 0025879453 scopus 로고
    • Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication
    • GoffD.A., Koolpe G.A., Kelson A.B., Vu H.M., Taylor D.L., Bedford C.D., Musallam H.A., Koplovitz I., Harris R.N. Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication. J. Med. Chem. 1991, 34:1363-1368.
    • (1991) J. Med. Chem. , vol.34 , pp. 1363-1368
    • Goff, D.A.1    Koolpe, G.A.2    Kelson, A.B.3    Vu, H.M.4    Taylor, D.L.5    Bedford, C.D.6    Musallam, H.A.7    Koplovitz, I.8    Harris, R.N.9
  • 26
    • 34447625200 scopus 로고    scopus 로고
    • Measurement of K-27, an oxime-type cholinesterase reactivator by high performance liquid chromatography with electrochemical detection from different biological samples
    • Gyenge M., Kalasz H., Petroianu G., Laufer R., Kuca K., Tekes K. Measurement of K-27, an oxime-type cholinesterase reactivator by high performance liquid chromatography with electrochemical detection from different biological samples. J. Chromatogr. A 2007, 1161:146-151.
    • (2007) J. Chromatogr. A , vol.1161 , pp. 146-151
    • Gyenge, M.1    Kalasz, H.2    Petroianu, G.3    Laufer, R.4    Kuca, K.5    Tekes, K.6
  • 31
    • 33751120661 scopus 로고    scopus 로고
    • New group xylene linker containing acetylcholinesterase reactivators as antidotes against nerve agent cyclosarin
    • Hrabinova M., Musilek K., Jun D., Kuca K. New group xylene linker containing acetylcholinesterase reactivators as antidotes against nerve agent cyclosarin. J. Enzyme Inhib. Med. Chem. 2006, 21:515-519.
    • (2006) J. Enzyme Inhib. Med. Chem. , vol.21 , pp. 515-519
    • Hrabinova, M.1    Musilek, K.2    Jun, D.3    Kuca, K.4
  • 32
    • 84884786766 scopus 로고
    • Hsiao, L.Y.Y., Musallam, H.A. U.S. Patent Appl. US 5130438.
    • Hsiao, L.Y.Y., Musallam, H.A. (1992) U.S. Patent Appl. US 5130438.
    • (1992)
  • 33
    • 37649006683 scopus 로고    scopus 로고
    • Potency of novel oximes to reactivate sarin inhibited human cholinesterases
    • Jun D., Kuca K., Picha J., Koleckar V., Marek J. Potency of novel oximes to reactivate sarin inhibited human cholinesterases. Drug Chem. Toxicol. 2008, 31:1-9.
    • (2008) Drug Chem. Toxicol. , vol.31 , pp. 1-9
    • Jun, D.1    Kuca, K.2    Picha, J.3    Koleckar, V.4    Marek, J.5
  • 35
    • 0032842369 scopus 로고    scopus 로고
    • A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with presently used oximes and H oximes against sarin by in vitro and in vivo methods
    • Kassa J., Cabal J. A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with presently used oximes and H oximes against sarin by in vitro and in vivo methods. Hum. Exp. Toxicol. 1999, 18:560-565.
    • (1999) Hum. Exp. Toxicol. , vol.18 , pp. 560-565
    • Kassa, J.1    Cabal, J.2
  • 36
    • 37649010527 scopus 로고    scopus 로고
    • A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice
    • Kassa J., Humlicek V. A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice. Drug Chem. Toxicol. 2008, 31:127-135.
    • (2008) Drug Chem. Toxicol. , vol.31 , pp. 127-135
    • Kassa, J.1    Humlicek, V.2
  • 37
    • 33748444160 scopus 로고    scopus 로고
    • A comparison of the efficacy of new asymmetric bispyridinium oximes (K027, K048) with currently available oximes against tabun by in vitro and in vivo methods
    • Kassa J., Kuca K., Cabal J., Paar M. A comparison of the efficacy of new asymmetric bispyridinium oximes (K027, K048) with currently available oximes against tabun by in vitro and in vivo methods. J. Toxicol. Environ. Health 2006, 69:1875-1882.
    • (2006) J. Toxicol. Environ. Health , vol.69 , pp. 1875-1882
    • Kassa, J.1    Kuca, K.2    Cabal, J.3    Paar, M.4
  • 38
    • 34547767717 scopus 로고    scopus 로고
    • A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin and tabun-poisoned rats
    • Kassa J., Jun D., Kuca K. A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin and tabun-poisoned rats. J. Enzyme Inhib. Med. Chem. 2007, 22:297-300.
    • (2007) J. Enzyme Inhib. Med. Chem. , vol.22 , pp. 297-300
    • Kassa, J.1    Jun, D.2    Kuca, K.3
  • 39
    • 37149011244 scopus 로고    scopus 로고
    • An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice
    • Kassa J., Karasova J., Musilek K., Kuca K. An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology 2008, 243:311-316.
    • (2008) Toxicology , vol.243 , pp. 311-316
    • Kassa, J.1    Karasova, J.2    Musilek, K.3    Kuca, K.4
  • 40
    • 19544367621 scopus 로고    scopus 로고
    • Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators
    • Kim T.H., Kuca K., Jun D., Jung Y.S. Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators. Bioorg. Med. Chem. Lett. 2005, 15:2914-2917.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 2914-2917
    • Kim, T.H.1    Kuca, K.2    Jun, D.3    Jung, Y.S.4
  • 41
    • 33744793990 scopus 로고    scopus 로고
    • Reactivation study of pyridinium oximes for acetylcholinesterases inhibited by paraoxon or DFP
    • Kim T.H., Oh K.A., Park N.J., Lim Y.J., Yum E.K., Jung Y.S. Reactivation study of pyridinium oximes for acetylcholinesterases inhibited by paraoxon or DFP. J. Appl. Biomed. 2006, 4:67-72.
    • (2006) J. Appl. Biomed. , vol.4 , pp. 67-72
    • Kim, T.H.1    Oh, K.A.2    Park, N.J.3    Lim, Y.J.4    Yum, E.K.5    Jung, Y.S.6
  • 42
    • 0025813053 scopus 로고
    • Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 5. Structure-activity relationships for side-chain nitro-, sulfone-, amino-, and aminosulfonyl-substituted analogues for therapy against anticholinesterase intoxication
    • Koolpe G.A., Lovejoy S.M., GoffD.A., Lin K.Y., Leung D.S., Bedford C.D., Musallam H.A., Koplovitz I., Harris R.N. Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 5. Structure-activity relationships for side-chain nitro-, sulfone-, amino-, and aminosulfonyl-substituted analogues for therapy against anticholinesterase intoxication. J. Med. Chem. 1991, 34:1368-1376.
    • (1991) J. Med. Chem. , vol.34 , pp. 1368-1376
    • Koolpe, G.A.1    Lovejoy, S.M.2    Goff, D.A.3    Lin, K.Y.4    Leung, D.S.5    Bedford, C.D.6    Musallam, H.A.7    Koplovitz, I.8    Harris, R.N.9
  • 43
    • 0024382814 scopus 로고
    • The efficacy of 1,10-(1,4-buten)-bis-(4-hydroxyiminomethyl-pyridinium) dibromide in the treatment of organophosphate poisoning
    • Kovacevic, V., Maksimovic, M., Deljac, V., Binenfeld, Z. (1989a). The efficacy of 1,10-(1,4-buten)-bis-(4-hydroxyiminomethyl-pyridinium) dibromide in the treatment of organophosphate poisoning. Acta Pharm.39: 167-70.
    • (1989) Acta Pharm. , vol.39 , pp. 167-70
    • Kovacevic, V.1    Maksimovic, M.2    Deljac, V.3    Binenfeld, Z.4
  • 44
    • 0024370360 scopus 로고
    • Protective and reactivating effects of HI-6 PAM-2 mixture in rats with nerve chemical warfare agents (nerve CWA)
    • Kovacevic, V., Maksimovic, M., Pantelic, D., Vojvodic, V., Binenfeld, Z. (1989b). Protective and reactivating effects of HI-6 PAM-2 mixture in rats with nerve chemical warfare agents (nerve CWA). Acta Pharm.39: 161-5.
    • (1989) Acta Pharm. , vol.39 , pp. 161-5
    • Kovacevic, V.1    Maksimovic, M.2    Pantelic, D.3    Vojvodic, V.4    Binenfeld, Z.5
  • 45
    • 17744420458 scopus 로고    scopus 로고
    • A comparison of the ability of a new bispyridinium oxime-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods
    • Kuca K., Kassa J. A comparison of the ability of a new bispyridinium oxime-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. J. Enzyme Inhib. Med. Chem. 2003, 18:529-535.
    • (2003) J. Enzyme Inhib. Med. Chem. , vol.18 , pp. 529-535
    • Kuca, K.1    Kassa, J.2
  • 46
    • 2342492936 scopus 로고    scopus 로고
    • Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent
    • Kuca K., Kassa J. Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent. Hum. Exp. Toxicol. 2004, 23:167-171.
    • (2004) Hum. Exp. Toxicol. , vol.23 , pp. 167-171
    • Kuca, K.1    Kassa, J.2
  • 47
    • 10744232850 scopus 로고    scopus 로고
    • Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes
    • Kuca K., Patocka J. Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes. J. Enzyme Inhib. Med. Chem. 2004, 19:39-43.
    • (2004) J. Enzyme Inhib. Med. Chem. , vol.19 , pp. 39-43
    • Kuca, K.1    Patocka, J.2
  • 48
    • 17444446525 scopus 로고    scopus 로고
    • Synthesis of a new reactivator of tabun inhibited acetylcholinesterase
    • Kuca, K., Bielavsky, J., Cabal, J., Kassa, J. (2003a). Synthesis of a new reactivator of tabun inhibited acetylcholinesterase. Bioorg. Med. Chem. Lett.13: 3545-7.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 3545-7
    • Kuca, K.1    Bielavsky, J.2    Cabal, J.3    Kassa, J.4
  • 49
    • 0037424754 scopus 로고    scopus 로고
    • Synthesis of a potential reactivator of acetylcholinesterase 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)-propane dibromide
    • Kuca, K., Bielavsky, J., Cabal, J., Bielavska, M. (2003b). Synthesis of a potential reactivator of acetylcholinesterase 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)-propane dibromide. Tetrahedron Lett.44: 3123-5.
    • (2003) Tetrahedron Lett. , vol.44 , pp. 3123-5
    • Kuca, K.1    Bielavsky, J.2    Cabal, J.3    Bielavska, M.4
  • 50
    • 0348213441 scopus 로고    scopus 로고
    • Reactivation of organophosphate inhibited acetylcholinesterase activity by a, u-bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro
    • Kuca, K., Patocka, J., Cabal, J. (2003c). Reactivation of organophosphate inhibited acetylcholinesterase activity by a, u-bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro. J. Appl. Biomed.1: 207-11.
    • (2003) J. Appl. Biomed. , vol.1 , pp. 207-11
    • Kuca, K.1    Patocka, J.2    Cabal, J.3
  • 51
    • 6344278709 scopus 로고    scopus 로고
    • Synthesis of bisquaternary symmetric -c, d-bis(2-hydroxyiminomethyl-pyridinium)alkane dibromides and their reactivation of cyclosarin-inhibited acetylcholinesterase
    • Kuca, K., Cabal, J., Patocka, J., Kassa, J. (2004a). Synthesis of bisquaternary symmetric -c, d-bis(2-hydroxyiminomethyl-pyridinium)alkane dibromides and their reactivation of cyclosarin-inhibited acetylcholinesterase. Lett. Org. Chem.1: 84-6.
    • (2004) Lett. Org. Chem. , vol.1 , pp. 84-6
    • Kuca, K.1    Cabal, J.2    Patocka, J.3    Kassa, J.4
  • 52
    • 2342608770 scopus 로고    scopus 로고
    • Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents
    • Kuca, K., Picha, J., Cabal, J., Liska, F. (2004b). Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents. J. Appl. Biomed.2: 51-6.
    • (2004) J. Appl. Biomed. , vol.2 , pp. 51-6
    • Kuca, K.1    Picha, J.2    Cabal, J.3    Liska, F.4
  • 53
    • 33646050378 scopus 로고    scopus 로고
    • Quaternary heteroarenium salts as the competitive inhibitors of the brain acetylcholinesterase
    • Kuca, K., Cabal, J., Patocka, J., Dohnal, V. (2004c). Quaternary heteroarenium salts as the competitive inhibitors of the brain acetylcholinesterase. Lett. Drug Des. Disc.1: 97-100.
    • (2004) Lett. Drug Des. Disc. , vol.1 , pp. 97-100
    • Kuca, K.1    Cabal, J.2    Patocka, J.3    Dohnal, V.4
  • 54
    • 30044433832 scopus 로고    scopus 로고
    • Effective bisquaternary reactivators of tabun-inhibited AChE
    • Kuca, K., Cabal, J., Musilek, K., Jun, D., Bajgar, J. (2005a). Effective bisquaternary reactivators of tabun-inhibited AChE. J. Appl. Toxicol.25: 491-5.
    • (2005) J. Appl. Toxicol. , vol.25 , pp. 491-5
    • Kuca, K.1    Cabal, J.2    Musilek, K.3    Jun, D.4    Bajgar, J.5
  • 55
    • 22544478825 scopus 로고    scopus 로고
    • In vitro reactivation of sarin-inhibited brain acetylcholinesterase from various species by various oximes
    • Kuca, K., Cabal, J., Kassa, J. (2005b). In vitro reactivation of sarin-inhibited brain acetylcholinesterase from various species by various oximes. J. Enzyme Inhib. Med. Chem.20: 227-32.
    • (2005) J. Enzyme Inhib. Med. Chem. , vol.20 , pp. 227-32
    • Kuca, K.1    Cabal, J.2    Kassa, J.3
  • 56
    • 22844435631 scopus 로고    scopus 로고
    • In vitro reactivation potency of some acetylcholinesterase reactivators against sarin and cyclosarin-induced inhibitions
    • Kuca, K., Cabal, J., Jun, D., Kassa, K., Bartosova, L., Kunesova, G. (2005c). In vitro reactivation potency of some acetylcholinesterase reactivators against sarin and cyclosarin-induced inhibitions. J. Appl. Toxicol.25: 296-300.
    • (2005) J. Appl. Toxicol. , vol.25 , pp. 296-300
    • Kuca, K.1    Cabal, J.2    Jun, D.3    Kassa, K.4    Bartosova, L.5    Kunesova, G.6
  • 57
    • 14344259587 scopus 로고    scopus 로고
    • In vitro searching for a new potent reactivator of acetylcholinesterase inhibited by nerve agent VX
    • Kuca, K., Cabal, J., Bajgar, J., Jun, D. (2005d). In vitro searching for a new potent reactivator of acetylcholinesterase inhibited by nerve agent VX. Lett. Drug Des. Disc.2: 23-5.
    • (2005) Lett. Drug Des. Disc. , vol.2 , pp. 23-5
    • Kuca, K.1    Cabal, J.2    Bajgar, J.3    Jun, D.4
  • 58
    • 33645233664 scopus 로고    scopus 로고
    • In vitro evaluation of new acetylcholinesterase reactivators as causal antidotes against tabun and cyclosarin
    • Kuca K., Jun D., Kim T.H., Cabal J., Jung Y.S. In vitro evaluation of new acetylcholinesterase reactivators as causal antidotes against tabun and cyclosarin. Bull. Korean Chem. Soc. 2006, 27:395-398.
    • (2006) Bull. Korean Chem. Soc. , vol.27 , pp. 395-398
    • Kuca, K.1    Jun, D.2    Kim, T.H.3    Cabal, J.4    Jung, Y.S.5
  • 59
    • 33847043946 scopus 로고    scopus 로고
    • Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro
    • Kuca, K., Jun, D., Bajgar, J. (2007a). Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro. Drug Chem. Toxicol.30: 31-40.
    • (2007) Drug Chem. Toxicol. , vol.30 , pp. 31-40
    • Kuca, K.1    Jun, D.2    Bajgar, J.3
  • 61
    • 34548447107 scopus 로고    scopus 로고
    • Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide -a new nerve agent reactivator
    • Kuca, K., Musilek, K., Paar, M., Jun, D., Stodulka, P., Hrabinova, M., Marek, J. (2007c). Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide -a new nerve agent reactivator. Molecules12: 1964-72.
    • (2007) Molecules , vol.12 , pp. 1964-72
    • Kuca, K.1    Musilek, K.2    Paar, M.3    Jun, D.4    Stodulka, P.5    Hrabinova, M.6    Marek, J.7
  • 62
    • 34249731938 scopus 로고    scopus 로고
    • In vitro reactivation potency of cetylcholinesterase reactivators -K074 and K075-to reactivate tabun-inhibited human brain cholinesterases
    • Kuca, K., Cabal, J., Jun, D., Musilek, K. (2007d). In vitro reactivation potency of cetylcholinesterase reactivators -K074 and K075-to reactivate tabun-inhibited human brain cholinesterases. Neurotoxicol. Res.11: 101-6.
    • (2007) Neurotoxicol. Res. , vol.11 , pp. 101-6
    • Kuca, K.1    Cabal, J.2    Jun, D.3    Musilek, K.4
  • 63
    • 34547922765 scopus 로고    scopus 로고
    • Entry of two new asymmetric bispyridinium oximes (K-27 and K-48) into the brain: comparison with obidoxime
    • Lorke D.E., Hasan M.Y., Nurulain S.M., Sheen R., Kuca K., Petroianu G.A. Entry of two new asymmetric bispyridinium oximes (K-27 and K-48) into the brain: comparison with obidoxime. J. Appl. Toxicol. 2007, 27:482-490.
    • (2007) J. Appl. Toxicol. , vol.27 , pp. 482-490
    • Lorke, D.E.1    Hasan, M.Y.2    Nurulain, S.M.3    Sheen, R.4    Kuca, K.5    Petroianu, G.A.6
  • 64
    • 44149119794 scopus 로고    scopus 로고
    • In vitro oxime reactivation of red blood cell acetylcholinesterase inhibitied by diisopropyl-fluorophosphate (DFP)
    • Lorke, D.E., Hasan, M.Y., Arafat, K., Kuca, K., Musilek, K., Schmitt, A., Petroianu, G.A. (2008a). In vitro oxime reactivation of red blood cell acetylcholinesterase inhibitied by diisopropyl-fluorophosphate (DFP). J. Appl. Toxicol.28: 422-9.
    • (2008) J. Appl. Toxicol. , vol.28 , pp. 422-9
    • Lorke, D.E.1    Hasan, M.Y.2    Arafat, K.3    Kuca, K.4    Musilek, K.5    Schmitt, A.6    Petroianu, G.A.7
  • 66
    • 34247096612 scopus 로고    scopus 로고
    • Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning
    • Lundy P.M., Raveh L., Amitai G. Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol. Rev. 2006, 25:231-243.
    • (2006) Toxicol. Rev. , vol.25 , pp. 231-243
    • Lundy, P.M.1    Raveh, L.2    Amitai, G.3
  • 67
    • 0027281533 scopus 로고
    • Organophosphate poisoning
    • Marrs T.C. Organophosphate poisoning. Pharmacol. Ther. 1993, 58:51-66.
    • (1993) Pharmacol. Ther. , vol.58 , pp. 51-66
    • Marrs, T.C.1
  • 71
    • 0028148162 scopus 로고
    • Reactivators of acetylcholinesterase inhibited by organophosphorus compounds. Imidazole derivatives. V
    • Mesic M., Roncevic R., Radic B., Fajdetic A., Binenfeld Z. Reactivators of acetylcholinesterase inhibited by organophosphorus compounds. Imidazole derivatives. V. Acta Pharm. 1994, 44:145-150.
    • (1994) Acta Pharm. , vol.44 , pp. 145-150
    • Mesic, M.1    Roncevic, R.2    Radic, B.3    Fajdetic, A.4    Binenfeld, Z.5
  • 73
    • 28244442740 scopus 로고    scopus 로고
    • Synthesis of the novel series of bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
    • Musilek K., Kuca K., Jun D., Dohnal V., Dolezal M. Synthesis of the novel series of bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase. J. Enzyme Inhib. Med. Chem. 2005, 20:409-415.
    • (2005) J. Enzyme Inhib. Med. Chem. , vol.20 , pp. 409-415
    • Musilek, K.1    Kuca, K.2    Jun, D.3    Dohnal, V.4    Dolezal, M.5
  • 74
    • 29644446302 scopus 로고    scopus 로고
    • Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
    • Musilek, K., Kuca, K., Jun, D., Dohnal, V., Dolezal, M. (2006a). Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against autyrifos-inhibited acetylcholinesterase. Biorg. Med. Chem. Lett16: 622-7.
    • (2006) Biorg. Med. Chem. Lett. , vol.16 , pp. 622-7
    • Musilek, K.1    Kuca, K.2    Jun, D.3    Dohnal, V.4    Dolezal, M.5
  • 75
    • 33646753799 scopus 로고    scopus 로고
    • New methods in synthesis of acetylcholinesterase reactivators and evaluation of their potency to reactivate cyclosarin-inhibited AChE
    • Musilek, K., Lipka, L., Racakova, V., Kuca, K., Jun, D., Dohnal, V., Dolezal, V. (2006b). New methods in synthesis of acetylcholinesterase reactivators and evaluation of their potency to reactivate cyclosarin-inhibited AChE. Chem. Papers60: 48-51.
    • (2006) Chem. Papers , vol.60 , pp. 48-51
    • Musilek, K.1    Lipka, L.2    Racakova, V.3    Kuca, K.4    Jun, D.5    Dohnal, V.6    Dolezal, V.7
  • 76
    • 33845870911 scopus 로고    scopus 로고
    • Synthesis of bispyridinium compounds bearing propane linker and evaluation of their reactivation activity against tabun-and paraoxon-inhibited acetylcholinesterase
    • Musilek, K., Holas, O., Hambalek, J., Kuca, K., Jun, D., Dohnal, V., Dolezal, M. (2006c). Synthesis of bispyridinium compounds bearing propane linker and evaluation of their reactivation activity against tabun-and paraoxon-inhibited acetylcholinesterase. Lett. Org. Chem.3: 831-5.
    • (2006) Lett. Org. Chem. , vol.3 , pp. 831-5
    • Musilek, K.1    Holas, O.2    Hambalek, J.3    Kuca, K.4    Jun, D.5    Dohnal, V.6    Dolezal, M.7
  • 77
    • 33748778822 scopus 로고    scopus 로고
    • Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
    • Musilek, K., Holas, O., Kuca, K., Jun, D., Dohnal, V., Dolezal, M. (2006d). Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Biorg. Med. Chem. Lett.16: 5673-6.
    • (2006) Biorg. Med. Chem. Lett. , vol.16 , pp. 5673-6
    • Musilek, K.1    Holas, O.2    Kuca, K.3    Jun, D.4    Dohnal, V.5    Dolezal, M.6
  • 78
    • 34547820435 scopus 로고    scopus 로고
    • Synthesis of the novel series of asymmetrical bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
    • Musilek, K., Holas, O., Kuca, K., Jun, D., Dohnal, V., Dolezal, M. (2007a). Synthesis of the novel series of asymmetrical bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. J. Enzyme Inhib. Med. Chem.22: 425-32.
    • (2007) J. Enzyme Inhib. Med. Chem. , vol.22 , pp. 425-32
    • Musilek, K.1    Holas, O.2    Kuca, K.3    Jun, D.4    Dohnal, V.5    Dolezal, M.6
  • 79
    • 33847714138 scopus 로고    scopus 로고
    • In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase
    • Musilek, K., Kuca, K., Jun, D., Dolezal, M. (2007b). In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase. J. Appl. Biomed.5: 25-30.
    • (2007) J. Appl. Biomed. , vol.5 , pp. 25-30
    • Musilek, K.1    Kuca, K.2    Jun, D.3    Dolezal, M.4
  • 80
    • 34248197142 scopus 로고    scopus 로고
    • Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker -synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
    • Musilek, K., Holas, O., Kuca, K., Jun, D., Dohnal, V., Opletalova, V., Dolezal, M. (2007c). Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker -synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Biorg. Med. Chem. Lett.17: 3172-6.
    • (2007) Biorg. Med. Chem. Lett. , vol.17 , pp. 3172-6
    • Musilek, K.1    Holas, O.2    Kuca, K.3    Jun, D.4    Dohnal, V.5    Opletalova, V.6    Dolezal, M.7
  • 81
    • 34548386615 scopus 로고    scopus 로고
    • Two step synthesis of non-symmetric reactivator of acetylcholinesterase
    • Musilek, K., Kuca, K., Dohnal, V., Jun, D., Marek, J., Koleckar, V. (2007d). Two step synthesis of non-symmetric reactivator of acetylcholinesterase. Molecules12: 1755-61.
    • (2007) Molecules , vol.12 , pp. 1755-61
    • Musilek, K.1    Kuca, K.2    Dohnal, V.3    Jun, D.4    Marek, J.5    Koleckar, V.6
  • 82
    • 34548524594 scopus 로고    scopus 로고
    • Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker -preparation and reactivation of tabun and paraoxon-inhibited acetylcholinesterase
    • Musilek, K., Holas, O., Jun, D., Dohnal, V., Gunn-Moore, F., Opletalova, V., Dolezal, M., Kuca, K. (2007e). Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker -preparation and reactivation of tabun and paraoxon-inhibited acetylcholinesterase. Biorg. Med. Chem.15: 6733-41.
    • (2007) Biorg. Med. Chem. , vol.15 , pp. 6733-41
    • Musilek, K.1    Holas, O.2    Jun, D.3    Dohnal, V.4    Gunn-Moore, F.5    Opletalova, V.6    Dolezal, M.7    Kuca, K.8
  • 83
    • 35848930605 scopus 로고    scopus 로고
    • Design of a potent reactivator of tabun-inhibited acetylcholinesterase -synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-e ne dibromide (K203)
    • Musilek, K., Jun, D., Cabal, J., Kassa, J., Gunn-Moore, F., Kuca, K. (2007f). Design of a potent reactivator of tabun-inhibited acetylcholinesterase -synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-e ne dibromide (K203). J. Med. Chem.50: 5514-18.
    • (2007) J. Med. Chem. , vol.50 , pp. 5514-18
    • Musilek, K.1    Jun, D.2    Cabal, J.3    Kassa, J.4    Gunn-Moore, F.5    Kuca, K.6
  • 84
    • 39349101032 scopus 로고    scopus 로고
    • Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun-and paraoxon-inhibited acetylcholinesterase
    • Musilek K., Holas O., Kuca K., Jun D., Dohnal V., Opletalova V., Dolezal M. Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun-and paraoxon-inhibited acetylcholinesterase. J. Enzyme Inhib. Med. Chem. 2008, 23:70-76.
    • (2008) J. Enzyme Inhib. Med. Chem. , vol.23 , pp. 70-76
    • Musilek, K.1    Holas, O.2    Kuca, K.3    Jun, D.4    Dohnal, V.5    Opletalova, V.6    Dolezal, M.7
  • 85
    • 33947678881 scopus 로고    scopus 로고
    • Evaluation of monoquaternary pyridinium oximes potency to reactivate tabun-inhibited human acetylcholinesterase
    • Odzak R., Calic M., Hrenar T., Primozic I., Kovarik Z. Evaluation of monoquaternary pyridinium oximes potency to reactivate tabun-inhibited human acetylcholinesterase. Toxicology 2007, 233:85-96.
    • (2007) Toxicology , vol.233 , pp. 85-96
    • Odzak, R.1    Calic, M.2    Hrenar, T.3    Primozic, I.4    Kovarik, Z.5
  • 86
    • 50649110261 scopus 로고    scopus 로고
    • Determination of reactivation potency for DFP-and paraoxon-inhibited acetylcholinesterases by pyridinium oximes
    • 365-7
    • Oh K.A., Park N.J., Park N.S., Kuca K., Jun D., Jung Y.S. Determination of reactivation potency for DFP-and paraoxon-inhibited acetylcholinesterases by pyridinium oximes. Chem. Biol. Interact. 2008, 175:1-3. 365-7.
    • (2008) Chem. Biol. Interact. , vol.175 , pp. 1-3
    • Oh, K.A.1    Park, N.J.2    Park, N.S.3    Kuca, K.4    Jun, D.5    Jung, Y.S.6
  • 88
    • 33845369068 scopus 로고    scopus 로고
    • New safe method for preparation of sarin-exposed human erythrocytes acetylcholinesterase using non-toxic and stable sarin analogue isopropyl p-nitrophenyl methylphosphonate and its application to evaluation of nerve agent antidotes
    • Ohta H., Ohmori T., Suzuki S., Ikegaya H., Sakurada K., Takatori T. New safe method for preparation of sarin-exposed human erythrocytes acetylcholinesterase using non-toxic and stable sarin analogue isopropyl p-nitrophenyl methylphosphonate and its application to evaluation of nerve agent antidotes. Pharm. Res. 2006, 23:2827-2833.
    • (2006) Pharm. Res. , vol.23 , pp. 2827-2833
    • Ohta, H.1    Ohmori, T.2    Suzuki, S.3    Ikegaya, H.4    Sakurada, K.5    Takatori, T.6
  • 89
    • 38849120721 scopus 로고    scopus 로고
    • Blood-brain barrier penetration of novel pyridinealdoxime methiodide (PAM)-type oximes examined by brain microdialysis with LC-MS/MS
    • Okuno S., Sakurada K., Ohta H., Ikegaya H., Kazui Y., Akutsu T., Iwadate K. Blood-brain barrier penetration of novel pyridinealdoxime methiodide (PAM)-type oximes examined by brain microdialysis with LC-MS/MS. Toxicol. Appl. Pharmacol. 2008, 227:8-15.
    • (2008) Toxicol. Appl. Pharmacol. , vol.227 , pp. 8-15
    • Okuno, S.1    Sakurada, K.2    Ohta, H.3    Ikegaya, H.4    Kazui, Y.5    Akutsu, T.6    Iwadate, K.7
  • 91
    • 0037492336 scopus 로고    scopus 로고
    • Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators
    • Pang Y.P., Kollmeyer T.M., Hong F., Lee J.C., Hammond P.I., Haugabouk S.P., Brimijoin S. Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem. Biol. 2003, 10:491-502.
    • (2003) Chem. Biol. , vol.10 , pp. 491-502
    • Pang, Y.P.1    Kollmeyer, T.M.2    Hong, F.3    Lee, J.C.4    Hammond, P.I.5    Haugabouk, S.P.6    Brimijoin, S.7
  • 92
    • 34548595843 scopus 로고    scopus 로고
    • Czech Republic, Grada Publishing As. (In Czech), Praha
    • Patocka J. Military Toxicology 2004, Czech Republic, Grada Publishing As. (In Czech), Praha. 1st edition.
    • (2004) Military Toxicology
    • Patocka, J.1
  • 93
    • 27444442890 scopus 로고    scopus 로고
    • Oxime reactivation of acetylcholinesterase inhibited by toxic phosphorus esters: in vitro kinetics and thermodynamics
    • Patocka J., Cabal J., Kuca K., Jun D. Oxime reactivation of acetylcholinesterase inhibited by toxic phosphorus esters: in vitro kinetics and thermodynamics. J. Appl. Biomed. 2005, 2:91-99.
    • (2005) J. Appl. Biomed. , vol.2 , pp. 91-99
    • Patocka, J.1    Cabal, J.2    Kuca, K.3    Jun, D.4
  • 94
    • 37449017242 scopus 로고    scopus 로고
    • Comparison of the ability of pyridinium aldoximes to reactivate human RBC cholinesterases inhibited by ethyl-and methyl-paraoxon
    • Petroianu G.A., Kalasz H. Comparison of the ability of pyridinium aldoximes to reactivate human RBC cholinesterases inhibited by ethyl-and methyl-paraoxon. Curr. Org. Chem. 2007, 11:1624-1634.
    • (2007) Curr. Org. Chem. , vol.11 , pp. 1624-1634
    • Petroianu, G.A.1    Kalasz, H.2
  • 95
    • 33646831462 scopus 로고    scopus 로고
    • Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon
    • Petroianu, G.A., Nurulain, S.M., Nagelkerke, N., Al-Sultan, M.A., Kuca, K., Kassa, J. (2006a). Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon. J. Appl. Toxicol.26: 262-8.
    • (2006) J. Appl. Toxicol. , vol.26 , pp. 262-8
    • Petroianu, G.A.1    Nurulain, S.M.2    Nagelkerke, N.3    Al-Sultan, M.A.4    Kuca, K.5    Kassa, J.6
  • 96
    • 31644432758 scopus 로고    scopus 로고
    • Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon
    • Petroianu, G.A., Arafat, K., Kuca, K., Kassa, J. (2006b). Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon. J. Appl. Toxicol.26: 64-71.
    • (2006) J. Appl. Toxicol. , vol.26 , pp. 64-71
    • Petroianu, G.A.1    Arafat, K.2    Kuca, K.3    Kassa, J.4
  • 97
    • 33947611114 scopus 로고    scopus 로고
    • In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon
    • Petroianu, G.A., Arafat, K., Nurulain, S.M., Kuca, K., Kassa, J. (2007a). In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon. J. Appl. Toxicol.27: 168-75.
    • (2007) J. Appl. Toxicol. , vol.27 , pp. 168-75
    • Petroianu, G.A.1    Arafat, K.2    Nurulain, S.M.3    Kuca, K.4    Kassa, J.5
  • 99
    • 34547869780 scopus 로고    scopus 로고
    • Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon
    • Petroianu, G.A., Nurulain, S.M., Nagelkerke, N., Shafiullah, M., Kassa, J., Kuca, K. (2007c). Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon. J. Appl. Toxicol.27: 453-7.
    • (2007) J. Appl. Toxicol. , vol.27 , pp. 453-7
    • Petroianu, G.A.1    Nurulain, S.M.2    Nagelkerke, N.3    Shafiullah, M.4    Kassa, J.5    Kuca, K.6
  • 100
    • 14344265002 scopus 로고    scopus 로고
    • An overview of syntheses of cholinesterase reactivators from 1980 to 1992
    • Czech
    • Petrova I., Bielavsky J. An overview of syntheses of cholinesterase reactivators from 1980 to 1992. Voj. Zdrav. Listy 2001, 70:63-73. Czech.
    • (2001) Voj. Zdrav. Listy , vol.70 , pp. 63-73
    • Petrova, I.1    Bielavsky, J.2
  • 101
    • 22544481464 scopus 로고    scopus 로고
    • New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents
    • Picha J., Kuca K., Kivala M., Kohout M., Cabal J., Liska F. New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents. J. Enzyme Inhib. Med. Chem. 2005, 20:233-237.
    • (2005) J. Enzyme Inhib. Med. Chem. , vol.20 , pp. 233-237
    • Picha, J.1    Kuca, K.2    Kivala, M.3    Kohout, M.4    Cabal, J.5    Liska, F.6
  • 103
    • 17144405799 scopus 로고    scopus 로고
    • Pyridinium, imidazolium, and quinucludinium oximes: synthesis, interaction with native and phosphylated cholinesterases, and antidotes against organophosphorus compounds
    • Primozic I., Odzak R., Tomic S., Simeon-Rudolf V., Reiner I. Pyridinium, imidazolium, and quinucludinium oximes: synthesis, interaction with native and phosphylated cholinesterases, and antidotes against organophosphorus compounds. J. Med. Def. Chem. 2004, 2:1-30.
    • (2004) J. Med. Def. Chem. , vol.2 , pp. 1-30
    • Primozic, I.1    Odzak, R.2    Tomic, S.3    Simeon-Rudolf, V.4    Reiner, I.5
  • 104
    • 33751316479 scopus 로고    scopus 로고
    • Reactivation of acetycholinesterase inhibited by pesticide chlorpyrifos
    • Racakova V., Jun D., Opletalova V., Kuca K. Reactivation of acetycholinesterase inhibited by pesticide chlorpyrifos. J. Appl. Biomed. 2006, 4:147-151.
    • (2006) J. Appl. Biomed. , vol.4 , pp. 147-151
    • Racakova, V.1    Jun, D.2    Opletalova, V.3    Kuca, K.4
  • 105
    • 0042338743 scopus 로고    scopus 로고
    • Nerve agent attacks on children: diagnosis and management
    • Rotenberg J.S., Newmark J. Nerve agent attacks on children: diagnosis and management. Pediatrics 2003, 112:648-658.
    • (2003) Pediatrics , vol.112 , pp. 648-658
    • Rotenberg, J.S.1    Newmark, J.2
  • 108
    • 0027270352 scopus 로고
    • Quaternary salts of 3,30-bis-pyridinium monooximes: synthesis and biological activity
    • Sikder A.K., Ghosh A.K., Jaiswal D.K. Quaternary salts of 3,30-bis-pyridinium monooximes: synthesis and biological activity. J. Pharm. Sci. 1993, 82:258-261.
    • (1993) J. Pharm. Sci. , vol.82 , pp. 258-261
    • Sikder, A.K.1    Ghosh, A.K.2    Jaiswal, D.K.3
  • 109
    • 34147103909 scopus 로고    scopus 로고
    • A rapid cation-exchange HPLC method for detection and quantification of pyridinium oximes in plasma and tissue
    • Singh H., Moorad-Doctor D., Ratcliffe R.H., Wachtel K., Castillo A., Garcia G.E. A rapid cation-exchange HPLC method for detection and quantification of pyridinium oximes in plasma and tissue. J. Anal. Toxicol. 2007, 31:69-74.
    • (2007) J. Anal. Toxicol. , vol.31 , pp. 69-74
    • Singh, H.1    Moorad-Doctor, D.2    Ratcliffe, R.H.3    Wachtel, K.4    Castillo, A.5    Garcia, G.E.6
  • 110
    • 0032856873 scopus 로고    scopus 로고
    • Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphonylation of the enzyme
    • Skrinjaric-Spoljar M., Burger N., Lovric J. Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphonylation of the enzyme. J. Enzyme Inhib. 1999, 14:331-341.
    • (1999) J. Enzyme Inhib. , vol.14 , pp. 331-341
    • Skrinjaric-Spoljar, M.1    Burger, N.2    Lovric, J.3
  • 111
    • 33644816547 scopus 로고    scopus 로고
    • Quaternary salts of 4,30 and 4,40 bis-pyridinium monooximes. Part 2: Synthesis and biological activity
    • Srinivas Rao C., Venkateswarlu V., Achaiah G. Quaternary salts of 4,30 and 4,40 bis-pyridinium monooximes. Part 2: Synthesis and biological activity. Bioorg. Med. Chem. Lett. 2006, 16:2134-2138.
    • (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 2134-2138
    • Srinivas Rao, C.1    Venkateswarlu, V.2    Achaiah, G.3
  • 112
    • 0025778840 scopus 로고
    • Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein
    • Sussman J.L., Harel M., Frolow F., Oefner C., Goldman A., Toker L., Silman I. Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein. Science 1991, 253:872-879.
    • (1991) Science , vol.253 , pp. 872-879
    • Sussman, J.L.1    Harel, M.2    Frolow, F.3    Oefner, C.4    Goldman, A.5    Toker, L.6    Silman, I.7
  • 114
    • 33745976170 scopus 로고    scopus 로고
    • HPLC determination of the serum concentration of K-27, a novel oxime-type cholinesterase reactivator
    • Tekes K., Hasan M.Y., Sheen R., Kuca K., Petroianu G., Ludanyi K., Kalasz H. HPLC determination of the serum concentration of K-27, a novel oxime-type cholinesterase reactivator. J. Chromatogr. A 2006, 1122:84-87.
    • (2006) J. Chromatogr. A , vol.1122 , pp. 84-87
    • Tekes, K.1    Hasan, M.Y.2    Sheen, R.3    Kuca, K.4    Petroianu, G.5    Ludanyi, K.6    Kalasz, H.7
  • 115
    • 0042094972 scopus 로고    scopus 로고
    • Overview of sarin terrorist attacks in Japan
    • Tu A.T. Overview of sarin terrorist attacks in Japan. ACS Symposium Series 2000, 745:304-317.
    • (2000) ACS Symposium Series , vol.745 , pp. 304-317
    • Tu, A.T.1
  • 116
    • 33846782965 scopus 로고    scopus 로고
    • Cholinesterase inhibitors as chemical warfare agents: community preparedness guidelines. In Toxicology of Organophosphate and Carbamate Compounds (R.C. Gupta, ed.), Academic Press, Amsterdam.
    • Watson, A., Bakshi, K., Opresko, D., Young, R., Hauschild, V., King, J. (2006). Cholinesterase inhibitors as chemical warfare agents: community preparedness guidelines. In Toxicology of Organophosphate and Carbamate Compounds (R.C. Gupta, ed.), pp. 47-68. Academic Press, Amsterdam.
    • (2006) , pp. 47-68
    • Watson, A.1    Bakshi, K.2    Opresko, D.3    Young, R.4    Hauschild, V.5    King, J.6
  • 117
    • 0029554581 scopus 로고
    • Protein ligand interactions 7 halogenated pyridinium salts as inhibitors of acetylcholinesterase from electrophorus electricus
    • Whiteley C.G., Ngwenya D.S. Protein ligand interactions 7 halogenated pyridinium salts as inhibitors of acetylcholinesterase from electrophorus electricus. Biochem. Mol. Biol. Int. 1995, 36:1107-1116.
    • (1995) Biochem. Mol. Biol. Int. , vol.36 , pp. 1107-1116
    • Whiteley, C.G.1    Ngwenya, D.S.2
  • 118
    • 0029930604 scopus 로고    scopus 로고
    • Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds
    • Worek F., Kirchner T., Backer M., Szinicz L. Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. Arch. Toxicol. 1996, 70:497-503.
    • (1996) Arch. Toxicol. , vol.70 , pp. 497-503
    • Worek, F.1    Kirchner, T.2    Backer, M.3    Szinicz, L.4
  • 119
    • 0036381465 scopus 로고    scopus 로고
    • Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates
    • Worek F., Reiter G., Eyer P., Szinicz L. Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates. Arch. Toxicol. 2002, 76:523-529.
    • (2002) Arch. Toxicol. , vol.76 , pp. 523-529
    • Worek, F.1    Reiter, G.2    Eyer, P.3    Szinicz, L.4
  • 120
    • 0346963355 scopus 로고    scopus 로고
    • Synthesis of bis-pyridinium oxime antidotes using bis(methylsulfonoxymethyl) ether for organophosphate nerve agents
    • Yang G.Y., Yoon J.H., Seong C.M., Park N.S., Jung Y.S. Synthesis of bis-pyridinium oxime antidotes using bis(methylsulfonoxymethyl) ether for organophosphate nerve agents. Bull. Korean Chem. Soc. 2003, 24:1368-1370.
    • (2003) Bull. Korean Chem. Soc. , vol.24 , pp. 1368-1370
    • Yang, G.Y.1    Yoon, J.H.2    Seong, C.M.3    Park, N.S.4    Jung, Y.S.5
  • 121
    • 35348866954 scopus 로고    scopus 로고
    • 2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase
    • 2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase. Bioorg. Med. Chem. 2007, 15:7704-7710.
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 7704-7710
    • Yang, G.Y.1    Oh, K.A.2    Park, N.J.3    Jung, Y.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.